메뉴 건너뛰기




Volumn 18, Issue 2, 2004, Pages 233-247

Pharmacogenetics of disease-modifying anti-rheumatic drugs

Author keywords

Adverse effect; Diplotype configuration; N acetyltransferase 2; Polymorphism; Rheumatoid arthritis (RA); Sulphasalazine

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTIRHEUMATIC AGENT; ARYLAMINE ACETYLTRANSFERASE; AZATHIOPRINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DRUG METABOLITE; DRUG METABOLIZING ENZYME; FOLIC ACID; FOLINIC ACID; GLUTATHIONE TRANSFERASE; HYDRALAZINE; HYDROXYCHLOROQUINE; ISONIAZID; LEFLUNOMIDE; MERCAPTOPURINE; METHOTREXATE; N DESETHYLHYDROXYCHLOROQUINE; PENICILLAMINE; PROCAINAMIDE; SALAZOSULFAPYRIDINE; TERIFLUNOMIDE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

EID: 2542486410     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.berh.2004.02.006     Document Type: Review
Times cited : (41)

References (61)
  • 2
    • 0025084541 scopus 로고
    • The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses
    • Felson DT, Anderson JJ & Meenan RF. The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses. Arthritis and Rheumatism 1990; 33: 1449-1461.
    • (1990) Arthritis and Rheumatism , vol.33 , pp. 1449-1461
    • Felson, D.T.1    Anderson, J.J.2    Meenan, R.F.3
  • 3
    • 0031950185 scopus 로고    scopus 로고
    • Methotrexate in rheumatoid arthritis: An update with focus on mechanisms involved in toxicity
    • van Ede AE, Laan RF, Blom HJ, et al. Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity. Seminars in Arthritis and Rheumatism 1998; 27: 277-292.
    • (1998) Seminars in Arthritis and Rheumatism , vol.27 , pp. 277-292
    • van Ede, A.E.1    Laan, R.F.2    Blom, H.J.3
  • 4
    • 0037215239 scopus 로고    scopus 로고
    • Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?
    • Ranganathan P, Eisen S, Yokoyama WM & McLeod HL. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis? Annals of the Rheumatic Diseases 2003; 62: 4-9.
    • (2003) Annals of the Rheumatic Diseases , vol.62 , pp. 4-9
    • Ranganathan, P.1    Eisen, S.2    Yokoyama, W.M.3    McLeod, H.L.4
  • 5
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genetics 1995; 10: 111-113.
    • (1995) Nature Genetics , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 6
    • 0032573077 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
    • Bagley PJ & Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proceedings of the National Academy of Sciences of the United States of America 1998; 95: 13217-13220.
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , pp. 13217-13220
    • Bagley, P.J.1    Selhub, J.2
  • 7
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular Genetics and Metabolism 1998; 64: 169-172.
    • (1998) Molecular Genetics and Metabolism , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3
  • 8
    • 0033007397 scopus 로고    scopus 로고
    • Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis
    • Haagsma CJ, Blom HJ, van Riel PL, et al. Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 1999; 58: 79-84.
    • (1999) Annals of the Rheumatic Diseases , vol.58 , pp. 79-84
    • Haagsma, C.J.1    Blom, H.J.2    van Riel, P.L.3
  • 9
    • 0035157121 scopus 로고    scopus 로고
    • The C677T mutation in the methylenetetrahydrofolate reductase gene: A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients
    • van Ede AE, Laan RF, Blom HJ, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. Arthritis and Rheumatism 2001; 44: 2525-2530.
    • (2001) Arthritis and Rheumatism , vol.44 , pp. 2525-2530
    • van Ede, A.E.1    Laan, R.F.2    Blom, H.J.3
  • 10
    • 0036263469 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses
    • Urano W, Taniguchi A, Yamanaka H, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses. Pharmacogenetics 2002; 12: 183-190.
    • (2002) Pharmacogenetics , vol.12 , pp. 183-190
    • Urano, W.1    Taniguchi, A.2    Yamanaka, H.3
  • 11
    • 0036562879 scopus 로고    scopus 로고
    • Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm
    • Kitamura Y, Moriguchi M, Kaneko H, et al. Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm. Annals of Human Genetics 2002; 66: 183-193.
    • (2002) Annals of Human Genetics , vol.66 , pp. 183-193
    • Kitamura, Y.1    Moriguchi, M.2    Kaneko, H.3
  • 12
    • 0642286407 scopus 로고    scopus 로고
    • Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis
    • Kumagai K, Hiyama K, Oyama T, et al. Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis. International Journal of Molecular Medicine 2003; 11: 593-600.
