Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: Assessment of acute toxicity and treatment compliance: Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group

European Journal of Cancer

Volumn 40, Issue 2, 2004, Pages 219-224

  Bosset, J F ^a   Calais, G ^b   Daban, A ^c   Berger, C ^d   Radosevic Jelic, L ^e   Maingon, P ^f   Bardet, E ^g   Pierart, M ^h   Briffaux, A ^h  

^a UNIVERSITY HOSPITAL OF BESANÇON   (France)

^b UNIVERSITY HOSPITAL OF TOURS   (France)

^c POITIERS UNIVERSITY HOSPITAL   (France)

^d Clinic Avignon   (France)

^e INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA   (Serbia)

^f CENTRE GEORGES FRANÇOIS LECLERC   (France)

^g CENTRE RENÉ GAUDUCHEAU   (France)

^h EORTC DATA CENTER   (Belgium)

Author keywords

Preoperative treatment; Randomised trial; Rectal cancer; Toxicity

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLINIC ACID;

ACUTE DIARRHEA; ACUTE TOXICITY; ADULT; AGED; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL EXAMINATION; CLINICAL PROTOCOL; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTITIS; DEHYDRATION; DERMATITIS; DISEASE SEVERITY; DOSE RESPONSE; DRUG INFUSION; FEMALE; HUMAN; INFECTION; INTERMETHOD COMPARISON; LEUKOCYTE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PATIENT COMPLIANCE; PERINEUM INJURY; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; RECTUM CARCINOMA; RECTUM TUMOR; STOMATITIS; THROMBOCYTE; VOMITING;

EID: 0347285242     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2003.09.032     Document Type: Conference Paper

References (19)

1. Gatta G., Faivre J., Capocaccia R.et al. Survival of colorectal cancer patients in Europe during the period 1978-1989. Eur. J. Cancer. 34:1998;2176-2183.
2. Raab R., Meyer H.-J. Surgery for rectal cancer. Bleiberg H., Rougier P., Wilke H.-J. Management of Colorectal Cancer. 1998;55-65 Martin Dunitz, London.
3. Galandiuk S., Wieand H.S., Moertel G.C.et al. Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surgery. 174:1992;27-32.
4. Prolongation of the disease-free interval in surgically treated rectal carcinoma. N. Engl. J. Med. 312:1985;1465-1472.
5. Douglas H.O., Moertel C.G. Survival after postoperative combination treatment of rectal cancer. N. Engl. J. Med. 315:1986;1294.
6. Adjuvant therapy for patients with colon and rectal cancer. JAMA. 264:1990;1444-1449.
7. Bosset J.F., Horiot J.C. Adjuvant treatment in the curative management of rectal cancer. a critical review of the results of clinical randomised trials Eur. J. Cancer. 29A:1993;770-774.
8. Bosset J.F., Pavy J.J., Hamers H.P.et al. Determination of the optimal dose of 5-Fluorouracil when combined with low dose D,L-Leucovorin and irradiation in reactal cancer. results of three consecutive phase II studies Eur. J. Cancer. 29A:1993;1406-1410.
9. Bosset J.F., Pavy J.J., Bolla M.et al. Four Arms Phase III Clinical Trial for T3-T4 Resectable Rectal Cancer Comparing Preoperative Pelvic Irradiation to Preoperative Irradiation Combined with Fluorouracil and Leucovorin with or without Postoperative Adjuvant Chemotherapy. Eortc Radiotherapy Cooperative Group. Protocol No. 22921. 1992;EORTC Data Center, Brussels.
10. ICRU. International Commission on Radiation Units and Measurement, Dose Specification for Reporting External Beam Therapy with Photons and Electrons. ICRU report 29, 1978.
11. Miller A.B., Hoogstraten B., Staquet M., Winkler A. Reporting results of cancer treatment. Cancer. 47:1981;207-214.
12. Poon M.A., O'Connell M.J., Moertel G.C.et al. Biochemical modulation of fluorouracil. evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma J. Clin. Oncol. 7:1989;1407-1418.
13. Koelbl O., Richter S., Flentje M. Influence of patients positioning on dose-volume histogram and normal tissue complication probability for small bowell and bladder in patients receiving pelvic irradiation. a prospective study using a 3D planning system and a radiobiological model Int. J. Radiat. Oncol. Biol. Phys. 45:1999;1193-1198.
14. Mundt A.J., Lujan A.E., Rotmensch J.et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int. J. Radiat. Oncol. Biol. Phys. 52:2002;1330-1337.
15. Sauer R., Fietkau R., Witteking C.et al. Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer. A progress report of a phase-III randomised trial (Protocol CAO/ARO/AIO-94). Strahlenther Onkol. 177:2001;173-181.
16. Hyams D.M., Mamounas E.P., Petrelli N.et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. A progress report of national surgical adjuvant breast and bowel project protocol R-03. Dis. Colon Rectum. 40:1997;131-139.
17. O'Connel M.J., Martenson J.A., Wieand H.S.et al. Improving adjuvant therapy of rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N. Engl. J. Med. 331:1994;502-507.
18. Initial report from a Swedhish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Br. J. Surg. 80:1993;1333-1336.
19. Marijnen C.A.M., Kapiteijn E., van de Velde C.J.H.et al. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer. report of a multicenter randomized trial J. Clin. Oncol. 20:2002;817-825.