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Volumn 30, Issue 2, 2004, Pages 405-415

Clinical experience with inhibition of interleukin-6

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; CYCLOSPORIN A; GLUCOCORTICOID; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; METHOTREXATE; PREDNISOLONE; PREDNISONE;

EID: 2542477009     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rdc.2004.01.008     Document Type: Review
Times cited : (31)

References (45)
  • 1
    • 0021212076 scopus 로고
    • Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years
    • Pincus T., Callahan L.F., Sale W.G., Brooks A.L., Payne L.E., Vaughn W.K. Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum. 27:1984;864-872
    • (1984) Arthritis Rheum , vol.27 , pp. 864-872
    • Pincus, T.1    Callahan, L.F.2    Sale, W.G.3    Brooks, A.L.4    Payne, L.E.5    Vaughn, W.K.6
  • 2
    • 0026780956 scopus 로고
    • Rheumatology function tests: Grip strength, walking time, button test and questionnaires document and predict longterm morbidity and mortality in rheumatoid arthritis
    • Pincus T., Callahan L.F. Rheumatology function tests: grip strength, walking time, button test and questionnaires document and predict longterm morbidity and mortality in rheumatoid arthritis. J Rheumatol. 19:1992;1051-1057
    • (1992) J Rheumatol , vol.19 , pp. 1051-1057
    • Pincus, T.1    Callahan, L.F.2
  • 3
    • 0037029418 scopus 로고    scopus 로고
    • Methotrexate and mortality in patients with rheumatoid arthritis: A prospective study
    • Choi H.K., Hernan M.A., Seeger J.D., Robins J.M., Wolfe F. Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet. 359:2002;1173-1177
    • (2002) Lancet , vol.359 , pp. 1173-1177
    • Choi, H.K.1    Hernan, M.A.2    Seeger, J.D.3    Robins, J.M.4    Wolfe, F.5
  • 4
    • 84960594761 scopus 로고
    • Long-term outcome in rheumatoid arthritis
    • Pincus T. Long-term outcome in rheumatoid arthritis. Br J Rheumatol. 34(Suppl 2):1995;59-73
    • (1995) Br J Rheumatol , vol.34 , Issue.SUPPL. 2 , pp. 59-73
    • Pincus, T.1
  • 5
    • 0023179033 scopus 로고
    • Long-term outcome of treating rheumatoid arthritis: Results after 20 years
    • Scott D.L., Symmons D.P., Coulton B.L., Popert A.J. Long-term outcome of treating rheumatoid arthritis: results after 20 years. Lancet. 1:1987;1108-1111
    • (1987) Lancet , vol.1 , pp. 1108-1111
    • Scott, D.L.1    Symmons, D.P.2    Coulton, B.L.3    Popert, A.J.4
  • 6
    • 0025253851 scopus 로고
    • Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
    • Akira S., Hirano T., Taga T., Kishimoto T. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 4:1990;2860-2867
    • (1990) FASEB J , vol.4 , pp. 2860-2867
    • Akira, S.1    Hirano, T.2    Taga, T.3    Kishimoto, T.4
  • 7
    • 0026619974 scopus 로고
    • Regulation of expression of the interleukin 6 gene: Structure and function of the transcription factor NF-IL6
    • Akira S., Isshiki H., Nakajima T., Kinoshita S., Nishio Y., Natsuka S., et al. Regulation of expression of the interleukin 6 gene: structure and function of the transcription factor NF-IL6. Ciba Found Symp. 167:1992;47-62
    • (1992) Ciba Found Symp , vol.167 , pp. 47-62
    • Akira, S.1    Isshiki, H.2    Nakajima, T.3    Kinoshita, S.4    Nishio, Y.5    Natsuka, S.6
  • 8
    • 0029084805 scopus 로고
    • Interleukin-6 family of cytokines and gp130
    • Kishimoto T., Akira S., Narazaki M., Taga T. Interleukin-6 family of cytokines and gp130. Blood. 86:1995;1243-1254
    • (1995) Blood , vol.86 , pp. 1243-1254
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 9
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga T., Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol. 15:1997;797-819
