Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease

American Journal of Gastroenterology

Volumn 100, Issue 8, 2005, Pages 1788-1795

  Di Sabatino, Antonio ^b   Rosado, Maria Manuela ^b   Ciccocioppo, Rachele ^b   Cazzola, Paolo ^b   Morera, Raffaele ^b   Corazza, Gino Roberto ^a   Carsetti, Rita ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENTERITIS; ERYTHROCYTE COUNT; FLOW CYTOMETRY; HUMAN; INTESTINE BIOPSY; INTESTINE MUCOSA; MEMORY CELL; PRIORITY JOURNAL; SPLEEN DISEASE; SPLEEN FUNCTION; ULCERATIVE COLITIS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; SPLEEN; SPLENECTOMY;

ADULT; AGED; B-LYMPHOCYTES; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; INFLAMMATORY BOWEL DISEASES; MIDDLE AGED; SPLEEN; SPLENECTOMY;

EID: 25644453573     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.41939.x     Document Type: Article

References (29)

1. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003;3:521-33.
2. Di Sabatino A, Corazza GR. Surviving too long in Crohn's disease. Gut 2001;49:6-8.
3. MacDermott RP, Nash GS, Bertovich MJ, et al. Alterations of IgM, IgG, and IgA synthesis and secretion by peripheral blood and intestinal mononuclear cells from patients with ulcerative colitis and Crohn's disease. Gastroenterology 1981;81:844-52.
4. Mizoguchi E, Mizoguchi A, Freffer FI, et al. Regulatory role of mature B-cells in a murine model of inflammatory bowel disease. Int Immunol 2000;12:597-605.
5. Mizoguchi A, Mizoguchi E, Smith RN, et al. Suppressive role of B cells in chronic colitis of T cell receptor α mutant mice. J Exp Med 1997;186:1749-56.
6. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998;188:1679-89.
7. + B cells are crucial in secondary immune response by producing high affinity IgM. Clin Immunol 2003;108:128-37.
8. Liu YJ, Malisan F, de Bouteiller O, et al. Within germinal centers, isotype switching of immunoglobulins genes occurs after the onset of somatic mutation. Immunity 1996;4:241-50.
9. Kruetzmann S, Rosado MM, Weber H, et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med 2003;197:939-45.
10. Carsetti R, Rosado MM, Wardemann H. Peripheral development of B cells in mouse and man. Immunol Rev 2004;197:179-91.
11. Muller AF, Cornford E, Toghill PJ. Splenic function in inflammatory bowel disease: Assessment by differential interference microscopy and splenic ultrasound. Q J Med 1993;86:333-40.
12. Corazza GR, Gasbarrini G. Defective splenic function and its relation to bowel disease. Clin Gastroenterol 1983;12:651-69.
13. Muller AF, Toghill PJ. Hyposplenism in gastrointestinal disease. Gut 1995;36:165-7.
14. Corazza GR, Bullen AW, Hall R, et al. Simple method of assessing splenic function in coeliac disease. Clin Sci 1981;60:109-13.
15. Best WR, Becktel JM, Singleton JW, et al. Development of a Crohn's disease activity index: National Cooperative Crohn's Disease Study. Gastroenterology 1976;70:439-44.
16. Rachmilewitz D. Coated mesalazine (5-aminosalicylic acid) versus sulfasalazine in the treatment of active ulcerative colitis: A randomized study. BMJ 1989;298:82-6.
17. Zoli G, Corazza GR, D'Amato G, et al. Splenic autotransplantation after splenectomy: Tuftsin activity correlates with residual splenic function. Br J Surg 1994;81:716-8.
18. Di Sabatino A, Ciccocioppo R, Cinque B, et al. Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease. Gut 2004;53:70-7.
19. Nitschke L, Carsetti R, Ocker B, et al. CD22 is a negative regulator of B-cell receptor signalling. Curr Biol 1997;7:133-43.
20. Cucino C, Sonnenberg A. The comorbid occurrence of other diagnosis in patients with ulcerative colitis and Crohn's disease. Am J Gastroenterol 2001;96:2107-12.
21. Ryan FP, Smart RC, Holdsworth CD, et al. Hyposplenism in inflammatory bowel disease. Gut 1978;19:50-5.
22. Palmer KR, Sherriff SB, Holdsworth CD, et al. Further experience of hyposplenism in inflammatory bowel disease. Q J Med 1981;50:463-71.
23. Foster KJ, Devitt N, Gallagher PJ, et al. Overwhelming pneumococcal septicaemia in a patient with ulcerative colitis and splenic atrophy. Gut 1982;23:630-2.
24. Pereira JLR, Hughes LE, Young HL. Spleen size in patients with inflammatory bowel disease: Does it have any clinical significance? Dis Colon Rectum 1987;30:403-9.
25. Bell SJ, Kamm MA. Review article: The clinical role of anti-TNFα antibody treatment in Crohn's disease. Aliment Pharmacol Ther 2000;14:501-4.
26. van der Poll T, Keogh CV, Buurman WA, et al. Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice. Am J Respir Crit Care Med 1997;155:603-8.
27. Ritz MA, Jost R. Severe pneumococcal pneumonia following treatment with infliximab for Crohn's disease. Inflamm Bowel Dis 2001;7:327.
28. Martin F, Kearney JF. Marginal-zone B cells. Nat Rev Immunol 2002;2:323-35.
29. Dalwadi H, Wei B, Schrage M, et al. B cell developmental requirement for the G αi2 gene. J Immunol 2003;170:1707-15.