A novel DNA vaccine containing four mimicry epitopes for gastric cancer

Cancer Biology and Therapy

Volumn 4, Issue 3, 2005, Pages 308-312

  Chen, Yu ^a   Wu, Kaichun ^a   Guo, Changcun ^a   Liu, Changjiang ^a   Han, Shuang ^a   Lin, Tao ^a   Ning, Xiaoxuan ^a   Shi, Rui ^a   Shi, Yongquan ^a   Fan, Daiming ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gastric cancer; Gene vaccine; Heat shock protein 70; MG7Ag; Multi epitope

Indexed keywords

ANTIBODY; CANCER VACCINE; DNA VACCINE; EPITOPE; GAMMA INTERFERON; MG7 ANTIGEN; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; CELL ASSAY; CELLULAR IMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; EXPERIMENTAL NEOPLASM; FEMALE; FUSION GENE; HUMORAL IMMUNITY; IMMUNIZATION; INOCULATION; MOUSE; MOUSE STRAIN; NONHUMAN; STATISTICAL SIGNIFICANCE; STOMACH CANCER; TUMOR VOLUME;

EID: 25144495556     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.4.3.1502     Document Type: Article

References (28)

1. Liu J, Hu JL, Zhang XY, Qiao TD, Chen XT, Wu KC, Ding J, Fan DM. The value of MG7 antigen in predicting cancerous change in dysplastic gastric mucosa. Int J Clin Pract 2002; 56:69-172.
2. Guo DL, Dong M, Wang L, Sun LP, Yuan Y. Expression of gastric cancer-associated MG7 antigen in gastric cancer, precancerous lesions and H. pylori -associated gastric diseases. World J Gastroenterol 2002; 8:1009-1013.
3. Xu L, Jin BQ, Fan DM. Selection and identification of mimic epitopes for gastric cancer-associated antigen MG7 Ag. Mol Cancer Ther 2003; 2:301-6.
4. Hang QL, Ding J, Gong AC, Yu ZC, Qiao TD, Chen BJ, Zhang XY, Fan DM. Screening of bioactive peptide that mimic the epitope of gastric cancer associated antigen. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2003; 19:308-10.
5. Le TP, Coonan KM, Hedstrom RC, Charoenvit Y, Sedegah M, Epstein JE, Kumar S, Wang R, Doolan DL, Maguire JD, Parker SE, Hobart P, Norman J, Hoffman SL. Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine 2000; 18:1893-901.
6. Nabel GJ, Gordon D, Bishop DK, et al. Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes. Proc Natl Acad Sci USA 1996; 93:15388-93.
7. MacGregor RR, Boyer JD, Ugen KE, Lacy KE, Gluckman SJ, Bagarazzi ML, Chattergoon MA, Baine Y, Higgins TJ, Ciccarelli RB, Coney LR, Ginsberg RS, Weiner DB. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: Safety and host response. J Infect Dis 1998; 178:92-100.
8. Roy MJ, Wu MS, Barr LJ, Fuller JT, Tussey LG, Speller S, Culp J, Burkholder JK, Swain WF, Dixon RM, Widera G, Vessey R, King A, Ogg G, Gallimore A, Haynes JR, Heydenburg Fuller D. Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine. Vaccine 2000; 19:764-78.
9. Ning XX, Wu KC, Guo CC, Li Y, Shi YQ, Xu Li, Han ZY, Liu N, Qiao TD, Chen BJ, Fan DM. Immunological Characterization of a DNA vaccine of gastric cancer-related MG7-Ag mimotope fused with heat shock protein 70. J Tumor Marker Oncology 2003; 18:53-60.
10. Zhang XY. Some recent works on diagnosis and treatment of gastric cancer. World J Gastroenterol 1999; 5:1-3.
11. Guo CC, Ding J, Pan BR, Yu ZC, Han QL, Meng FP, Liu N, Fan DM. Development of an oral DNA vaccine against of gastric cancer using attenuated salmonella typhimurium as carrier. World J Gastroenterol 2003; 9:1191-5.
12. Lin T, Ding J, Meng FP, Fan DM. Construction and identification of recombinant adenovirus vaccines of gastric cancer mimotopes. World Chin J Digestol 2003; 11(1):14-17.
