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Volumn 175, Issue 6, 2005, Pages 3663-3673

Fusion to Listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2/neu and reveals subdominant epitopes in the FVB/N mouse

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; DNA VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPITOPE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; LISTERIA MONOCYTOGENES LISTERIOLYSIN O E7 FUSION PROTEIN; LISTERIA MONOCYTOGENES LISTERIOLYSIN O EXTRACELLULAR DOMAIN 1 FUSION PROTEIN; LISTERIA MONOCYTOGENES LISTERIOLYSIN O EXTRACELLULAR DOMAIN 2 FUSION PROTEIN; LISTERIA MONOCYTOGENES LISTERIOLYSIN O EXTRACELLULAR DOMAIN 3 FUSION PROTEIN; LISTERIA MONOCYTOGENES LISTERIOLYSIN O INTRACELLULAR DOMAIN 1 FUSION PROTEIN; LISTERIA MONOCYTOGENES LISTERIOLYSIN O INTRACELLULAR DOMAIN 2 FUSION PROTEIN; LISTERIOLYSIN; LISTERIOLYSIN O; TUMOR VACCINE; UNCLASSIFIED DRUG;

EID: 24744433094     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.6.3663     Document Type: Article
Times cited : (101)

References (51)
  • 1
    • 0022600388 scopus 로고
    • The neu oncogene encodes an epidermal growth factor receptor-related protein
    • Bargmann, C. I., M. C. Hung, and R. A. Weinberg. 1986. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 319: 226-230.
    • (1986) Nature , vol.319 , pp. 226-230
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 2
    • 0033604516 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis
    • Kim, H., and W. J. Muller. 1999. The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis. Exp. Cell Res. 253: 78-87.
    • (1999) Exp. Cell Res. , vol.253 , pp. 78-87
    • Kim, H.1    Muller, W.J.2
  • 3
    • 0022406444 scopus 로고
    • Amplification of a novel v-erB-related gene in human mammary carcinoma
    • King, C. R., M. H. Kraus, and S. A. Aaronson. 1985. Amplification of a novel v-erB-related gene in human mammary carcinoma. Science 229: 974-976.
    • (1985) Science , vol.229 , pp. 974-976
    • King, C.R.1    Kraus, M.H.2    Aaronson, S.A.3
  • 5
    • 0030633566 scopus 로고    scopus 로고
    • HER-2/neu protein: A target for antigen-specific immunotherapy of human cancer
    • Disis, M. L., and M. A. Cheever. 1997. HER-2/neu protein: a target for antigen-specific immunotherapy of human cancer. Adv. Cancer Res. 71: 343-371.
    • (1997) Adv. Cancer Res. , vol.71 , pp. 343-371
    • Disis, M.L.1    Cheever, M.A.2
  • 7
    • 0028360534 scopus 로고
    • Detection of HER-2/neu oncogene amplification in flow cytometry-sorted breast ductal cells by competitive polymerase chain reaction
    • Li, B. D., S. P. Harlow, R. M. Budnick, D. L. Sheedy, and C. C. Stewart. 1994. Detection of HER-2/neu oncogene amplification in flow cytometry-sorted breast ductal cells by competitive polymerase chain reaction. Cancer 73: 2771-2778.
    • (1994) Cancer , vol.73 , pp. 2771-2778
    • Li, B.D.1    Harlow, S.P.2    Budnick, R.M.3    Sheedy, D.L.4    Stewart, C.C.5
  • 9
    • 0035504918 scopus 로고    scopus 로고
    • Evidence for an antigen-driven humoral immune response in medullary ductal breast cancer
    • Coronella, J. A., P. Telleman, G. A. Kingsbury, T. D. Truoung, S. Hays, and R. P. Junghans. 2001. Evidence for an antigen-driven humoral immune response in medullary ductal breast cancer. Cancer Res. 61: 7889-7899.
    • (2001) Cancer Res. , vol.61 , pp. 7889-7899
    • Coronella, J.A.1    Telleman, P.2    Kingsbury, G.A.3    Truoung, T.D.4    Hays, S.5    Junghans, R.P.6
  • 12
    • 0029870228 scopus 로고    scopus 로고
    • Intracellular pathogenesis of listeriosis
    • Southwick, F. S., and D. L. Purich. 1996. Intracellular pathogenesis of listeriosis. N. Engl. J. Med. 334: 770-776.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 770-776
    • Southwick, F.S.1    Purich, D.L.2
  • 13
    • 7944222097 scopus 로고    scopus 로고
    • Molecular determinants of Listeria monocytogenes virulence
    • Dussurget, O., J. Pizarro-Cerda, and P. Cossart. 2004. Molecular determinants of Listeria monocytogenes virulence. Ann. Rev. Microbiol. 58: 587-610.
