Inappropriate sexual behaviors in dementia

Journal of Geriatric Psychiatry and Neurology

Volumn 18, Issue 3, 2005, Pages 155-162

  Black, Benjamin ^a   Muralee, Sunanda ^a   Tampi, Rajesh R ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yale New Haven Psychiatric Hospital   (United States)

Author keywords

Behavioral disturbance; Dementia; Hypersexuality; Inappropriate sexual behaviors

Indexed keywords

ADRENALIN; ALCOHOL; ANTIANDROGEN; CHOLINESTERASE INHIBITOR; CIMETIDINE; CITALOPRAM; CLOMIPRAMINE; COCAINE; DONEPEZIL; ESTROGEN; GALANTAMINE; GONADORELIN; KETOCONAZOLE; LEUPRORELIN; LEVODOPA; MEDROXYPROGESTERONE ACETATE; MOOD STABILIZER; NEUROLEPTIC AGENT; PAROXETINE; PINDOLOL; QUETIAPINE; RIVASTIGMINE; SEROTONIN UPTAKE INHIBITOR; SPIRONOLACTONE; TRAZODONE;

ABDOMINAL PAIN; ANXIETY DISORDER; ARTHRALGIA; ARTICLE; ASTHENIA; ATTITUDE; BEHAVIOR DISORDER; CENTRAL NERVOUS SYSTEM DISEASE; COGNITIVE DEFECT; CONSTIPATION; CORPUS STRIATUM; DELIRIUM; DEMENTIA; DEPRESSION; DIABETES MELLITUS; DIZZINESS; DRUG HALF LIFE; EJACULATION DISORDER; ETHICS; FAMILY; FATIGUE; FLUID RETENTION; FRONTAL CORTEX; GASTROINTESTINAL DISEASE; GYNECOMASTIA; HEADACHE; HOT FLUSH; HUMAN; HYPOTHALAMUS; IMPOTENCE; INCREASED APPETITE; INSOMNIA; LIBIDO; MASTALGIA; MASTURBATION; MOOD DISORDER; NAUSEA; NEUROBIOLOGY; ORTHOSTATIC HYPOTENSION; PELVIS PAIN SYNDROME; PRIAPISM; PRIORITY JOURNAL; PSYCHOSIS; PSYCHOTHERAPY; SEDATION; SEXUAL BEHAVIOR; SEXUAL DEVIATION; SIDE EFFECT; SOCIAL ASPECT; SOMNOLENCE; SWEATING; TEMPORAL CORTEX; TREMOR; VOMITING; WEIGHT GAIN; XEROSTOMIA;

AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS; CORPUS STRIATUM; DEMENTIA; DEPRESSION; DIAGNOSIS, DIFFERENTIAL; FEMALE; FRONTAL LOBE; HUMANS; HYPOTHALAMUS; LIMBIC SYSTEM; MALE; PARAPHILIAS; TEMPORAL LOBE;

EID: 24644483184     PISSN: 08919887     EISSN: None     Source Type: Journal    
DOI: 10.1177/0891988705277541     Document Type: Article

References (63)