    • (2003) International Journal of Molecular Medicine , vol.11 , pp. 593-600
    • Kumagai, K.1    Hiyama, K.2    Oyama, T.3
  • 13
    • 0042068263 scopus 로고    scopus 로고
    • A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: Critical role of arginine-482 in methotrexate transport
    • Mitomo H, Kato R, Ito A, et al. A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport. Biochemical Journal 2003; 373: 767-774.
    • (2003) Biochemical Journal , vol.373 , pp. 767-774
    • Mitomo, H.1    Kato, R.2    Ito, A.3
  • 14
    • 0028998289 scopus 로고
    • Sulfasalazine. A review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis
    • Rains CP, Noble S & Faulds D. Sulfasalazine. A review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis. Drugs 1995; 50: 137-156.
    • (1995) Drugs , vol.50 , pp. 137-156
    • Rains, C.P.1    Noble, S.2    Faulds, D.3
  • 16
    • 0022406889 scopus 로고
    • Effect of acetylator phenotype on efficacy and toxicity of sulphasalazine in rheumatoid arthritis
    • Pullar T, Hunter JA & Capell HA. Effect of acetylator phenotype on efficacy and toxicity of sulphasalazine in rheumatoid arthritis. Annals of the Rheumatic Diseases 1985; 44: 831-837.
    • (1985) Annals of the Rheumatic Diseases , vol.44 , pp. 831-837
    • Pullar, T.1    Hunter, J.A.2    Capell, H.A.3
  • 17
    • 0026463006 scopus 로고
    • Influence of acetylator status on sulphasalazine efficacy and toxicity in patients with rheumatoid arthritis
    • Kitas GD, Farr M, Waterhouse L & Bacon PA. Influence of acetylator status on sulphasalazine efficacy and toxicity in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology 1992; 21: 220-225.
    • (1992) Scandinavian Journal of Rheumatology , vol.21 , pp. 220-225
    • Kitas, G.D.1    Farr, M.2    Waterhouse, L.3    Bacon, P.A.4
  • 18
    • 0025372354 scopus 로고
    • A one-year, open, prospective study of sulfasalazine in the treatment of rheumatoid arthritis: Adverse reactions and clinical response in relation to laboratory variables, drug and metabolite serum levels, and acetylator status
    • Chalmers IM, Sitar DS & Hunter T. A one-year, open, prospective study of sulfasalazine in the treatment of rheumatoid arthritis: adverse reactions and clinical response in relation to laboratory variables, drug and metabolite serum levels, and acetylator status. Journal of Rheumatology 1990; 17: 764-770.
    • (1990) Journal of Rheumatology , vol.17 , pp. 764-770
    • Chalmers, I.M.1    Sitar, D.S.2    Hunter, T.3
  • 20
    • 0027183777 scopus 로고
    • Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans
    • Bell DA, Taylor JA, Butler MA, et al. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis 1993; 14: 1689-1692.
    • (1993) Carcinogenesis , vol.14 , pp. 1689-1692
    • Bell, D.A.1    Taylor, J.A.2    Butler, M.A.3
  • 21
    • 0025364134 scopus 로고
    • Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver
    • Deguchi T, Mashimo M & Suzuki T. Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver. Journal of Biological Chemistry 1990; 265: 12757-12760.
    • (1990) Journal of Biological Chemistry , vol.265 , pp. 12757-12760
    • Deguchi, T.1    Mashimo, M.2    Suzuki, T.3
  • 22
    • 0025887858 scopus 로고
    • N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans
    • Hickman D & Sim E. N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans. Biochemical Pharmacology 1991; 42: 1007-1014.
    • (1991) Biochemical Pharmacology , vol.42 , pp. 1007-1014
    • Hickman, D.1    Sim, E.2
  • 23
    • 0028270681 scopus 로고
    • Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene
    • Lin HJ, Han CY, Lin BK & Hardy S. Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics 1994; 4: 125-134.
    • (1994) Pharmacogenetics , vol.4 , pp. 125-134
    • Lin, H.J.1    Han, C.Y.2    Lin, B.K.3    Hardy, S.4
  • 24
    • 0036896055 scopus 로고    scopus 로고
    • Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene
    • Tanaka E, Taniguchi A, Urano W, et al. Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene. Journal of Rheumatology 2002; 29: 2492-2499.
    • (2002) Journal of Rheumatology , vol.29 , pp. 2492-2499
    • Tanaka, E.1    Taniguchi, A.2    Urano, W.3
  • 26
    • 0030724065 scopus 로고    scopus 로고
    • Predisposing factors in sulphasalazine-induced systemic lupus erythematosus
    • Gunnarsson I, Kanerud L, Pettersson E, et al. Predisposing factors in sulphasalazine-induced systemic lupus erythematosus. British Journal of Rheumatology 1997; 36: 1089-1094.