    • (2004) Ann. Rev. Microbiol. , vol.58 , pp. 587-610
    • Dussurget, O.1    Pizarro-Cerda, J.2    Cossart, P.3
  • 14
    • 73849167296 scopus 로고
    • Cellular resistance to infection
    • Mackaness, G. B. 1962. Cellular resistance to infection. J. Exp. Med. 116: 381-406.
    • (1962) J. Exp. Med. , vol.116 , pp. 381-406
    • Mackaness, G.B.1
  • 15
    • 0033977538 scopus 로고    scopus 로고
    • Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes
    • Gedde, M. M., D. E. Higgins, L. G. Tilney, and D. A. Portnoy. 2000. Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes. Infect. Immun. 68: 999-1003.
    • (2000) Infect. Immun. , vol.68 , pp. 999-1003
    • Gedde, M.M.1    Higgins, D.E.2    Tilney, L.G.3    Portnoy, D.A.4
  • 17
    • 0027959410 scopus 로고
    • Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes
    • Ikonomidis, G., Y. Paterson, F. J. Kos, and D. A. Portnoy. 1994. Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes. J. Exp. Med. 180: 2209-2218.
    • (1994) J. Exp. Med. , vol.180 , pp. 2209-2218
    • Ikonomidis, G.1    Paterson, Y.2    Kos, F.J.3    Portnoy, D.A.4
  • 18
    • 4344573008 scopus 로고    scopus 로고
    • Progress towards the use of Listeria monocytogenes as a live bacterial vaccine vector for the delivery of HIV antigens
    • Paterson, Y., and R. S. Johnson. 2004. Progress towards the use of Listeria monocytogenes as a live bacterial vaccine vector for the delivery of HIV antigens. Expert Rev. Vac. 3(4 Suppl.): S119-S134.
    • (2004) Expert Rev. Vac. , vol.3 , Issue.4 SUPPL.
    • Paterson, Y.1    Johnson, R.S.2
  • 19
    • 0035576230 scopus 로고    scopus 로고
    • Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16
    • Gunn, G. R., A. Zubair, C. Peters, Z. K. Pan, T. C. Wu, and Y. Paterson. 2001. Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16. J. Immunol. 167: 6471-6479.
    • (2001) J. Immunol. , vol.167 , pp. 6471-6479
    • Gunn, G.R.1    Zubair, A.2    Peters, C.3    Pan, Z.K.4    Wu, T.C.5    Paterson, Y.6
  • 20
    • 0032723880 scopus 로고    scopus 로고
    • Regression of established B16F10 melanoma with a recombinant Listeria monocytogenes vaccine
    • Pan, Z. K., L. M. Weiskirch, and Y. Paterson. 1999. Regression of established B16F10 melanoma with a recombinant Listeria monocytogenes vaccine. Cancer Res. 59: 5264-5269.
    • (1999) Cancer Res. , vol.59 , pp. 5264-5269
    • Pan, Z.K.1    Weiskirch, L.M.2    Paterson, Y.3
  • 21
    • 0029047262 scopus 로고
    • A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours
    • Pan, Z. K., G. Ikonomidis, A. Lazenby, D. Pardoll, and Y. Paterson. 1995. A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours. Nat. Med. 1: 471-477.
    • (1995) Nat. Med. , vol.1 , pp. 471-477
    • Pan, Z.K.1    Ikonomidis, G.2    Lazenby, A.3    Pardoll, D.4    Paterson, Y.5
  • 22
    • 0035328683 scopus 로고    scopus 로고
    • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice
    • Machiels, J. P. H., R. T. Reilly, L. A. Emens, A. M. Ercolini, R. Y. Lei, D. Weintraub, F. I. Okoye, and E. M. Jaffee. 2001. Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice. Cancer Res. 61: 3689-3697.
    • (2001) Cancer Res. , vol.61 , pp. 3689-3697
    • Machiels, J.P.H.1    Reilly, R.T.2    Emens, L.A.3    Ercolini, A.M.4    Lei, R.Y.5    Weintraub, D.6    Okoye, F.I.7    Jaffee, E.M.8
  • 24
    • 0141992909 scopus 로고    scopus 로고
    • HSP110-HER-2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic mice
    • Manjili, M. H., X. Y. Wang, X. Chen, T. Martin, E. A. Repasky, R. Henderson, and J. R. Subjeck. 2003. HSP110-HER-2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic mice. J. Immunol. 171: 4054-4061.
