Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats

Clinical Science

Volumn 107, Issue 6, 2004, Pages 571-581

  Hägg, Ulrika ^a   Andersson, Irene ^a   Naylor, Andrew S ^a   Grönros, Julia ^a   Jonsdottir, Ingibjörg H ^a,b   Bergström, Göran ^a   Gan, Li Ming ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Institute of Laboratory Medicine   (Sweden)

Author keywords

Endothelial function; Haemodynamics; Nitric oxide; Oxygen radical; Ultrasound

Indexed keywords

ACETYLCHOLINE; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ANIMAL MODEL; AORTA WALL; ARTICLE; BLOOD VESSEL COMPLIANCE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; EXERCISE; FEMALE; GENE EXPRESSION; HYPERTENSION; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; VASODILATATION;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; BODY WEIGHT; ECHOCARDIOGRAPHY, DOPPLER; ENDOTHELIUM, VASCULAR; EXERTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTENSION; MESENTERIC ARTERIES; MOTOR ACTIVITY; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORGAN SIZE; RATS; RATS, INBRED SHR; SUPEROXIDE DISMUTASE; VASODILATION;

EID: 10344226150     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20040171     Document Type: Article

References (53)

1. Green, D. J., Cable, N. T., Fox, C., Rankin, J. M. and Taylor, R. R. (1994) Modification of forearm resistance vessels by exercise training in young men. J. Appl. Physiol. 77, 1829-1833
2. Cameron, J. D. and Dart, A. M. (1994) Exercise training increases total systemic arterial compliance in humans. Am. J. Physiol. 266, H693-H701
3. Hoffmann, P., Friberg, P., Ely, D. and Thoren, P. (1987) Effect of spontaneous running on blood pressure, heart rate and cardiac dimensions in developing and established spontaneous hypertension in rats. Acta Physiol. Scand. 129, 535-542
4. Knowles, R. G. and Moncada, S. (1994) Nitric oxide synthases in mammals. Biochem. J. 298, 249-258
5. Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A. and Freeman, B. A. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A. 87, 1620-1624
6. Ji, L. L. (1999) Antioxidants and oxidative stress in exercise. Proc. Soc. Exp. Biol. Med. 222, 283-292
7. Fukai, T., Folz, R. J., Landmesser, U. and Harrison, D. G. (2002) Extracellular superoxide dismutase and cardiovascular disease. Cardiovasc. Res. 55, 239-249
8. Meilhac, O., Ramachandran, S., Chiang, K., Santanam, N. and Parthasarathy, S. (2001) Role of arterial wall antioxidant defense in beneficial effects of exercise on atherosclerosis in mice. Arterioscler., Thromb., Vasc. Biol. 21, 1681-1688
9. Yen, M. H., Yang, J. H., Sheu, J. R., Lee, Y. M. and Ding, Y. A. (1995) Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats. Life Sci. 57, 2205-2213
10. Graham, D. A. and Rush, J. W. (2004) Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J. Appl. Physiol. 96, 2088-2096
11. Husain, K. (2004) Interaction of regular exercise and chronic nitroglycerin treatment on blood pressure and rat aortic antioxidants. Biochim. Biophys. Acta 1688, 18-25
12. Shyu, B. C., Andersson, S. A. and Thoren, P. (1984) Spontaneous running in wheels. A microprocessor assisted method for measuring physiological parameters during exercise in rodents. Acta Physiol. Scand. 121, 103-109
13. Shyu, B. C. and Thoren, P. (1986) Circulatory events following spontaneous muscle exercise in normotensive and hypertensive rats. Acta Physiol. Scand. 128, 515-524
14. Friberg, P., Hoffmann, P., Nordlander, M. and Thoren, P. (1988) Effects of voluntary physical exercise on cardiac function and energetics in spontaneously hypertensive rats. Acta Physiol. Scand. 133, 495-500
15. Jonsdottir, I. H., Jungersten, L., Johansson, C., Wennmalm, A., Thoren, P. and Hoffmann, P. (1998) Increase in nitric oxide formation after chronic voluntary exercise in spontaneously hypertensive rats. Acta Physiol. Scand. 162, 149-153
16. Moshage, H. (1997) Nitric oxide determinations: much ado about NO-thing? Clin. Chem. 43, 553-556
17. Viinikka, L. (1996) Nitric oxide as a challenge for the clinical chemistry laboratory. Scand. J. Clin. Lab. Invest. 56, 577-581
18. B antagonist, TAK-044, on blood pressure and renal excretory function after unclipping of conscious one-kidney-one-clip hypertensive rats. J. Hypertens. 19, 659-665
19. Mulvany, M. J. and Halpern, W. (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41, 19-26
20. Pelle, G., Pascal, O., Adnot, S., Gueret, P., Dubois-Rande, J. L. and Belhassen, L. (2002) Characterization of peripheral arterial wall motion by Doppler tissue echography: a validation study. J. Am. Soc. Echocardiogr. 15, 1218-1225
21. Gan, L., Doroudi, R., Hägg, U., Johansson, A., Selin-Sjogren, L. and Jern, S. (2000) Differential immediate-early gene responses to shear stress and intraluminal pressure in intact human conduit vessels. FEBS Lett. 477, 89-94
22. Meuer, S., Wittwer, C. and Nakagawara, K. (2001) Rapid Cycle Real-Time PCR: Methods and Applications, Springer Verlag, Berlin
23. Husken, B. C., Hendriks, M. G., Pfaffendorf, M. and Van Zwieten, P. A. (1994) Effects of aging and hypertension on the reactivity of isolated conduit and resistance vessels. Microvasc. Res. 48, 303-315