1. Mortimer JA. Alzheimer's disease and senile dementia: prevalence and incidence. In: Reisberg B, ed. Alzheimer's Disease: The Standard Reference. New York, NY: Free Press; 1983:141-148.
2. Bharucha AJ, Rosen J, Mulsant BH, Pollock BG. Assessment of behavioral and psychological symptoms of dementia. CNS Spectr. 2002;7:797-802.
3. Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from Cache County Study on Memory and Aging. Am J Psychiatry. 2000;157:708-714.
4. Margallo-Lana M, Swann A, O'Brien J, et al. Prevalence and pharmacological management of behavioral and psychological symptoms amongst dementia sufferers living in care environments. Int J Geriatr Psychiatry. 2001;16:39-44.
5. Finkel SI, Costa e Silva J, Cohen G, Miller S, Sartorius N. Behavioral and psychological symptoms of dementia: a consensus statement on current knowledge and implication for research and treatment. Int Psychogeriatr. 1996;8(3 suppl):497-500.
6. Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement patients with Alzheimer's disease. Am J Psychiatry. 1990;147:1049-1051.
7. O'Donnell BF, Drachman DA, Barnes HJ, Peterson KE, Swearer JM, Lew RA. Incontinence and troublesome behaviors predict institutionalization in dementia. J Geriatr Psychiatry Neurol. 1992;5:45-52.
8. Starr BD, Weiner MB. The Starr-Weiner Report on Sex and Sexuality in Mature Years. New York, NY: McGraw-Hill; 1981.
9. Marsiglio W, Donnelly D. Sexual relations in later life: a national study of married persons. J Gerontol. 1991;46:S338-S344.
10. Comfort A, Dial LK. Sexuality and aging: an overview. Clin Geriatr Med. 1991;7:1-7.
11. Kligman EW. Office evaluation of sexual function and complaints. Clin Geriatr Med. 1991;7:15-39.
12. Burns A, Jacoby R, Levy R. Psychiatric phenomena in Alzheimer's disease, IV: disorders of behaviour. Br J Psychiatry. 1990;157:86-94.
13. Szasz G. Sexual incidents in an extended care unit for aged men. J Am Geriatr Soc. 1983;31:407-411.
14. Levitsky AM, Owens NJ. Pharmacological treatment of hypersexuality and paraphilias in nursing home residents. J Am Geriatr Soc. 1999;47:231-234.
15. Potocnick F. Successful treatment of hypersexuality in AIDS dementia with cyproterone acetate. S Afr Med J. 1992;81:433-434.
16. Huws R, Shubsachs AP, Taylor PJ. Hypersexuality, fetishism and multiple sclerosis. Br J Psychiatry. 1991;158:280-281.
17. Cooper AJ. Medroxyprogesterone acetate (MPA) treatment of sexual acting out in men suffering from dementia. J Clin Psychiatry. 1987;48:368-370.
18. Persinger MA. Maintained hypersexuality between male rats following chronically induced limbic seizures: implications for bisexuality in complex partial seizures. Psychol Rep. 1994;74:647-652.
19. Lilly R, Cummings JL, Benson DF, Frankle M. The human Kluver-Bucy syndrome. Neurology. 1983;33:1141-1145.
20. Monga TN, Monga M, Raina MS, Hardjasudarma M. Hypersexuality in stroke. Arch Phys Med Rehabil. 1986;67:415-417.
21. Blustein J, Seeman MV. Brain tumor presenting as functional psychiatric disturbance. Can Psychiatr Assoc J. 1972;17:S59-S63.
22. Bear DM, Fedio P. Quantitative analysis of interictal behavior in temporal lobe epilepsy. Arch Neurol. 1977;34:454-467.
23. Miller BL, Cummings JL, McIntyre H, Ebers G, Grode M. Hypersexuality or altered sexual preference following brain injury. J Neurol Neurosurg Psychiatry. 1986;49:867-873.
24. Mendez MF, Chow T, Ringman J, Twitchell G, Hinkin CH. Pedophilia and temporal lobe disturbance. J Neuropsychiatry Clin Neurosci. 2000;12:71-76.
25. Janati A. Kluver-Bucy syndrome in Huntington's chorea. J Nerv Ment Dis. 1985;173:632-635.
26. Comings DE, Comings BG. A case of familial exhibitionism in Tourette's syndrome successfully treated with haloperidol. 1982;139:913-915.
27. Akil M, Brewer GJ. Psychiatric and behavioral abnormalities in Wilson's disease. Adv Neurol. 1995;65:171-178.
28. Bowers MB Jr, Van Woert M, Davis L. Sexual behaviors during L-dopa treatment for Parkinsonism. Am J Psychiatry. 1971;127:1691-1693.
29. Brown E, Brown GM, Kofman O, Quarrington B. Sexual function and affect in parkinsonian men treated with L-dopa. Am J Psychiatry. 1978;135:1552-1555.
30. McLean PD. Special award lecture: new findings on brain function and sociosexual behavior. In: Zubin J, Money J, eds. Contemporary Sexual Behaviors: Critical Issues in the 1970s. Baltimore, Md: Johns Hopkins University Press; 1973:53-74.
31. Hashmi FH, Krady AL, Qayum F, Grossberg GT. Sexually disinhibited behavior in the cognitively impaired elderly. Clin Geriatr. 2000;8:631-637.