    • (1997) British Journal of Rheumatology , vol.36 , pp. 1089-1094
    • Gunnarsson, I.1    Kanerud, L.2    Pettersson, E.3
  • 27
    • 0030898186 scopus 로고    scopus 로고
    • NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus
    • Sabbagh N, Delaporte E, Marez D, et al. NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus. Pharmacogenetics 1997; 7: 131-135.
    • (1997) Pharmacogenetics , vol.7 , pp. 131-135
    • Sabbagh, N.1    Delaporte, E.2    Marez, D.3
  • 28
    • 0037863063 scopus 로고    scopus 로고
    • Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine
    • Ohtani T, Hiroi A, Sakurane M & Furukawa F. Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine. British Journal of Dermatology 2003; 148: 1035-1039.
    • (2003) British Journal of Dermatology , vol.148 , pp. 1035-1039
    • Ohtani, T.1    Hiroi, A.2    Sakurane, M.3    Furukawa, F.4
  • 29
    • 0034091884 scopus 로고    scopus 로고
    • Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis
    • Wadelius M, Stjernberg E, Wiholm BE & Rane A. Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. Pharmacogenetics 2000; 10: 35-41.
    • (2000) Pharmacogenetics , vol.10 , pp. 35-41
    • Wadelius, M.1    Stjernberg, E.2    Wiholm, B.E.3    Rane, A.4
  • 30
  • 31
    • 0033805156 scopus 로고    scopus 로고
    • Mammalian class theta GST and differential susceptibility to carcinogens: A review
    • Landi S. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutation Research 2000; 463: 247-283.
    • (2000) Mutation Research , vol.463 , pp. 247-283
    • Landi, S.1
  • 32
    • 0032708418 scopus 로고    scopus 로고
    • The therapeutic response to D-penicillamine in rheumatoid arthritis: Influence of glutathione S-transferase polymorphisms
    • Layton MA, Jones PW, Alldersea JE, et al. The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumotology (Oxford) 1999; 38: 43-47.
    • (1999) Rheumotology (Oxford) , vol.38 , pp. 43-47
    • Layton, M.A.1    Jones, P.W.2    Alldersea, J.E.3
  • 33
    • 0036184942 scopus 로고    scopus 로고
    • Smoking and disease severity in rheumatoid arthritis: Association with polymorphism at the glutathione S-transferase MI locus
    • Mattey DL, Hutchinson D, Dawes PT, et al. Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase MI locus. Arthritis and Rheumatism 2002; 46: 640-646.
    • (2002) Arthritis and Rheumatism , vol.46 , pp. 640-646
    • Mattey, D.L.1    Hutchinson, D.2    Dawes, P.T.3
  • 34
    • 0032954166 scopus 로고    scopus 로고
    • Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: Comparison with the shared epitope
    • Mattey DL, Hassell AB, Plant M, et al. Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. Annals of the Rheumatic Diseases 1999; 58: 164-168.
    • (1999) Annals of the Rheumatic Diseases , vol.58 , pp. 164-168
    • Mattey, D.L.1    Hassell, A.B.2    Plant, M.3
  • 35
    • 0028044714 scopus 로고
    • Thiopurine methyltransferase activity in American white subjects and black subjects
    • McLeod HL, Lin JS, Scott EP, et al. Thiopurine methyltransferase activity in American white subjects and black subjects. Clinical Pharmacology and Therapeutics 1994; 55: 15-20.
    • (1994) Clinical Pharmacology and Therapeutics , vol.55 , pp. 15-20
    • McLeod, H.L.1    Lin, J.S.2    Scott, E.P.3
  • 36
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM & Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. American Journal of Human Genetics 1980; 32: 651-662.
    • (1980) American Journal of Human Genetics , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 37
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltransferase gene locus-implications for clinical pharmacogenomics
    • McLeod HL & Siva C. The thiopurine S-methyltransferase gene locus-implications for clinical pharmacogenomics. Pharmacogenomics 2002; 3: 89-98.
    • (2002) Pharmacogenomics , vol.3 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 38
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
    • Yates CR, Krynetski EY, Loennechen T, et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Annals of Internal Medicine 1997; 126: 608-614.
    • (1997) Annals of Internal Medicine , vol.126 , pp. 608-614
    • Yates, C.R.1    Krynetski, E.Y.2    Loennechen, T.3
  • 39
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    • Relling MV, Hancock ML, Rivera GK, et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. Journal of the National Cancer Institute 1999; 91: 2001-2008.
