Essential role for cellular phosphoglucomutase in virulence of type 3 Streptococcus pneumoniae

Infection and Immunity

Volumn 69, Issue 4, 2001, Pages 2309-2317

  Hardy, G G ^a   Magee, A D ^a   Ventura, C L ^a   Caimano, M J ^a   Yother, J ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIAL POLYSACCHARIDE; COMPLEMENT COMPONENT C3; GLUCOSE 1 PHOSPHATE; GLUCOSE 6 PHOSPHATE; MEMBRANE ANTIGEN; PHOSPHOGLUCOMUTASE; PHOSPHORYLCHOLINE; SYNTHETASE; URIDINE DIPHOSPHATE GLUCOSE; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; URIDINE DIPHOSPHATE GLUCURONIC ACID; URIDINE TRIPHOSPHATE GLUCOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; COMPLEMENT FIXATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIBODIES, BACTERIAL; COMPLEMENT SYSTEM PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; PHOSPHOGLUCOMUTASE; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 0035081426     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.4.2309-2317.2001     Document Type: Article

References (49)

1. Demonstration of UDP-glucose dehydrogenase activity in cell extracts of Escherichia coil expressing the pneumococcal cap3A gene required for the synthesis of type 3 capsular polysaccharide
2. Sequence and transcriptional analysis of a DNA region involved in the production of capsular polysaccharide in Streptococcus pneumoniae type 3
3. Type 3-specific synthase of Streptococcus pneumoniae (Cap3B) directs type 3 polysaccharide biosynthesis in Escherichia coli and in pneumococcal strains of different serotypes
4. Simultaneous production of two capsular polysaccharides by pneumococcus. II. The genetic and biochemical basis of binary capsulation
5. The protective action of a specific enzyme against type III pneumococcus infection in mice
6. Antipneumococcal effects of C reactive protein and monoclonal antibodies to pneumococcal cell wall and capsular antigens
7. Genetic control of susceptibility to pneumococcal infection
8. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae
9. Interaction of gram-positive organisms with complement
10. Capsule genetics in Streptococcus pneumoniae and a possible role for transposition in the generation of the type 3 locus
11. Mechanism of type 3 capsular polysaccharide synthesis in Streptococcus pneumoniae
12. The serotype of type Ia and III group B streptococci is determined by the polymerase gene within the polycistronic capsule operon
13. Pneumococcal surface protein A (PspA) is serologically variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae
14. Molecular characterization of hasC from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose pyrophosphorylase activity
15. Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniae
16. Genetic and molecular characterization of capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 3
17. Genetic aspects of transformations of pneumococci
18. Biosynthesis of type 3 capsular polysaccharide in Streptococcus pneumoniae: Enzymatic chain re lease by an abortive translocation process
19. Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains
20. Analysis of C3 deposition and degradation on bacterial surfaces after opsonization
21. The significance of pneumococcal types
22. Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase
23. Six newly recognized types of Streptococcus pneumoniae
24. The type 2 capsule locus of Streptococcus pneumoniae
25. Effect of genetic switching of capsular type on virulence of Streptococcus pneumoniae
26. Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: Molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunit
27. Control Dy factors distinct from the S transforming principle of the amount of capsular polysaccharide produced by type III pneumococci
28. Relation of virulence of pneumococcal strains for mice to the quantity of capsular polysaccharide formed in vitro
29. Characterization of the galU gene of Streptococcus pneumoniae encoding a uridine diphosphoglucose pyrophosphorylase: A gene essential for capsular polysaccharide biosynthesis
30. Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biosynthetic pathway
31. Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide bio-synthesis in Streptococcus pneumoniae
32. Characterization of the type 8 capsular gene cluster of Streptococcus pneumoniae
33. Molecular organization of the genes required for the synthesis of type 1 polysaccharide of Streptococcus pneumoniae: Formation of binary encapsulated pneumococci and identification of cryptic dTDP-rhamnose biosynthesis genes
34. Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H
35. Molecular characterization of the complete 23F capsular polysaccharide locus of Streptococcus pneumoniae
36. Linked mutations borne by deoxyribonucleic acid controlling the synthesis of capsular polysaccharide in pneumococcus
37. Reciprocal capsular transformations of pneumococci
38. Hyaluronic acid capsule and the role of streptococcal entry into keratinocytes in invasive skin infection
39. Serogroup-specific epidemiology of Streptococcus pneumoniae: Association with age, sex and geography in 7,000 episodes of invasive disease
40. Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae
41. Co-localization of X-linked agammaglobulinemia and X-linked immunodeficiency genes
42. Interruption of capsule production in Streptococcus pneumoniae serotype 3 by insertion of transposon Tn916
43. X-linked immune deficiency (xid) of CBA/N mice
44. Complement and the host's defense against the pneumococcus
45. Common themes in the genetics of streptococcal capsular polysaccharides
46. Genetics of Streptococcus pneumoniae
47. Association of a partial H-rpt element with the type 3 capsule locus of Streptococcus pneumoniae
48. Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of pspA gene