E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer

Oncology Reports

Volumn 13, Issue 5, 2005, Pages 831-835

  Bendardaf, R ^a,b   Elzagheid, A ^a   Lamlum, H ^a,b   Ristamaki R ^a   Collan, Y ^a   Pyrhonen S ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

CD44s; CD44v6; Colorectal carcinoma; E cadherin; Immunohistochemistry; Tumour differentiation

Indexed keywords

ANTINEOPLASTIC AGENT; CADHERIN; CD44S ANTIGEN; CD44V6 ANTIGEN; GLYCOPROTEIN; HERMES ANTIGEN;

ADULT; AGED; ARTICLE; CANCER INVASION; CARCINOMA; COLORECTAL TUMOR; FEMALE; HUMAN; IMMUNOLOGY; MALE; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; SURVIVAL; TIME;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD44; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CADHERINS; CARCINOMA; COLORECTAL NEOPLASMS; FEMALE; GLYCOPROTEINS; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 25144480508     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.13.5.831     Document Type: Article

References (40)

1. Streit M, Schmidt R, Hilgenfeld RU, Thiel E and Kreuser ED: Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. J Mol Med 74: 253-268, 1996. (Pubitemid 26176682)
2. Jalkanen S, Bargatze RF, de los Toyos J and Butcher EC: Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kDa glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol 105: 983-990, 1987. (Pubitemid 18043858)
3. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U and Bell JI: Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 89: 12160-12164, 1992. (Pubitemid 23004805)
4. Naor D, Nedvetzki S, Golan I, Melnik L and Faitelson Y: CD44 in cancer. Crit Rev Clin Lab Sci 39: 527-579, 2002. (Pubitemid 35425379)
5. Jackson PA, Green MA, Pouli A, Hubbard R, Marks CG and Cook MG: Relation between stage, grade, proliferation, and expression of p53 and CD44 in adenomas and carcinomas of the colorectum. J Clin Pathol 48: 1098-1101, 1995. (Pubitemid 26013258)
6. Wielenga VJ, Heider KH, Offerhaus GJ, Adolf GR, et al: Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Res 53: 4754-4756, 1993. (Pubitemid 23326158)
7. Mulder JW, Wielenga VJ, Polak MM, van den Berg FM, Adolf GR, Herrlich P, et al: Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. Gut 36: 76-80, 1995.
8. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E and Kosma VM: Expression of CD44 and variant proteins in human colorectal cancer and its relevance for prognosis. Scand J Gastroenterol 33: 301-309, 1998. (Pubitemid 28156922)
9. Wood B and Leong A: The biology and diagnostic applications of cadherins in neoplasia: a review. Pathology 35: 101-105, 2003. (Pubitemid 36609779)
10. Menger MD and Vollmar B: Adhesion molecules as determinants of disease: from molecular biology to surgical research. Br J Surg 83: 588-601, 1996. (Pubitemid 26163543)
11. Wijnhoven BP, Dinjens WN and Pignatelli M: E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg 87: 992-1005, 2000. (Pubitemid 30496847)
12. Shiozaki H, Oka H, Inoue M, Tamura S and Monden M: E-cadherin mediated adhesion system in cancer cells. Cancer 77: 1605-1613, 1996. (Pubitemid 26111841)
13. Birchmeier W and Behrens J: Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198: 11-26, 1994. (Pubitemid 24159061)
14. Khoursheed M, Mathew TC, Makar RR, Sonia L, Abul H, Asfar S, et al: Expression of CD44s in human colorectal cancer. Pathol Oncol Res 8: 170-174, 2002. (Pubitemid 35407636)
15. Liu D, Huang C, Kameyama K, Hayashi E, Yamauchi A, Kobayashi S, et al: E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer. Ann Thorac Surg 71: 949-955, 2001.
16. Hirohashi S: Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 153: 333-339, 1998.
17. Goodsell DS: The molecular perspective: cadherin. Oncologist 7: 467-468, 2002.
18. Kowalski PJ, Rubin MA and Kleer CG: E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res 5: R217-222, 2003.
19. Takayama T, Shiozaki H, Doki Y, Oka H, Inoue M, et al: Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer. Br J Cancer 77: 605-613, 1998. (Pubitemid 28059468)