32. Haddad P, Benbow S. Sexual problems associated with dementia, part 2: aetiology, assessment and treatment. Int J Geriatr Psychiatry. 1993;8:631-637.
33. Kamel HK, Hajjar RR. Sexuality in the nursing home, part 2: managing abnormal behavior-legal and ethical issues. J Am Med Dir Assoc. 2004;5:S49-S52.
34. Kuhn DR, Greiner D, Arseneau L. Addressing hypersexuality in Alzheimer's disease. J Gerontol Nurs. 1998;24:44-50.
35. Reidenbaugh EM, Zeiss AM, Davies HD, Tinklenberg, JR. Sexual behaviors in men with dementing illness. Clin Geriatr. 1997;5:45-50.
36. Kamel HK. Sexuality in aging: focus on institutionalized elderly. Annals of long-term care. Clinical Care and Aging. 2001;9:64-72.
37. White CB, Catania JA. Psychoeducational interventions for sexuality with the aged, family members of the aged, and people who work with the aged. Int J Aging Hum Dev. 1982;15:121-138.
38. Aja A, Self D. Alternate methods of changing nursing home staff attitudes towards sexual behavior in the aged. J Sex Educ Ther. 1986;12:37-41.
39. Sullivan-Miller BH. Dealing with attitudes, preconceived notions. Provider. 1987;13:24-26.
40. Perilstein RD, Lipper S, Friedman LJ. Three cases of paraphilias responsive to fluoxetine treatment. J Clin Psychiatry. 1991;52:169-170.
41. McElroy SL, Phillip KA, Keck PE. Obsessive compulsive spectrum disorder. J Clin Psychiatry. 1994;55(suppl):33-51, discussion 52-53.
42. Guidotti A, Costa E. Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3-alfa and 5-alfa-tetrahydroprogesterone (allopregnelone) availability? Biol Psychiatry. 1998;44:865-873.
43. Stewart JT, Shin KJ. Paroxetine treatment of sexual disinhibition in dementia. Am J Psychiatry. 1997;154:1474.
44. Raji M, Dongjie L, Wallace D. Sexual aggressiveness in a patient with dementia: sustained clinical response to citalopram. Annals of Long-Term Care. 2000;8:81-83.
45. Leo RJ, Kim KY. Clomipramine treatment of paraphilias in elderly demented patients. J Geriatr Psychiatry Neurol. 1995;8:123-124.
46. Nagaratnam N, Gayagay G. Hypersexuality in nursing care facilities-a descriptive study. Arch Gerontol Geriatr. 2002;35:195-203.
47. Maixner SM, Mellow AM, Tandon R. The efficacy, safety, and tolerability of antipsychotics in the elderly. J Clin Psychiatry. 1999;60(suppl 8):29-41.
48. Macknight C, Rojas-Fernandez C. Quetiapine for sexually inappropriate behavior in dementia. J Am Geriatr Soc. 2000;48:707.
49. Simpson DM, Foster D. Improvement in organically disturbed behavior with trazodone treatment. J Clin Psychiatry. 1986;47:191-193.
50. Weiner MF, Denke M, Williams K, Guzman R. Intramuscular medroxyprogesterone acetate for sexual aggression in elderly men. Lancet. 1992;339:1121-1121.
51. Cooper AJ. Progestogens in the treatment of male sex offenders: a review. Can J Psychiatry. 1986;31:73-79.
52. Mellor CS, Farid NR, Craig DF. Female hypersexuality treated with cyproterone acetate. Am J Psychiatry. 1988;145:1037.
53. Kyomen HH, Noble KW, Wei JY. The use of estrogen to decrease aggressive physical behavior in elderly men with dementia. J Am Geriatr Soc. 1991;39:1110-1112.
54. Lothstein LM, Fogg-Waberski J, Reynolds P. Risk management and treatment of sexual disinhibition in geriatric patients. Conn Med. 1997;612:609-618.
55. Ott BR. Leuprolide treatment of sexual aggression in a patient with dementia and Kluver-Bucy syndrome. Clin Neuropharmacol. 1995;18:443-447.
56. Rich SS, Ovsiew F. Leuprolide acetate for exhibitionism in Huntington's disease. Mov Dis. 1994;9:353-357.
57. Wiseman SV, McAuley JW, Freidenberg GR, Freidenberg DL. Hypersexuality in patients with dementia: possible response to cimetidine. Neurology. 2000;54:2024.
58. Jensen CF. Hypersexual agitation in Alzheimer's disease. J Am Geriatr Soc. 1989;37:917.
59. Young RC, Gyulai L, Mulsant BH, et al. Pharmacotherapy of bipolar disorder: review and recommendations. Am J Geriatr Psychiatry. 2001;12:342-357.
60. Lonergan ET, Cameron M, Luxenberg J. Valproate preparation for agitation in dementia [review]. Cochrane Database Syst Rev. 2004;4:CD003945.
61. Cummings JL. Use of cholinesterase inhibitors in clinical practice: evidence-based recommendations. Am J Geriatr Psychiatry. 2002;11:131-145.
62. Areosa SA, Sherriff F, McShane R. Memantine for dementia [review]. Cochrane Database Syst Rev. 2005;18:CD003154.
63. Lichtenberg PA, Strzepek DM. Assessments of institutionalized dementia patient's competencies to participate in intimate relationships. Gerontologist. 1990;30:117-120.