Constant light-induced retinal damage and the RPE65-MET450 variant: Assessment of the NZW/LacJ mouse

Molecular Vision

Volumn 11, Issue , 2005, Pages 374-379

  Danciger, Michael ^a   Yang, Haidong ^b   Hanschumacher, Lisa ^a   LaVail, Matthew M ^b  

^a LOYOLA MARYMOUNT UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EYE PROTEIN; METHIONINE; PROTEIN RPE65; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE INTERACTION; GENE MUTATION; GENOME; GENOTYPE; LIGHT EXPOSURE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTECTION; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT; RETINA INJURY;

ANIMALS; CARRIER PROTEINS; CHROMOSOMES; EYE PROTEINS; FEMALE; GENOTYPE; LIGHT; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; QUANTITATIVE TRAIT LOCI; RADIATION INJURIES, EXPERIMENTAL; RETINA; RETINAL DEGENERATION;

EID: 25444503060     PISSN: 10900535     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

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2. Grimm C, Wenzel A, Hafezi F, Yu S, Redmond TM, Reme CE. Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration. Nat Genet 2000; 25:63-6.
3. LaVail MM, Gorrin GM, Repaci MA, Thomas LA, Ginsberg HM. Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 1987; 28:1043-8.
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6. Nusinowitz S, Nguyen L, Radu R, Kashani Z, Farber D, Danciger M. Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65. Exp Eye Res 2003; 77:627-38.
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8. Danciger M, Lyon J, Worrill D, LaVail MM, Yang H. A strong and highly significant QTL on chromosome 6 that protects the mouse from age-related retinal degeneration. Invest Ophthalmol Vis Sci 2003; 44:2442-9.
9. Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C. New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant. Mamm Genome 2004; 15:277-83.