Salivary antibodies induced by the seven-valent PncOMPC conjugate vaccine in the Finnish Otitis Media Vaccine Trial

BMC Infectious Diseases

Volumn 5, Issue , 2005, Pages

  Nurkka, Anu ^a   Lahdenkari, Mika ^a   Palmu, Arto A I ^a   Käyhty, Helena ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS HAEMOPHILUS INFLUENZAE TYPE B VACCINE; DIPLOID CELL VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN A1 ANTIBODY; IMMUNOGLOBULIN A2 ANTIBODY; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MEASLES MUMPS RUBELLA VACCINE; MMR II; PNEUMOCOCCUS VACCINE; POLYSACCHARIDE VACCINE; RECOMBINANT HEPATITIS B VACCINE; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MENINGOCOCCUS VACCINE; PNCOMPC VACCINE;

ANTIBODY DETECTION; ARTICLE; CLINICAL STUDY; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FINLAND; FOLLOW UP; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNIZATION; INFANT; MOUTH MUCOSA; OTITIS MEDIA; QUANTITATIVE ANALYSIS; SALIVA ANALYSIS; SEROTYPE; STREPTOCOCCUS INFECTION; AGE; IMMUNOLOGY; MUCOSAL IMMUNITY; PNEUMOCOCCAL INFECTION; SALIVA;

AGE FACTORS; ANTIBODIES, BACTERIAL; FINLAND; HUMANS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFANT; MENINGOCOCCAL VACCINES; OTITIS MEDIA; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; SALIVA;

EID: 25444509822     PISSN: 14712334     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-5-41     Document Type: Article

References (39)

