Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?

International Journal of Radiation Oncology Biology Physics

Volumn 63, Issue 3, 2005, Pages 745-752

  Mawdsley, Suzannah ^a   Glynne Jones, Rob ^a   Grainger, Juliet ^a   Richman, Paul ^a   Makris, Andreas ^a   Harrison, Mark ^a   Ashford, Richard ^a   Harrison, Richard A ^b   Osborne, Melanie ^a   Livingstone, Jeremy I ^c   MacDonald, Peter ^d   Mitchell, Ian C ^b   Meyrick Thomas, John ^c   Northover, John M A ^d   Windsor, Alastair ^d   Novell, Richard ^e   Wallace, Marina ^c  

^a MOUNT VERNON CANCER CENTRE   (United Kingdom)

^b BARNET HOSPITAL   (United Kingdom)

^c WATFORD GENERAL HOSPITAL   (United Kingdom)

^d NORTHWICK PARK HOSPITAL   (United Kingdom)

^e Gynaecology at Luton and Dunstable University Hospital   (United Kingdom)

Author keywords

Circumferential resection margin; Preoperative chemoradiotherapy; Prognostic factors; Rectal adenocarcinoma; Tumor downstaging

Indexed keywords

CHEMOTHERAPY; PATHOLOGY; PATIENT TREATMENT; RADIOTHERAPY;

LOCAL RECURRENCE; PATHOLOGIC DOWNSTAGING; RECTAL ADENOCARCINOMA;

ONCOLOGY;

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; FEMALE; FOLLOW UP; HISTOLOGY; HISTOPATHOLOGY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; PREDICTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; RECTUM CANCER; SURVIVAL TIME; VALIDATION PROCESS;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; MITOMYCIN; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASM, RESIDUAL; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; SURVIVAL RATE;

EID: 25844507873     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.03.003     Document Type: Article

References (39)

