Mutations of the PC2 substrate binding pocket alter enzyme specificity

Journal of Biological Chemistry

Volumn 280, Issue 36, 2005, Pages 31850-31858

  Kacprzak, Magdalena M ^a   Than, Manuel E ^b   Juliano, Luis ^c   Juliano, Maria A ^c   Bode, Wolfram ^b   Lindberg, Iris ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

SUBSTRATES;

CATALYTIC DOMAIN; HOMOLOGY; MUTATIONS;

ENZYMES;

AMINO ACID; COMPLEMENTARY DNA; FURIN; MUTANT PROTEIN; PROENKEPHALIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; RECOMBINANT ENZYME;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC TRANSFECTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CATALYTIC DOMAIN; CELL LINE; CRICETINAE; FURIN; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY;

EID: 24744452183     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505567200     Document Type: Article

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