Aliphatic amino acids in helix VI of the AT1 receptor play a relevant role in agonist binding and activity

Regulatory Peptides

Volumn 106, Issue 1-3, 2002, Pages 33-38

  Correa, Silvana A A ^a   Zalcberg, Heloisa ^a   Han, Sang W ^a   Oliveira, Laerte ^a   Costa Neto, Claudio M ^a   Paiva, Antonio C M ^a   Shimuta, Suma I ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin II; CHO cells; Inositol phosphate; Mutant receptors; Receptor binding

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II [1 SARCOSINE 8 ISOLEUCINE]; INOSITOL PHOSPHATE; LOSARTAN; RHODOPSIN; AMINO ACID; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; LIGAND;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; IC 50; LIGAND BINDING; LIPID BILAYER; MOLECULAR MODEL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DRUG POTENTIATION; FEMALE; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACIDS; ANGIOTENSIN II; ANIMAL; CHO CELLS; FEMALE; HAMSTERS; INOSITOL PHOSPHATES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; ANIMALS; CRICETINAE; RECEPTOR, ANGIOTENSIN, TYPE 1;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0037096137     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(02)00033-2     Document Type: Article

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