13. Meng FP, Ding J, Yu ZC, Han QL, Guo CC, Fan DM. Development and preliminary identification of the attenuated Salmonella typhimurium vaccine expressing the gastric cancer mimotope. Chin J Cell Mol Immunol 2002; 02:138-04.
14. Wells AD, Rai SK, Salvato MS, Band H, Malkovsky M. Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation. Int Immunol 1998; 10:609-17.
15. Casey DG, Lysaght J, James T, Bateman A, Melcher AA, Todryk SM. Heat shock protein derived from a nonautologous tumour can be used as an anti-tumour vaccine. Immunology 2003; 110:105-11.
16. Janetzki S, Palla D, Rosenhauer V, Lochs H, Lewis JJ, Srivastava PK. Immunotherapy of tumor with autologous cancer-derived heat shock gp96 preparations: A pilot study. Int J Cancer 2000; 88:232-8.
17. Chen CH, Wang TL, Hung CF, Yang YQ, Young RA, Pardoll DM, Wu TC. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res 2002; 60:1035-42.
18. Astori M, Kraehenbuhl JP. Recombinant fusion peptides containing single or multiple repeats of a ubiquitous T-helper epitope are highly immunogenic. Molecular Immunology 1996; 33(13):1017-24.
19. Dadaglio G, Moukrim Z, Lo-Man R, Sheshko V, Sebo P, Leclerc C. Induction of a polarized Th1 response by insertion of multiple copies of a viral T-cell epitope into adenylate cyclase of bordetella pertussis. Infection and Immunity 2000; 3867-72.
20. Velders MP, Weijzen S, Eiben GL, Elmishad AG, Kloetzel PM, Higgins T, Ciccarelli RB, Evans M, Man S, Smith L, Kast WM. Defined flanking spacers and enhanced proteolysis is essential for eradication of established tumors by an epitope string DNA vaccine. J Immunol 2001; 166:5366-73.
21. Livingston B, Newman M, Crimi C, McKinney D, Chesnut R, Sette A. Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines. Vaccine 2001; 19:4652-60.
22. Livingston B, Crimi C, Newman M, Higashimoto Y, Appella E, Sidney J, Sette A. A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes. J Immunol 2002; 168:5499-506.
23. Desmezieres E, Jacob Y, Saron MF. Lyssavirus glycoproteins expressing immunologically potent B cell and cytotoxic T lymphocyte epitopes as prototypes for multivalent vaccine. J Gene Virol 1999; 80:2343.
24. Correale P, Walmsley K, Zaremba S, Zhu M, Schlom J, Tsang KY. Generation of human cytolytic T lymphocyte lines directed against prostate-specific antigen (PSA) employing a PSA oligoepitopepeptide. J Immunol 1998; 161:3186-94.
25. Eberl G, Renggli J, Men Y, Roggero MA, Lopez JA, Corradin G. Extracellular processing and presentation of a 69-mer synthetic polypetide to MHC Class I-restricted T cells. Mol Immunol 1999; 36:103-12.
26. Monzavi-Karbassi B, Cunto-Amesty G, Luo P, Kieber-Emmons T. Peptide mimotopes as surrogate antigens of carbohydrates in vaccine discovery. TRENDS in Biotechnology 2002; 20:207-14.
27. Tumenjargal S, Gellrich S, Linnemann T, Muche JM, Lukowsky A, Audring H, Wiesmuller KH, Sterry W, Walden P. Anti-tumor immune responses and tumor regression induced with mimotopes of a tumor-associated T cell epitope. Eur J Immunol 2003; 33:3175-85.
28. Riemer AB, Klinger M, Wagner S, Bernhaus A, Mazzucchelli L, Pehamberger H, Scheiner O, Zielinski CC, Jensen-Jarolim E. Generation of Peptide mimics of the epitope recognized by trastuzumab on the oncogenic protein Her-2/neu. J Immunol 2004; 173:394-401.