Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells

Free Radical Biology and Medicine

Volumn 39, Issue 8, 2005, Pages 1030-1040

  Cheng, Lin Ling ^a   Li, Bing ^b   Luo, Jian Dong ^b   Tu, Hong Bin ^b   Liu, Qi Cai ^b   Ran, Pixin ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Chronic obstructive pulmonary disease; E box element; Glutamate cysteine ligase; Glutathione; Oxidative stress; Upstream stimulatory factor

Indexed keywords

ANTIBODY; BINDING PROTEIN; DNA; GLUTAMATE CYSTEINE LIGASE; RETROVIRUS VECTOR; UPSTREAM STIMULATORY FACTOR 1; UPSTREAM STIMULATORY FACTOR 2;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DNA FLANKING REGION; E BOX ELEMENT; ENZYME ACTIVE SITE; ENZYME SUBUNIT; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; LUNG ALVEOLUS EPITHELIUM; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SEQUENTIAL ANALYSIS; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

5' FLANKING REGION; ANIMALS; ANTIBODIES; CELLS, CULTURED; DOWN-REGULATION; E-BOX ELEMENTS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; LUNG; PROMOTER REGIONS (GENETICS); RATS; UPSTREAM STIMULATORY FACTORS;

EID: 25144504732     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.05.025     Document Type: Article

References (50)

