Hot flashes revisited: Pharmacological and herbal options for hot flashes management. What does the evidence tell us?

Acta Obstetricia et Gynecologica Scandinavica

Volumn 84, Issue 10, 2005, Pages 972-979

  Haimov Kochman, Ronit ^a   Hochner Celnikier, Drorith ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Alternative treatment; Herbal; Hot flashes; Menopause

Indexed keywords

ALPHA TOCOPHEROL; ANGELICA SINENSIS EXTRACT; BIOCHANIN A; CIMICIFUGA RACEMOSA EXTRACT; CLONIDINE; COUMESTROL; DAIDZEIN; ESTRADIOL; ESTROGEN; FLUOXETINE; FORMONONETIN; GABAPENTIN; GENISTEIN; GINSENG EXTRACT; ISOFLAVONE; ISOFLAVONE DERIVATIVE; LOFEXIDINE; MEDROXYPROGESTERONE; METHYLDOPA; PAROXETINE; PHYTOESTROGEN; PLANT EXTRACT; PRIMROSE OIL; PROGESTERONE; RED CLOVER EXTRACT; TAMOXIFEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VENLAFAXINE; VITEX AGNUS CASTUS EXTRACT; YAM EXTRACT;

ALTERNATIVE MEDICINE; ANOREXIA; BLOATING; CLINICAL TRIAL; CONSTIPATION; DEPRESSION; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG TOLERABILITY; ESTROGEN ACTIVITY; ESTROGEN THERAPY; FATIGUE; GASTROINTESTINAL SYMPTOM; HEADACHE; HERBAL MEDICINE; HOT FLUSH; HUMAN; LIPID BLOOD LEVEL; MENOPAUSE; NAUSEA; NONHUMAN; PRIORITY JOURNAL; RASH; REVIEW; SIDE EFFECT; SOYBEAN; SYMPTOM; UTERUS BLEEDING; XEROSTOMIA; YAM;

ADRENERGIC ALPHA-AGONISTS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; CLINICAL TRIALS; FEMALE; HOT FLASHES; HUMANS; MENOPAUSE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 25844459982     PISSN: 00016349     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0001-6349.2005.00769.x     Document Type: Review

References (48)

