Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-β

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4703-4707

  Hong, Feng ^a   Hollenback, David ^a   Singer, Jack W ^a   Klein, Peter ^a  

^a Cell Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; ACYLTRANSFERASE INHIBITOR; PYRIDINE DERIVATIVE;

ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; INHIBITION KINETICS;

ACYLTRANSFERASES; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOMERISM; PROTEIN ISOFORMS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 25444460324     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.055     Document Type: Article

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27. 2), 6.27 (d, 1H, J = 1.1 Hz, Ar), 6.38 (d, 1H, J = 1.1 Hz, Ar), 7.14 (d, 1H, J = 8.8 Hz, Ar), 7.32 (d, 1H, J = 2.7 Hz, Ar), 7.38 (dd, 1H, J = 8.8 Hz, J = 2.7 Hz, Ar), 7.78 (d, 2H, J = 8.7 Hz, Ar), 7.96 (d, 2H, J = 8.7 Hz, Ar), 8.59 (s, 1H, NH), 9.84 (s, 1H, CH).10d:
28. 2 values for the goodness-of-fit were ≥0.95.