Independent induction of morphological transformation of CHO cells by receptor-activated cyclic AMP synthesis or by receptor-operated calcium influx

Biochemical Pharmacology

Volumn 51, Issue 4, 1996, Pages 495-502

  Singer Lahat, Dafna ^a   Ma, Alice L ^a   Felder, Christian C ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Adenylate cyclase; Morphological transformation of cells; Phospholipase C; Receptor; Receptor operated calcium channel; Second messengers

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; ADENYLATE CYCLASE; ARGIPRESSIN; CALCIUM; CALCIUM CHANNEL; CARBACHOL; CYCLIC AMP; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; FORSKOLIN; INOSITOL 1,4,5 TRISPHOSPHATE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M5 RECEPTOR; PHOSPHOLIPASE C; PROSTAGLANDIN E2; RECEPTOR; UNCLASSIFIED DRUG; VASOPRESSIN V1A RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL STRUCTURE; CELL TRANSFORMATION; CHO CELL; CONTROLLED STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ANIMALS; ARGININE VASOPRESSIN; CALCIUM; CARBACHOL; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CHO CELLS; CRICETINAE; CYCLIC AMP; DINOPROSTONE; DOPAMINE AGONISTS; GTP-BINDING PROTEINS; INOSITOL 1,4,5-TRISPHOSPHATE; KINETICS; RECEPTORS, CELL SURFACE; RECEPTORS, DOPAMINE D1; RECEPTORS, MUSCARINIC; RECEPTORS, VASOPRESSIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 0030030441     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02226-0     Document Type: Article

References (22)

1. Julius D, Livelli TJ, Jessell TM and Axel R, Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 244: 1057-1062, 1989.
2. 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci USA 88: 11354-11358, 1991.
3. Gutkind JS, Novotny EA, Brann MR and Robbins KC, Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci USA 88: 4703-4707, 1991.
4. Felder CC, MacArthur L, Ma AL, Gusovsky F and Kohn EC, Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx. Proc Natl Acad Sci USA 90: 1706-1710, 1993.
5. Ashall F, Sullivan N and Puck TT, Specificity of the cAMP-induced gene exposure reaction in CHO cells. Proc Natl Acad Sci USA 85: 3908-3912, 1988.
6. Guerrant RL, Brunton LL, Schnaitman TC, Rebhun LI and Gilman AG, Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: A rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun 10: 320-327, 1974.
7. Puck TT, Cyclic AMP, the microtubule-microfilament system, and cancer. Proc Natl Acad Sci USA 74: 4491-4495, 1977.
8. Puck TT, Studies on cell transformation. Somat Cell Genet 5: 973-990, 1979.
9. Ashall F and Puck TT, Cytoskeleton involvement in cAMP-induced sensitization of chromatin to nuclease digestion in transformed Chinese hamster ovary K1 cells. Proc Natl Acad Sci USA 81: 5145-5149, 1984.
10. Felder CC, Ma AL and Conklin BR, Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor. FEBS Lett 245: 75-79, 1989.
11. Felder CC, Ma AL, Liotta LA and Kohn EC, The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther 257: 967-971, 1991.
12. Bonner TI, Young AC, Brann MR and Buckley NJ, Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron 1: 403-410, 1988.
13. Sobue K, Actin-based cytoskeleton in growth cone activity. Neurosci Res 18: 91-102, 1993.
14. 2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts. J Biol Chem 266: 1403-1409, 1991.
15. Felder CC, Kanterman RY, Ma AL and Axelrod J, A transfected m1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis. J Biol Chem 264: 20356-20362, 1989.
16. 2+. Proc Natl Acad Sci USA 89: 509-513, 1992.
17. Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI and Axelrod J, Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc Natl Acad Sci USA 85: 8698-8702, 1988.
18. Gusovsky F, Lueders JE, Kohn EC and Felder CC, Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-γ. J Biol Chem 268: 7768-7772, 1993.
19. Gurwitz D, Haring R, Heldman E, Fraser CM, Manor D and Fisher A, Discrete activation of transduction pathways associated with acetylcholine m1 receptor by several muscarinic ligands. Eur J Pharmacol 267: 21-31, 1994.
20. Thibonnier M, Signal transduction of V1a-vascular vasopressin receptors. Regul Pept 38: 1-11, 1992.
21. 2, phospholipase C, and phospholipase D through activation of receptor-operated calcium channels. Neuropeptides 27: 63-74, 1994.
22. Felder CC, Singer-Lahat D and Mathes C, Voltage-independent calcium channels: Regulation by receptors and intracellular calcium stores. Biochem Pharmacol 48: 1997-2004, 1994.