    • (2003) J. Immunol. , vol.171 , pp. 4054-4061
    • Manjili, M.H.1    Wang, X.Y.2    Chen, X.3    Martin, T.4    Repasky, E.A.5    Henderson, R.6    Subjeck, J.R.7
  • 25
    • 0035116901 scopus 로고    scopus 로고
    • The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors
    • Reilly, R. T., J. P. H. Machiels, L. A. Emens, A. M. Ercolini, R. I. Okoye, R. Y. Lei, D. Weintraub, and E. M. Jaffee. 2001. The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors. Cancer Res. 61: 880-883.
    • (2001) Cancer Res. , vol.61 , pp. 880-883
    • Reilly, R.T.1    Machiels, J.P.H.2    Emens, L.A.3    Ercolini, A.M.4    Okoye, R.I.5    Lei, R.Y.6    Weintraub, D.7    Jaffee, E.M.8
  • 26
    • 0037446542 scopus 로고    scopus 로고
    • Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice
    • Ercolini, A. M., J. P. Machiels, Y. C. Chen, J. E. Slansky, M. Giedlen, R. T. Reilly, and E. M. Jaffee. 2003. Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice. J. Immunol. 170: 4273-4280.
    • (2003) J. Immunol. , vol.170 , pp. 4273-4280
    • Ercolini, A.M.1    Machiels, J.P.2    Chen, Y.C.3    Slansky, J.E.4    Giedlen, M.5    Reilly, R.T.6    Jaffee, E.M.7
  • 28
    • 0035090249 scopus 로고    scopus 로고
    • The tumor recall response of antitumor immunity primed by a live, recombinant Listeria monocytogenes vaccine comprises multiple effector mechanisms
    • Weiskirch, L. M., Z. K. Pan, and Y. Paterson. 2001. The tumor recall response of antitumor immunity primed by a live, recombinant Listeria monocytogenes vaccine comprises multiple effector mechanisms. Clin. Immunol. 98: 346-357.
    • (2001) Clin. Immunol. , vol.98 , pp. 346-357
    • Weiskirch, L.M.1    Pan, Z.K.2    Paterson, Y.3
  • 30
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy, C. T., M. A. Webster, M. Schaller, T. J. Parsons, R. D. Cardiff, and W. J. Muller. 1992. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc. Natl. Acad. Sci. USA 89: 10578-10582.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10578-10582
    • Guy, C.T.1    Webster, M.A.2    Schaller, M.3    Parsons, T.J.4    Cardiff, R.D.5    Muller, W.J.6
  • 31
    • 10844276509 scopus 로고    scopus 로고
    • Recombinant Listeria vaccines containing PEST sequences are potent immune adjuvants for the tumor-associated antigen human papillomavirus-16 E7
    • Sewell, D. A., V. Shahabi, G. R. Gunn 3rd, Z. K. Pan, M. E. Dominiecki, and Paterson Y. 2004. Recombinant Listeria vaccines containing PEST sequences are potent immune adjuvants for the tumor-associated antigen human papillomavirus-16 E7. Cancer Res. 64: 8821-8825.
    • (2004) Cancer Res. , vol.64 , pp. 8821-8825
    • Sewell, D.A.1    Shahabi, V.2    Gunn III, G.R.3    Pan, Z.K.4    Dominiecki, M.E.5    Paterson, Y.6
  • 32
    • 0034602312 scopus 로고    scopus 로고
    • A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity
    • Decatur, A. L., and D. A. Portnoy. 2000. A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity. Science 290: 992-995.
    • (2000) Science , vol.290 , pp. 992-995
    • Decatur, A.L.1    Portnoy, D.A.2
  • 33
    • 2442563529 scopus 로고    scopus 로고
    • The ability of two Listeria monocytogenes vaccines targeting human papillomavirus-16 E7 to induce an antitumor response correlates with myeloid dendritic cell function
    • Peng, X., S. F. Hussain, and Y. Paterson. 2004. The ability of two Listeria monocytogenes vaccines targeting human papillomavirus-16 E7 to induce an antitumor response correlates with myeloid dendritic cell function. J. Immunol. 172: 6030-6038.
    • (2004) J. Immunol. , vol.172 , pp. 6030-6038
    • Peng, X.1    Hussain, S.F.2    Paterson, Y.3
  • 34
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci, S., and P. Matzinger. 2001. Danger signals: SOS to the immune system. Cur. Opin. Immunol. 13: 114-119.
