Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach

BMC Immunology

Volumn 2, Issue , 2001, Pages

  Stevens, James ^a,b   Joly, Etienne ^a,c   Trowsdale, John ^b   Butcher, Geoffrey W ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA E ANTIGEN; LEUCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1B; METHIONINE; MONOCLONAL ANTIBODY; PEPTIDE LIBRARY; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING ASSAY; CELL SURFACE; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; MOLECULAR CLONING; NATURAL KILLER CELL; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MOTIF; RANDOMIZATION; T LYMPHOCYTE;

EID: 2542448472     PISSN: 14712172     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2172-2-5     Document Type: Article

References (31)

1. Lee N, Llano M, Carretero M, Ishitani A, Navarro F, López-Botet M, Geraghty DE: HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci U S A 1998, 95:5199-5204
2. Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG: Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J Exp Med 1998, 187:813-818
3. Braud VM, Allan DS, O'Callaghan CA, Soderstrom K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 1998, 391:795-799
4. Braud V, Jones EY, McMichael A: The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur J Immunol 1997, 27:1164-1169
5. Lee N, Goodlett DR, Ishitani A, Marquardt H, Geraghty DE: HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J Immunol 1998, 160:4951-4960
6. Braud VM, Allan DS, Wilson D, McMichael AJ: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr Biol 1998, 8:1-10
7. Tomasec P, Braud VM, Rickards C, Powell MB, McSharry BP, Gadola S, Cerundolo V, Borysiewicz LK, McMichael AJ, Wilkinson GW: Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 2000, 287:1031-1033
8. O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY: Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. Mol Cell 1998, 1:531-541
9. Llano M, Lee N, Navarro F, Garcia P, Albar JP, Geraghty DE, López-Botet M: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G- derived nonamer. Eur J Immunol 1998, 28:2854-2863
10. Brooks AG, Borrego F, Posch PE, Patamawenu A, Scorzelli CJ, Ulbrecht M, Weiss EH, Coligan JE: Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. J Immunol 1999, 162:305-313
11. Valés-Gómez M, Reyburn HT, Erskine RA, López-Botet M, Strominger JL: Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J 1999, 18:4250-4260
12. Kraft JR, Vance RE, Pohl J, Martin AM, Raulet DH, Jensen PE: Analysis of Qa-1b peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. J Exp Med 2000, 192:613-623
13. Pacasova R, Martinozzi S, Boulouis HJ, Szpak Y, Ulbrecht M, Sigaux F, Weiss EH, Pla M: Cell surface detection of HLA-E gene products with a specific monoclonal antibody. J Reprod Immunol 1999, 43:195-201
14. Stevens J, Wiesmüller K-H, Barker PJ, Walden P, Butcher GW, Joly E: Efficient generation of MHC class I-peptide complexes using synthetic peptide libraries. J Biol Chem 1998, 273:2874-2884
15. Bhuyan PK, Young LL, Lindahl KF, Butcher GW: Identification of the rat maternally transmitted minor histocompatibility antigen. J Immunol 1997, 158:3753-3760
16. Powis SJ, Young LL, Joly E, Barker PJ, Richardson L, Brandt RP, Melief CJ, Howard JC, Butcher GW: The rat cim effect - TAP allele-dependent changes in a class-I MHC anchor motif and evidence against C-terminal trimming of peptides in the ER. Immunity 1996, 4:159-165
17. Falk K, Rötzschke O, Stevanovic S, Jung G, Rammensee HG: Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991, 351:290-296
18. Ulbrecht M, Modrow S, Srivastava R, Peterson PA, Weiss EH: Interaction of HLA-E with peptides and the peptide transporter in vitro: implications for its function in antigen presentation. J Immunol 1998, 160:4375-4385
19. Aldrich CJ, Decloux A, Woods AS, Cotter RJ, Soloski MJ, Forman J: Identification of a TAP-dependent leader peptide recognized by alloreactive T-cells specific for a class Ib antigen. Cell 1994, 79:649-658
20. Wei ML, Cresswell P: HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 1992, 356:443-446
21. Basu S, Srivastava PK: Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J Exp Med 1999, 189:797-802
22. Paz P, Brouwenstijn N, Perry R, Shastri N: Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER. Immunity 1999, 11:241-251
23. Guo HC, Jardetzky TS, Garrett TPJ, Lane WS, Strominger JL, Wiley DC: Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature 1992, 360:364-366
24. Joyce S, Kuzushima K, Kepecs G, Angeletti RH, Nathenson SG: Characterization of an incompletely assembled major histocompatibility class-I molecule (H-2Kb) associated with unusually long peptides - implications for antigen-processing and presentation. Proc Natl Acad Sci U S A 1994, 91:4145-4149
25. Urban RG, Chicz RM, Lane WS, Strominger JL, Rehm A, Kenter MJH, UytdeHaag FGCM, Ploegh H, Uchanska-Ziegler B, Ziegler A: A subset of HLA-B27 molecules contains peptides much longer than nonamers. Proc Natl Acad Sci U S A 1994, 91:1534-1538
26. Stevens J, Jones RC, Bordoli RS, Trowsdale J, Gaskell SJ, Butcher GW, Joly E: Specificity of RT1-A1c, an Inhibitory Rat Major Histocompatibility Complex Class I Natural Killer Cell Ligand. J Biol Chem 2000, 275:29217-29224
27. Stevanovic S, Wiesmüller K-H, Metzger J, Beckickinger AG, Jung G: Natural and synthetic peptide pools - characterization by sequencing and electrospray mass-spectrometry. Bioorg Med Chem Lett 1993, 3:431-436
28. Metzger JW, Kempter C, Wiesmüller K-H, Jung G: Electrospray mass-spectrometry and tandem mass-spectrometry of synthetic multicomponent peptide mixtures - determination of composition and purity. Anal Biochem 1994, 219:261-277
29. Wiesmüller K-H, Feiertag S, Fleckenstein B, Kienle S, Stoll D, Herrmann M, Jung G: Peptide and Cyclopeptide Libraries: Automated Synthesis, Analysis and Receptor Binding Assays. In: Combinatorial Peptide and Nonpeptide Libraries-A Handbook for the Search of Lead Structures. Edited by Jung G. pp. Weinheim, FRG: Verlag Chemie; 1996203-246
30. Garboczi DN, Hung DT, Wiley DC: HLA-A2-peptide complexes - refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc Natl Acad Sci U S A 1992, 89:3429-3433
31. Reid SW, Smith KJ, Jakobsen BK, O'Callaghan CA, Reyburn H, Harlos K, Stuart DI, McMichael AJ, Bell JI, Jones EY: Production and crystallization of MHC class-Ib allele single peptide complexes. FEBS Lett 1996, 383:119-123