    • (1999) Journal of the National Cancer Institute , vol.91 , pp. 2001-2008
    • Relling, M.V.1    Hancock, M.L.2    Rivera, G.K.3
  • 40
    • 0035183513 scopus 로고    scopus 로고
    • Pharmacogenetics: The therapeutic drug monitoring of the future?
    • Ensom MH, Chang TK & Patel P. Pharmacogenetics: the therapeutic drug monitoring of the future? Clinical Pharmacokinetics 2001; 40: 783-802.
    • (2001) Clinical Pharmacokinetics , vol.40 , pp. 783-802
    • Ensom, M.H.1    Chang, T.K.2    Patel, P.3
  • 41
    • 0032212759 scopus 로고    scopus 로고
    • Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine
    • Black AJ, McLeod HL, Capell HA, et al. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine. Annals of Internal Medicine 1998; 129: 716-718.
    • (1998) Annals of Internal Medicine , vol.129 , pp. 716-718
    • Black, A.J.1    McLeod, H.L.2    Capell, H.A.3
  • 42
    • 0033376417 scopus 로고    scopus 로고
    • Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese
    • Ishioka S, Hiyama K, Sato H, et al. Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese. Internal Medicine 1999; 38: 944-947.
    • (1999) Internal Medicine , vol.38 , pp. 944-947
    • Ishioka, S.1    Hiyama, K.2    Sato, H.3
  • 43
    • 0037244866 scopus 로고    scopus 로고
    • Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients?
    • Corominas H, Domenech M, Laiz A, et al. Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients? Rheumatology (Oxford) 2003; 42: 40-45.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 40-45
    • Corominas, H.1    Domenech, M.2    Laiz, A.3
  • 44
    • 0036894866 scopus 로고    scopus 로고
    • Practical pharmacogenetics: The cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine
    • Marra CA, Esdaile JM & Anis AH. Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine. Journal of Rheumatology 2002; 29: 2507-2512.
    • (2002) Journal of Rheumatology , vol.29 , pp. 2507-2512
    • Marra, C.A.1    Esdaile, J.M.2    Anis, A.H.3
  • 45
    • 0032805244 scopus 로고    scopus 로고
    • Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter
    • Spire-Vayron de la Moureyre C, Debuysere H, Fazio F, et al. Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter. Pharmacogenetics 1999; 9: 189-198.
    • (1999) Pharmacogenetics , vol.9 , pp. 189-198
    • Spire-Vayron de la Moureyre, C.1    Debuysere, H.2    Fazio, F.3
  • 46
    • 0033837392 scopus 로고    scopus 로고
    • Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis
    • Yan L, Zhang S, Eiff B, et al. Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis. Clinical Pharmacology and Therapeutics 2000; 68: 210-219.
    • (2000) Clinical Pharmacology and Therapeutics , vol.68 , pp. 210-219
    • Yan, L.1    Zhang, S.2    Eiff, B.3
  • 47
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes
    • Chang TK, Weber GF, Crespi CL & Waxman DJ. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Research 1993; 53: 5629-5637.
    • (1993) Cancer Research , vol.53 , pp. 5629-5637
    • Chang, T.K.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 48
    • 0030758131 scopus 로고    scopus 로고
    • Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation
    • Chang TK, Yu L, Goldstein JA & Waxman DJ. Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics 1997; 7: 211-221.
    • (1997) Pharmacogenetics , vol.7 , pp. 211-221
    • Chang, T.K.1    Yu, L.2    Goldstein, J.A.3    Waxman, D.J.4
  • 50
    • 0032963703 scopus 로고    scopus 로고
    • US consensus guidelines for the use of cyclosporin A in rheumatoid arthritis
    • Cush JJ, Tugwell P, Weinblatt M & Yocum D. US consensus guidelines for the use of cyclosporin A in rheumatoid arthritis. Journal of Rheumatology 1999; 26: 1176-1186.
    • (1999) Journal of Rheumatology , vol.26 , pp. 1176-1186
    • Cush, J.J.1    Tugwell, P.2    Weinblatt, M.3    Yocum, D.4
  • 51
    • 0037766006 scopus 로고    scopus 로고
    • Association of the CYP3A4* IB 5′-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjects
    • Min DI & Ellingrod VL. Association of the CYP3A4* IB 5′-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjects. Therapeutic Drug Monitoring 2003; 25: 305-309.
    • (2003) Therapeutic Drug Monitoring , vol.25 , pp. 305-309
    • Min, D.I.1    Ellingrod, V.L.2
  • 52
    • 0034744113 scopus 로고    scopus 로고
    • No influence of the MDR-I C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients
    • von Ahsen N, Richter M, Grupp C, et al. No influence of the MDR-I C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients. Clinical Chemistry 2001; 47: 1048-1052.