1. Gray BM, Turner ME, Dillon HC, Jr: Epidemiologic studies of Streptococcus pneumoniae in infants. The effects of season and age on pneumococcal acquisition and carriage in the first 24 months of life. Am J Epidemiol 1982, 116:692-703.
2. Stenfors LE, Räisänen S: Occurrence of middle ear pathogens in the nasopharynx of young individuals. A quantitative study in four age groups. Acta Otolaryngol 1990, 109:142-148.
3. Obaro S, Adegbola R: The pneumococcus: carriage, disease and conjugate vaccines. J Med Microbiol 2002, 51:98-104.
4. Musher DM, Chapman AJ, Goree A, Jonsson S, Briles D, Baughn RE: Natural and vaccine-related immunity to Streptococcus pneumoniae. J Infect Dis 1986, 154:245-256.
5. Nieminen T, Käyhty H, Virolainen A, Eskola J: Circulating antibody secreting cell response to parenteral pneumococcal vaccines as an indicator of a salivary IgA antibody response. Vaccine 1998, 16:313-319.
6. Berneman A, Belec L, Fischetti VA, Bouvet JP: The specificity patterns of human immunoglobulin G antibodies in serum differ from those in autologous secretions. Infect Immun 1998, 66:4163-4168.
7. Simell B, Kilpi TM, Käyhty H: Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal capsular polysaccharides in children. J Infect Dis 2002, 186:1106-1114.
8. Simell B, Korkeila M, Pursiainen H, Kilpi TM, Käyhty H: Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin a, pneumolysin, and pneumococcal surface protein a in children. J Infect Dis 2001, 183:887-896.
9. Choo S, Zhang Q, Seymour L, Akhtar S, Finn A: Primary and booster salivary antibody responses to a 7-valent pneumococcal conjugate vaccine in infants. J Infect Dis 2000, 182:1260-1263.
10. Nurkka A, Lahdenkari M, Palmu A, Käyhty H, and the FinOM Study Group: Salivary antibodies induced by the seven-valent PncCRM conjugate vaccine in Finnish Otitis Media Vaccine Trial. Vaccine 2004, 23:298-304.
11. Korkeila M, Lehtonen H, Åhman H, Leroy O, Eskola J, Käyhty H: Salivary anticapsular antibodies in infants and children immunised with Streptococcus pneumoniae capsular polysaccharides conjugated to diphtheria or tetanus toxoid. Vaccine 2000, 18:1218-1226.
12. Nieminen T, Eskola J, Käyhty H: Pneumococcal conjugate vaccination in adults: circulating antibody secreting cell response and humoral antibody responses in saliva and in serum. Vaccine 1998, 16:630-636.
13. Nieminen T, Käyhty H, Leroy O, Eskola J: Pneumococcal conjugate vaccination in toddlers: mucosal antibody response measured as circulating antibody-secreting cells and as salivary antibodies. Pediat Infect Dis J 1999, 18:764-772.
14. Nurkka A, Åhman H, Korkeila M, Jäntti V, Käyhty H, Eskola J: Serum and salivary anti-capsular antibodies in infants and children immunized with the heptavalent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2001, 20:25-33.
15. Nurkka A, Åhman H, Yaich M, Eskola J, Käyhty H: Serum and salivary anticapsular antibodies in infants and children vaccinated with octavalent pneumococcal conjugate vaccines, PncD and PncT. Vaccine 2001, 20:194-201.
16. Black S, Shinefield H, Fireman B, Lewis E, Ray P, Hansen JR et al: Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J 2000, 19:187-195.
17. Black SB, Shinefield HR, Ling S, Hansen J, Fireman B, Spring D et al: Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia. Pediatr Infect Dis J 2002, 21:810-815.
18. Dagan R, Givon-Lavi N, Zamir O, Sikuler-Cohen M, Guy L, Janco J et al: Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. J Infect Dis 2002, 185:927-936.
19. Eskola J, Kilpi T, Palmu A, Jokinen J, Haapakoski J, Herva E et al: Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med 2001, 344:403-409.
20. Fireman B, Black SB, Shinefield HR, Lee J, Lewis E, Ray P: Impact of the pneumococcal conjugate vaccine on otitis media. Pediatr Infect Dis J 2003, 22:10-16.
21. Mbelle N, Huebner RE, Wasas AD, Kimura A, Chang I, Klugman KP: Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine. J Infect Dis 1999, 180:1171-1176.
22. Kilpi T, Åhman H, Jokinen J, Lankinen KS, Palmu A, Savolainen H et al: Protective Efficacy of a Second Pneumococcal Conjugate Vaccine against Pneumococcal Acute Otitis Media in Infants and Children: Randomized, Controlled Trial of a 7-Valent Pneumococcal Polysaccharide-Meningococcal Outer Membrane Protein Complex Conjugate Vaccine in 1666 Children. Clin Infect Dis 2003, 37:1155-1164.
23. Malley R, Stack AM, Ferretti ML, Thompson CM, Saladino RA: Anticapsular polysaccharide antibodies and nasopharyngeal colonization with Streptococcus pneumoniae in infant rats. J Infect Dis 1998, 178:878-882.
24. O'Brien KL, Moulton LH, Reid R, Weatherholtz R, Oski J, Brown L et al: Efficacy and safety of seven-valent conjugate pneumococcal vaccine in American Indian children: group randomised trial. Lancet 2003, 362:355-361.
25. Klugman K, Shabir M, Huebner R, Kohberger R, Mbelle N, Pierce N: A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med. 2003, 349:1341-8.
26. Jokinen J, Åhman H, Kilpi T, Mäkelä PH, Käyhty H: The concentration of antipneumococcal antibodies as a serological correlate or protection: An application to acute otitis media. J Infect Dis 2004, 190:545-50.
27. Kilpi T, Herva E, Kaijalainen T, Syrjänen R, Takala AK: Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life. Pediatr Infect Dis J 2001, 20:654-662.
28. Quataert SA, Kirch CS, Wiedl LJ, Phipps DC, Strohmeyer S, Cimino CO et al: Assignment of weight-based antibody units to a human antipneumococcal standard reference serum, lot 89-S. Clin Diagn Lab Immunol 1995, 2:590-597.
29. Zhang Q, Arnaoutakis K, Murdoch C, Lakshman R, Race G, Burkinshaw R, Finn A: Mucosal immune responses to capsular pneumococcal polysaccharides in immunized preschool children and controls with similar nasal pneumococcal colonization rates. Pediatr Infect Dis 2004, 23:307-313.
30. Delacroix DL, Dive C, Rambaud JC, Vaerman JP: IgA subclasses in various secretions and in serum. Immunology 1982, 47:383-385.
31. Kilian M, Reinholdt J, Lomholt H, Poulsen K, Frandsen EV: Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence. Apmis 1996, 104:321-338.
32. Weiser JN, Bae D, Fasching C, Scamurra RW, Ratner AJ, Janoff EN: Antibodyenhanced pneumococcal adherence requires IgA1 protease. Proc Natl Acad Sci U S A 2003, 100:4215-4220.
33. Kauppi-Korkeila M, Saarinen L, Eskola J, Käyhty H: Subclass distribution of IgA antibodies in saliva and serum after immunization with Haemophilus influenzae type b conjugate vaccines. Clin Exp Immunol 1998, 111:237-242.
34. Blum MD, Dagan R, Mendelman PM, Pinsk V, Giordani M, Li S et al: A comparison of multiple regimens of pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine and pneumococcal polysaccharide vaccine in toddlers. Vaccine 2000, 18:2359-2367.
35. Anttila M, Eskola J, Åhman H, Käyhty H: Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood. Vaccine 1999, 17:1970-1977.
36. MacLennan J, Obaro S, Deeks J, Lake D, Elie C, Carlone G et al: Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy. J Infect Dis 2001, 183:97-104.
37. Veenhoven RH, Bogaert D, Schilder AG, Rijkers GT, Uiterwaal CS, Kiezebrink HH et al: Nasopharyngeal pneumococcal carriage after combined pneumococcal conjugate and polysaccharide vaccination in children with a history of recurrent acute otitis media. Clin Infect Dis. 2004, 39:911-9.
38. Lee LH. Frasch CE, Falk LA, Klein DL, Deal CD: Correlates of immunity for pneumococcal conjugate vaccines. Vaccine 2003, 21:2199-2205.
39. Jodar L, Butler J, Carlone G, Dagan R, Goldblatt D, Käyhty H et al: Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants. Vaccine 2003, 21:3265-3272.