Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens

Toxicology and Applied Pharmacology

Volumn 207, Issue 2 SUPPL., 2005, Pages 225-229

  Fukushima, Shoji ^a   Morimura, Keiichirou ^a   Wanibuchi, Hideki ^a   Kinoshita, Anna ^a   Salim, Elsayed I ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Arsenics carcinogenicity; Hormesis; Medium term liver bioassay; Multiorgan carcinogenicity test

Indexed keywords

ANTICONVULSIVE AGENT; ARSENIC; CACODYLIC ACID; CARCINOGEN; PHENOBARBITAL; SEDATIVE AGENT;

ANALYTIC METHOD; BIOASSAY; BLADDER; CANCER RISK; CARCINOGEN TESTING; CARCINOGENICITY; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; HORMESIS; LIVER; LIVER CARCINOGENESIS; NONHUMAN; PATHOLOGY; RELIABILITY; RISK ASSESSMENT; TOXICOLOGY;

EID: 24644507323     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.01.037     Document Type: Conference Paper

References (8)

1. K. Imaida, S. Tamano, A. Hagiwara, S. Fukushima, T. Shirai, and N. Ito Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances Pure Appl. Chem. 75 11-12 2003 2491 2495
2. N. Ito H. Sugano Modification of Tumor Development in Rodents Prog. Exp. Tumor Res. vol. 33 1991 Karger Basel
3. N. Ito, S. Tamano, and T. Shirai A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals Cancer Sci. 94 2003 3 8
4. A. Kinoshita, H. Wanibuchi, K. Morimura, M. Wei, J. Shen, S. Imaoka, Y. Funae, and S. Fukushima Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression Carcinogenesis 24 2003 1389 1399
5. M. Kitano, T. Ichihara, T. Matsuda, H. Wanibuchi, S. Tamano, A. Hagiwara, S. Imaoka, Y. Funae, T. Shirai, and S. Fukushima Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat Carcinogenesis 19 1998 1475 1480
6. S. Takahashi, R. Hasegawa, T. Masui, M. Mizoguchi, S. Fukushima, and N. Ito Establishment of multiorgan carcinogenesis bioassay using rats treated with a combination of five carcinogens J. Toxicol. Pathol. 5 1992 151 156
7. M. Wei, H. Wanibuchi, S. Yamamoto, W. Li, and S. Fukushima Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats Carcinogenesis 20 1999 1873 1876
8. S. Yamamoto, Y. Konishi, T. Matsuda, T. Murai, M.A. Shibata, I. Matsui-Yuasa, S. Otani, K. Kuroda, G. Endo, and S. Fukushima Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens Cancer Res. 55 1995 1271 1276