Analysis of pathological defects in methionine metabolism using a simple mathematical model

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1741, Issue 3, 2005, Pages 331-338

  Prudova, Anna ^a   Martinov, Mikhail V ^b   Vitvitsky, Victor M ^a,b   Ataullakhanov, Fazoil I ^b   Banerjee, Ruma ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b NATIONAL RESEARCH CENTER FOR HEMATOLOGY   (Russian Federation)

Author keywords

Cystathionine beta synthase; Homocysteine; Methionine; Methylation; S adenosylmethionine

Indexed keywords

HOMOCYSTEINE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; S ADENOSYLMETHIONINE;

ALLOSTERISM; AMINO ACID METABOLISM; ARTICLE; CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC DISORDER; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER; LIVER CELL; LIVER METABOLISM; MATHEMATICAL MODEL; POLYAMINE METABOLISM; PREDICTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THEORETICAL MODEL;

CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CYSTATHIONINE BETA-SYNTHASE; GLYCINE N-METHYLTRANSFERASE; HOMOCYSTEINE; HUMANS; LIVER; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MODELS, BIOLOGICAL; MUTATION;

EID: 25144484893     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2005.04.008     Document Type: Article

References (48)

1. H. Refsum, P.M. Ueland, O. Nygard, and S.E. Vollset Homocysteine and cardiovascular disease Annu. Rev. Med. 49 1998 31 62
2. R. Clarke, A.D. Smith, K.A. Jobst, H. Refsum, L. Sutton, and P.M. Ueland Folate, vitmain B12, and serum total homocysteine levels in confirmed Alzheimer's disease Arch. Neurol. 55 1998 1449 1455
3. J.L. Mills, J.M. McPartlin, P.N. Kirke, Y.J. Lee, M.R. Conle, and D.G. Weir Homocysteine metabolism in pregnancies complicated by neural tube defects Lancet 345 1995 149 151
4. C.L. Hsieh, and P.A. Jones Meddling with methylation Nat. Cell Biol. 5 2003 502 504
5. R.M. Hoffman Methionine dependence in cancer cells-A review In Vitro 18 1982 421 428
6. J.P. Kraus, M. Janosik, V. Kozich, R. Mandell, V. Shih, M.P. Sperandeo, and G. Sebastio R. de Franchis G. Andria L.A. Kluijtmans H. Blom G.H. Boers R.B. Gordon P. Kamoun M.Y. Tsai W.D. Kruger H.G. Koch T. Ohura M. Gaustadnes Cystathionine beta-synthase mutations in homocystinuria Hum. Mutat. vol. 13 1999 362 375
7. S.H. Mudd, H.L. Levy, and F. Skovby The metabolic and molecular basis of inherited diseases 1995 McGraw-Hill New York
8. L.A.J. Kluitjmans, G.H.J. Boers, E.M.B. Stevens, W.O. Renie, J.P. Kraus, F.J.M. Trijbels, L.P.W.J.v.d. Heuvel, and H.J. Blom Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria J. Clin. Invest. 98 1996 285 289
9. M. Janosik, V. Kery, M. Gaustadnes, K.N. Maclean, and J.P. Kraus Regulation of human cystathionine beta-synthase by S-adenosyl-l-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region Biochemistry 40 2001 10625 10633
10. R. Evande, G.H.J. Boers, H.J. Blom, and R. Banerjee Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase Biochemistry 41 2002 11832 11837
11. J.D. Finkelstein, W.E. Kyle, J.J. Martin, and A.-M. Pick Activation of cystathionine β-synthase by adenosylmethionine and adenosylethionine Biochem. Biophys. Res. Commun. 66 1975 81 87
12. S. Taoka, S. Ohja, X. Shan, W.D. Kruger, and R. Banerjee Evidence for heme-mediated redox regulation of human cystathionine β-synthase activity J. Biol. Chem. 273 1998 25179 25184
13. M.D. Roper, and J.P. Kraus Rat cystathionine β-synthase: expression of four alternatively spliced isoforms in transfected cultured cells Arch. Biochem. Biophys. 298 1992 514 521
14. G. Bukovska, V. Kery, and J.P. Kraus Expression of human cystathionine β-synthase in Escherichia coli: purification and characterization Protein Expr. Purif. 5 1994 442 448
15. J. Cai, W.M. Sun, J.J. Hwang, S.C. Stain, and S.C. Lu Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance Hepatology 24 1996 1090 1097
16. M.A. Avila, C. Berasain, L. Torres, A. Martin-Duce, F.J. Corrales, H. Yang, J. Prieto, S.C. Lu, J. Caballeria, J. Rodes, and J.M. Mato Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma J. Hepatol. 33 2000 907 914
17. S.J. Kerr Competing methyltransferase systems J. Biol. Chem. 247 1972 4248 4252
18. Y.M. Chen, J.Y. Shiu, S.J. Tzeng, L.S. Shih, Y.J. Chen, W.Y. Lui, and P.H. Chen Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma Int. J. Cancer 75 1998 787 793
19. H.H. Liu, K.H. Chen, Y.P. Shih, W.Y. Lui, F.H. Wong, and Y.M. Chen Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies J. Biomed. Sci. 10 2003 87 97
20. M.A. Desiderio, G. Pogliaghi, and P. Dansi Regulation of spermidine/spermine N1-acetyltransferase expression by cytokines and polyamines in human hepatocarcinoma cells (HepG2) J. Cell. Physiol. 174 1998 125 134
