Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development

Infection and Immunity

Volumn 73, Issue 10, 2005, Pages 6935-6944

  Buchanan, John T ^a,b   Stannard, Jason A ^c   Lauth, Xavier ^c   Ostland, Vaughn E ^c   Powell, Henry C ^b   Westerman, Mark E ^c   Nizet, Victor ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Kent SeaTech Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; LIVE VACCINE; MORONECIDIN; PHOSPHOGLUCOMUTASE; PLASMID VECTOR; POLYPEPTIDE ANTIBIOTIC AGENT; STREPTOCCOCUS VACCINE; UNCLASSIFIED DRUG; VACCINE; VIRULENCE FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; AQUACULTURE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIUM MUTANT; BASS; BLOOD; BRAIN; CELL SIZE; CLEARANCE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FISH DISEASE; GENE DISRUPTION; GENE INSERTION; HIGH THROUGHPUT SCREENING; IMMUNITY; LETHAL DOSE; MENINGOENCEPHALITIS; MORTALITY; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PGM GENE; PRIORITY JOURNAL; SPLEEN; STREPTOCOCCUS INFECTION; STREPTOCOCCUS INIAE;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BASS; FISH DISEASES; FISH PROTEINS; GENE DELETION; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOGLUCOMUTASE; STREPTOCOCCAL INFECTIONS; STREPTOCOCCAL VACCINES; STREPTOCOCCUS; VIRULENCE; VIRULENCE FACTORS;

EID: 25444437918     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.10.6935-6944.2005     Document Type: Article

References (46)