1. P.J. Barnes, K. Ito, and I.M. Adcock Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase Lancet 363 2004 731 733
2. W. MacNee Oxidants/antioxidants and COPD Chest 117 2000 303S 317S
3. P.N. Dekhuijzen Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease Eur. Respir. J. 23 2004 629 636
4. B.J. Day, A.M. van Heeckeren, E. Min, and L.W. Velsor Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection Infect. Immun. 72 2004 2045 2051
5. I. Rahman, D. Morrison, K. Donaldson, and W. MacNee Systemic oxidative stress in asthma, COPD, and smokers Am. J. Respir. Crit. Care Med. 154 1996 1055 1060
6. I. Rahman, and W. MacNee Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease Am. J. Physiol. 277 1999 L1067 L1088
7. C.C. White, H. Viernes, C.M. Krejsa, D. Botta, and T.J. Kavanagh Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity Anal. Biochem. 318 2003 175 180
8. D.M. Krzywanski, D.A. Dickinson, K.E. Iles, A.F. Wigley, C.C. Franklin, R.M. Liu, T.J. Kavanagh, and H.J. Forman Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress Arch. Biochem. Biophys. 423 2004 116 125
9. C.S. Huang, L.S. Chang, M.E. Anderson, and A. Meister Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine syntethase J. Biol. Chem. 268 1993 19675 19680
10. I. Rahman, and W. MacNee Oxidative stress and regulation of glutathione in lung inflammation Eur. Respir. J. 16 2000 534 554
11. I. Rahman, F. Antonicelli, and W. Macnee Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-α and dexamethasone in human alveolar epithelial cells J. Biol. Chem. 274 1999 5088 5096
12. W.H.J. Douglas, and P.M. Farrell Isolation of cells that retain differentiated functions in vitro: properties of clonally isolated type II alveolar pneymonocytes Environ. Health Perspect. 16 1976 83 88
13. W.H.J. Douglas, and M.E. Kaighn Clonal isolation of differentiated rat lung cells In Vitro (Rockuille) 10 1974 230 237
14. H. Yang, J. Wang, Z.Z. Huang, X. Ou, and S.C. Lu Cloning and characterization of the 5-flanking region of the rat glutamate-cysteine ligase catalytic subunit Biochem. J. 357 2001 447 455
15. J. Sambrook David Russell Molecular Cloning: A Laboratry Manual 2001 Cold Spring Harbor Lab Press
16. B. Baron, C. Poirier, D. Simon-Chazottes, C. Barnier, and J.L. Guenet A new strategy useful for rapid identification of microsatellites from DNA libraries with large size inserts Nucleic Acids Res. 20 1992 3665 3669
17. B. Baron, P. Metezeau, H. Kiefer-Gachelin, and M.E. Goldberg Construction and characterization of a DNA library from mouse chromosomes 19 purified by flow cytometry Biol. Cell 69 1990 1 8
18. J. Byun, J.M. Kim, S.H. Kim, J. Yim, P.D. Robbins, and S. Kim A simple and rapid method for the determination of recombinant retrovirus titer by G418 selection Gene Ther. 3 1996 1018 1020
19. W.R. Atchley, and W.M. Fitch A natural classification of the basic helix-loop-helix class of transcription factors Proc. Natl. Acad. Sci. USA 94 1997 5172 5176
20. J.H. Suh, S.V. Shenvi, B.M. Dixon, H. Liu, A.K. Jaiswal, R.M. Liu, and T.M. Hagen Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid Proc. Natl. Acad. Sci. USA 101 2004 3381 3386
21. Y. Kawakita, M. Ikekita, R. Kurozumi, and S. Kojima Increase of intracellular glutathione by low-dose gamma-ray irradiation is mediated by transcription factor AP-1 in RAW 264.7 cells Biol. Pharm. Bull. 26 2003 19 23
22. M. Iwanaga, K. Mori, T. Iida, Y. Urata, T. Matsuo, A. Yasunaga, S. Shibata, and T. Kondo Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells Free Radic. Biol. Med. 24 1998 1256 1268
23. R.T. Mulcahy, M.A. Wartman, H.H. Bailey, and J.J. Gipp Constitutive and ß-naphthoflavone-induced expression of the human-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence J. Biol. Chem. 272 1997 7445 7454
24. K.R. Sekhar, S.R. Soltaninassab, M.J. Borrelli, Z.Q. Xu, M.J. Meredith, F.E. Domann, and M.L. Freeman Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase Biochem. Biophys. Res. Commun. 270 2000 311 317
25. I. Rahman, A. Bel, B. Mulier, M.F. Lawson, D.J. Harrison, W. Macnee, and C.A. Smith Transcriptional regulation of γ-glutamylcysteine syntethase-heavy subunit by oxidants in human alveolar epithelial cells Biochem. Biophys. Res Commun. 229 1996 832 837
26. I. Rahman, C.A. Smith, F. Antonicelli, and W. MacNee Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1 FEBS Lett. 427 1998 129 133
27. G. Church, A. Ephrussi, W. Gilbert, and S. Tonegawa Cell-type-specific contacts to immunoglobulin enhancers in nuclei Nature 313 1985 798 801
28. P.J. Hurlin, Z.Q. Zhou, K. Toyo-Oka, S. Ota, W.L. Walker, S. Hirotsune, and A. Wynshaw-Boris Evidence of mnt-myc antagonism revealed by mnt gene deletion Cell Cycle 3 2004 97 99
29. S.L. Levine, and G.H. Perdew Okadaic acid increases ARNT homodimer transactivation potential Cell Biol. Toxicol. 18 2002 109 120
30. S. Park, S. Chung, K.M. Kim, K.C. Jung, C. Park, E.R. Hahm, and C.H. Yang Determination of binding constant of transcription factor myc-max/max-max and E-box DNA: the effect of inhibitors on the binding Biochim. Biophys. Acta 1670 2002 217 228
31. B.B. Friday, P.O. Mitchell, K.M. Kegley, and G.K. Pavlath Calcineurin initiates skeletal muscle differentiation by activating MEF2 and MyoD Differentiation 71 2002 217 227
32. G. Patane, H. Kaneto, E. Toschi, A. Sharma, S. Gupta, and G.C. Weir Induction of Mad expression leads to augmentation of insulin gene transcription Biochem. Biophys. Res. Commun. 303 2003 1199 1208
33. M.E. Bruno, R.B. West, T.A. Schneeman, E.H. Bresnick, and C.S. Kaetzel Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene Mol. Immunol. 40 2003 695 708
34. I. Manni, P. Tunici, N. Cirenei, R. Albarosa, B.M. Colombo, L. Roz, A. Sacchi, G. Piaggio, and G. Finocchiaro Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression Br. J. Cancer 86 2002 477 484
35. H.J. Kim, J.Y. Kim, Y.Y. Park, and H.S. Choi Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1 Nucleic Acids Res. 31 2003 6860 6872
36. P.H. Giangrande, T.C. Hallstrom, C. Tunyaplin, K. Calame, and J.R. Nevins Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor Mol. Cell. Biol. 23 2003 3707 3720
37. S. Huang, and S.J. Brandt mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor Mol. Cell. Biol. 20 2000 2248 2259
38. J.A. Schoenhard, L.H. Smith, C.A. Painter, M. Eren, C.H. Johnson, and D.E. Vaughan Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2 J. Mol. Cell Cardiol. 35 2003 473 481
39. D. Vallone, S.B. Gondi, D. Whitmore, and N.S. Foulkes E-box function in a period gene repressed by light Proc. Natl. Acad. Sci. USA 101 2004 4106 4111
40. M. Malatesta, B. Baldelli, F. Marcheggiani, and G. Gazzanelli Immunocytochemical analysis of the circadian clock protein in mouse hepatocytes Microsc. Res. Tech. 61 2003 414 418
41. K. Sayasith, N. Bouchard, M. Sawadogo, J.G. Lussier, and J. Sirois Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells J. Biol. Chem. 279 2004 6327 6336
42. J.M. Coulson, J.L. Edgson, Z.V. Marshall-Jones, R. Mulgrew, J.P. Quinn, and P.J. Woll Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box Biochem. J. 369 2003 549 561
43. S.S. Lee, S.H. Kwon, J.S. Sung, M.Y. Han, and Y.M. Park Cloning and characterization of the rat Hsf2 promoter: a critical role of proximal E-box element and USF protein in Hsf2 regulation in different compartments of the brain Biochim. Biophys. Acta 1625 2003 52 63
44. P. Pognonec, K.E. Boulukos, C. Aperlo, M. Fujimoto, H. Ariga, A. Nomoto, and H. Kato Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity Oncogene 14 1997 2091 2098
45. V.K. Harris, C.M. Coticchia, H.J. List, A. Wellstein, and A.T. Riegel Mitogen-induced expression of the fibroblast growth factor-binding protein is transcriptionally repressed through a non-canonical E-box element J. Biol. Chem. 275 2000 28539 28548
46. B. Gao, and G. Kunos Cell type-specific transcriptional activation and suppression of the a1B adrenergic receptor gene middle promoter by nuclear factor 1 J. Biol. Chem. 273 1998 31784 31787
47. A.P. Bird, and A.P. Wolffe Methylation-induced repression-Belts, braces, and chromatin Cell 99 1999 451 454
48. F. Watt, and P.L. Molloy Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter Genes Dev. 2 1988 1136 1143
49. Y. Takahashi, K. Nakayama, S. Itoh, Y. Fujii-Kuriyama, and T. Kamataki Inhibition of the transcription of CYP1A1 gene by the upstream stimulatory factor 1 in rabbits. Competitive binding of USF1 with AhR.Arnt complex J. Biol. Chem. 272 1997 30025 30031
50. A. Cvekl, C.M. Sax, E.H. Bresnick, and J. Piatigorsky A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins Mol. Cell. Biol. 14 1994 7363 7376