Voluntary physical exercise and coronary flow velocity reserve: A transthoracic colour Doppler echocardiography study in spontaneously hypertensive rats

Clinical Science

Volumn 109, Issue 3, 2005, Pages 325-334

  Hägg, Ulrika ^a   Grönros, Julia ^a   Wikström, Johannes ^a   Jonsdottir, Ingibjörg H ^a,b   Bergström, Göran ^a,c   Gan, Li Ming ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Institute of Laboratory Medicine   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Colour Doppler echocardiography; Coronary flow velocity reserve; CuZnSOD (copper zinc superoxide dismutase); Exercise; Gene expression

Indexed keywords

ADENOSINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOPPLER ECHOGRAPHY; EXERCISE; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; VOLUNTARY MOVEMENT;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CORONARY VESSELS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY, DOPPLER, COLOR; FEASIBILITY STUDIES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART RATE; HYPERTENSION; MALE; MOTOR ACTIVITY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RUNNING; SUPEROXIDE DISMUTASE;

EID: 25144520891     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20050052     Document Type: Article

References (50)

1. Paffenbarger, R. S., Hyde, R. T., Wing, A. L., Lee, I.-M., Jung, D. L. and Kampert, J. B. (1993) The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. New Engl. J. Med. 328, 538-545
2. Pescatello, L. S., Fargo, A. E., Leach, Jr, C. N. and Scherzer, H. H. (1991) Short-term effect of dynamic exercise on arterial blood pressure. Circulation 83, 1557-1561
3. Zhang, B., Sakai, T., Noda, K. et al. (2003) Multivariate analysis of the prognostic determinants of the depressor response to exercise therapy in patients with essential hypertension. Circ. J. 67, 579-584
4. Hornig, B., Maier, V. and Drexler, H. (1996) Physical training improves endothelial function in patients with chronic heart failure. Circulation 93, 210-214
5. Hambrecht, R., Walther, C., Mobius-Winkler, S. et al. (2004) Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation 109, 1371-1378
6. Ji, L. L. (1999) Antioxidants and oxidative stress in exercise. Proc. Soc. Exp. Biol. Med. 222, 283-292
7. Hägg, U., Andersson, I., Naylor, A. S. et al. (2004) Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats. Clin. Sci. 107, 571-581
8. Wilson, D. O. and Johnson, P. (2000) Exercise modulates antioxidant enzyme gene expression in rat myocardium and liver. J. Appl. Physiol. 88, 1791-1796
9. Brown, D. A., Jew, K. N., Sparagna, G. C., Musch, T. I. and Moore, R. L. (2003) Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart. J. Appl. Physiol. 95, 2510-2518
10. Wicker, P., Abdul-Samad, M., Rakusan, K., Tarazi, R. C. and Healy, B. (1987) Effects of chronic exercise on the coronary circulation in conscious rats with renovascular hypertension. Hypertension 10, 74-81
11. Hirata, K., Amudha, K., Elina, R. et al. (2004) Measurement of coronary vasomotor function: getting to the heart of the matter in cardiovascular research. Clin. Sci. 107, 449-460
12. Gan, L. M., Wikstrom, J., Bergstrom, G. and Wandt, B. (2004) Non-invasive imaging of coronary arteries in living mice using high-resolution echocardiography. Scand. Cardiovasc. J. 38, 121-126
13. Graham, D. A. and Rush, J. W. (2004) Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J. Appl. Physiol. 96, 2088-2096
14. Laughlin, M. H., Pollock, J. S., Amann, J. F., Hollis, M. L., Woodman, C. R. and Price, E. M. (2001) Training induces nonuniform increases in eNOS content along the coronary arterial tree. J. Appl. Physiol. 90, 501-510
15. Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J. and Hintze, T. H. (1994) Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74, 349-353
16. B antagonist, TAK-044, on blood pressure and renal excretory function after unclipping of conscious one-kidney-one-clip hypertensive rats. J. Hypertens. 19, 659-665
17. Shyu, B. C., Andersson, S. A. and Thoren, P. (1984) Spontaneous running in wheels. A microprocessor assisted method for measuring physiological parameters during exercise in rodents. Acta Physiol. Scand. 121, 103-109
18. Collins, K. A., Korcarz, C. E., Shroff, S. G. et al. (2001) Accuracy of echocardiographic estimates of left ventricular mass in mice. Am. J. Physiol. Heart Circ. Physiol. 280, H1954-H1962
19. Longo, M. R., Guzman, A. W. and Triebwasser, J. H. (1975) Normal values and commonly used echocardiographic formulae for adults. Aviat. Space Environ. Med. 46, 1062-1064
20. Meuer, S., Wittwer, C. and Nakagawara, K. (2001) Rapid Cycle Real-Time PCR: Methods and Applications, Springer Verlag, Berlin
21. Hozumi, T., Yoshida, K., Akasaka, T. et al. (1998) Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J. Am. Coll. Card. 32, 1251-1259
22. Hozumi, T., Yoshida, K., Ogata, Y., et al. (1998) Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography. Circulation 97, 1557-1562
