Medical and surgical management of melting corneal ulcers exhibiting hyperproteinase activity in the horse

Clinical Techniques in Equine Practice

Volumn 4, Issue 1, 2005, Pages 50-71

  Ollivier, Franck J ^a  

^a University of Florida College of Veterinary Medicine   (United States)

Author keywords

Amniotic membrane; Conjunctiva; Cornea; Graft; Horse; Melting ulcer; Proteinases; Ulcerative keratitis

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

EID: 24944461935     PISSN: 15347516     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ctep.2005.03.012     Document Type: Article

References (65)

1. NAHMS Equine'98 Study. Part I: Baseline reference of 1998 Equine Health and Management. United States Department of Agriculture: animal and plant health inspection service: national animal health monitoring system. Availabel at: http://www.aphis.usda.gov/vs/ceah/cahm/Equine/eq98des1.htm. Accessed August 1981.
2. D.E. Brooks Equine ophthalmology K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 1053 1116
3. D.E. Brooks Corneal ulceration D.E. Brooks Equine ophthalmology for equine practitioner (ed 1) 2004 Teton Newmedia Jackson, WY 58 87
4. G.A. Severin Veterinary Ophthalmology Notes (ed 2) 1976 Colorado State University Fort Collins, CO
5. T.D. Strubbe, K.N. Gelatt Ophthalmic examination and diagnostic procedures K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 427 466
6. B.C. Gilger, R.D. Whitley Surgery of the cornea and sclera K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 675 754
7. S.M. Crispin Examination of the eye and adnexa K.C. Barnett S.M. Crispin J.D. Lavach Equine Ophthalmology (ed 2) 2004 Saunders London 1 13
8. D. Ward Ocular pharmacology K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 336 354
9. C.P. Moore, M.P. Nasisse Clinical microbiology K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 259 290
10. M.P. Nasisse, S. Nelms Equine ulcerative keratitis Vet Clin North Am Equine Pract 8 1992 537 555
11. K.L. Massa, C.J. Murphy, F.A. Hartmann Usefulness of aerobic microbial culture and cytologic evaluation of corneal specimens in the diagnosis of infectious ulcerative keratitis in animals J Am Vet Med Assoc 15 1999 1671 1674
12. R.E. Hamor, N.C. Whelan Equine infectious keratitis Vet Clin North Am Equine Pract 15 1999 623 646
13. S.A. McLaughlin, B.C. Gilger, R.D. Whitley Infectious keratitis in horses evaluations and management Compend Equine 14 1992 372 379
14. C.L. Cullen, B.H. Grahn Diagnostic ophthalmology. Corneal ulcer with severe secondary anterior uveitis in a pony Can Vet 41 2000 887 889
15. A.G. Matthews Cornea K.C. Barnett S.M. Crispin J.D. Lavach Equine Ophthalmology (ed 2) 2004 Saunders London 107 148
16. S.E. Andrew, A. Nguyen, G.L. Jones Seasonal effects on the aerobic bacterial and fungal conjunctival flora of normal thoroughbred brood mares in Florida Vet Ophthalmol 6 2003 45 50
17. C.P. Moore, W.H. Fales, P. Whittington Bacterial and fungal isolates from Equidae with ulcerative keratitis J Am Vet Med Assoc 182 1983 600 603
18. J.E. Gaarder, W.C. Rebhun, M.A. Ball Clinical appearances, healing patterns, risk factors, and outcomes of horses with fungal keratitis 53 cases (1978-1996) J Am Vet Med Assoc 213 1998 105 112
19. J.D. Lavach Cornea J.D. Lavach Large Animal Ophthalmology (ed 1) 1990 Mosby St Louis, MO 101 149
