Quercetin, a bioflavonoid, attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats

Drug and Chemical Toxicology

Volumn 27, Issue 2, 2004, Pages 145-156

  Singh, Devinder ^a   Chander, Vikas ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Nitrilotriacetic acid; Oxidative stress; Quercetin

Indexed keywords

BIOFLAVONOID; CATALASE; GLUTATHIONE REDUCTASE; IRON CHELATE; NITRILOTRIACETATE IRON; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ACUTE KIDNEY TUBULE NECROSIS; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY CARCINOMA; KIDNEY DYSFUNCTION; KIDNEY INJURY; KIDNEY OXIDATIVE INJURY; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTECTION; RAT; RENAL PROTECTION; TISSUE INJURY;

ANIMALS; CHELATING AGENTS; FLAVONOIDS; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; NITRILOTRIACETIC ACID; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; RODENTIA; VERTEBRATA;

EID: 2542441601     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-120030729     Document Type: Article

References (30)

1. Afanas, E. V., Dorozkho, A. I., Brodskii, A. V., Kostyuk, V. A., Potapovitch, A. I. (1989). Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem. Pharmacol. 38:1763-1769.
2. Anderson, R. L., Bishop, W. E., Campbell, R. L. (1985). A review of the environment and mammalian toxicology of nitrilotriacetic acid. Crit. Rev. Toxicol. 15:1-102.
3. Awai, M., Narasaki, M., Yamanoi, Y., Seno, S. (1979). Induction of diabetes in animals by parentral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis. Am. J. Pathol. 95:663-672.
4. Baud, L., Ardaillou, R. (1993). Involvement of reactive oxygen species in kidney damage. Br. Med. Bull. 49:621-629.
5. Bomzon, A., Holt, S., Moore, K. (1997). Bile acids, oxidative stress, and renal function in biliary obstruction. Semin. Nephrol. 17:549-562.
6. Carlberg, I., Mannerviek, B. (1975). Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem. 250:5475-5490.
7. Cheng, I. F., Breen, K. (2000). On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the Fenton reaction of the iron-ATP complex. BioMetals 13:77-83.
8. Claiborne, A. (1985). CRC Handbook of Methods for Oxygen Radical Research. Boca Raton, FL: CRC Press, pp. 283-284.
9. Hamazaki, S., Okada, S., Ebina, Y., Fujioka, M., Midorikawa, O. (1985). Acute renal failure and glycosuria induced by ferric nitrilotriacetate in rats. Toxicol. Appl. Pharmacol. 77:267-274.
10. Hamazaki, S., Okada, S., Li, J. L., Toyokuni, S., Midorikoe, O. (1989). Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. Arch. Biochem. Biophys. 272:10-17.
11. Hanasaki, Y., Ogawa, S., Fukui, S. (1994). The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radic. Biol. Med. 16:845-853.
12. Jollow, D. J., Mitchell, L. R., Zampaglione, N., Gillete, J. R. (1974). Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzeneoxide as the hepatotoxic intermediate. Pharmacology 11:151-169.
13. Jones, E. A., Shoskes, D. A. (2000). The effect of mycophenolate mofitil and poly phenolic bioflavonoids on renal ischemia-reperfusion injury and repair. J. Urol. 163:999-1004.
14. Kono, Y. (1978). Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch. Biochem. Biophys. 186:189-195.
15. Kuhlmann, M. K., Burkhardt, G., Horsch, E., Wagner, M., Kohler, H. (1998). Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PK1) by quercetin. Free Radic. Res. 29:451-460.
16. Li, J. L., Okada, S., Hamazaki, Y., Ebina, O. (1987). Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res. 47:1867-1869.
17. Liu, M., Okada, S., Kawabata, T. (1991). Radical promoting free iron level in the serum of rats treated with ferric nitrilotriacetate, comparison with iron chelate complexes. Acta Med. Okayama 45:401-408.
18. Mohandas, J., Marshall, J. J., Duggin, G. G., Horvath, J. S., Tiller, D. (1984). Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res. 44:5086-5091.
19. Nath, A. K., Suzame, M. N. (2000). Reactive oxygen species and acute renal failure. Am. J. Med. 109:665-678.
20. Ohkawa, H., Ohishi, N., Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358.
21. Okada, S., Hamazaki, S., Zhang, D., Ma, Y. (1998). Iron induced, free radical-mediated renal carcinogenesis in rats and mice: modification by sex and vitamin E. In: Packer, L., Ong, A. S. H., eds. Biological Antioxidants: Mechanism and Health Effects. Champaign: AOCS Press, IL, pp. 358-361.
22. Oyanagui, Y. (1997). Natural antioxidants enhance and prolong the oxyradical NO-related suppression by dexamethasone of ischemic and histamine paw oedema in mice. Inflammation 21:643-654.
23. Robak, J., Gryglewski, R. J. (1988). Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 37:837-841.
24. Satyanarayana, P. S. V., Singh, D., Chopra, K. (2001). Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats. Methods Find. Exp. Clin. Pharmacol. 23:175-181.
25. Toyokuni, S. (1996). Iron-induced carcinogenesis: the role of redox regulation. Free Radic. Biol. Med. 20:553-566.
26. Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H., Stadtman, E. R. (1994). Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc. Natl. Acad. Sci. U.S.A. 91:2616-2620.
27. Umemura, T. Y., Sai, K., Takagi, A., Hasegawa, R., Kurokawa, Y. (1990a). Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 11:345-347.
28. Umemura, T. Y., Sai, K., Takagi, A., Hasegawa, R., Kurokawa, Y. (1990b). Oxidative DNA damage, lipid peroxidation and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration. Cancer Lett. 54:95-100.
29. Varley, H. (1988). Practical Clinical Biochemistry. CBS Delhi: Harold Varley.
30. Zielinska, M., Kostrzewa, A., Ignatowicz, E. (2000). Antioxidative activity of flavonoids in stimulated human neutrophils. Folia Histochem. Cytobiol. 28:25-30.