23. Saraste, M., Koskenvuo, J. W., Knuuti, J. et al. (2001) Coronary flow reserve: measurement with transthoracic Doppler echocardiography is reproducible and comparable with positron emission tomography. Clin. Physiol. 21, 114-122
24. Buus, N. H., Bottcher, M., Hermansen, F., Sander, M., Nielsen, T. T. and Mulvany, M. J. (2001) Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia. Circulation 104, 2305-2310
25. Duffy, S. J., Castle, S. F., Harper, R. W. and Meredith, I. T. (1999) Contribution of vasodilator prostanoids and nitric oxide to resting flow, metabolic vasodilation, and flow-mediated dilation in human coronary circulation. Circulation 100, 1951-1957
26. Otsuka, R., Watanabe, H., Hirata, K. et al. (2001) Acute effects of passive smoking on the coronary circulation in healthy young adults. JAMA, J. Am. Med. Assoc. 286, 436-441
27. 13N-ammonia and small animal PET: impact of anesthesia and pharmacologic stress agents. J. Nucl. Med. 45, 1924-1930
28. Sudhir, K., MacGregor, J. S., Barbant, S. D. et al. (1993) Assessment of coronary conductance and resistance vessel reactivity in response to nitroglycerin, ergonovine and adenosine: in vivo studies with simultaneous intravascular two-dimensional and Doppler ultrasound. J. Am. Coll. Cardiol. 21, 1261-1268
29. Sala, C., Monopoli, A., Alberti, C. et al. (1996) Humoral effects of selective adenosine agonists in spontaneously hypertensive rats. J. Hypertens. 14, 75-79
30. Webb, R. L., McNeal, Jr, R. B., Barclay, B. W. and Yasay, G. D. (1990) Hemodynamic effects of adenosine agonists in the conscious spontaneously hypertensive rat. J. Pharmacol. Exp. Ther. 254, 1090-1099
31. Windecker, S., Allemann, Y., Billinger, M. et al. (2002) Effect of endurance training on coronary artery size and function in healthy men: an invasive followup study. Am. J. Physiol. Heart Circ. Physiol. 282, H2216-H2223
32. Hambrecht, R., Wolf, A., Gielen, S. et al. (2000) Effect of exercise on coronary endothelial function in patients with coronary artery disease. New Engl. J. Med. 342, 454-460
33. Buttrick, P. M., Levite, H. A., Schaible, T. F., Ciambrone, G. and Scheuer, J. (1985) Early increases in coronary vascular reserve in exercised rats are independent of cardiac hypertrophy. J. Appl. Physiol. 59, 1861-1865
34. Hambrecht, R., Adams, V., Erbs, S. et al. (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107, 3152-3158
35. Sen, C. K. (1995) Oxidants and antioxidants in exercise. J. Appl. Physiol. 79, 675-686
36. Inoue, N., Ramasamy, S., Fukai, T., Nerem, R. M. and Harrison, D. G. (1996) Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ. Res. 79, 32-37
37. Somani, S. M. and Rybak, L. P. (1996) Comparative effects of exercise training on transcription of antioxidant enzyme and the activity in old rat heart. Ind. J. Physiol. Pharmacol. 40, 205-212
38. Ji, L. L. (1993) Antioxidant enzyme response to exercise and aging. Med. Sci. Sports Exercise 25, 225-231
39. Moran, M., Delgado, J., Gonzalez, B., Manso, R. and Megias, A. (2004) Responses of rat myocardial antioxidant defences and heat shock protein HSP72 induced by 12 and 24-week treadmill training. Acta Physiol. Scand. 180, 157-166
40. Powers, S. K., Criswell, D., Lawler, J. et al. (1993) Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium. Am. J. Physiol. 265, H2094-H2098
41. Husain, K. (2004) Physical conditioning modulates rat cardiac vascular endothelial growth factor gene expression in nitric oxide-deficient hypertension. Biochem. Biophys. Res. Commun. 320, 1169-1174
42. Iemitsu, M., Miyauchi, T., Maeda, S. et al. (2000) Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 279, R951-R959
43. Seki, T., Hagiwara, H., Naruse, K. et al. (1996) In situ identification of messenger RNA of endothelial type nitric oxide synthase in rat cardiac myocytes. Biochem. Biophys. Res. Commun. 218, 601-605
44. Vaziri, N. D., Ni, Z. and Oveisi, F. (1998) Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 31, 1248-1254
45. Hoshida, S., Yamashita, N., Otsu, K. and Hori, M. (2002) Repeated physiologic stresses provide persistent cardioprotection against ischemia-reperfusion injury in rats. J. Am. Coll. Cardiol. 40, 826-831
46. Siu, P. M., Bryner, R. W., Martyn, J. K. and Alway, S. E. (2004) Apoptotic adaptations from exercise training in skeletal and cardiac muscles. FASEB J. 18, 1150-1152
47. Olsen, M. H., Wachtell, K., Meyer, C. et al. (2004) Association between vascular dysfunction and reduced myocardial flow reserve in patients with hypertension: a LIFE substudy. J. Hum. Hypertens. 18, 445-452
48. Yoshinari, K., Yaoita, H., Maehara, K. and Maruyama, Y. (2005) Different therapeutic responses to treadmill exercise of heart failure due to ischemia and infarction in rats. Cardiovasc. Res. 65, 457-468
49. Oshita, A., Ohmori, K., Yu, Y. et al. (2002) Myocardial blood flow measurements in rats with simple pulsing contrast echocardiography. Ultrasound Med. Biol. 28, 459-466
50. Miller, D. L., Li, P., Gordon, D. and Armstrong, W. F. (2005) Histological characterization of microlesions induced by myocardial contrast echocardiography. Echocardiography 22, 25-34