1. N. Wolmark, B. Fisher, H. Rockette Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer Results from NSABP protocol R-01 J Natl Cancer Inst 80 1988 21 29
2. W.E. Enker, N. Kemeny, B. Shank Defining the needs for adjuvant therapy of rectal and colonic cancer Surg Clin North Am 61 1981 1295 1310
3. E.L. Bokey, B. Ojerskog, P.H. Chapuis Local recurrence after curative excision of the rectum for cancer without adjuvant therapy Role of total anatomical dissection Br J Surg 86 1999 1164 1170
4. E. Kapiteijn, C.A. Marijnen, I.D. Nagtegaal Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer N Engl J Med 345 2001 638 646
5. F. Kockerling, M.A. Reymond, C. Schneider Laparoscopic Colorectal Surgery Study Group Prospective multicenter study of the quality of oncologic resections in patients undergoing laparoscopic colorectal surgery for cancer Dis Colon Rectum 41 1998 963 970
6. C.A. Marijnen, I.D. Nagtegaal, E. Kapiteijn Radiotherapy does not compensate for positive resection margins in rectal cancer patients Report of a multicenter randomized trial Int J Radiat Oncol Biol Phys 55 2003 1311 1320
7. K. Bujko, M.P. Nowacki, A. Nasierowska-Guttmejer Sphincter preservation following preoperative radiotherapy for rectal cancer Report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy Radiother Oncol 72 2004 15 24
8. J.E. Tepper, M. O'Connell, D. Niedzwiecki Adjuvant therapy in rectal cancer Analysis of stage, sex, and local control - Final report of intergroup 0114 J Clin Oncol 20 2002 1744 1750
9. L.L. Gunderson, D.J. Sargent, J.E. Tepper Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer A pooled analysis Int J Radiat Oncol Biol Phys 54 2002 386 396
10. A. Wibe, P.R. Rendedal, E. Svensson Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer Br J Surg 89 2002 327 334
11. G. Brown, S. Davies, G.T. Williams Effectiveness of preoperative staging in rectal cancer Digital rectal examination, endoluminal ultrasound, or magnetic resonance imaging? Br J Cancer 91 2004 23 29
12. I.D. Botterill, D.M. Blunt, P. Quirke Evaluation of the role of pre-operative magnetic resonance imaging in the management of rectal cancer Colorectal Dis 3 2001 295 303
13. R.G. Beets-Tan, G.L. Beets, R.F. Vliegen Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery Lancet 357 2001 497 504
14. I.P. Bissett, C.C. Fernando, D.M. Hough Identification of the fascia propria by magnetic resonance imaging and its relevance to preoperative assessment of rectal cancer Dis Colon Rectum 44 2001 259 265
15. B.D. Minsky, A.M. Cohen, M. Kemeny Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy J Clin Oncol 10 1992 79 84
16. M.W. Wichmann, C. Muller, G. Meyer Effect of preoperative radiochemotherapy on lymph node retrieval after resection of rectal cancer Arch Surg 137 2002 206 210
17. Medical Research Council Rectal Cancer Working Party Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum Lancet 348 1996 1610 1614
18. C. Camma, M. Giunta, F. Fiorica Preoperative radiotherapy for resectable rectal cancer A meta-analysis JAMA 284 2000 1008 1015
19. R. Sauer, H. Becker, W. Hohenberger Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 2004 1731 1740
20. V. Valentini, C. Coco, A. Picciocchi Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients Int J Radiat Oncol Biol Phys 53 2002 664 674
21. M. Mohiuddin, M. Hayne, W.F. Regine Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers Int J Radiat Oncol Biol Phys 48 2000 1075 1080
22. I.R. Daniels, B.J. Moran, R.J. Heald Surgery alone Is total mesorectal excision sufficient for rectal cancer? Front Radiat Ther Oncol 38 2004 28 36
23. P. Quirke, G.T. Williams Minimum dataset for colorectal cancer Royal College of Pathologists 1999
24. UICC TNM classification of malignant tumours 5th ed 1997 Wiley-Liss New York
25. P. Quirke, P. Durdey, M.F. Dixon Local recurrence of rectal adenocarcinoma due to inadequate surgical resection Histopathological study of lateral tumour spread and surgical excision Lancet 2 1986 996 999
26. B. Emami, M. Pilepich, C. Willett Effect of preoperative irradiation on resectability of colorectal carcinomas Int J Radiat Oncol Biol Phys 8 1982 1295 1299
27. L.L. Gunderson, A.C. Cohen, D.D. Dosoretz Residual, unresectable, or recurrent colorectal cancer External beam irradiation and intraoperative electron beam boost ± resection Int J Radiat Oncol Biol Phys 9 1983 1597 1606
28. W.M. Mendenhall, R.R. Million, K.I. Bland Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery Ann Surg 205 1987 41 44
29. J.E. Krook, C.G. Moertel, L.L. Gunderson Effective surgical adjuvant therapy for high-risk rectal carcinoma N Engl J Med 324 1991 709 715
30. Gastrointestinal Tumor Study Group Prolongation of the disease-free interval in surgically treated rectal carcinoma N Engl J Med 312 1985 1465 1472
31. K.M. Tveit, I. Guldvog, S. Hagen Norwegian Adjuvant Rectal Cancer Project Group Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer Br J Surg 84 1997 1130 1135
32. L. Ruo, S. Tickoo, D.S. Klimstra Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy Ann Surg 236 2002 75 81
33. P.T. Phang, J.K. MacFarlane, R.H. Taylor Effects of positive resection margin and tumor distance from anus on rectal cancer treatment outcomes Am J Surg 183 2002 504 508
34. P. Quirke, M.F. Dixon The prediction of local recurrence in rectal adenocarcinoma by histopathological examination Int J Colorectal Dis 3 1988 127 131
35. I.J. Adam, M.O. Mohamdee, I.G. Martin Role of circumferential margin involvement in the local recurrence of rectal cancer Lancet 344 1994 707 711
36. N.R. Hall, P.J. Finan, T. al-Jaberi Circumferential margin involvement after mesorectal excision of rectal cancer with curative intent Predictor of survival but not local recurrence? Dis Colon Rectum 41 1998 979 983
37. I.O. Ng, I.S. Luk, S.T. Yuen Surgical lateral clearance in resected rectal carcinomas A multivariate analysis of clinicopathologic features Cancer 71 1993 1972 1976
38. J.F. Bosset, G. Calais, A. Daban Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients Assessment of acute toxicity and treatment compliance - Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group Eur J Cancer 40 2004 219 224
39. N.R. Ahmad, A. Topham Pathologic complete response predicts long-term survival following preoperative radiotherapy for rectal cancer [Abstract] Int J Radiat Biol Phys 39 Suppl 1997 284