The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-γ secretion

Journal of Clinical Immunology

Volumn 25, Issue 5, 2005, Pages 437-444

  Gibbons, Fiona K ^a   Israel, Elliot ^b   Deykin, Aaron ^b   Schaub, Bianca ^b   He, Hong Z ^b   Perkins, David L ^b   Finn, Patricia W ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Allergen; Asthma; Cytokines; Proliferation

Indexed keywords

ALLERGEN; BUDESONIDE; GAMMA INTERFERON; INTERLEUKIN 13; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; PREDNISONE; ZAFIRLUKAST;

ADULT; ALLERGIC REACTION; ARTICLE; ASTHMA; CAT; CELL ISOLATION; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERFERON PRODUCTION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AGED; ASTHMA; BUDESONIDE; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; GLYCOPROTEINS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-13; LEUKOCYTES, MONONUCLEAR; LEUKOTRIENE ANTAGONISTS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHYTOHEMAGGLUTININS; PREDNISONE; TOSYL COMPOUNDS;

EID: 24744442361     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-005-5625-6     Document Type: Article

References (41)

1. Robinson D, Hamid Q, Ying S, et al.: Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression: Am Rev Respir Dis 148:401-406, 1993
2. Hoekstra MO, Hoekstra Y, De Reus D, et al.: Interleukin-4, interferon-gamma and interleukin-5 in peripheral blood of children with moderate atopic asthma. Clin Exp Allergy 27:1254-1260, 1997
3. Corrigan CJ, Kay AB: CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis 141:970-977, 1990
4. Cembrzynska-Nowak M, Szklarz E, Inglot AD, et al.: Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am Rev Respir Dis 147:291-295, 1993
5. Krug N, Madden J, Redington AE, et al.: T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 14: 319-326, 1996
6. Gajewski TF, Joyce J, Fitch FW: Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma. J Immunol 143:15-22, 1989
7. Coyle AJ, Tsuyuki S, Bertrand C, et al.: Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J Immunol 156:2680-2685, 1996
8. Hessel EM, Van Oosterhout AJ, Van Ark I, et al.: Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration. Am J Respir Cell Mol Biol 16:325-334, 1997
9. Randolph DA, Carruthers CJ, Szabo SJ, et al.: Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. J Immunol 162:2375-2383, 1999
10. Hansen G, Berry G, DeKruyff RH, et al.: Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 103:175-183, 1999
11. Wills-Karp M, Luyimbazi J, Xu X, et al.: Interleukin-13: central mediator of allergic asthma. Science 282:2258-2261, 1998
12. Cohn L, Tepper JS, Bottomly K: IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol 161:3813-3816, 1998
13. Yang M, Hogan SP, Henry PJ, et al.: Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 25:522-530, 2001
14. Nagano Y, Kondo M, Tamaoki J, et al.: Peripheral blood Th1 and Th2 profile in patients with moderate asthma: effect of inhaled corticosteroid. J Asthma 39:247-253, 2002
15. Naseer T, Minshall EM, Leung DY, et al.: Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. Am J Respir Crit Care Med 155(3):845-851, 1997
16. Bentley AM, Hamid Q, Robinson DS, et al.: Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 153:551-556, 1996
17. Gemou-Engesaeth V, Bush A, Kay AB, et al.: Inhaled glucocorticoid therapy of childhood asthma is associated with reduced peripheral blood T cell activation and 'Th2-type' cytokine mRNA expression. Pediatrics 99:695-703, 1997
18. Braun CM, Huang SK, Bashian GG, et al.: Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses. J Allergy Clin Immunol 100:400-407, 1997
19. Vargaftig BB, Singer M: Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol 28:410-419, 2003
