Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2β protein in patients with chronic Chagas' heart disease

Clinical and Experimental Immunology

Volumn 136, Issue 3, 2004, Pages 527-534

  Mahler, E ^a,b   Hoebeke, J ^c   Levin, M J ^a,b,d  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Inst Invest Ing Genet y Biol M   (Argentina)

^c INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d Inst Genetic Eng and Molec Biol   (Argentina)

Author keywords

1 adrenergic receptor; Chronic Chagas' heart disease; M2 cholinergic receptor; Ribosomal P proteins; Trypanosoma cruzi

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; EPITOPE; GLUTAMYLGLUTAMYLSERYLASPARTYLASPARTYLASPARTYLMETHIONYLGLYCYLPHENYLALANYLGLY CYLLEUCYLPHENYLALANYLASPARTIC ACID; MUSCARINIC M2 RECEPTOR; PARASITE ANTIGEN; PEPTIDE ANTIBODY; PEPTIDE DERIVATIVE; PROTOZOAL PROTEIN; R13 ANTIBODY; RIBOSOME PROTEIN; TRYPANOSOMA CRUZI RIBOSOMAL P2BETA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CHAGAS DISEASE; CHRONIC DISEASE; CONTROLLED STUDY; CROSS REACTION; HOST PARASITE INTERACTION; HUMAN; HUMORAL IMMUNITY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MOLECULAR RECOGNITION; NONHUMAN; PARASITE VIRULENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTOZOAL INFECTION; RAT; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; ANTIBODIES, PROTOZOAN; CELLS, CULTURED; CHAGAS DISEASE; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; HUMANS; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, CHOLINERGIC; RIBOSOMAL PROTEINS; TRYPANOSOMA CRUZI;

EID: 2542614419     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2004.02480.x     Document Type: Article

References (29)