20. C.P. Moore, B.K. Collins, W.H. Fales Antibacterial susceptibility patterns for microbial isolates associated with infectious keratitis in horses 63 cases (1986-1994) J Am Vet Med Assoc 207 1995 928 933
21. C.R. Sweeney, N.L. Irby Topical treatment of Pseudomonas sp-infected corneal ulcers in horses 70 cases (1977-1994) J Am Vet Med Assoc 209 1996 954 957
22. J.M. da Silva Curiel, C.J. Murphy, S.S. Jang Nutritionally variant streptococci associated with corneal ulcers in horses 35 cases (1982-1988) J Am Vet Med Assoc 197 1990 624 626
23. N.T. Chmielewski, D.E. Brooks, P.J. Smith Visual outcome and ocular survival following iris prolapse in the horse a review of 32 cases Equine Vet J 29 1997 31 39
24. D.V. Hacker, C.J. Murphy, K.C. Lloyd Surgical repair of collagenolytic ulcerative keratitis in the horse Equine Vet J 22 1990 88 92
25. D.E. Brooks, S.E. Andrew, D.J. Biros Ulcerative keratitis caused by beta-hemolytic Streptococcus equi in 11 horses Vet Ophthalmol 3 2000 121 125
26. M.E. Fini, M.T. Girard, M. Matsubara Collagenolytic/gelatinolytic enzymes in corneal wound healing Acta Ophthalmol Suppl 1992 26 33
27. M.E. Fini, M.T. Girard Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea Invest Ophthalmol Vis Sci 31 1990 1779 1788
28. K. Matsumoto, N.B. Shams, L.A. Hanninen Cleavage and activation of corneal matrix metalloproteases by Pseudomonas aeruginosa proteases Invest Ophthalmol Vis Sci 34 1993 1945 1953
29. S.S. Twining, T. Fukuchi, B.Y. Yue Alpha 2-macroglobulin is present in and synthesized by the cornea Invest Ophthalmol Vis Sci 35 1994 3226 3233
30. S.S. Twining, T. Fukuchi, B.Y. Yue Corneal synthesis of alpha 1-proteinase inhibitor (alpha 1-antitrypsin) Invest Ophthalmol Vis Sci 35 1994 458 462
31. S.S. Twining Regulation of proteolytic activity in tissues Crit Rev Biochem Mol Biol 29 1994 315 383
32. K. Hibbets, B. Hines, D. Williams An overview of protease inhibitors J Vet Intern Med 13 1999 302 308
33. D.T. Strubbe, D.E. Brooks, G.S. Schultz Evaluation of tear film proteinases in horses with ulcerative keratitis Vet Ophthalmol 3 2000 111 119
34. F.J. Ollivier The precorneal tear film in horses its importance and disorders Vet Clin North Am Equine Pract 20 2004 301 318
35. S.E. Andrew, D.E. Brooks, P.J. Smith Equine ulcerative keratomycosis visual outcome and ocular survival in 39 cases (1987-1996) Equine Vet J 30 1998 109 116
36. S.M. Crispin Ocular and adnexal emergencies K.C. Barnett S.M. Crispin J.D. Lavach Equine Ophthalmology (ed 2) 2004 Saunders London 25 49
37. C.R. Sweeney, G.E. Russell Complications associated with use of a one-hole subpalpebral lavage system in horses 150 cases (1977-1996) J Am Vet Med Assoc 211 1997 1271 1274
38. A. Regnier Antimicrobials, anti-inflammatory agents, and antiglaucoma drugs K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 297 336
39. D.E. Brooks, S.E. Andrew, C.L. Dillavou Antimicrobial susceptibility patterns of fungi isolated from horses with ulcerative keratomycosis Am J Vet Res 59 1998 138 142
40. F.J. Woessner MMP inhibition. From the Jurassic to the third millennium Ann NY Acad Sci 878 1999 388 403
41. M. Berman, J. Gordon, L.A. Garcia Corneal ulceration and the serum antiproteases. II. Complexes of corneal collagenases and alpha-macroglobulins Exp Eye Res 20 1975 231 244
42. M.B. Berman, J.C. Barber, R.C. Talamo Corneal ulceration and the serum antiproteases. I. Alpha 1-antitrypsin Invest Ophthalmol Vis Sci 12 1973 759 770