20. NAEPP Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma. National Institutes of Health Publication: 17-20, 1997
21. Finn PW, Boudreau JO, He H, et al.: Children at risk for asthma: Home allergen levels, lymphocyte proliferation, and wheeze. J Allergy Clin Immunol 105:933-942, 2000
22. Lemanske RF, Jr, Sorkness CA, Mauger EA, et al.: Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA 285:2594-2603, 2001
23. Drazen JM, Israel E, Boushey HA, et al.: Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med 335:841-847, 1996
24. Lara-Marquez ML, Deykin A, Krinzman S, et al.: Analysis of T-cell activation after bronchial allergen challenge in patients with atopic asthma. J Allergy Clin Immunol 101:699-708, 1998
25. Aleksza M, Lukacs A, Antal-Szalmas P, et al.: Increased frequency of intracellular interleukin (IL)-13 and IL-10, but not IL-4, expressing CD4+ and CD8+ peripheral T cells of patients with atopic dermatitis. Br J Dermatol 147:1135-1141, 2002
26. Li Y, Simons FE, HayGlass KT: Environmental antigen-induced IL-13 responses are elevated among subjects with allergic rhinitis, are independent of IL-4, and are inhibited by endogenous IFN-gamma synthesis. J Immunol 161:7007-7014, 1998
27. Jenmalm MC, Van Snick J, Cormont F, et al.: Allergen-induced Th1 and Th2 cytokine secretion in relation to specific allergen sensitization and atopic symptoms in children. Clin Exp Allergy 31:1528-1535, 2001
28. Macaubas C, Sly PD, Burton P, et al.: Regulation of T-helper cell responses to inhalant allergen during early childhood. Clin Exp Allergy 29:1223-1231, 1999
29. Rawle FC, Mitchell EB, Platts-Mills TA: T cell responses to the major allergen from the house dust mite Dermatophagoides pteronyssinus, Antigen P1: comparison of patients with asthma, atopic dermatitis, and perennial rhinitis. J Immunol 133:195-201, 1984
30. Jeng KC, Liu MT, Wu CH, et al.: American cockroach Cr-PI allergen induces lymphocyte proliferation and cytokine production in atopic patients. Clin Exp Allergy 26:349-356, 1996
31. Blaher B, McCluskey J, Puy R, et al.: T cell response to grass pollen allergens: Correlation with skin test reactivity and serum IgE levels. Immunol Cell Biol 73:17-22, 1995
32. Sahid El-Radhi A, Hogg CL, Bungre JK, et al.: Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma. Arch Dis Child 83:158-162, 2000
33. Leung DY, Martin RJ, Szefler SJ, et al.: Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. J Exp Med 181: 33-40, 1995
34. Henderson WR, Jr, Tang LO, Chu SJ, et al.: A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 165:108-116, 2002
35. Stelmach I, Jerzynska J, Kuna P: A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICAM-1) in children with asthma. J Allergy Clin Immunol 109:257-263, 2002
36. Tohda Y, Nakahara H, Kubo H, et al.: Effects of ONO-1078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma. Clin Exp Allergy 29:1532-1536, 1999
37. Morita H, Takeda K, Yagita H, et al.: Immunosuppressive effect of leukotriene B(4) receptor antagonist in vitro. Biochem Biophys Res Commun 264:321-326, 1999
38. O'Sullivan S, Akveld M, Burke CM, et al.: Effect of the Addition of Montelukast to Inhaled Fluticasone Propionate on Airway Inflammation. Am J Respir Crit Care Med 167:745-750, 2003
39. Di Lorenzo G, Pacor ML, Pellitteri ME, et al.: In vitro effects of fluticasone propionate on IL-13 production by mitogen-stimulated lymphocytes. Mediat Inflamm 11:187-190, 2002
40. Visser MJ, Postma DS, Brand PL, et al.: Influence of different dosage schedules of inhaled fluticasone propionate on peripheral blood cytokine concentrations in childhood asthma. Clin Exp Allergy 32:1497-1503, 2002
41. Spahn JD, Landwehr LP, Nimmagadda S, et al.: Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma. J Allergy Clin Immunol 98:1073-1079, 1996