Development of an oral DNA vaccine against MG7-Ag of gastric cancer using attenuated salmonella typhimurium as carrier

World Journal of Gastroenterology

Volumn 9, Issue 6, 2003, Pages 1191-1195

  Guo, Chang Cun ^a   Ding, Jie ^a   Pan, Bo Rong ^a   Yu, Zhao Cai ^a   Han, Quan Li ^a   Meng, Fan Ping ^a   Liu, Na ^a   Fan, Dai Ming ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; COMPLEMENTARY DNA; DNA VACCINE; DRUG CARRIER; EPITOPE; MG7 ANTIGEN; PLASMID DNA; TRITIUM; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; ASSAY; CANCER MODEL; CARCINOGENESIS; CELL PROLIFERATION; CELLULAR IMMUNITY; COLONY FORMING UNIT; CONTROLLED STUDY; DNA SYNTHESIS; DNA VECTOR; DRUG EFFICACY; DRUG TARGETING; EHRLICH ASCITES TUMOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUSION GENE; GENE SEQUENCE; HUMORAL IMMUNITY; IMMUNOGENICITY; IN VITRO STUDY; MICROBIAL ATTENUATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM; SERUM; SPLEEN CELL; STATISTICAL ANALYSIS; STOMACH CANCER; STOMACH PROTECTION; VACCINATION;

EID: 0038391031     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i6.1191     Document Type: Article

References (25)

1. Zhang XY. Some recent works on diagnosis and treatment of gastric cancer. World J Gastroenterol 1999; 5: 1-3
2. Liu J, Hu JL, Zhang XY, Qiao TD, Chen XT, Wu KC, Ding J, Fan DM. The value of MG7 antigen in predicting cancerous change in dysplastic gastric mucosa. Int J Clin Pract 2002; 56: 169-172
3. Xu L, Qiao T, Chen B. Mimic epitope recognized by monoclonal antibody MG7 against gastric cancer through screening phage displayed random peptide library. Zhonghua Yixue Zazhi 2000; 80: 304-307
4. Xu L, Xu H, Ma F. Immunogenicity of phage-displayed tumor antigen-mimic peptide. Zhonghua Zhongliu Zazhi 2001; 23: 187-189
5. Xiang R, Lode HN, Chao TH, Ruehlmann JM, Dolman CS, Rodriguez F, Whitton JL, Overwijk WW, Restifo NP, Reisfeld RA. An autologous oral DNA vaccine protects against murine melanoma. Proc Natl Acad Sci U S A 2000; 97: 5492-5497
6. Pinilla-Ibarz J, Cathcart K, Korontsvit T, Soignet S, Bocchia M, Caggiano J, Lai L, Jimenez J, Kolitz J, Scheinberg DA. Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood 2000; 95: 1781-1787
7. Sirard JC, Niedergang F, Kraehenbuhl JP. Live attenuated Salmonella: A paradigm of mucosal vaccines. Immunol Rev 1999; 171: 5-26
8. Darji A, Guzman CA, Gerstel B, Wachholz P, Timmis KN, Wehland J, Chakraborty T, Weiss S. Oral somatic transgene vaccination using attenuated S. typhimurium. Cell 1997; 91: 765-775
9. Paglia P, Medina E, Arioli I, Guzman CA, Colombo MP. Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma. Blood 1998; 92: 3172-3176
10. Darji A, Zur Lage S, Garbe AI, Chakraborty T, Weiss S. Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier. FEMS Immunol Med Microbiol 2000; 27: 341-349
11. Cochlovius B, Stassar MJ, Schreurs MW, Benner A, Adema GJ. Oral DNA vaccination: Antigen uptake and presentation by dendritic cells elicits protective immunity. Immunol Lett 2002; 80: 89-96
12. Hopkins SA, Niedergang F, Corthesy-Theulaz IE, Krahenbuhl JP. A recombinant Salmonella typhimurium vaccine strain is taken up and survives within murine Peyer's patch dendritic cells. Cell Microbiol 2000; 2: 59-68
13. Niethammer AG, Primus FJ, Xiang R, Dolman CS, Ruehlmann JM, Ba Y, Gillies SD, Reisfeld RA. An oral DNA vaccine against human carcinoembryonic antigen (CEA) prevents growth and dissemination of Lewis lung carcinoma in CEA transgenic mice. Vaccine 2001; 20: 421-429
14. Zheng B, Woo PC, Ng M, Tsoi H, Wong L, Yuen K. A crucial role of macrophages in the immune responses to oral DNA vaccination against hepatitis B virus in a murine model. Vaccine 2001; 20: 140-147
15. Alexander J, Sidney J, Southwood S, Ruppert J, Oseroff C, Maewal A, Snoke K, Serra HM, Kubo RT, Sette A. Development of high potency univeral DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity 1994; 1: 751-761
16. Ishioka GY, Fikes J, Hermanson G, Livingston B, Crimi C, Qin M, Del Guercio MF, Oseroff C, Dahlberg C, Alexander J, Chesnut RW, Sette A. Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes. J Immunol 1999; 162: 3915-3925
17. An LL, Rodriguez F, Harkins S, Zhang J, Whitton JL. Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine. Vaccine 2000; 18: 2132-2141
18. Yu ZC, Ding J, Nie YZ, Fan DM, Zhang XY. Preparation of single chain variable fragment of MG(7) mAb by phage display technology. World J Gastroenterol 2001; 7: 510-514
19. Nie YZ, He FT, Li ZK, Wu KC, Cao YX, Chen BJ, Fan DM. Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells. World J Gastroenterol 2002; 8: 619-623
20. Kieber-Emmons T, Monzavi-Karbassi B, Wang B, Luo P, Weiner DB. Cutting edge: DNA immunization with minigenes of carbohydrate mimotopes induce functional anti-carbohydrate antibody response. J Immunol 2000; 165: 623-627
21. Lesinski GB, Smithson SL, Srivastava N, Chen D, Widera G, Westerink MA. A DNA vaccine encoding a peptide mimic of Streptococcus pnemoniae serotype 4 capsular polysaccharide induces specific anti-carbohydrate antibodies in Balb/c mice. Vaccine 2001; 19: 1717-1726
22. Monzavi-Karbassi B, Cunto-Amesty G, Luo P, Lees A, Kieber-Emmons T. Immunological characterization of peptide mimetics of carbohydrate antigens in vaccine design strategies. Biologicals 2001; 29: 249-257
23. Han Y, Han ZY, Zhou XM, Shi R, Zheng Y, Shi YQ, Miao JY, Pan BR, Fan DM. Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines. World J Gastroenterol 2002; 8: 441-445
24. Wang X, Lan M, Shi YQ, Lu J, Zhong YX, Wu HP, Zai HH, Ding J, Wu KC, Pan BR, Jin JP, Fan DM. Differential display of vincristine-resistance-related genes in gastric cancer SGC7901 cell. World J Gastroenterol 2002; 8: 54-59
25. Chen Q, Ye YB, Chen Z. Activation of killer cells with soluble gastric cancer antigen combined with anti-CD(3) McAb. World J Gastroenterol 1999; 5: 179-180