    • (1997) Annu Rev Immunol , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 10
    • 0029553205 scopus 로고
    • Cytokine signal transduction through a homo- or heterodimer of gp130
    • Kishimoto T., Tanaka T., Yoshida K., Akira S., Taga T. Cytokine signal transduction through a homo- or heterodimer of gp130. Ann N Y Acad Sci. 766:1995;224-234
    • (1995) Ann N Y Acad Sci , vol.766 , pp. 224-234
    • Kishimoto, T.1    Tanaka, T.2    Yoshida, K.3    Akira, S.4    Taga, T.5
  • 11
    • 0034213975 scopus 로고    scopus 로고
    • Receptor recognition by gp130 cytokines
    • Bravo J., Heath J.K. Receptor recognition by gp130 cytokines. EMBO J. 19:2000;2399-2411
    • (2000) EMBO J , vol.19 , pp. 2399-2411
    • Bravo, J.1    Heath, J.K.2
  • 12
    • 0029975904 scopus 로고    scopus 로고
    • STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line
    • Minami M., Inoue M., Wei S., Takeda K., Matsumoto M., Kishimoto T., et al. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A. 93:1996;3963-3966
    • (1996) Proc Natl Acad Sci U S a , vol.93 , pp. 3963-3966
    • Minami, M.1    Inoue, M.2    Wei, S.3    Takeda, K.4    Matsumoto, M.5    Kishimoto, T.6
  • 13
    • 0028593918 scopus 로고
    • Signal transduction through homo- or heterodimers of gp130
    • Kishimoto T. Signal transduction through homo- or heterodimers of gp130. Stem Cells. 12(Suppl 1):1994;37-44
    • (1994) Stem Cells , vol.12 , Issue.SUPPL. 1 , pp. 37-44
    • Kishimoto, T.1
  • 14
    • 0030940081 scopus 로고    scopus 로고
    • The anti-human tumor effect and generation of human cytotoxic T cells in SCID mice given human peripheral blood lymphocytes by the in vivo transfer of the interleukin-6 gene using adenovirus vector
    • Tanaka F., Abe M., Akiyoshi T., Nomura T., Sugimachi K., Kishimoto T., et al. The anti-human tumor effect and generation of human cytotoxic T cells in SCID mice given human peripheral blood lymphocytes by the in vivo transfer of the interleukin-6 gene using adenovirus vector. Cancer Res. 57:1997;1335-1343
    • (1997) Cancer Res , vol.57 , pp. 1335-1343
    • Tanaka, F.1    Abe, M.2    Akiyoshi, T.3    Nomura, T.4    Sugimachi, K.5    Kishimoto, T.6
  • 15
    • 0033783333 scopus 로고    scopus 로고
    • IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage
    • Flannery C.R., Little C.B., Hughes C.E., Curtis C.L., Caterson B., Jones S.A. IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix Biol. 19:2000;549-553
    • (2000) Matrix Biol , vol.19 , pp. 549-553
    • Flannery, C.R.1    Little, C.B.2    Hughes, C.E.3    Curtis, C.L.4    Caterson, B.5    Jones, S.A.6
  • 16
    • 0025967588 scopus 로고
    • Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: Possible involvement of NF-IL6 in acute phase protein gene expression
    • Isshiki H., Akira S., Sugita T., Nishio Y., Hashimoto S., Pawlowski T., et al. Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression. New Biol. 3:1991;63-70
    • (1991) New Biol , vol.3 , pp. 63-70
    • Isshiki, H.1    Akira, S.2    Sugita, T.3    Nishio, Y.4    Hashimoto, S.5    Pawlowski, T.6
  • 17
    • 0031908779 scopus 로고    scopus 로고
    • The use of knockout mice to understand the role of cytokines in fever
    • Kluger M.J., Kozak W., Leon L.R., Conn C.A. The use of knockout mice to understand the role of cytokines in fever. Clin Exp Pharmacol Physiol. 25:1998;141-144
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 141-144
    • Kluger, M.J.1    Kozak, W.2    Leon, L.R.3    Conn, C.A.4
  • 18
    • 0026081754 scopus 로고
    • Interleukin-1 and -6 stimulate the release of corticotrophin realising hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway
