Inhibition of experimental colon cancer metastasis by the GABA-receptor agonist nembutal

Cancer Biology and Therapy

Volumn 4, Issue 7, 2005, Pages 753-758

  Thaker, Premal H ^a   Yokoi, Kenji ^a   Jennings, Nicholas B ^a   Li, Yang ^a   Rebhun, Robert B ^a   Rousseau Jr , Dennis L ^b   Fan, Dominic ^a   Sood, Anil K ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Colon carcinoma; GABA agonist; Metastasis

Indexed keywords

GELATINASE A; GELATINASE B; METHOXYFLURANE; PENTOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INCIDENCE; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER METASTASIS; METASTASIS; MOUSE; NONHUMAN; SPLEEN;

EID: 25144521768     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.4.7.1827     Document Type: Article

References (25)

1. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ. Cancer statistics, 2005. CA Cancer J Clin 2005; 55:10-30.
2. Entschladen F, Lang K, Drell TL, Joseph J, Zanker KS. Neurotransmitters are regulators for the migration of tumor cells and leukocytes. Cancer Immunol Immunother 2002; 51:467-82.
3. Joseph J, Niggemann B, Zaenker KS, Entschladen F. The neurotransmitter γ-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res 2002; 62:6467-9.
4. Burgmeier N, Zawislak R, Defeudis FV, Bollack C, Helwig JJ. Glutamic acid decarboxylase in tubules and glomeruli isolated from rat kidney cortex. Eur J Biochem 1985; 151:361-4.
5. Nicholson-Guthrie CS, Guthrie GD, Sutton GP, Baenziger JC. Urine GABA levels in ovarian cancer patients: Elevated GABA in malignancy. Cancer Lett 2001; 162:27-30.
6. Watanabe M, Maemura K, Kanabara K, Tamayama T, Hayasaki H. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol 2002; 213:1-47.
7. Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdelles B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA. Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann NY Acad Sci 1999; 868:645-53.
8. Bowery N. GABAB receptors and their significance in mammalian pharmacology. Trends Pharmacol Sci 1989; 10:401-7.
9. Krantis A, Nichols K, Staines W. Neurochemical characterization and distribution of enteric GABAergic neurons and nerve fibers in the human colon. J Auton Nerv Sys 1998; 68:33-42.
10. Jansen A, Hoepfner M, Herzig KH, Riecken EO, Scherubl H. GABAC receptors in neuroendocrine gut cells: A new GABA-binding site in the gut. Eur J Physiol 2000; 441:294-300.
11. Tatsuta M, Iishi H, Baba M, Nakaizumi A, Ichii M, Taniguchi H. Inhibition by γ-amino-n-butyric acid and baclofen of gastric carcinogenesis induced by N-methyl-N′-nitrosoguanidine in Wistar rats. Cancer Res 1990; 50:4931-4.
12. Morikawa K, Walker SM, Nakajima M, Pathak S, Jessup JM, Fidler IJ. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res 1988; 48:6863-71.
13. Thaker PH, Deavers M, Celestino J, Thornton A, Fletcher MS, Landen CN, Kinch MS, Kiener PA, Sood AK. EphA2 expression is associated with aggressive features in ovarian carcinoma. Clin Cancer Res 2004; 10:2415-50.
14. Sood AK, Fletcher MS, Coffin JE, Yang M, Seftor EA, Gruman LM, Gershenson DM, Hendrix MJ. Functional role of matrix metalloproteinases in ovarian tumor cell plasticity. Am J Obstet Gynecol 2004; 190:899-909.
15. Watson SA, Morris TM, Robinson G, Crimmin MJ, Brown PD, Hardcastle JD. Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models. Cancer Res 1995; 55:3629-33.
16. Collins HM, Morris TM, Watson SA. Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: Relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase. Br J Cancer 2001; 84:1664-70.
17. Huang S, Van Arsdall M, Tedjarati S, et al. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice. Journal of the National Cancer Institute 2002; 94:1134-42.
18. Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann NY Acad Sci 1999; 878:236-70.
19. Lozonschi L, Sunamura M, Kobari M, Egawa S, Ding L, Matsuno S. Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models. Cancer Res 1999; 59:1252-8.
20. Azuma H, Inamoto T, Sakamoto T, Kiyama S, Ubai T, Shinohara Y, Maemura K, Tsuji M, Segawa N, Masuda H, Takahara K, Katsuoka Y, Watanabe M. γ-aminobutyric acid as promoting factor of cancer metastasis: Induction of matrix metalloproteinase production is potentially its underlying mechanism. Cancer Res 2003; 63:8090-6.
21. A receptor channels. Eur J Pharmacol 2002; 435:1-8.
22. A chloride channels in mammalian dorsal root ganglion neurones. Br J Pharmacol 1989; 98:167-76.
23. A receptor by depressant barbiturates and pregnane steroids. Br J Pharmacol 1988; 94:1257-69.
24. A receptors. Trends Pharmacol Sci 1995; 16:162-68.
25. Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eiger EI. Inhaled anesthetics and immobility: Mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anes Analg 2003; 97:718-40.