    • (2001) Cur. Opin. Immunol. , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 35
    • 0032080809 scopus 로고    scopus 로고
    • DNA vaccines encoding full-length or truncated neu induce protective immunity against neu-expressing mammary tumors
    • Chen, Y., D. Hu, D. J. Eling, J. Robbins, and T. J. Kipps. 1998. DNA vaccines encoding full-length or truncated neu induce protective immunity against neu-expressing mammary tumors. Cancer Res. 58: 1965-1971.
    • (1998) Cancer Res. , vol.58 , pp. 1965-1971
    • Chen, Y.1    Hu, D.2    Eling, D.J.3    Robbins, J.4    Kipps, T.J.5
  • 36
    • 3042817388 scopus 로고    scopus 로고
    • Enhanced efficacy of DNA vaccination against Her-2/neu tumor antigen by genetic adjuvants
    • Chang, S. Y., K. C. Lee, S. Y. Ko, H. J. Ko, and C. Y. Kang. 2004. Enhanced efficacy of DNA vaccination against Her-2/neu tumor antigen by genetic adjuvants. Int. J. Cancer 111: 86-95.
    • (2004) Int. J. Cancer , vol.111 , pp. 86-95
    • Chang, S.Y.1    Lee, K.C.2    Ko, S.Y.3    Ko, H.J.4    Kang, C.Y.5
  • 37
    • 0034326620 scopus 로고    scopus 로고
    • DNA vaccination against rat Her-2/neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice
    • Rovero, S., A. Amici, E. Di Carlo, R. Bei, P. Nanni, E. Quagliano, P. Porcedda, K. Boggio, A. Smorlesi, P. L. Lollini, et al. 2000. DNA vaccination against rat Her-2/neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice. J. Immunol. 165: 5133-5142.
    • (2000) J. Immunol. , vol.165 , pp. 5133-5142
    • Rovero, S.1    Amici, A.2    Di Carlo, E.3    Bei, R.4    Nanni, P.5    Quagliano, E.6    Porcedda, P.7    Boggio, K.8    Smorlesi, A.9    Lollini, P.L.10
  • 38
    • 4344596965 scopus 로고    scopus 로고
    • Therapeutic HER2/Neu DNA vaccine inhibits mouse tumor naturally overexpressing endogenous neu
    • Lin, C. C., C. W. Chou, A. L. Shiau, C. F. Tu, T. M. Ko, Y. L. Chen, B. C. Yang, M. H. Tao, and M. D. Lai. 2004. Therapeutic HER2/Neu DNA vaccine inhibits mouse tumor naturally overexpressing endogenous neu. Mol. Ther. 10: 290-301.
    • (2004) Mol. Ther. , vol.10 , pp. 290-301
    • Lin, C.C.1    Chou, C.W.2    Shiau, A.L.3    Tu, C.F.4    Ko, T.M.5    Chen, Y.L.6    Yang, B.C.7    Tao, M.H.8    Lai, M.D.9
  • 39
    • 4744355872 scopus 로고    scopus 로고
    • Escape from immunotherapy: Possible mechanisms that influence tumor regression/progression
    • Ahmad, M., R. C. Rees, and S. A. Ali. 2004. Escape from immunotherapy: possible mechanisms that influence tumor regression/progression. Cancer Immunol. Immunother. 53: 844-854.
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 844-854
    • Ahmad, M.1    Rees, R.C.2    Ali, S.A.3
  • 40
    • 0842282556 scopus 로고    scopus 로고
    • neu antigen-negative variants can be generated after neu-specific antibody therapy in neu transgenic mice
    • Knutson, K. L., B. Almand, Y. Dang, and M. L. Disis. 2004. neu antigen-negative variants can be generated after neu-specific antibody therapy in neu transgenic mice. Cancer Res. 64: 1146-1151.
    • (2004) Cancer Res. , vol.64 , pp. 1146-1151
    • Knutson, K.L.1    Almand, B.2    Dang, Y.3    Disis, M.L.4
  • 41
    • 1242293637 scopus 로고    scopus 로고
    • Induction of therapeutic T cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccine
    • Duraiswamy, J., M. Bhardwaj, J. Tellam, G. Connolly, L. Cooper, D. Moss, S. Thomson, P. Yotnda, and R. Khanna. 2004. Induction of therapeutic T cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccine. Cancer Res. 64: 1483-1489.