1. Kronenberg F. Hot flashes. In: Lobo RA (ed). Treatment of the Postmenopausal Woman. Basic and Clinical Aspects. Philadelphia, Lippincott: Williams & Wilkins 1999, 157-77.
2. Speroff L, Gass RH, Kase NG. Clinical Gynecologic Endocrinology and Infertility, 6th edn. Baltimore, Lippincott: Williams & Wilkins 1999, 643-724.
3. Bachmann GA. Vasomotor flushes in menopausal women. Am J Obstet Gynecol 1999; 180.
4. Wilson RA. Feminine Forever. New York: Evans (with Lipincott) 1966.
5. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321-33.
6. MacLennan A, Lester S, Moore V. Oral oestrogen replacement therapy versus placebo for hot flushes. Cochrane Database Syst Rev 2001: (1): CD002978.
7. Bullock JL, Massey FM, Gambrell RD Jr. Use of medroxyprogesterone acetate to prevent menopausal symptoms. Obstet Gynecol 1975; 46: 165-8.
8. Lobo RA, McCormick W, Singer F, Roy S. Depo-medroxyprogesterone acetate compared with conjugated estrogens for the treatment of postmenopausal women. Obstet Gynecol 1984; 63: 1-5.
9. Schiff I, Tulchinsky D, Cramer D, Ryan KJ. Oral medroxyprogesterone in the treatment of postmenopausal symptoms. JAMA 1980; 244: 1443-5.
10. Morrison JC, Martin DC, Blair RA, Anderson GD, Kincheloe BW, Bates GW et al. The use of medroxyprogesterone acetate for relief of climacteric symptoms. Am J Obstet Gynecol 1980; 138: 99-104.
11. Leonetti HB, Longo S, Anasti JN. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol 1999; 94: 225-8.
12. Wren BG, Champion SM, Willetts K, Manga RZ, Eden JA. Transdermal progesterone and its effect on vasomotor symptoms, blood lipid levels, bone metabolic markers, moods, and quality of life for postmenopausal women. Menopause 2003; 10: 13-8.
13. Nesheim BI, Saetre T. Reduction of menopausal hot flushes by methyldopa. A double blind crossover trial. Eur J Clin Pharmacol 1981; 20: 413-6.
14. Andersen O, Engebretsen T, Solberg VM, Orbo A. Alpha-Methyldopa for climacteric hot flushes. A double-blind, randomized, cross-over study. Acta Obstet Gynecol Scand 1986; 65: 405-9.
15. Wren BG, Brown LB. A double-blind trial with clonidine and a placebo to treat hot flushes. Med J Aust 1986; 144: 369-70.
16. Gass ML, Taylor MB. Alternatives for women through menopause. Am J Obstet Gynecol 2001; 185: 147-56.
17. Jones KP, Ravnikar V, Schiff I. A preliminary evaluation of the effect of lofexidine on vasomotor flushes in post-menopausal women. Maturitas 1985; 7: 135-9.
18. Stearns V, Isaacs C, Rowland J, Crawford J, Ellis MJ, Kramer R et al. A pilot trial assessing the efficacy of paroxetine hydrochloride (Paxil) in controlling hot flashes in breast cancer survivors. Ann Oncol 2000; 11: 17-22.
19. Loprinzi CL, Pisansky TM, Fonseca R, Sloan JA, Zahasky KM, Quella SK et al. Pilot evaluation of venlafaxine hydrochloride for the therapy of hot flashes in cancer survivors. J Clin Oncol 1998; 16: 2377-81.
20. Stearns V, Beebe KL, Iyengar M, Dube E. Paroxetine controlled release in the treatment of menopausal hot flashes: A randomized controlled trial. JAMA 2003; 289: 2827-34.
21. Loprinzi CL, Sloan JA, Perez EA, Quella SK, Stella PJ, Milliad JA et al. Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol 2003; 20: 1578-83.
22. Loprinzi CL, Kugler JW, Sloan JA, Mailliard JA, LaVasseur BI, Barton DL et al. Venlafaxine in management of hot flashes in survivors of breast cancer: A randomised controlled trial. Lancet 2000; 356: 2059-63.
23. Loprinzi L, Barton DL, Sloan JA, Zahasky KM, Smith de AR, Pruthi S et al. Pilot evaluation of gabapentin for treating hot flashes. Mayo Clin Proc 2002; 77: 1159-63.
24. Albertazzi P, Bottazzi M, Purdie DW. Gabapentin for the management of hot flushes: a case series. Menopause 2003; 10: 214-7.
25. Guttuso T, Kurlan R, McDermott MP, Kieburtz K. Gabapentin's effects on hot flashes in postmenopausal women: a randomized controlled trial. Obstet Gynecol 2003; 101: 337-45.
26. Dietary Supplement Health and Education Act of 1994. S784.
27. North American Menopause Society. Treatment of menopause-associated vasomotor symptoms, position statement of The North American Menopause Society. Menopause 2004; 11: 11-33.
28. Shu XO, Jin F, Dai Q, Wen W, Potter JD, Kushi LH et al. Soyfood Intake during Adolescence and Subsequent Risk of Breast Cancer among Chinese Women. Cancer Epidemiol Biomarkers Prev 2001; 10: 483-8.
29. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Sag PT et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 4252-63.
30. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms, a review of randomized, controlled trials. Ann Intern Med 2002; 137: 805-13.
31. Burke GL, Legault C, Anthony M, Bland DR, Morgan TM, Naughton MJ et al. Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study. Menopause 2003; 10: 147-53.
32. Penotti M, Fabio E, Modena AB, Rinaldi M, Omodei U, Vigano P. Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril 2003; 79: 1112-7.
33. Mahady GB. Is black cohosh estrogenic? Nutr Rev 2003; 61: 183-6.
34. Lupu R, Mehmi I, Atlas E, Tsai MS, Pisha E, Oketch-Rabah HA et al. Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth. Int J Oncol 2003; 23: 1407-12.
35. Hernandez Munoz G, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 2003; 44: 59-65.
36. Huntley A, Ernst E. A systematic review of the safety of black cohosh. Menopause 2003; 10: 58-64.
37. Tyler VE, Foster S. Tyler's Honest Herbal, 4th edn. Binghamton, NY: The Hawthorn Press 1999.
38. Hoffman PC, Combs DK, Brehm NM, Welch DA. Performance of lactating dairy cows fed red clover or alfalfa silage. J Dairy Sci 1997; 80: 3308-15.
39. Baber RJ, Templeman C, Morton T, Kelly GE, West L. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric 1999; 2: 85-92.
40. Knight DC, Howes JB, Eden JA. The effect of Promensil, an isoflavone extract, on menopausal symptoms. Climacteric 1999; 2: 79-84.
41. Tice JA, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings SR. Phytoestrogen supplements for the treatment of hot flashes: The Isoflavone Clover Extract (ICE) Study: A randomized controlled trial. JAMA 2003; 290: 207-14.
42. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs and spices. Proc Soc Exp Biol Med 1998; 217: 369-78.
43. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002; 9: 145-50.
44. Hirata JD, Swiersz LM, Zell B. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997; 68: 981-6.
45. Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: A double-blind, placebo-controlled trial. Swedish alternative medicine group. Int J Clin Pharmacol Res 1999; 19: 89-99.
46. Barton DL, Loprinzi CL, Quella SK, Sloan JA, Veeder MH, Egner JR et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol 1998; 16: 495-500.
47. Chenoy R, Hussain S, Tayob Y, O'Brien PM, Moss MY, Morse PF. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. BMJ 1994; 308: 501-3.
48. Komesaroff PA, Black CV, Cable V, Sudhir K. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001; 4: 144-50.