    • Navarra P., Tsagarakis S., Faria M.S., Rees L.H., Besser G.M., Grossman A.B. Interleukin-1 and -6 stimulate the release of corticotrophin realising hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology. 128:1990;37-44
    • (1990) Endocrinology , vol.128 , pp. 37-44
    • Navarra, P.1    Tsagarakis, S.2    Faria, M.S.3    Rees, L.H.4    Besser, G.M.5    Grossman, A.B.6
  • 19
    • 0033773859 scopus 로고    scopus 로고
    • Relationship between interleukin-6 (IL-6) and hypothalamic-pituitary- adrenal axis hormones in rheumatoid arthritis
    • Mastorakos G., Ilias I. Relationship between interleukin-6 (IL-6) and hypothalamic-pituitary-adrenal axis hormones in rheumatoid arthritis. Zeitschrift fur Rheumatologie. 59(Suppl 2):2000;75-79
    • (2000) Zeitschrift fur Rheumatologie , vol.59 , Issue.SUPPL. 2 , pp. 75-79
    • Mastorakos, G.1    Ilias, I.2
  • 20
    • 0033777670 scopus 로고    scopus 로고
    • The hypothalamic-pituitary-adrenocortical and gonadal axis function in rheumatoid arthritis
    • Cutolo M., Giusti M., Foppiani L., Seriolo B., Briata M., Bisso A., et al. The hypothalamic-pituitary-adrenocortical and gonadal axis function in rheumatoid arthritis. Zeitschrift fur Rheumatologie. 59(Suppl 2):2000;II/65-II/69
    • (2000) Zeitschrift fur Rheumatologie , vol.59 , Issue.SUPPL. 2 , pp. 65-II/69
    • Cutolo, M.1    Giusti, M.2    Foppiani, L.3    Seriolo, B.4    Briata, M.5    Bisso, A.6
  • 21
    • 0031080815 scopus 로고    scopus 로고
    • Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice
    • Katsume A., Miyai T., Suzuki H., Moriguchi Y., Kawata H., Tatsumi T., et al. Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice. Clin Immunol Immunopathol. 82:1997;117-124
    • (1997) Clin Immunol Immunopathol , vol.82 , pp. 117-124
    • Katsume, A.1    Miyai, T.2    Suzuki, H.3    Moriguchi, Y.4    Kawata, H.5    Tatsumi, T.6
  • 22
    • 0033560836 scopus 로고    scopus 로고
    • Soluble interleukin-6 (IL-6) receptor with IL-6 stimulates megakaryopoiesis from human CD34(+) cells through glycoprotein (gp)130 signaling
    • Sui X., Tsuji K., Ebihara Y., Tanaka R., Muraoka K., Yoshida M., et al. Soluble interleukin-6 (IL-6) receptor with IL-6 stimulates megakaryopoiesis from human CD34(+) cells through glycoprotein (gp)130 signaling. Blood. 93:1999;2525-2532
    • (1999) Blood , vol.93 , pp. 2525-2532
    • Sui, X.1    Tsuji, K.2    Ebihara, Y.3    Tanaka, R.4    Muraoka, K.5    Yoshida, M.6
  • 23
    • 0028786577 scopus 로고
    • Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors
    • Udagawa N., Takahashi N., Katagiri T., Tamura T., Wada S., Findlay D.M., et al. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med. 182:1995;1461-1468
    • (1995) J Exp Med , vol.182 , pp. 1461-1468
    • Udagawa, N.1    Takahashi, N.2    Katagiri, T.3    Tamura, T.4    Wada, S.5    Findlay, D.M.6
  • 24
    • 0026527781 scopus 로고
    • Interleukin 6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production
    • Brozik M., Rosztoczy I., Meretey K., Balint G., Gaal M., Balogh Z., et al. Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production. J Rheumatol. 19:1992;63-68
    • (1992) J Rheumatol , vol.19 , pp. 63-68
    • Brozik, M.1    Rosztoczy, I.2    Meretey, K.3    Balint, G.4    Gaal, M.5    Balogh, Z.6
  • 26
    • 0344534939 scopus 로고    scopus 로고
    • Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies
    • Uson J., Balsa A., Pascual-Salcedo D., Cabezas J.A., Gonzalez-Tarrio J.M., Martin-Mola E., et al. Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J Rheumatol. 24:1997;2069-2075
    • (1997) J Rheumatol , vol.24 , pp. 2069-2075
    • Uson, J.1    Balsa, A.2    Pascual-Salcedo, D.3    Cabezas, J.A.4    Gonzalez-Tarrio, J.M.5    Martin-Mola, E.6