1. Adhya, S., and M. Schwartz. 1971. Phosphoglucomutase mutants of Escherichia coli K-12. J. Bacteriol. 108:621-626.
2. Altschul, S. F., W. Gish, W. Miller, E. W. Meyers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
3. Anzai, T., J. F. Timoney, Y. Kuwamoto, Y. Fujita, R. Wada, and T. Inoue. 1999. In vivo pathogenicity and resistance to phagocytosis of Streptococcus equi strains with different levels of capsule expression. Vet. Microbiol. 67:277-286.
4. Barnes, A. C., F. M. Young, M. T. Home, and A. E. Ellis. 2003. Streptococcus iniae: serological differences, presence of capsule and resistance to immune serum killing. Dis. Aquat. Org. 53:241-247.
5. Bercovier, H., C. Ghittino, and A. Eldar. 1997. Immunization with bacterial antigens: infections with streptococci and related organisms. Dev. Biol. Stand. 90:153-160.
6. Bromage, E. S., A. Thomas, and L. Owens. 1999. Streptococcus iniae, a bacterial infection in barramundi Lates calcarifer. Dis. Aquat. Org. 36:177-181.
7. Chaffin, D. O., and C. E. Rubens. 1998. Blue/white screening of recombinant plasmids in gram-positive bacteria by interruption of alkaline phosphatase gene (phoZ) expression. Gene 219:91-99.
8. Dai, J., Y. Liu, W. Ray, Jr., and M. Konno. 1992. The crystal structure of muscle phosphoglucomutase refined at 2.7-angstrom resolution. J. Biol. Chem. 267:6322-6337.
9. Daly, J. G., S. G. Griffiths, A. K. Kew, A. R. Moore, and G. Olivier. 2001. Characterization of attenuated Renibacterium salmoninarum strains and their use as live vaccines. Dis. Aquat. Org. 44:121-126.
10. Eldar, A., and C. Ghittino. 1999. Lactococcus garvieae and Streptococcus iniae infections in rainbow trout Oncorhynchus mykiss: similar, but different diseases. Dis. Aquat. Org. 36:227-231.
11. Evans, J. J., C. A. Shoemaker, and P. J. Klesius. 2000. Experimental Streptococcus iniae infection of hybrid striped bass (Morone chrysops × Morone saxatilis) and tilapia (Oreochromis niloticus) by nares inoculation. Aquaculture 189:197-210.
12. Framson, P. E., A. Nittayajarn, J. Merry, P. Youngman, and C. E. Rubens. 1997. New genetic techniques for group B streptococci: high-efficiency transformation-sensitive pVW01 plasmids, and mutagenesis with Tn917. Appl. Environ. Microbiol. 63:3539-3547.
13. Gutierrez, J. A., P. J. Crowley, D. P. Brown, J. D. Hillman, P. Youngman, and A. S. Bleiweis. 1996. Insertional mutagenesis and-recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants displaying acid sensitivity and nutritional requirements. J. Bacteriol. 178:4166-4175.
14. Hakansson, S., A. M. Bergholm, S. E. Holm, B. Wagner, and M. Wagner. 1988. Properties of high and low density subpopulations of group B streptococci: enhanced virulence of the low density variant. Microb. Pathog. 5:345-355.
15. Hardy, G. G., M. J. Caimano, and J. Yother. 2000. Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase. J. Bacteriol. 182:1854-1863.
16. Hardy, G. G., A. D. Magee, C. L. Ventura, M. J. Caimano, and J. Yother. 2001. Essential role for cellular phosphoglucomutase in virulence of type 3 Streptococcus pneumoniae. Infect. Immun. 69:2309-2317.
17. Hermann, S. R., J. A. Miller, S. O'Neill, T. T. Tsao, R. M. Harding, and J. L. Dale. 2000. Single-primer amplification of flanking sequences. BioTechniques 29:1176-1178, 1180.
18. Karlyshev, A. V., M. J. Pallen, and B. W. Wren. 2000. Single-primer PCR procedure for rapid identification of transposon insertion sites. BioTechniques 28:1078, 1080, 1082.
19. Kitao, T. 1982. The methods for detection of Streptococcus sp., causative bacteria of streptococcal disease of cultured yellowtail (Senola quinqueradiata)-especially their cultural, biochemical and serologic properties. Fish Pathol. 17:17-26.
20. Lau, S. K., P. C. Woo, H. Tse, K. W. Leung, S. S. Wong, and K. Y. Yuen. 2003. Invasive Streptococcus iniae infections outside North America. J. Clin. Microbiol. 41:1004-1009.
21. Lauth, X., H. Shike, J. C. Burns, M. E. Westerman, V. E. Ostland, J. M. Carlberg, J. C. Van Olst, V. Nizet, S. W. Taylor, C. Shimizu, and P. Bulet. 2002. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J. Biol. Chem. 277:5030-5039.
22. Lawrence, M. L., R. K. Cooper, and R. L. Thune. 1997. Attenuation, persistence, and vaccine potential of an Edwardsiella ictaluri purA mutant. Infect. Immun. 65:4642-4651.