43. H.H. Slansky, M.B. Berman, C.H. Dohlman Cysteine and acetylcysteine in the prevention of corneal ulcerations Ann Ophthalmol 2 1970 488 491
44. G. Petroutsos, R. Guimaraes, J.P. Giraud Effect of acetylcysteine (Mucomyst) on epithelial wound healing Ophthalmic Res 14 1982 241 248
45. S.Y. Rawal, Y.B. Rawal Non-antimicrobial properties of Tetraccyclines dental and medical implications West Indian Med 50 1984 105 108
46. L.M. Golub, N. Ramamurthy, T.F. McNamara Tetracyclines inhibit tissue collagenase activity J Perdiodontal Res 19 1984 651 655
47. J.C. Haffner, K.A. Fecteau, H. Eiler Inhibition of collagenase breakdown of equine corneas by tetanus antitoxin, equine serum and acetylcysteine Vet Ophthalmol 6 2003 67 72
48. G.S. Schultz, S. Strelow, G.A. Stern Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases Invest Ophthalmol Vis Sci 33 1992 3325 3331
49. J.P. Barletta, G. Angella, K.C. Balch Inhibition of pseudomonal ulceration in rabbit corneas by a synthetic matrix metalloproteinase inhibitor Invest Ophthalmol Vis Sci 37 1996 20 28
50. F.J. Ollivier, D.E. Brooks, M.E. Kallberg Evaluation of various compounds to inhibit activity of matrix metalloproteinases in the tear film of horses with ulcerative keratitis Am J Vet Res 64 2003 1081 1087
51. H.M. Denis Equine corneal surgery and transplantation Vet Clin North Am Equine Pract 20 2004 361 380
52. D.A. Samuelson Ophthalmic anatomy K.N. Gelatt Veterinary Ophthalmology (ed 3) 1999 Lippincott Williams & Wilkins Philadelphia, PA 31 150
53. J. Shimazaki, H.Y. Yang, K. Tsubota Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns Ophthalmology 104 1997 2068 2076
54. J.S. Kim, J.C. Kim, B.K. Na Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn Exp Eye Res 70 2000 329 337
55. Y. Hao, D.H. Ma, D.G. Hwang Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane Cornea 19 2000 348 352
56. S.J. Fortunato, R. Menon, S.J. Lombardi Collagenolytic enzymes (gelatinases) and their inhibitors in human amniochorionic membrane Am J Obstet Gynecol 177 1997 731 741
57. S.C. Tseng, P. Prabhasawat, S.H. Lee Amniotic membrane transplantation for conjunctival surface reconstruction Am J Ophthalmol 124 1997 765 774
58. B.A. Azuara, C.T. Pillai, H.S. Dua Amniotic membrane transplantation for ocular surface reconstruction Br J Ophthalmol 83 1999 399 402
59. J.C. Kim, S.C. Tseng Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas Cornea 14 1995 473 484
60. F.E. Kruse, A.M. Joussen, K. Rohrschneider Cryopreserved human amniotic membrane for ocular surface reconstruction Graefes Arch Clin Exp Ophthalmol 238 2000 68 75
61. F.E. Kruse, K. Rohrschneider, H.E. Volcker Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers Ophthalmology 106 1999 1504 1510
62. A.L. Andrade, J.L. Laus, F. Figueiredo The use of preserved equine renal capsule to repair lamellar corneal lesions in normal dogs Vet Ophthalmol 2 1999 79 82
63. H.J. Featherstone, J. Sansom, C.L. Heinrich The use of porcine small intestinal submucosa in ten cases of feline corneal disease Vet Ophthalmol 4 2001 147 153
64. D.E. Brooks, F.J. Ollivier Matrix metalloproteinase inhibition in corneal ulceration Vet Clin North Am Small Anim Pract 34 2004 611 622
65. D.E. Brooks Inflammatory stromal keratopathies medical management of stromal keratomalacia, stromal abscesses, eosinophilic keratitis, and band keratopathy in the horse Vet Clin North Am Equine Pract 20 2004 345 360