High concentrations of the melatonin metabolite, N1-acetyl- N2-formyl-5-methoxykynuramine, in cerebrospinal fluid of patients with meningitis: A possible immunomodulatory mechanism

Journal of Pineal Research

Volumn 39, Issue 3, 2005, Pages 302-306

  De Oliveira Silva, Sueli ^a   Ximenes, Valdecir F ^b   Livramento, José A ^a   Catalani, Luiz H ^a   Campa, Ana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Cerebrospinal fluid; Cytokines; Inflammation; Kynurenines; Melatonin; N 1 acetyl N2 formyl 5 methoxykynuramine

Indexed keywords

BIOLOGICAL MARKER; DICHLOROMETHANE; INTERLEUKIN 1BETA; INTERLEUKIN 8; KYNURENINE; MELATONIN DERIVATIVE; N1 ACETYL N2 FORMYL 5 METHOXYKYNURAMINE; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CHILD; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOMODULATION; INFLAMMATION; MALE; PROTEIN CEREBROSPINAL FLUID LEVEL; QUANTITATIVE ANALYSIS; VIRUS MENINGITIS;

ADJUVANTS, IMMUNOLOGIC; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; KYNURAMINE; MELATONIN; MENINGITIS;

EID: 25144445731     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2005.00247.x     Document Type: Article

References (23)

1. SILVA SO, XIMENES VF, CATALANI LH et al. Myeloperoxidase-catalyzed oxidation of melatonin by activated PMN. Biochem Biophys Res Commun 2000; 279:657-662.
2. RODRIGUES MR, RODRIGUEZ D, CATALANI LH et al. Interferon-gamma independent oxidation of melatonin by macrophage. J Pineal Res 2003; 34:69-74.
3. 1-acetyl-5-methoxykynuramine, by activated leukocytes. J Pineal Res 2004; 37:171-175.
4. SILVA SO, RODRIGUES MR, XIMENES VF et al. Neutrophils as a specific target for melatonin and kynuramines: effects on cytokines release. J Neuroimmunol 2004; 156:146-152.
5. REITER RJ. Pineal melatonin: cell biology of its synthesis and its physiological interactions. Endocr Rev 1991; 12:151-180.
6. TAN DX, MANCHESTER LC, REITER RJ et al. Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. Biochim Biophys Acta 1999; 1472:206-214.
7. FINOCHIARO LME, NAHMOD VE, LAUNAY JM. Melatonin biosynthesis and metabolism in peripheral-blood mononuclear leukocytes. Biochem J 1991; 280:727-731.
8. CARRILLO-VICO A, CALVO JR, ABREU P et al. Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance. FASEB J 2004; 18:537-539. Epub 2004 Jan 8.
9. TAN DX, MANCHESTER LC, HARDELAND R et al. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003; 34:75-78. Review.
10. HAMPTON MB, KETTLE AJ, WINTERBOURN CC. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 1998; 92:3007-3017.
11. RODRIGUES MR, RODRIGUEZ D, RUSSO M et al. Macrophage activation include high intracellular myeloperoxidase activity. Biochem Biophys Res Commun 2002; 292:869-873.
12. MUNN DH, SHAFIZADEH E, ATTWOOD JT et al. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999; 189:1363-1372.
13. TAN DX, CHEN LD, POEGGELER B et al. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993; 1:57-60.
14. 2-formyl-5- methoxykynurenine. J Pineal Res 2003; 35:131-137.
15. 2-formyl-5-methoxykynuramine for their quantification using an on-line liquid chromatography-electrospray tandem mass spectrometry system. J Pineal Res 2004; 36:64-71.
16. HARTHE C, CLAUDY D, DECHAUD H et al. Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): a melatonin oxidative metabolite. Life Sci 2003; 73:1587-1597.
17. 2-formyl-5-methoxykynuramine is a product of melatonin oxidation in rats. J Pineal Res 2003; 35:245-250.
18. TAN DX, MANCHESTER LC, REITER RJ et al. Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformation. Free Radical Biol Med 2000; 29:1177-1185.
19. SHAHANGIAN S, BROWN PI, ASH KO. Turbidimetric measurement of total urinary proteins: a revised method. Am J Clin Pathol 1984; 81:651-654.
20. TAKINO M, DAISHIMA S, NAKAHARA T. Determination of perfluorooctane sulfonate in river water by liquid chromatography/atmospheric pressure photoionization mass spectrometry by automated on-line extraction using turbulent flow chromatography. Rapid Commun Mass Spect 2003; 17:383-390.
21. ADAMS DH, LLOYD AR. Chemokines: leukocyte recruitment and activation cytokines. Lancet 1997; 349:490-495.
22. BAGGIOLINI M, DEWALD B, MOSER B. Human chemokines: an update. Annu Ver Immunol 1997; 15:675-705.
23. FABRIS C, SOARDO G, FALLETI E et al. Relationship among hepatic inflammatory changes, circulating levels of cytokines, and response to IFN-alpha in chronic hepatitis C. J Interferon Cytokine Res 1998; 18:705-709.