Cross-recognition between histones and La/SSB may account for anti-DNA reactivity in SLE patients

Clinical and Experimental Immunology

Volumn 142, Issue 1, 2005, Pages 172-179

  Touloupi, E ^a   Routsias, J G ^a   Tzioufas, A G ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Anti La SSB; B cell epitopes; Histones; Sjogren's syndrome; Systemic lupus erythematosus

Indexed keywords

DNA ANTIBODY; DOUBLE STRANDED DNA; HISTONE; LA ANTIBODY; LA ANTIGEN; RO ANTIBODY;

ANTIBODY BLOOD LEVEL; ANTIGEN ANTIBODY REACTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; PRIORITY JOURNAL; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; CRITHIDIA; CROSS REACTIONS; DNA; EPITOPES, B-LYMPHOCYTE; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; HUMANS; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; SJOGREN'S SYNDROME;

EID: 25444440571     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02892.x     Document Type: Article

References (18)

1. Pruijn GJ, Simons FH, van Venrooij WJ. Intracellular localization and nucleocytoplasmic transport of Ro RNP components. Eur J Cell Biol 1997; 74:123-32.
2. Tzioufas AG, Yiannaki E, Sakarellos-Daitsiotis M, Routsias JG, Sakarellos C, Moutsopoulos HM. Fine specificity of autoantibodies to La/SSB. epitope mapping, and characterization. Clin Exp Immunol 1997; 108:191-8.
3. Yiannaki EE, Tzioufas AG, Bachmann M et al. The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of methods. Clin Exp Immunol 1998; 112:152-8.
4. Routsias JG, Touloupi E, Dotsika E et al. Unmasking the anti-La/SSB response in sera from patients with Sjogren's syndrome by specific blocking of anti-idiotypic antibodies to La/SSB antigenic determinants. Mol Med 2002; 8:293-305.
5. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25:1271-7.
6. Vitali C, Bombardieri S, Moutsopoulos HM et al. Preliminary criteria for the classification of Sjogren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993; 36:340-7.
7. Troster H, Metzger TE, Semsei I et al. One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrens' syndrome. J Exp Med 1994; 180:2059-67.
8. Stefano JE. Purified lupus antigen La recognizes an oligouridylate stretch common to the 3′ termini of RNA polymerase III transcripts. Cell 1984; 36:145-54.
9. Tzioufas AG, Manoussakis MN, Drosos AA, Silis G, Gharavi AE, Moutsopoulos HM. Enzyme immunoassays for the detection of IgG and IgM anti-dsDNA antibodies: clinical significance and specificity. Clin Exp Rheumatol 1987; 5:247-53.
10. Arbuckle MR, McClain MT, Rubertone MV et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Medical 2003; 349:1526-33.
11. Purcell AW, Chen W, Ede NJ et al. Avoidance of self-reactivity results in skewed CTL responses to rare components of synthetic immunogens. J Immunol 1998; 160:1085-90.
12. Darnel J. Molecular Cell Biology, 3rd edn. New York: Scientific American Books Inc., 1998.
13. Schett G, Rubin RL, Steiner G, Hiesberger H, Muller S, Smolen J. The lupus erythematosus cell phenomenon: comparative analysis of antichromatin antibody specificity in lupus erythematosus cell-positive and - negative sera. Arthritis Rheum 2000; 43:420-8.
14. Schett G, Steiner G, Smolen JS. Nuclear antigen histone H1 is primarily involved in lupus erythematosus cell formation. Arthritis Rheum 1998; 41:1446-55.
15. Gripenberg M, Helve T, Kurki P. Profiles of antibodies to histones, DNA and IgG in patients with systemic rheumatic diseases determined by ELISA. J Rheumatol 1985; 12:934-9.
16. Beer RG, Rischmueller M, Coates T et al. Nonprecipitating anti-La (SS-B) autoantibodies in primary Sjogren's syndrome. Clin Immunol Immunopathol 1996; 79:314-8.
17. Aarden LA, de Groot ER, Feltkamp TE, Immunology of DNA. III Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence techniquE. Ann NY Acad Sci 1975; 254:505-15.
18. Crowe W, Kushner I. An immunofluorescent method using Crithidia luciliae to detect antibodies to double-stranded DNA. Arthritis Rheum 1977; 20:811-4.