Antibodies from Trypanosoma cruzi infected mice recognize the second extracellular loop of the β1-adrenergic and M2-muscarinic receptors and regulate calcium channels in isolated cardiomyocytes

Molecular and Cellular Biochemistry

Volumn 163-164, Issue , 1996, Pages 107-112

  Mijares, Alfredo ^a   Verdot, Ludovic ^a,b   Peineau, Nicolas ^a   Vray, Bernard ^b   Hoebeke, Johan ^a   Argibay, Jorge ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Adrenergic; Antibodies; Calcium channel; Chagas' disease; Muscarinic; Receptor; Trypanosoma cruzi

Indexed keywords

ANTIBODY; ATROPINE; AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CYCLIC AMP; EPITOPE; IMMUNOGLOBULIN; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR; PROPRANOLOL;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CALCIUM CURRENT; CHAGAS DISEASE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; HEART MUSCLE CELL; MALE; MOUSE; NONHUMAN; PATCH CLAMP; PROTEIN STRUCTURE; TRYPANOSOMA CRUZI;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0029730836     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00408646     Document Type: Article

References (22)

1. Wallukat G, Wollenberger A: Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic β-adrenoceptor function in cultured neonatal rat heart myocytes. Biomed Biochim Acta 46: S634-S639, 1987
2. Limas CJ, Goldenberg IF, Limas C: Autoantibodies against β-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 64: 97-103, 1989
3. 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest 86: 1658-1663, 1990
4. Magnusson Y, Wallukat G, Waagstein MD, Hjarlmarson A, Hoebeke J: Autoimmunity in idiopathic dilated cardiomyopathy - Characterization of antibodies against the β-adrenoceptor with positive chronotropic effect. Circulation 89: 2760-2767, 1994
5. Fu M LX, Magnusson Y, Bergh CH, Liljeqvist JA, Waagstein F, Hjalmarson A, Hoebeke J: Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy. J Clin Invest 91: 1964-1968, 1993
6. Fu M LX, Hoebeke J, Matsui S, Matoba M, Magnusson Y, Hedner T, Herlitz H, Hjalmarson A: Autoantibodies against cardiac G-protein-coupled receptors define populations with cardiomyopathies but not with hypertension. Clin Immunol Immunopathol 72: 15-20, 1994
7. Borda E, Pascual J, Cossio P, De La Vega M, Arana R, Sterin-Borda L: A circulating Immunoglobulin in Chagas' disease which binds to β-adrenoceptor of myocardium and modulates their activity. Clin Exp Immunol 57: 679-686, 1984
8. 2-adrenoreceptors in Chagas' disease. Clin Exp Immunol 74: 349-354, 1988
9. Goin JC, Borda E, Segovia A, Sterin-Borda L: Distribution of antibodies against β-adrenoceptors in the course of human Trypanosoma cruzi infection. Proc Soc Exp Biol Med 197: 186-192, 1991
10. Lozykowski MG, McCormick TS, Rowland EC: Coincidence of tissue antibody and cardiac pathology in mice infected with Trypanosoma cruzi. Trans Royal Soc Trop Med Hygiene 85: 225-226, 1991
11. Gorelik G, Genaro AM, Sterin-Borda L, Cappa SG, Borda ES: Antibodies bind and activate β-adrenergic and cholinergic lymphocyte receptors in Chagas'disease. Clin Immunol Immunopathol 55: 221-236, 1990
12. Sterin-Borda L, Gorelik G, Borda ES: Chagasic Immunoglobulin binding with cardiac muscarinic cholinergic receptors modifies cholinergic-mediated cellular transmembrane signals. Clin Immunol Immunopathol 61: 387-397, 1991
13. Reuter H: Calcium channel modulation by β-adrenergic neurotransmitters in the heart. Experientia 43: 1173-1174, 1987
14. Fischmeister R, Hartzell HC: Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle. J Physiol 376: 183-202, 1986
15. Le Guennec JY, Peineau N, Esnard F, Lacampagne A, Gannier F, Argibay J, Gauthier F, Gamier D: A simple method for calibrating collagenase/pronase E ratio to optimise heart cell isolation. Biol Cell 79: 161-165, 1993
16. Rosenbaum MB, Chiale PA, Schejtman D, Levin M, Elizari M: Antibodies to beta-adrenergic receptors disclosing agonist-like properties in idiopathic dilated cardiomyopathy and Chagas' heart disease. J Cardiovasc Electrophysiol 5: 367-375, 1994
17. Hoebeke J: Autoimmunity against cardiovascular receptors: structural and functional implications. Revista Argentina de Cardiologia 63: 221-230, 1995
18. 1-adrenergic receptor. J Exp Med 182: 59-65, 1995
19. 1-adrenergic receptor gene. Biochim Biophys Acta 1178: 307-309, 1993
20. 2-adrenergic receptor gene into Y1 cells. EMBO J 7: 133-138, 1988
21. Reuter H: Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 301: 569-574, 1983
22. Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC: Mechanisms of Ca channel modulation by β-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol 18: 691-710, 1986