Synthesis and activity of tyropeptin A derivatives as potent and selective inhibitors of mammalian 20S proteasome

Bioscience, Biotechnology and Biochemistry

Volumn 69, Issue 9, 2005, Pages 1733-1742

  Momose, Isao ^a   Umezawa, Yoji ^b   Hirosawa, Sehei ^c   Iijima, Masatomi ^a   Iinuma, Hironobu ^b   Ikeda, Daishiro ^a  

^a Numazu Bio Medical Research Institute   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^c Microbial Chemistry Research Center   (Japan)

Author keywords

Proteasome inhibitor; Tyropeptin A derivative

Indexed keywords

BIOSYNTHESIS; CELLS; DERIVATIVES; ENZYME INHIBITION; ENZYMES; GROWTH KINETICS;

ENZYME ACTIVITIES; POTENT COMPOUNDS; PROTEASOME INHIBITORS; TYROPEPTIN A DERIVATIVES;

POLYPEPTIDES;

1 NAPHTHYLACETYL (O METHYL) TYROSYL VALYL (O METHYL) TYROSINAL; 1-NAPHTHYLACETYL-(O-METHYL)-TYROSYL-VALYL-(O-METHYL)-TYROSINAL; ANTINEOPLASTIC AGENT; CHYMOTRYPSIN; DIPEPTIDE; OLIGOPEPTIDE; PROTEASOME; TYROPEPTIN A;

ANIMAL; ARTICLE; CELL PROLIFERATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; HUMAN; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHYMOTRYPSIN; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; OLIGOPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX;

KITASATOSPORA; MAMMALIA;

EID: 25844501335     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.69.1733     Document Type: Article

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