21. T. Thomas, and T.J. Thomas Polyamine metabolism and cancer J. Cell. Mol. Med. 7 2003 113 126
22. M.V. Martinov, V.M. Vitvitsky, E.V. Mosharov, R. Banerjee, and F.I. Ataullakhanov A substrate switch: a new mode of regulation in the methionine metabolic pathway J. Theor. Biol. 204 2000 521 532
23. E. Borcsok, and R.H. Abeles Mechanism of action of cystathionine synthase Arch. Biochem. Biophys. 213 1982 695 707
24. R.L. Jacobs, L.M. Stead, M.E. Brosnan, and J.T. Brosnan Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver J. Biol. Chem. 276 2001 43740 43747
25. A. Sessa, M.A. Desiderio, M. Baizini, and A. Perin Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas Cancer Res. 41 1981 1929 1934
26. R.M. Pascale, M.M. Simile, L. Gaspa, L. Daino, M.A. Seddaiu, G. Pinna, M. Carta, P. Zolo, and F. Feo Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis Carcinogenesis 14 1993 1077 1080
27. J.E. Heady, and S.J. Kerr Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues Cancer Res. 35 1975 640 643
28. D.M. Sullivan, and J.L. Hoffman Fractionation and kinetic properties of rat liver and kidney methionine adenosyltransferase isozymes Biochemistry 22 1983 1636 1641
29. M.J. Feldman, C.C. Levy, and D.H. Russell Purification and characterization of S-adenosyl-l-methionine decarboxylase from rat liver Biochemistry 11 1972 671 677
30. H. Poso, and A.E. Pegg Comparison of S-adenosylmethionine decarboxylases from rat liver and muscle Biochemistry 21 1982 3116 3122
31. A.E. Pegg, and H. Poso S-adenosylmethionine decarboxylase (rat liver) Methods Enzymol. 94 1983 234 239
32. E. Mosharov, M.R. Cranford, and R. Banerjee The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes Biochemistry 39 2000 13005 13011
33. G. Scalabrino, H. Poso, E. Holtta, P. Hannonen, A. Kallio, and J. Janne Synthesis and accumulation of polyamines in rat liver during chemical carcinogenesis Int. J. Cancer 21 1978 239 245
34. C.K. Wise, C.A. Cooney, S.F. Ali, and L.A. Poirier Measuring S-adenosylmethionine in whole blood, red blood cells and cultured cells using a fast preparation method and high-performance liquid chromatography J. Chromatogr., B, Biomed. Sci. Appl. 696 1997 145 152
35. O. Kabil, and R. Banerjee Deletion of the regulatory domain in the pyridoxal phosphate-dependent heme protein cystathionine beta-synthase alleviates the defect observed in a catalytic site mutant J. Biol. Chem. 274 1999 31256 31260
36. M. Janosik, J. Oliveriusova, B. Janosikova, J. Sokolova, E. Kraus, J.P. Kraus, and V. Kozich Impaired heme binding and aggregation of mutant cystathionine beta-synthase subunits in homocystinuria Am. J. Hum. Genet. 68 2001 1506 1513
37. S. Ojha, J. Wu, R. LoBrutto, and R. Banerjee Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta synthase Biochemistry 41 2002 4649 4654
38. J.D. Finkelstein, and J.J. Martin Methionine metabolism in mammals: adaptation to methionine excess J. Biol. Chem. 261 1986 1582 1587
39. A.M. Rao, M.R. Drake, and M.H. Stipanuk Role of the transsulfuration pathway and of γ-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes J. Nutr. 120 1990 837 845
40. M.H. Stipanuk, R.M. Coloso, R.A. Garcia, and M.F. Banks Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes J. Nutr. 122 1992 420 427
41. S.T. Wang, H.W. Chen, L.Y. Sheen, and C.K. Lii Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes J. Nutr. 127 1997 2135 2141
42. M. Regina, V.P. Korhonen, T.K. Smith, L. Alakuijala, and T.O. Eloranta Methionine toxicity in the rat in relation to hepatic accumulation of S-adenosylmethionine: prevention by dietary stimulation of the hepatic transsulfuration pathway Arch. Biochem. Biophys. 300 1993 598 607
43. J.D. Finkelstein, W.E. Kyle, B.J. Harris, and J.J. Martin Methionine metabolism in mammals: concentration of metabolites in rat tissues J. Nutr. 112 1982 1011 1018
44. M.J. Rowling, M.H. McMullen, D.C. Chipman, and K.L. Schalinske Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats J. Nutr. 132 2002 2545 2550
45. M.C. Reed, H.F. Nijhout, R. Sparks, and C.M. Ulrich A mathematical model of the methionine cycle J. Theor. Biol. 226 2004 33 43
46. F. Skovby, J.P. Kraus, and L.E. Rosenberg Biosynthesis and proteolytic activation of cystathionine β-synthase in rat liver J. Biol. Chem. 259 1984 588 593
47. J. Kraus, S. Packman, B. Fowler, and L.E. Rosenberg Purification and properties of cystathionine β-synthase from human liver J. Biol. Chem. 253 1978 6523 6528
48. M. Kotb, and N.M. Kredich S-adenosylmethionine synthetase from human lymphocytes. Purification and characterization J. Biol. Chem. 260 1985 3923 3930