24. Radaelli, A., Mircoli, L., Mori, I., Mancia, G. and Ferrari, A. U. (1998) Nitric oxide dependent vasodilation in young spontaneously hypertensive rats. Hypertension 32, 735-739
25. Tominaga, M., Fujii, K., Abe, I., Takata, Y., Kobayashi, K. and Fujishima, M. (1994) Hypertension and ageing impair acetylcholine-induced vasodilation in rats. J. Hypertens. 12, 259-268
26. Chen, Y., Collins, H. L. and DiCarlo, S. E. (1999) Daily exercise enhances acetylcholine-induced dilation in mesenteric and hindlimb vasculature of hypertensive rats. Clin. Exp. Hypertens. 21, 353-376
27. Ji, L. L. (2002) Exercise-induced modulation of antioxidant defense. Ann. N.Y. Acad. Sci. 959, 82-92
28. Fukai, T., Siegfried, M. R., Ushio-Fukai, M., Cheng, Y., Kojda, G. and Harrison, D. G. (2000) Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J. Clin. Invest. 105, 1631-1639
29. Rush, J. W., Turk, J. R. and Laughlin, M. H. (2003) Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium. Am. J. Physiol. Heart Circ. Physiol. 284, H1378-H1387
30. Sen, C. K. (1995) Oxidants and antioxidants in exercise. J. Appl. Physiol. 79, 675-686
31. Didion, S. P., Ryan, M. J., Didion, L. A., Fegan, P. E., Sigmund, C. D. and Faraci, F. M. (2002) Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ. Res. 91, 938-944
32. Carlsson, L. M., Marklund, S. L. and Edlund, T. (1996) The rat extracellular superoxide dismutase dimer is converted to a tetramer by the exchange of a single amino acid. Proc. Natl. Acad. Sci. U.S.A. 93, 5219-5222
33. Chu, Y., Iida, S., Lund, D. D. et al. (2003) Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Circ. Res. 92, 461-468
34. Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J. and Hintze, T. H. (1994) Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74, 349-353
35. Indolfi, C., Torella, D., Coppola, C. et al. (2002) Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats. Circ. Res. 91, 1190-1197
36. Laufs, U., Werner, N., Link, A. et al. (2004) Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109, 220-226
37. Vaziri, N. D., Ni, Z. and Oveisi, F. (1998) Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 31, 1248-1254
38. Can, L., Wikström, J., Bergström, G. and Wandt, B. (2004) Non-invasive imaging of coronary arteries in living mice using high resolution echocardiography. Scand. Cardiovasc. J. 38, 121-126
39. Schmidt-Trucksass, A., Grathwohl, D., Schmid, A. et al. (1998) Assessment of carotid wall motion and stiffness with tissue Doppler imaging. Ultrasound Med. Biol. 24, 639-646
40. Weber, T., Auer, J., O'Rourke, M. F. et al. (2004) Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation 109, 184-189
41. Wilkinson, I. B., Qasem, A., McEniery, C. M., Webb, D. J., Avolio, A. P. and Cockcroft, J. R. (2002) Nitric oxide regulates local arterial distensibility in vivo. Circulation 105, 213-217
42. Kingwell, B. A., Arnold, P. J., Jennings, G. L. and Dart, A. M. (1997) Spontaneous running increases aortic compliance in Wistar-Kyoto rats. Cardiovasc. Res. 35, 132-137
43. Gimbrone, Jr, M. A., Topper, J. N., Nagel, T., Anderson, K. R. and Garcia-Cardena, G. (2000) Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann. N.Y. Acad. Sci. 902, 230-239
44. Gan, L. M., Selin-Sjogren, L., Doroudi, R. and Jern, S. (2000) Temporal regulation of endothelial ET-1 and eNOS expression in intact human conduit vessels exposed to different intraluminal pressure levels at physiological shear stress. Cardiovasc. Res. 48, 168-177
45. Taylor, C. A., Cheng, C. P., Espinosa, L. A., Tang, B. T., Parker, D. and Herfkens, R. J. (2002) In vivo quantification of blood flow and wall shear stress in the human abdominal aorta during lower limb exercise. Ann. Biomed. Eng. 30, 402-408
46. Inoue, N., Ramasamy, S., Fukai, T., Nerem, R. M. and Harrison, D. G. (1996) Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res. 79, 32-37
47. Eriksen, M. and Waaler, B. A. (1994) Priority of blood flow to splanchnic organs in humans during pre- and post-meal exercise. Acta Physiol. Scand. 150, 363-372
48. Perko, M. J., Nielsen, H. B., Skak, C., Clemmesen, J. O., Schroeder, T. V. and Secher, N. H. (1998) Mesenteric, coeliac and splanchnic blood flow in humans during exercise. J. Physiol. (Cambridge, U.K.) 513, 907-913
49. Sun, D., Huang, A., Koller, A. and Kaley, G. (1994) Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats. J. Appl. Physiol. 76, 2241-2247
50. Sun, D., Huang, A., Koller, A. and Kaley, G. (1998) Adaptation of flow-induced dilation of arterioles to daily exercise. Microvasc. Res. 56, 54-61
51. Niebauer, J. and Cooke, J. P. (1996) Cardiovascular effects of exercise: role of endothelial shear stress. J. Am. Coll. Cardiol. 28, 1652-1660
52. Lind, L., Sarabi, M., Millgard, J. and Kahan, T. (2002) Endothelium-dependent vasodilation is impaired in apparently healthy subjects with a family history of myocardial infarction. J. Cardiovasc. Risk. 9, 53-57
53. Bohlooly, Y. M., Carlson, L., Olsson, B. et al. (2001) Vascular function and blood pressure in GH transgenic mice. Endocrinology 142, 3317-3323