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Volumn 15, Issue 21, 2005, Pages 4799-4802
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Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
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Author keywords
AKT mTOR signaling pathway kinase; Indole methylene lactones; Inhibitors
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Indexed keywords
ANTINEOPLASTIC AGENT;
GAMMA LACTONE DERIVATIVE;
INDOLE DERIVATIVE;
INITIATION FACTOR 4E BINDING PROTEIN 1;
MAMMALIAN TARGET OF RAPAMYCIN;
PHOSPHOTRANSFERASE INHIBITOR;
PROTEIN KINASE B;
S6 KINASE;
ARTICLE;
DRUG ACTIVITY;
DRUG INHIBITION;
DRUG POTENCY;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME INHIBITION;
ENZYME PHOSPHORYLATION;
HUMAN;
HUMAN CELL;
SIGNAL TRANSDUCTION;
ADAPTOR PROTEINS, SIGNAL TRANSDUCING;
ANTINEOPLASTIC AGENTS;
CARRIER PROTEINS;
HUMANS;
INDOLES;
LACTONES;
PHOSPHOPROTEINS;
PHOSPHORYLATION;
PROTEIN KINASE INHIBITORS;
PROTEIN KINASES;
RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;
SIGNAL TRANSDUCTION;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 25144514550
PISSN: 0960894X
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmcl.2005.07.050 Document Type: Article |
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Times cited : (23)
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References (12)
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