The effect of dietary fatty acids on the expression levels and activities of hepatic drug metabolizing enzymes

Journal of Health Science

Volumn 49, Issue 2, 2003, Pages 105-114

  Kato, Junko ^a   Ikemoto, Atsushi ^a   Mizutani, Takaharu ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

CYP4A1; Cytochrome P 450; Perilla oil; Safflower oil; UDP glucuronosyltransferase

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 4A; DOCOSAHEXAENOIC ACID; DRUG METABOLIZING ENZYME; FATTY ACID; GLUCURONOSYLTRANSFERASE; OMEGA 3 FATTY ACID; PERILLA OIL; SAFFLOWER OIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FAT INTAKE; LIPID COMPOSITION; LIVER; MALE; MICROSOME; NONHUMAN; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALIA; CARTHAMUS TINCTORIUS; PERILLA;

EID: 24944556774     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.49.105     Document Type: Article

References (26)

1. Evans, W. E. and Relling, M. V. (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science, 286, 487-491.
2. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. L., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C. and Nebert, D. W. (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42.
3. Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chpwdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F. and Nebert, D. W. (1997) The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics, 7, 255-269.
4. Burr, G. O. and Burr, M. M. (1930) On the nature and role of the fatty acids essential in nutrition. J. Biol. Chem., 86, 587-621.
5. Futo, T., Hitaka, T., Mizutani, T., Okuyama, H., Watanabe, K. and Totsuka, T. (1989) Fatty acid composition of lipids in tongue and hindleg muscles of muscular dystrophic mice. J. Neurol. Sci., 91, 337-344.
6. Bazan, N. G. (1990) Supply of n-3 polyunsaturated fatty acids and their significance in the central nervous system. Nutrition and Brain, 8, 1-24.
7. Watanabe, I., Kato, M., Hashimoto, A., Naito, Y., Moriuchi, A. and Okuyama, H. (1987) Effect of dietary α-linolenate/linoleate balance on the lipid composition and electroretinographic responses in rats. Adv. Biosci., 62, 563-570.
8. Okuyama, H., Fujii, Y. and Ikemoto, A. (2000) N-6/n-3 ratio of dietary fatty acids rather than hypercholesterolemia as the major risk factor for atherosclerosis and coronary heart disease. J. Health Sci., 46, 157-177.
9. Simopoulos, A. P. (1991) Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr., 54, 345-367.
10. Dannenberg, A. J. and Zakim, D. (1992) Dietary lipid regulates the amount and functional state of UDP-glucuronosyltransferase in rat liver. J. Nutr., 122, 1607-1613.
11. Yoo, J. S. H., Smith, T. J., Ning, S. M., Lee, M. J., Thomas, P. E. and Yang, C. S. (1992) Modulation of the level of cytochrome P450 in rat liver and lung by dietary lipid. Biochem. Pharmacol., 43, 2435-2542.
12. Lutz, M., Bonilla, S., Concha, J., Alvarado, J. and Barraza, P. (1998) Effect of dietary oils, cholesterol and antioxidant vitamin supplementation on liver microsomal fluidity and xenobiotic-metabolizing enzymes in rats. Ann. Nutr. Metab., 42, 350-359.
13. Saito, M. and Yamaguchi, M. (1994b) Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. Ann. Nutr. Metab., 38, 212-220.
14. Ikemoto, A., Ohishi, M., Sato, Y., Hata, N., Misawa, Y., Fujii, Y. and Okuyama, H. (2001) Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. J. Lipid Res., 42, 1655-1663
15. Bligh, E. G. and Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37, 911-917.
16. Kanou, M., Saeki, K., Kato, T., Takahashi, K. and Mizutani, T. (2002) Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes. Fundam. Clin. Pharmacology, 16, 513-517.
17. Yang, C. S., Brady, J. F. and Hong, J. Y. (1992) Dietary effects on cytochrome P450, xenobiotic metabolism and toxicity. FASEB J., 6, 737-744.
18. Wade, A. E. (1986) Effects of dietary fat on drug metabolism. J. Environ. Pathol. Toxicol. Oncol., 6, 161-189.
19. Yamazaki, H. and Shimada, T. (1999) Effects of arachidonic acid, prostaglandins, retinal, retinoic acid and cholecalciferol on xenobiotic oxidations catalyzed by human cytochrome P450 enzymes. Xenobiotica, 29, 231-241.
20. Boucher, P., Seree, E., Vidon, C., Souza, A. C., Villard, P. H., Chambon, R., Barra, Y. and Vallon, J. J. (2000) Dietary lipids affect human ethanol-inducible CYP2E1 gene expression in vivo in mononuclear cells. Life Sci., 67, 1307-1316.
21. Saito, M. and Yamaguchi, M. (1994a) Liver microsomal mixed-function oxidases in response to polyunsaturated/saturated and n-6/n-3 fatty acid ratios of dietary lipids in rats. Ann. Nutr. Metab., 38, 28-39.
22. Engler, M. M., Engler, M. B., Goodfriend, T. L., Ball, D. L., Yu, Z., Su, P. and Kroetz, D. L. (1999) Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. Proc. Soc. Exp. Biol. Med., 221, 32-38.
23. Jump, D. B. and Clarke, S. D. (1999) Regulation of gene expression by dietary fat. Annu. Rev. Nutr., 19, 63-90.
24. Radiminska-Pandya, A., Czernik, P. J., Little, J. M., Battaglia, E. and Mackenzie, P. I. (1999) Structure and functional studies of UDP- glucuronosyltransferases. Drug Met. Review, 31, 817-818.
25. Yang, E. K., Radominska, A., Winder, B. S. and Dannenberg, A. J. (1993) Dietary lipids coinduce xenobiotic metabolizing enzymes in rat liver. Biochim. Biophys. Acta, 1168, 52-58.
26. Yamashita, A., Nagatsuka, T., Watanabe, M, Kondo, H., Sugiura, T. and Waku, K. (1997) Inhibition of UDP-glucuronosyltransferase activity by fatty acyl-CoA. Biochem. Pharmacol., 53, 561-570.