23. Lee, C. J., L. H. Lee, C. S. Lu, and A. Wu. 2001. Bacterial polysaccharides as vaccines-immunity and chemical characterization. Adv. Exp. Med. Biol. 491:453-471.
24. Levander, F., U. Andersson, and P. Rådström. 2001. Physiological role of β-phosphoglucomutase in Lactococcus lactis. Appl. Environ. Microbiol. 67:4546-4553.
25. Levander, F., and P. Rådström. 2001. Requirement for phosphoglucomutase in exopolysaccharide biosynthesis in glucose- and lactose-utilizing Streptococcus thermophilus. Appl. Environ. Microbiol. 67:2734-2738.
26. Llull, D., R. Lopez, and E. Garcia. 2001. Genetic bases and medical relevance of capsular polysaccharide biosynthesis in pathogenic streptococci. Curr. Mol. Med. 1:475-491.
27. Lu, M., and N. Kleckner. 1994. Molecular cloning and characterization of the pgm gene encoding phosphoglucomutase of Escherichia coli. J. Bacteriol. 176:5847-5851.
28. Marsden, M. J., L. M. Vaughan, R. M. Fitzpatrick, T. J. Foster, and C. J. Secombes. 1998. Potency testing of a live, genetically attenuated vaccine for salmonids. Vaccine 16:1087-1094.
29. Marsden, M. J., L. M. Vaugban, T. J. Foster, and C. J. Secombes. 1996. A live (ΔaroA) Aeromonas salmonidda vaccine for furuncuiosis preferentially stimulates T-cell responses relative to B-cell responses in rainbow trout (Oncorhynchus mykiss). Infect. Immun. 64:3863-3869.
30. McKay, G. A., D. E. Woods, K. L. MacDonald, and K. Poole. 2003. Role of phosphoglucomutase of Stenotrophomonas maltophilia in lipopolysaccharide biosynthesis, virulence, and antibiotic resistance. Infect. Immun. 71:3068-3075.
31. Miller, J. D., and M. N. Neely. 2005. Large-scale screen highlights the importance of capsule for virulence in the zoonotic pathogen Streptococcus iniae. Infect. Immun. 73:921-934.
32. Monteiro, M. A., M. Fortuna-Nevin, J. Farley, and V. Pavliak. 2003. Phase-variation of the truncated lipo-oligosaccharide of Neisseria meningitidis NMB phosphoglucomutase isogenic mutant NMB-R6. Carbohydr. Res. 338:2905-2912.
33. Neumann, N. F., J. L. Stafford, D. Barreda, A. J. Ainsworth, and M. Belosevic. 2001. Antimicrobial mechanisms of fish phagocytes and their role in host defense. Dev. Comp. Immunol. 25:807-825.
34. Nizet, V., T. Ohtake, X. Lauth, J. Trowbridge, J. Rudisill, R. A. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, and R. L. Gallo. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457.
35. Patrzykat, A., and S. E. Douglas. 2003. Gone gene fishing: how to catch novel marine antimicrobials. Trends Biotechnol. 21:362-369.
36. Peschel, A. 2002. How do bacteria resist human antimicrobial peptides? Trends Microbiol. 10:179-186.
37. Pier, G. B., and S. H. Madin. 1976. Streptococcus iniae sp. nov., a beta-hemolytic streptococcus isolated from an Amazon freshwater dolphin, Inia geoffrensis. Int. J. Syst. Bacteriol. 26:545-553.
38. Rapin, A. M., H. M. Kalckar, and L. Alberico. 1968. The metabolic basis for masking of receptor-sites on E. coli K-12 for C21, a lipopolysaccharide core-specific phage. Arch. Biochem. Biophys. 128:95-105.
39. Shoemaker, C. A., P. H. Klesius, and J. J. Evans. 2001. Prevalence of Streptococcus iniae in tilapia, hybrid striped bass, and channel catfish on commercial fish farms in the United States. Am. J. Vet. Res. 62:174-177.
40. Silphaduang, U., and E. J. Noga. 2001. Peptide antibiotics in mast cells of fish. Nature 414:268-269.
41. Thornton, J. C., R. A. Garduno, S. G. Newman, and W. W. Kay. 1991. Surface-disorganized, attenuated mutants of Aeromonas salmonicida as furunculosis live vaccines. Microb. Pathog. 11:85-99.
42. Weinstein, M. R., M. Litt, D. A. Kertesz, P. Wyper, D. Rose, M. Coulter, A. McGeer, R. Facklam, C. Ostach, B. M. Willey, A. Borczyk, D. E. Low, et al. 1997. Invasive infections due to a fish pathogen, Streptococcus iniae. N. Engl. J. Med. 337:589-594.
43. Wessels, M. R., J. B. Goldberg, A. E. Moses, and T. J. DiCesare. 1994. Effects on virulence of mutations in a locus essential for hyaluronic acid capsule expression in group A streptococci. Infect. Immun. 62:433-441.
44. West, N. P., H. Jungnitz, J. T. Fitter, J. D. McArthur, C. A. Guzman, and M. J. Walker. 2000. Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infect. Immun. 68:4673-4680.
45. Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415:389-395.
46. Zlotkin, A., H. Hershko, and A. Eldar. 1998. Possible transmission of Streptococcus iniae from wild fish to cultured marine fish. Appl. Environ. Microbiol. 64:4065-4067.