    • (2004) Cancer Res. , vol.64 , pp. 1483-1489
    • Duraiswamy, J.1    Bhardwaj, M.2    Tellam, J.3    Connolly, G.4    Cooper, L.5    Moss, D.6    Thomson, S.7    Yotnda, P.8    Khanna, R.9
  • 42
    • 4544252430 scopus 로고    scopus 로고
    • Humoral epitope-spreading following immunizations with a HER-2/neu peptide based vaccine in cancer patients
    • Disis, M. L., V. Goodell, K. Schiffman, and K. L. Knutson. 2004. Humoral epitope-spreading following immunizations with a HER-2/neu peptide based vaccine in cancer patients. J. Clin. Immunol. 24: 571-578.
    • (2004) J. Clin. Immunol. , vol.24 , pp. 571-578
    • Disis, M.L.1    Goodell, V.2    Schiffman, K.3    Knutson, K.L.4
  • 43
    • 0242300038 scopus 로고    scopus 로고
    • Changing immu-nodominance patterns in antiviral CD8 T cell responses after loss of epitope presentation or chronic antigenic stimulation
    • van der Most, R. G., K. Murali-Krishna, J. G. Lanier, E. J. Wherry, M. T. Puglielli, J. N. Blattman, A. Sette, and R. Ahmed. 2003. Changing immu-nodominance patterns in antiviral CD8 T cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology 315: 93-102.
    • (2003) Virology , vol.315 , pp. 93-102
    • Most, R.G.1    Murali-Krishna, K.2    Lanier, J.G.3    Wherry, E.J.4    Puglielli, M.T.5    Blattman, J.N.6    Sette, A.7    Ahmed, R.8
  • 44
    • 8444223429 scopus 로고    scopus 로고
    • Cutting edge: Tumor-specific CTL are constitutively cross-armed in draining lymph nodes and transiently disseminate to mediate tumor regression following systemic CD40 activation
    • Stumbles, P. A., R. Himbeck, J. A. Frelinger, E. J. Collins, R. A. Lake, and B. W. S. Robinson. 2004. Cutting edge: Tumor-specific CTL are constitutively cross-armed in draining lymph nodes and transiently disseminate to mediate tumor regression following systemic CD40 activation. J. Immunol. 173: 5923-5928.
    • (2004) J. Immunol. , vol.173 , pp. 5923-5928
    • Stumbles, P.A.1    Himbeck, R.2    Frelinger, J.A.3    Collins, E.J.4    Lake, R.A.5    Robinson, B.W.S.6
  • 45
    • 0038326676 scopus 로고    scopus 로고
    • Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells
    • Nowak, A. K., R. A. Lake, A. L. Marzo, B. Scott, W. R. Heath, E. J. Collins, J. A. Frelinger, and B. W. S. Robinson. 2003. Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells. J. Immunol. 170: 4905-4913.
    • (2003) J. Immunol. , vol.170 , pp. 4905-4913
    • Nowak, A.K.1    Lake, R.A.2    Marzo, A.L.3    Scott, B.4    Heath, W.R.5    Collins, E.J.6    Frelinger, J.A.7    Robinson, B.W.S.8
  • 47
    • 1642316449 scopus 로고    scopus 로고
    • + T cell repertoire against HER-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity
    • + T cell repertoire against HER-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity. Eur. J. Immunol. 34: 752-761.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 752-761
    • Lustgarten, J.1    Dominguez, A.L.2    Cuadros, C.3
  • 49
    • 85044705017 scopus 로고    scopus 로고
    • Immunization against a dominant tumor antigen abrogates immunogenicity of the tumor
    • Makki, A., G. Weidt, N. E. Blachere, L. Lefrancois, and P. K. Srivastava. 2002. Immunization against a dominant tumor antigen abrogates immunogenicity of the tumor. Cancer Immun. 2: 4-12.
    • (2002) Cancer Immun. , vol.2 , pp. 4-12
    • Makki, A.1    Weidt, G.2    Blachere, N.E.3    Lefrancois, L.4    Srivastava, P.K.5
  • 50
    • 0037290768 scopus 로고    scopus 로고
    • Epitope dominance, competition and T cell affinity maturation
    • Kedl, R. M., J. W. Kappler, and P. Marrack. 2003. Epitope dominance, competition and T cell affinity maturation. Curr. Opin. Immunol. 15: 120-127.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 120-127
    • Kedl, R.M.1    Kappler, J.W.2    Marrack, P.3


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