Drug-induced agranulocytosis: Impact of different Fcγ receptor polymorphisms?

Journal of Clinical Psychopharmacology

Volumn 25, Issue 5, 2005, Pages 435-440

  Mosyagin, Igor ^a,b   Cascorbi, Ingolf ^a,b   Schaub, Rainer ^c   Krüger, Timo ^d   Dettling, Michael ^d  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c Center for Psychiatry   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; FC GAMMA RECEPTOR IIA; FC GAMMA RECEPTOR IIIA; FC GAMMA RECEPTOR IIIB; FC RECEPTOR; TICLOPIDINE; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; AGRANULOCYTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; HIGH RISK PATIENT; HLA TYPING; HUMAN; IMMUNOGENETICS; MAJOR CLINICAL STUDY; MALE; ORGANIC BRAIN SYNDROME; PARANOID SCHIZOPHRENIA; PRIORITY JOURNAL; RARE DISEASE; SCHIZOAFFECTIVE PSYCHOSIS;

ADULT; AGRANULOCYTOSIS; ANTIPSYCHOTIC AGENTS; ANTITHYROID AGENTS; CLOZAPINE; DNA; FEMALE; FIBRINOLYTIC AGENTS; GENOTYPE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, IGG; TICLOPIDINE;

EID: 25444520580     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jcp.0000177551.13714.33     Document Type: Article

References (29)

1. Patton WN, Duffull SB. Idiosyncratic drug-induced hematological abnormalities: incidence, pathogenesis, management and avoidance. Drug Saf. 1994;11:445-462.
2. Andrès E, Kurtz JE, Maloisel F. Nonchemotherapy drug-induced agranulocytosis: experience of the Strasbourg teaching hospital (1985-2000) and review of the literature. Clin Lab Haematol. 2002;24:99-106.
3. Liu ZC, Uetrecht JP. Metabolism of ticlopidine by activated neutrophils: implications for ticlopidine-induced agranulocytosis. Drug Metab Dispos. 2000;28:726-730.
4. Ono K, Kurohara K, Yoshihara M, et al. Agranulocytosis caused by ticlopidine and its mechanisms. Am J Hematol. 1991;37:239-242.
5. Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993;329:162-167.
6. Guest I, Sokoluk B, Mac Crimmon J, et al. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. Toxicology. 1998;131:53-65.
7. Uetrecht JP. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metab Rev. 1992;24:299-366.
8. Dettling M, Cascorbi I, Roots I, et al. Genetic determinants of clozapine-induced agranulocytosis: recent results of HLA-subtyping in a non-Jewish Caucasian sample. Arch Gen Psychiatry. 2001;58:93-94.
9. Dearon M. Structural basis of Fc-y R functions. Int Rev Immunol. 1997;16:1-27.
10. van der Pol WL, van de Winkel JGJ. IgG receptor polymorphisms: risk factors for disease. Immunogenetics. 1998;48:222-232.
11. Tridanapani S, Siefker K, Teillaud JL, et al. Regulated expression and inhibitory function of Fcγ RIIb in human monocytic cells. J Biol Chem. 2002;277:5082-5089.
12. Taniuchi S, Masuda M, Yamamoto A, et al. Fc RIIIb and Fc RIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy. Hum Immunol. 2001;62:408-413.
13. Sondermann P, Kaiser J, Jacob U. Molecular basis for immune complex recognition: a comparison of Fc receptor structures. J Mol Biol. 2002;309:737-749.
14. Carlsson LE, Santoso S, Baurichter G, et al. Heparin-induced thrombocytopenia: new insights into the impact of the Fcγ RIIa-R-H131 polymorphism. Blood. 1998;92:1526-1531.
15. Koene HR, Kleijer M, Algra J, et al. Fcγ RIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fcγ RIIIa, independently of the Fcγ RIIIa-48L/R/H phenotype. Blood. 1997;90:1109-1114.
16. Bux J. Molecular nature of granulocyte antigens. Transfus Clin Biol. 2001;8:242-247.
17. Huizinga TW, Kleijer M, Tetteroo PA, et al. Biallelic neutrophil antigen systems is associated with a polymorphism on the phospho-inositol-linked Fcγ receptor III (CD16). Blood. 1990;75:213-217.
18. Flesch BK, Bauer F, Neppert J. Rapid typing of the human Fcγ receptor IIa polymorphism by polymerase chain reaction amplification with allele-specific primers. Transfusion. 1998;38:174-176.
19. Leppers-van de Straat FG, van der Pol WL, Jansen MD, et al. A novel PCR-based method for direct Fcγ receptor IIIa (CD16) allotyping. J Immunol Methods. 2000;28:127-132.
20. de Haas M, Kleijer M, van Zwieten R, et al. Neutrophil Fcγ RIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families. Blood. 1995;86:2403-2413.
21. Andres E, Noel E, Kurtz JE, et al. Life-threatening idiosyncratic drug-induced agranulocytosis in elderly patients. Drugs Aging. 2004;21:427-435.
22. Van der Klauw M, Goudsmit R, Halie MR, et al. A population-based case-cohort study of drug-associated agranulocytosis. Arch Intern Med. 1999;159:369-374.
23. Rekand T, Langeland N, Aarli JA, et al. Fcgamma receptor IIIA polymorphism as a risk factor for acute poliomyelitis. J Infect Dis. 2002;186:1840-1843.
24. Dettling M, Schaub RT, Mueller-Oerlinghausen B, et al. Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry. Pharmacogenetics. 2001;11:135-141.
25. Matsuo K, Procter J, Stroncek D. Variations in genes encoding neutrophil antigens NA1 and NA2. Transfusion. 2000;40:645-653.
26. Claas FHJ, Abort PA, Witvliet MD, et al. No direct clinical relevance of the human leukocyte antigen (HLA-) system in clozapine-induced agranulocytosis. Drug Saf. 1992;7(suppl 1):3-6.
27. Akamizu T, Ozaki S, Hiratani H, et al. Drug-induced neutropenia associated with anti-neutrophil cytoplasmatic antibodies (ANCA): possible involvement of complement in granulocyte toxicity. Clin Exp Immunol. 2002;127:92-98.
28. Galati G, Tafazoli S, Sabzevari O, et al. Idiosyncratic NSAID drug induced oxidative stress. Chem Biol Interact. 2002;142:25-41.
29. Loeffler S, Fehsel K, Henning U, et al. Increased apoptosis of neutrophils in a case of clozapine-induced agranulocytosis-a case report. Pharmacopsychiatry. 2003;36:37-41.