1. Elizari MV, Chiale PA. Cardiac arrhythmias in Chagas' heart disease. J Cardiovasc Electrophysiol 1993; 4:596-608.
2. Rassi A, Lorga AM, Rassi SG. Diagnostic and therapeutic approach of the chronic Chagas-related cardiopathy. In: Germiniani H, ed. Diagnosis and Treatment of Cardiac Arrhythmias, 3rd edn. Rio de Janeiro, Guanabara Koogan S.A. 1990:225-44.
3. Halperin C, Rassi S. Clinical Relevance of Invasive Electrophysiologic Studies in Patients with Chagas' Disease. In: Arrhythmia Management in Chagas' Disease, (ed. Armonk NY). Futura Publishing Co Inc., 2000:83-93.
4. Rosenbaum MB, Chiale PA, Schejtman D, Levin M, Elizari MV. Antibodies to beta-adrenergic receptors disclosing agonist-like properties in idiopathic dilated cardiomyopathy and Chagas' heart disease. J Cardiovasc Electrophysiol 1994; 5:367-75.
5. Goin JC, Borda E, Leiros CP, Storino R, Sterin-Borda L. Identification of antibodies with muscarinic cholinergic activity in human Chagas' disease: pathological implications. J Auton Nerv Syst 1994; 47:45-52.
6. Elies R, Ferrari I, Wallukat G et al. Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease. J Immunol 1996; 157:4203-11.
7. Chiale PA, Ferrari I, Mahler E, Vallazza MA, Elizari MV, Rosenbaum MR, Levin MJ. Differential profile and biochemical effects of antiautonomic membrane receptor antibodies in ventricular arrhythmias and sinus node dysfunction. Circulation 2001; 103:1765-71.
8. Ferrari I, Levin MJ, Wallukat G et al. Molecular mimicry between the immunodominant ribosomal P0 protein of Trypanosoma cruzi and a functional epitope on the human β-adrenergic receptor. J Exp Med 1995; 182:59-65.
9. Mijares A, Verdot L, Peineau N, Vray B, Hoebeke J, Argibay J. Antibodies from Trypanosoma cruzi infected mice recognize the second extracellular loop of the β1-adrenergic and M2-muscarinic receptors and regulate calcium channels in isolated cardiomyocytes. Mol Cell Biochem 1996; 163-164:107-12.
10. Sterin-Borda L, Gorelik G, Borda ES. Chagasic IgG binding with cardiac muscarinic cholinergic receptors modifies cholinergic-mediated cellular transmembrane signals. Clin Immunol Immunopathol 1991; 61:387-97.
11. De Oliveira SF, Pedrosa RC, Nascimento JH, Campos de Carvalho AC, Masuda MO. Sera from chronic chagasic patients with complex cardiac arrhythmias depress electrogenesis and conduction in isolated rabbit hearts. Circulation 1997; 96:2031-7.
12. Kaplan D, Ferrari I, Lopez-Bergami P et al. Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas' disease possess functional autoreactivity with heart tissue and differ from anti-P autoantibodies in lupus. Proc Natl Acad Sci USA 1997; 94:10301-6.
13. Lopez Bergami P, Scaglione J, Levin MJ. Antibodies against the carboxyl-terminal end of the Trypanosoma cruzi ribosomal P proteins are pathogenic. FASEB J 2001; 15:2602-12.
14. Mahler E, Sepulveda P, Jeannequin O et al. A monoclonal antibody against the immunodominant epitope of the ribosomal P2β protein of Trypanosoma cruzi interacts with the human β1-adrenergic receptor. Eur J Immunol 2001; 31:2210-6.
15. Ferrari I, Levin MJ, Elizari MV, Rosenbaum MB, Chiale PA. Cholinergic autoantibodies in sinus-node dysfunction. Lancet 1997; 350:262-3.
16. WHO/ISFC Task Force. Report on the definition and classification of cardiomyopathies. Br Heart J 1980; 44:672-3.
17. Levin MJ, Vazquez M, Kaplan D, Schijman AG. The Trypanosoma cruzi ribosomal P protein family. Classification Antigenicity Parasitol Today 1993; 9:381-4.
18. Rich BE, Steitz JA. Human acidic ribosomal proteins P0, P1 and P2: analysis of cDNA clones, in vitro synthesis and assembly. Mol Cell Biol 1987; 7:4065-74.
19. Lopez Bergami P, Cabeza Meckert P, Kaplan D et al. Immunization with recombinant Trypanosoma cruzi ribosomal P2β protein induces changes in the electrocardiogram of immunized mice. FEMS Immunol Med Microbiol 1997; 18:75-85.
20. Levitus G, Hontebeyrie-Joskowicz M, Van Regenmortel MH, Levin MJ. Humoral autoimmune response to ribosomal P proteins in chronic Chagas heart disease. Clin Exp Immunol 1991; 85:413-7.
21. Wallukat G, Wollenberger A. Effects of the serum gamma-globulin fraction of patients with allergic asthma and :dilated cardiomyopathy on chronotropic β-adrenoceptor function in cultured neonatal rat heart myocytes. Biomed Biochim Acta 1987; 46:634-9.
22. Gomez EB, Medina G, Ballesta JP, Levin MJ, Tellez-Inon MT. Acidic ribosomal P proteins are phosphorylated in Trypanosoma cruzi. Int J Parasitol 2001; 31:1032-9.
23. Piehler J, Brecht A, Giersch T, Hock B, Gauglitz G. Assessment of affinity constants by rapid solid phase detection of equilibrium binding in a flow system. J Immunol Meth 1997; 201:189-206.
24. Levin MJ, Mestri EA, Benarous R et al. Identification of major Trypanosoma cruzi antigenic determinants in chronic Chagas' heart disease. Am J Trop Med Hyg 1989; 41:530-8.
25. Levitus G, Grippo V, Labovsky V, Ghio S, Hontebeyrie M, Levin MJ. DNA immunization with the ribosomal P2β gene of Trypanosoma cruzi fails to induce pathogenic antibodies. Microbes and Infection 2003; 5:1381-8.
26. Levy MN. Cardiac sympathetic-parasympathetic interactions. Fed Proc 1984; 43:2598-602.
27. Zurdo J, Sanz JM, Gonzalez C, Rico M, Ballesta JP. The exchangeable yeast ribosomal acidic protein YP2β shows characteristics of a partly folded state under physiological conditions. Biochemistry 1997; 36:9625-35.
28. Wallukat G, Muller J, Hetzer R. Specific removal of β1-adrenergic autoantibodies from patients with idiopathic dilated cardiomyopathy. N Engl J Med 2002; 347:1806.
29. Apt W, Arribada A, Zulantay I, Sanchez G, Vargas SL, Rodriguez J. Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the regression and prevention of electrocardiographic abnormalities during 9 years of follow-up. Ann Trop Med Parasitol 2003; 97:23-9.