    • (2001) Clinical Chemistry , vol.47 , pp. 1048-1052
    • von Ahsen, N.1    Richter, M.2    Grupp, C.3
  • 53
    • 0033626281 scopus 로고    scopus 로고
    • Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance
    • Rivory LP, Qin H, Clarke SJ, et al. Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance. European Journal of Clinical Pharmacology 2000; 56: 395-398.
    • (2000) European Journal of Clinical Pharmacology , vol.56 , pp. 395-398
    • Rivory, L.P.1    Qin, H.2    Clarke, S.J.3
  • 54
    • 0037906108 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDRI polymorphic expression on cyclosporine oral disposition in renal transplant patients
    • Yates CR, Zhang W, Song P, et al. The effect of CYP3A5 and MDRI polymorphic expression on cyclosporine oral disposition in renal transplant patients. The Journal of Clinical Pharmacology 2003; 43: 555-564.
    • (2003) The Journal of Clinical Pharmacology , vol.43 , pp. 555-564
    • Yates, C.R.1    Zhang, W.2    Song, P.3
  • 55
    • 0037330517 scopus 로고    scopus 로고
    • Genetic polymorphisms in MDRI and CYP3A4 genes in Asians and the influence of MDRI haplotypes on cyclosporin disposition in heart transplant recipients
    • Chowbay B, Cumaraswamy S, Cheung YB, et al. Genetic polymorphisms in MDRI and CYP3A4 genes in Asians and the influence of MDRI haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003; 13: 89-95.
    • (2003) Pharmacogenetics , vol.13 , pp. 89-95
    • Chowbay, B.1    Cumaraswamy, S.2    Cheung, Y.B.3
  • 56
    • 0036310615 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of leflunomide
    • Rozman B. Clinical pharmacokinetics of leflunomide. Clinical Pharmacokinetics 2002; 41: 421-430.
    • (2002) Clinical Pharmacokinetics , vol.41 , pp. 421-430
    • Rozman, B.1
  • 57
    • 0141569613 scopus 로고    scopus 로고
    • In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: Mechanistic similarities with the cytochrome p450-catalyzed dehydration of aldoximes
    • Kalgutkar AS, Nguyen HT, Vaz AD, et al. In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome p450-catalyzed dehydration of aldoximes. Drug Metabolism and Disposition 2003; 31: 1240-1250.
    • (2003) Drug Metabolism and Disposition , vol.31 , pp. 1240-1250
    • Kalgutkar, A.S.1    Nguyen, H.T.2    Vaz, A.D.3
  • 58
    • 0037518218 scopus 로고    scopus 로고
    • In vitro metabolism of chloroquine: Identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation
    • Projean D, Baune B, Farinotti R, et al. In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. Drug Metabolism and Disposition 2003; 31: 748-754.
    • (2003) Drug Metabolism and Disposition , vol.31 , pp. 748-754
    • Projean, D.1    Baune, B.2    Farinotti, R.3
  • 59
    • 2342578929 scopus 로고    scopus 로고
    • Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes
    • Kim KA, Park JY, Lee JS & Lim S. Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes. Archives of Pharmacal Research 2003; 26: 631-637.
    • (2003) Archives of Pharmacal Research , vol.26 , pp. 631-637
    • Kim, K.A.1    Park, J.Y.2    Lee, J.S.3    Lim, S.4
  • 60
    • 0036272067 scopus 로고    scopus 로고
    • Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis
    • Munster T, Gibbs JP, Shen D, et al. Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis. Arthritis and Rheumatism 2002; 46: 1460-1469.
    • (2002) Arthritis and Rheumatism , vol.46 , pp. 1460-1469
    • Munster, T.1    Gibbs, J.P.2    Shen, D.3
  • 61
    • 0035008168 scopus 로고    scopus 로고
    • Analysis of the ABCR (ABCA4) gene in 4-aminoquinoline retinopathy: Is retinal toxicity by chloroquine and hydroxychloroquine related to Stargardt disease?
    • Shroyer NF, Lewis RA & Lupski JR. Analysis of the ABCR (ABCA4) gene in 4-aminoquinoline retinopathy: is retinal toxicity by chloroquine and hydroxychloroquine related to Stargardt disease? American Journal of Ophthalmology 2001; 131: 761-766.
    • (2001) American Journal of Ophthalmology , vol.131 , pp. 761-766
    • Shroyer, N.F.1    Lewis, R.A.2    Lupski, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.