Drift in susceptibility of Neisseria gonorrhoeae to ciprofloxacin and emergence of therapeutic failure

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 11, 1998, Pages 2919-2922

  Ison, Catherine A ^a,c   Woodford, Patricia J ^a   Madders, Helen ^a,d   Claydon, Elizabeth ^b  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c ICSM   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADA TABS; BACTERIAL DNA; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); NALIDIXIC ACID; PENICILLIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; DRUG SENSITIVITY; DRUG SURVEILLANCE PROGRAM; GENE MUTATION; GONORRHEA; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NEISSERIA GONORRHOEAE; PRIORITY JOURNAL; TREATMENT FAILURE;

EID: 0031724518     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.11.2919     Document Type: Article

References (33)

1. Abeyewickereme, I., L. Senaratne, and V. B. Prithiviraj. 1996. Rapid emergence of 4-fluoroquinolone resistance with associated decline in penicillinase-producing Neisseria gonorrhoeae in Colombo, Sri Lanka. Genitourin. Med. 72:302.
2. Belland, R. J., S. G. Morrison, C. Ison, and W. M. Huang. 1994. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol. Microbiol. 14:371-380.
3. Birley, H., P. McDonald, P. Carey, and J. Fletcher. 1994. High-level ciprofloxacin resistance in Neisseria gonorrhoeae. Genitourin. Med. 70:292-293.
4. Centers for Disease Control and Prevention. 1995. Fluoroquinolone resistance in Neisseria gonorrhoeae - Colorado and Washington, 1995. Morbid. Mortal. Weekly Rep. 44:761-764.
5. Davies, P. O., N. Low, and C. A. Ison. 1998. The role of effective diagnosis for the control of gonorrhoea in high prevalence populations. Int. J. Sex. Transm. Dis. AIDS 9:435-443.
6. Deguchi, T., I. Saito, M. Tanaka, K.-I. Sato, K.-I. Deguchi, M. Yasuda, M. Nakano, Y. Nishino, E. Kanematsu, S. Ozeki, and Y. Kawada. 1997. Fluoroquinolone treatment failure in gonorrhoea. Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones. Sex. Transm. Dis. 24:247-250.
7. Deguchi, T., M. Yasuda, M. Asano, K. Tada, H. Iwata, H. Komeda, T. Ezaki, I. Saito, and Y. Kawada. 1995. DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 39: 561-563.
8. Deguchi, T., M. Yasuda, M. Nakano, S. Ozeki, T. Ezaki, I. Saito, and Y. Kawada. 1996. Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob. Agents Chemother. 40:1020-1023.
9. Deguchi, T., M. Yasuda, M. Nakano, S. Ozeki, T. Ezaki, S. Maeda, I. Saito, and Y. Kawada. 1996. Rapid detection of point mutations of the Neisseria gonorrhoeae gyrA gene associated with decreased susceptibilities to quinolones. J. Clin. Microbiol. 34:2255-2258.
10. Deguchi, T., M. Yasuda, M. Nakano, E. Kanematsu, S. Ozeki, Y. Nishino, T. Ezaki, S.-I. Maeda, I. Saito, and Y. Kawada. 1997. Rapid screening of point mutations of the Neisseria gonorrhoeae parC gene associated with resistance to quinolones. J. Clin. Microbiol. 35:948-950.
11. Echols, R. M., A. Heyd, B. J. O'Keeffe, and P. Schacht. 1994. Single dose ciprofloxacin for the treatment of gonorrhoea: a worldwide summary Sex, Transm. Dis. 21:345-352.
12. Fitzgerald, M. 1997. Antibiotic treatment for gonorrhoea in the UK. Genitourin. Med. 73:149.
13. Gill, M. J., S. Simjee, K. Al-Hattawi, B. D. Robertson, C. S. F. Easmon, and C. A. Ison. 1998. Gonococcal resistance to β-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus. Antimicrob. Agents Chemother. 42:2799-2803.
14. Gransden, W. R., C. A. Warren, I. Phillips, M. Hodges, and D. Barlow. 1990. Decreased susceptibility of Neisseria gonorrhoeae to ciprofloxacin. Lancet 335:51.