  • 27
    • 0024271851 scopus 로고
    • Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases
    • Swaak A.J., van Rooyen A., Nieuwenhuis E., Aarden L.A. Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases. Scand J Rheumatol. 17:1988;469-474
    • (1988) Scand J Rheumatol , vol.17 , pp. 469-474
    • Swaak, A.J.1    Van Rooyen, A.2    Nieuwenhuis, E.3    Aarden, L.A.4
  • 28
    • 0026560489 scopus 로고
    • Interleukin-6 and its receptor in autoimmunity
    • Kishimoto T. Interleukin-6 and its receptor in autoimmunity. J Autoimmun. 5(Suppl A):1992;123-132
    • (1992) J Autoimmun , vol.5 , Issue.SUPPL. A , pp. 123-132
    • Kishimoto, T.1
  • 29
    • 0024592982 scopus 로고
    • Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis
    • Guerne P.A., Zuraw B.L., Vaughan J.H., Carson D.A., Lotz M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest. 83:1989;585-592
    • (1989) J Clin Invest , vol.83 , pp. 585-592
    • Guerne, P.A.1    Zuraw, B.L.2    Vaughan, J.H.3    Carson, D.A.4    Lotz, M.5
  • 30
    • 0024269961 scopus 로고
    • Excessive production of interleukin-6/B cell stimulatory factor-2 in rheumatoid arthritis
    • Hirano T., Matsuda T., Turner M., Miyasaka N., Buchan G., Tang B., et al. Excessive production of interleukin-6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol. 18:1988;1797-1801
    • (1988) Eur J Immunol , vol.18 , pp. 1797-1801
    • Hirano, T.1    Matsuda, T.2    Turner, M.3    Miyasaka, N.4    Buchan, G.5    Tang, B.6
  • 31
    • 0026537579 scopus 로고
    • Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis
    • Dasgupta B., Corkill M., Kirkham B., Gibson T., Panayi G. Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol. 19:1992;22-25
    • (1992) J Rheumatol , vol.19 , pp. 22-25
    • Dasgupta, B.1    Corkill, M.2    Kirkham, B.3    Gibson, T.4    Panayi, G.5
  • 32
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S., Sato K., Kim K.J., Takahashi N., Udagawa N., Nakamura I., et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res. 11:1996;88-95
    • (1996) J Bone Miner Res , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3    Takahashi, N.4    Udagawa, N.5    Nakamura, I.6
  • 33
    • 0032429668 scopus 로고    scopus 로고
    • Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • Takagi N., Mihara M., Moriya Y., Nishimoto N., Yoshizaki K., Kishimoto T., et al. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 41:1998;2117-2121
    • (1998) Arthritis Rheum , vol.41 , pp. 2117-2121
    • Takagi, N.1    Mihara, M.2    Moriya, Y.3    Nishimoto, N.4    Yoshizaki, K.5    Kishimoto, T.6
  • 34
    • 0035090840 scopus 로고    scopus 로고
    • Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
    • Mihara M., Kotoh M., Nishimoto N., Oda Y., Kumagai E., Takagi N., et al. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol. 98:2001;319-326
    • (2001) Clin Immunol , vol.98 , pp. 319-326
    • Mihara, M.1    Kotoh, M.2    Nishimoto, N.3    Oda, Y.4    Kumagai, E.5    Takagi, N.6
  • 35
    • 0027402917 scopus 로고
    • Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody
    • Wendling D., Racadot E., Wijdenes J. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J Rheumatol. 20:1993;259-262
    • (1993) J Rheumatol , vol.20 , pp. 259-262
    • Wendling, D.1    Racadot, E.2    Wijdenes, J.3
  • 36
    • 0030911156 scopus 로고    scopus 로고
    • Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule-1 monoclonal antibody
    • Kavanaugh A.F., Schulze-Koops H., Davis L.S., Lipsky P.E. Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule-1 monoclonal antibody. Arthritis Rheum. 40:1997;849-853
    • (1997) Arthritis Rheum , vol.40 , pp. 849-853
    • Kavanaugh, A.F.1    Schulze-Koops, H.2    Davis, L.S.3    Lipsky, P.E.4
