Angiotensin II AT 1 receptor mutants expressed in CHO cells caused morphological change and inhibition of cell growth

Regulatory Peptides

Volumn 131, Issue 1-3, 2005, Pages 18-22

  Correa, Silvana A A ^a   Pacheco, Nelson A S ^a   Costa Neto, Claudio M ^b   Oliveira, Laerte ^a   Pesquero, João B ^a   Han, Sang W ^a   Paiva, Antonio C M ^a   Shimuta, Suma I ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

AT 1 receptor; Ca +2 signaling; Cell proliferation; Cyclic AMP; Morphology regulation; Mutagenesis

Indexed keywords

ADENYLATE CYCLASE; ANGIOTENSIN 1 RECEPTOR; CALCIUM ION; CYCLIC AMP; FORSKOLIN; LEUCINE; CALCIUM;

ANIMAL CELL; ARTICLE; CARCINOGENIC ACTIVITY; CELL GROWTH; CELL STIMULATION; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOARCHITECTURE; DNA SYNTHESIS; ENZYME INHIBITION; FEMALE; GROWTH REGULATION; INHIBITION KINETICS; MUTANT; NONHUMAN; PEPTIDE SYNTHESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; WILD TYPE; ANIMAL; CELL PROLIFERATION; CELL SHAPE; CHO CELL; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CELL PROLIFERATION; CELL SHAPE; CHO CELLS; CRICETINAE; CYCLIC AMP; FORSKOLIN; LEUCINE; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION;

EID: 25844490474     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2005.05.005     Document Type: Article

References (26)

1. S. Kim, and H. Iwao Molecular and cellular mechanisms of angiotensin II mediated cardiovascular and renal diseases Pharmacol Rev 52 2000 11 34
2. K.M. Baker, G.W. Booz, and D.E. Dostal Cardiac actions of angiotensin II role of an intracardiac renin-angiotensin system Ann Ver Physiol 54 1992 227 247
3. W. Schorb, T.C. Peeler, N.N. Madigan, K.M. Conrad, and K.M. Baker Angiotensin II induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblast J Biol Chem 269 1994 19626 19632
4. W. Schorb, H.A. Singer, D.E. Dostal, and K.M. Baker Angiotensin II is a potent simulator of MAP-kinase activity in neonatal rat cardiac fibroblasts J Mol Cell Cardiol 27 1995 1151 1160
5. M.C. Johnson, and G. Aguilera Studies on the mechanism of the novel stimulatory effect of angiotensin-II on adenylate cyclase in rat fetal skin fibroblasts Endocrinology 131 1992 2404 2412
6. T. Inagami, and S. Eguchi Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase Regul Pept 91 2000 13 20
7. J. Ohnishi, M. Ishido, T. Shibata, T. Inagami, K. Murakami, and H. Miyazaki The rat angiotensin II AT1A receptor couples with three different signal transduction pathways Biochem Biophys Res Commun 186 1992 1094 1101
8. S. Kuroda, H. Konishi, M. Okishio, and Y. Fujisawa Novel subtype of human angiotensin II type 1 receptor: analysis of signal transduction mechanism in transfected Chinese hamster ovary cells Biochem Biophys Res Commun 199 1994 475 481
9. S.A.A. Correa, H. Zalcberg, S.W. Han, C.M. Costa-Neto, L. Oliveira, and A.C.M. Paiva Aliphatic amino acids in helix VI of the AT(1) receptor play a relevant role in agonist binding and activity Regul Pept 106 2002 33 38
10. D. Singer-Lahat, A.L. Ma, and C. Felder Independent induction of morphological transformation of CHO cells by receptor-activated cyclic AMP synthesis or by receptor-operated calcium influx Biochem Pharmacol 1996 495 502
11. 1 cells Mol Cell Biochem 152 1995 77 86
12. K. Sobue Actin-based cytoskeleton in growth cone activity Neurosci Res 18 1993 91 102
13. 2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts J Biol Chem 266 1991 1403 1409
14. F. Horn, J. Weare, M.W. Beukers, S. Horsch, A. Bairoch, and W. Chen Cyclic AMPagne F, Vriend G. GPCRDB: an information system for G protein-coupled receptors Nucleic Acids Res 26 1998 275 279 GPCRDB, available at: www.cmbi.bun.ne/7.
15. 1 receptor Eur J Pharmacol 476 2003 25 30
16. J. Sambrook, E.F. Fritsch, and T. Maniatis Plasmid vectors: extraction and purification of plasmid DNA Molecular Cloning 1989 Cold Spring Harbor Laboratory Press 1.21 1.32
17. 1]-angiotensin: II Reg Pept 119 2004 183 188
18. S.S. Taylor, J.A. Buechler, and W. Yonemoto cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes Annu Rev Biochem 59 1990 971 1005
19. F. Ashall, N. Sullivan, and T.T. Puck Specificity of the cAMP-induced gene exposure reaction in CHO cells Proc Natl Acad Sci U S A 85 1988 3908 3912
20. A. Sachinidis, C. Seul, I. Gouni-Berthold, S. Seewald, Y. Ko, and H. Vetter Cholera toxin treatment of vascular smooth muscle cells decreases smooth muscle α-actin content and abolishes the platelet-derived growth factor-BB-stimulated DNA synthesis 130 2000 1561 1570
21. K. Hogarth, N. Sandho, S. Tauein, V. Kolenko, J.M. Miano, and N.O. Dulin Ddual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP Am J Physiol 287 2004 C449 C456
22. 1 angiotensin receptor is generated by angiotensin II induction Biochemistry 35 1996 16435 16442
23. 1A angiotensin II receptor induces its constitutive activation J Biol Chem 272 1997 1822 1826
24. S. Miura, and S.S. Karnick Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane helix-2 J Biol Chem 277 2002 24299 24305
25. A.A. Boucard, M. Roy, M.-E. Beaulieu, P. Lavigne, E. Escher, and G. Guillemette Constitutive activation of the angiotensin II type I alters the spatial proximity of transmembrane 7 to the ligand-binding pocket J Biol Chem 278 2003 36628 36636
26. T. Thekkumkara, and S.L. Linas Evidence for involvement of 3′-untranslated region in determining angiotensin II receptor coupling specificity to G-protein Biochem J 370 2003 631 639