Aprotinin preserves cellular junctions and reduces myocardial edema after regional ischemia and cardioplegic arrest

Circulation

Volumn 112, Issue 9 SUPPL., 2005, Pages

  Khan, Tanveer A ^a   Bianchi, Cesario ^a   Araujo, Eugenio ^a   Voisine, Pierre ^a   Xu, Shu Hua ^a   Feng, Jun ^a   Li, Jian ^a   Sellke, Frank W ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cardioplegia; Cardiopulmonary bypass; Cell adhesion molecules; Edema; Endothelium; Ischemia; Signal transduction

Indexed keywords

APROTININ; BETA CATENIN; CADHERIN; INFUSION FLUID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN; PLAKOGLOBIN; RECEPTOR; THROMBIN; THROMBIN PROTEINASE ACTIVATED RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL PERMEABILITY; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CELL JUNCTION; CONTINUOUS INFUSION; CONTROLLED STUDY; CORONARY ARTERY; CRYSTALLOID; DRUG EFFECT; HEART EDEMA; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART SURGERY; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SWINE; VASCULAR ENDOTHELIUM; WATER CONTENT;

ADHERENS JUNCTIONS; ANIMALS; ANTIGENS, CD; APROTININ; BETA CATENIN; BODY WATER; CADHERINS; CAPILLARY PERMEABILITY; CARDIOMYOPATHIES; DRUG EVALUATION; EDEMA; GAMMA CATENIN; HEART ARREST, INDUCED; MAP KINASE SIGNALING SYSTEM; MYOCARDIAL ISCHEMIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POTASSIUM COMPOUNDS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SUS SCROFA;

EID: 24644514813     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.104.526053     Document Type: Article

References (20)

1. Sellke FW, Boyle EM Jr, Verrier ED. Endothelial cell injury in cardiovascular surgery: the pathophysiology of vasomotor dysfunction. Ann Thorac Surg. 1996;62:1222-1228.
2. Lampugnani MG, Corada M, Caveda L, Breviario F, Ayalon O, Geiger B, Dejana E. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol. 1995;129:203-217.
3. Corada M, Mariotti M, Thurston G, Smith K, Kunkel R, Brockhaus M, Lampugnani MG, Martin-Padura I, Stoppacciaro A, Ruco L, McDonald DM, Ward PA, Dejana E. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A. 1999;96:9815-9820.
4. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev. 2004;84:869-901.
5. Ukropec JA, Hollinger MK, Salva SM, Woolkalis MJ. SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. J Biol Chem. 2000;275:5983-5986.
6. Borbiev T, Verin AD, Birukova A, Liu F, Crow MT, Garcia JG. Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2003;285: L43-L54.
7. Vogel SM, Gao X, Mehta D, Ye RD, John TA, Andrade-Gordon P, Tiruppathi C, Malik AB. Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol Genomics. 2000;4:137-145.
8. Poullis M, Manning R, Laffan M, Haskard DO, Taylor KM, Landis RC. The antithrombotic effect of aprotinin: actions mediated via the protease-activated receptor 1. J Thorac Cardiovasc Surg. 2000;120:370-378.
9. Day JR, Punjabi PP, Randi AM, Haskard DO, Landis RC, Taylor KM. Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery. Circulation. 2004;110:2597-2600.
10. Bianchi C, Araujo EG, Sato K, Sellke FW. Biochemical and structural evidence for pig myocardium adherens junction disruption by cardiopulmonary bypass. Circulation. 2001;104:1319-1324.
11. Xiao K, Allison DF, Kottke MD, Summers S, Sorescu GP, Faundez V, Kowalczyk AP. Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells. J Biol Chem. 2003;278:19199-19208.
12. Fremes SE, Wong BI, Lee E, Mai R, Christakis GT, McLean RF, Goldman BS, Naylor CD. Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding. Ann Thorac Surg. 1994;58:1580-1588.
13. Frumento RJ, O'Malley CM, Bennett-Guerrero E. Stroke after cardiac surgery: a retrospective analysis of the effect of aprotinin dosing regimens. Ann Thorac Surg. 2003;75:479-483.
14. Khan TA, Bianchi C, Voisine P, Feng J, Baker J, Hart M, Takahashi M, Stahl G, Sellke FW. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. J Thorac Cardiovasc Surg. 2004;128:602-608.
15. O'Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ, Woulfe DS, Brass LF. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem. 2000;275:13502-13509.
16. Klarenbach SW, Chipiuk A, Nelson RC, Hollenberg MD, Murray AG. Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. Circ Res. 2003;92:272-278.
17. Vouret-Craviari V, Grail D, Van Obberghen-Schilling E. Modulation of Rho GTPase activity in endothelial cells by selective proteinase-activated receptor (PAR) agonists. J Thromb Haemost. 2003;1:1103-1111.
18. Borbiev T, Birukova A, Liu F, Nurmukhambetova S, Gerthoffer WT, Garcia JG, Verin AD. p38 MAP kinase-dependent regulation of endothelial cell permeability. Am J Physiol Lung Cell Mol Physiol. 2004;287: L911-L918.
19. Asimakopoulos G, Thompson R, Nourshargh S, Lidington EA, Mason JC, Ratnatunga CP, Haskard DO, Taylor KM, Landis RC. An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation. J Thorac Cardiovasc Surg. 2000;120:361-369.
20. Hallett MB, Shandall A, Young HL. Mechanism of protection against "reperfusion injury" by aprotinin. Roles of polymorphonudear leucocytes and oxygen radicals. Biochem Pharmacol. 1985;34:1757-1761.