20. Cohen MB, Griebling TL, Ahaghotu CA, Rokhlin OW and Ross JS: Cellular adhesion molecules in urologie malignancies. Am J Clin Pathol 107: 56-63, 1997. (Pubitemid 27104637)
21. Morita N, Uemura H, Tsumatani K, Cho M, Hirao Y, Okajima E, et al: E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion. Br J Cancer 79: 1879-1883, 1999. (Pubitemid 29132319)
22. Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S, Ruers TG, et al: Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Arch 426: 149-154, 1995.
23. Glimelius B, Ristamaki R, Kjaer M, Pfeiffer P, Toren JS, Tveit KM, et al: Irinotecan combined with bolus 5-fluorouracil and folinic acid Nordic schedule as first line therapy in advanced colorectal cancer. Ann Oncol 13: 1868-1873, 2002. (Pubitemid 36040775)
24. Miller AB, Hoogstraten B, Staquet M and Winkler A: Reporting results of cancer treatment. Cancer 47: 207-214, 1981. (Pubitemid 11167383)
25. Maula S, Huuhtanen RL, Blomqvist CP, Wiklund TA, Laurila P and Ristamaki R: The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas. Br J Cancer 84: 244-252, 2001. (Pubitemid 32113453)
26. Elzagheid A, Kuopio T, Ilmen M and Collan Y: Prognostication of invasive ductal breast cancer by quantification of E-cadherin immunostaining: the methodology and clinical relevance. Histopathology 41: 127-133, 2002. (Pubitemid 34985185)
27. Bendardaf R, Lamlum H, Ristamaki R and Pyrhonen S: CD44 variant 6 expression predicts response to treatment in advanced colorectal cancer. Oncol Rep 11: 41-45, 2004.
28. Hart IR, Goode NT and Wilson RE: Molecular aspects of the metastatic cascade. Biochim Biophys Acta 989: 65-84, 1989. (Pubitemid 19180351)
29. Ylagan LR, Scholes J and Demopoulos R: Cd44: a marker of squamous differentiation in adenosquamous neoplasms. Arch Pathol Lab Med 124: 212-215, 2000. (Pubitemid 30090604)
30. Stefanou D, Goussia AC, Arkoumani E and Agnantis NJ: Expression of vascular endothelial growth factor and the adhesion molecule E-cadherin in non-small cell lung cancer. Anticancer Res 23: 4715-4720, 2003. (Pubitemid 38173889)
31. Karatzas G, Karayiannakis AJ, Syrigos KN, Chatzigianni E, Papanikolaou S, et al: E-cadherin expression correlates with tumor differentiation in colorectal cancer. Hepatogastroenterology 46: 232-235, 1999. (Pubitemid 29154753)
32. Gotley DC, Fawcett J, Walsh MD, Reeder JA, Simmons DL and Antalis TM: Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer. Br J Cancer 74: 342-351, 1996. (Pubitemid 26254561)
33. Finke LH, Zorb C, Haensch W, Schlag PM and Terpe HJ: [Expression of CD44 isoforms - a new histopathologic parameter in colorectal carcinoma?]. Zentralbl Chir 121: 450-454, 1996.
34. Koretz K, Moller P, Lehnert T, Hinz U, Otto HF and Herfarth C: Effect of CD44v6 on survival in colorectal carcinoma. Lancet 345:327-328, 1995.
35. Coppola D, Hyacinthe M, Fu L, Cantor AB, Karl R, Marcet J, et al: CD44V6 expression in human colorectal carcinoma. Hum Pathol 29: 627-635, 1998. (Pubitemid 28272719)
36. Wimmenauer S, Keller H, Ruckauer KD, Rahner S, et al: Expression of CD44, ICAM-1 and N-CAM in colorectal cancer. Correlation with the tumor stage and the phenotypical characteristics of tumor-infiltrating lymphocytes. Anticancer Res 17: 2395-2400, 1997. (Pubitemid 27352626)
37. Mulder JW, Kruyt PM, Sewnath M, Oosting J, Seldenrijk CA, Weidema WF, et al: Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet 344: 1470-1472, 1994. (Pubitemid 24351702)
38. Wielenga VJ, van der Voort R, Mulder JW, Kruyt PM, et al: CD44 splice variants as prognostic markers in colorectal cancer. Scand J Gastroenterol 33: 82-87, 1998. (Pubitemid 28114074)
39. Mulder JW, Wielenga VJ, Pals ST and Offerhaus GJ: p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis. Histochem J 29: 439-452, 1997. (Pubitemid 27272079)
40. Sobin LH and Greene FL: TNM classification: clarification of number of regional lymph nodes for pNo. Cancer 92: 452, 2001. (Pubitemid 32664454)