15. Hagman, K. E., W. Pan, B. G. Spratt, J. T. Balthazar, R. C. Judd, and W. M. Shafer. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modified by the mtrRCDE efflux system. Microbiology 141: 611-622.
16. Ison, C. A., N. S. Branley, K. Kirtland, and C. S. F. Easmon. 1991. Surveillance of antibiotic resistance in clinical isolates of Neisseria gonorrhoeae. Br. Med. J. 303:1307.
17. Ison, C. A., J. R. Dillon, and J. W. Tapsall. 1998. The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi. Lancet 351(Suppl. III):8-11.
18. Jephcott, A. E., and A. Turner. 1990. Ciprofloxacin resistance in gonococci. Lancet 335:165.
19. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1993. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 37:1086-1094.
20. Kam, K. M., K. K. Lo, N. K. Y. Ho, and M. M. Cheung. 1995. Rapid decline in penicillinase-producing Neisseria gonorrhoeae in Hong Kong associated with emerging 4-fluoroquinolone resistance. Genitourin. Med. 71:141-144.
21. Knapp, J. S., R. Ohye, S. W. Neal, M. C. Parekh, H. Higa, and R. J. Rice. 1994. Emerging in vitro resistance to quinolones in penicillinase-producing Neisseria gonorrhoeae strains in Hawaii. Antimicrob. Agents Chemother. 38: 2200-2203.
22. Knapp, J. S., V. P. Mesola, S. W. Neal, T. E. Wi, C. Tuazon, R. Manalastas, P. L. Perine, and W. L. Whittington. 1997. Molecular epidemiology, in 1994, of Neisseria gonorrhoeae in Manila and Cebu City, Republic of the Philippines. Sex. Transm. Dis. 24:1-7.
23. Knapp, J. S., J. A. Washington, L. J. Doyle, S. W. Neal, M. C. Parekh, and R. J. Rice. 1994. Persistence of Neisseria gonorrhoeae strains with decreased susceptibilities to ciprofloxacin and ofloxacin in Cleveland. Ohio, from 1992 through 1993. Antimicrob. Agents Chemother. 38:2194-2196.
24. National Committee for Clinical Laboratory Standards. 1998. Performance standards for antimicrobial susceptibility testing. M100-38. National Committee for Clinical Laboratory Standards, Wayne, Pa.
25. Tanaka, M., J. Kumazawa, T. Matsumoto, and I. Kobayashi. 1994. High prevalence of Neisseria gonorrhoeae strains with reduced susceptibility to fluoroquinolones in Japan. Genitourin. Med. 70:90-93.
26. Tanaka, M., T. Matsumoto, M. Sakumoto, K. Takahashi, T. Saika, I. Kabayashi, J. Kumazawa, and The Pazufloxacin STD Group. 1998. Reduced clinical efficacy of pazufloxacin against gonorrhoea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. Antimicrob. Agents Chemother. 42:579-582.
27. Tapsall, J. W., T. R. Shultz, and E. A. Phillips. 1992. Characteristics of Neisseria gonorrhoeae isolated in Australia showing decreased sensitivity to quinolone antibiotics. Pathology 24:27-31.
28. Tapsall, J. W., E. A. Limnios, C. Thacker, B. Donovan, S. D. Lynch, L. J. Kirby, K. A. Wise, and C. J. Carmody. 1995. High-level quinolone resistance in Neisseria gonorrhoeae: a report of two cases. Sex. Transm. Dis. 22:310-311.
29. Tapsall, J. W., E. A. Phillips, T. R. Schultz, and C. Thacker. 1996. Quinolone-resistant Neisseria gonorrhoeae in Sydney, Australia, 1991-1995. Sex. Transm. Dis. 23:425-428.
30. Turner, A., K. R. Gough, A. E. Jephcott, and A. N. McClean. 1995. Importation into the UK of a strain of Neisseria gonorrhoeae resistant to penicillin, ciprofloxacin and tetracycline. Genitourin. Med. 71:265-266.
31. Woodford, N., K. M. Bindayna, C. S. F. Easmon, and C. A. Ison. 1989. Associations between serotype and susceptibility to antibiotics of Neisseria gonorrhoeae. Genitourin. Med. 65:86-91.
32. Woodford, N., and C. A. Ison. 1988. The effect of media on antimicrobial susceptibility testing of Neisseria gonorrhoeae. J. Antimicrob. Chemother. 22: 463-471.
33. Zeller, V., C. Janoir, M.-D. Kitzis, L. Gutmann, and N. Moreau. 1997. Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:1973-1978.