  • 37
    • 0025978976 scopus 로고
    • Man-made antibodies
    • Winter G., Milstein C. Man-made antibodies. Nature. 349:1991;293-299
    • (1991) Nature , vol.349 , pp. 293-299
    • Winter, G.1    Milstein, C.2
  • 38
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
    • Choy E.H., Isenberg D.A., Garrood T., Farrow S., Ioannou Y., Bird H., et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum. 46:2002;3143-3150
    • (2002) Arthritis Rheum , vol.46 , pp. 3143-3150
    • Choy, E.H.1    Isenberg, D.A.2    Garrood, T.3    Farrow, S.4    Ioannou, Y.5    Bird, H.6
  • 39
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett F.C., Edworthy S.M., Bloch D.A., McShane D.J., Fries J.F., Cooper N.S., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:1988;315-324
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 40
    • 0030068817 scopus 로고    scopus 로고
    • Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria
    • van Gestel A.M., Prevoo M.L., van 't Hof M.A., van Rijswijk M.H., van de Putte L.B., van Riel P.L. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria. Arthritis Rheum. 39:1996;34-40
    • (1996) Arthritis Rheum , vol.39 , pp. 34-40
    • Van Gestel, A.M.1    Prevoo, M.L.2    Van Hof, '.T.M.A.3    Van Rijswijk, M.H.4    Van De Putte, L.B.5    Van Riel, P.L.6
  • 42
    • 0013093506 scopus 로고    scopus 로고
    • A multi-center, randomized, double-blind, placebo-controlled trial of humanized anti-interleukin-6 (IL-6) receptor monoclonal antibody (MRA) in rheumatoid arthritis
    • Nishimoto N., Yoshizaki K., Miyasaka N., Yamamoto K., Takeuchi T., Hashimoto F., et al. A multi-center, randomized, double-blind, placebo-controlled trial of humanized anti-interleukin-6 (IL-6) receptor monoclonal antibody (MRA) in rheumatoid arthritis. Arthritis Rheum. 46(Suppl):2002;S559
    • (2002) Arthritis Rheum , vol.46 , Issue.SUPPL. , pp. 559
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3    Yamamoto, K.4    Takeuchi, T.5    Hashimoto, F.6
  • 43
    • 2542441032 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy normalizes serum vascular endotherial growth factor (VEGF) in patients with rheumatoid arthritis (RA)
    • Nishimoto N., Nakahara K., Kishimoto T. Anti-interleukin-6 receptor antibody therapy normalizes serum vascular endotherial growth factor (VEGF) in patients with rheumatoid arthritis (RA). Arthritis Rheum. 46(Suppl):2002;S250
    • (2002) Arthritis Rheum , vol.46 , Issue.SUPPL. , pp. 250
    • Nishimoto, N.1    Nakahara, K.2    Kishimoto, T.3
  • 44
    • 0142132569 scopus 로고    scopus 로고
    • A double-blind, randomised, parallel group, controlled, dose ranging study of the safety, tolerability, pharmacokinetics and efficacy of repeat doses of MRA given alone or in combination with methotrexate in patients with rheumatoid arthritis
    • Maini R. Charisma Study Group A double-blind, randomised, parallel group, controlled, dose ranging study of the safety, tolerability, pharmacokinetics and efficacy of repeat doses of MRA given alone or in combination with methotrexate in patients with rheumatoid arthritis. Ann Rheum Dis. 62(Suppl):2003;64
    • (2003) Ann Rheum Dis , vol.62 , Issue.SUPPL. , pp. 64
    • Maini, R.1
  • 45
    • 0036898472 scopus 로고    scopus 로고
    • Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease
    • Iwamoto M., Nara H., Hirata D., Minota S., Nishimoto N., Yoshizaki K. Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease. Arthritis Rheum. 46:2002;3388-3389
    • (2002) Arthritis Rheum , vol.46 , pp. 3388-3389
    • Iwamoto, M.1    Nara, H.2    Hirata, D.3    Minota, S.4    Nishimoto, N.5    Yoshizaki, K.6


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