Extrahepatic manifestations of cholestatic liver diseases: Pathogenesis and therapy

Clinical Reviews in Allergy and Immunology

Volumn 28, Issue 2, 2005, Pages 147-157

  Pusl, Thomas ^a   Beuers, Ulrich ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cholestasis; Extrahepatic; Fatigue; Metabolic bone disease; Osteoporosis; Pathogenesis; Primary biliary cirrhosis; Primary sclerosing cholangitis; Pruritus; Symptoms

Indexed keywords

ALENDRONIC ACID; ANION EXCHANGE RESIN; ANTIOXIDANT; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CALCIUM; CLONIDINE; COLESTIPOL; COLESTYRAMINE; ESTROGEN; ETIDRONIC ACID; FLUORIDE SODIUM; NALMEFENE; NALOXONE; NALTREXONE; ONDANSETRON; OPIATE; OPIATE ANTAGONIST; PREDNISONE; RIFAMPICIN; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; URSODEOXYCHOLIC ACID; VITAMIN D;

ABDOMINAL DISCOMFORT; ANOREXIA; BREAST CANCER; CLINICAL FEATURE; CLINICAL TRIAL; CONSTIPATION; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG MECHANISM; FATIGUE; HEPATITIS; HORMONE SUBSTITUTION; HUMAN; INTRAHEPATIC CHOLESTASIS; LIVER DYSFUNCTION; LIVER TRANSPLANTATION; MALABSORPTION; META ANALYSIS; METABOLIC BONE DISEASE; NONHUMAN; OSTEOLYSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PRIMARY BILIARY CIRRHOSIS; PRURITUS; QUALITY OF LIFE; REVIEW; SCRATCHING; SIDE EFFECT; TASTE DISORDER; THROMBOEMBOLISM; TREATMENT PLANNING; WITHDRAWAL SYNDROME;

BONE DISEASES, METABOLIC; CHOLANGITIS, SCLEROSING; CHOLESTASIS; FATIGUE; HUMANS; PRURITUS;

EID: 24644475134     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1385/CRIAI:28:2:147     Document Type: Review

References (164)

1. Gross, C.R., Malinchoc, M., Kim, W.R., et al. (1999), Hepatology 29, 356-364.
2. Younossi, Z.M., Kiwi, M.L., Boparai, N., Price, L.L., and Guyatt, G. (2000), Am J Gastroenterol 95, 497-502.
3. Krajnik, M. and Zylicz, Z. (2001), J Pain Symptom Manage 21, 151-168.
4. Heathcote, J. (2000), Can J Gastroenterol 14, 43-48.
5. Elias, E. and Burra, P. (1991), J Gastroenterol Hepatol 6, 570-573.
6. Neuberger, J. and Jones, E.A. (2001), Eur J Gastroenterol Hepatol 13, 1393-1394.
7. Swain, M. In: Primary Biliary Cirrhosis, Neuberger, J., ed., Eastbourne, UK: West End Studios, 1999, pp. 75-81.
8. Lucey, M.R., Neuberger, J.M., and Williams, R. (1986), Gut 27, 1373-1376.
9. Bergasa, N.V., Mehlman, J.K., and Jones, E.A. (2000), Baillieres Best Pract Res Clin Gastroenterol 14, 643-655.
10. McCormack, H.M., Horne, D.J., and Sheather, S. (1988), Psychol Med 18, 1007-1019.
11. Talbot, T.L., Schmitt, J.M., Bergasa, N.V., Jones, E.A., and Walker, E.C. (1991), Biomed Instrum Technol 25, 400-403.
12. Molenaar, H.A., Oosting, J., and Jones, E.A. (1998), Med Biol Eng Comput 36, 220-224.
13. Jones, E.A. and Bergasa, N.V. (1999), Hepatology 29, 1003-1006.
14. Jones, E.A. and Bergasa, N.V. (2000), Can J Gastroenterol 14, 33-40.
15. Ghent, C.N. (1987), Am J Gastroenterol 82, 117,118.
16. Jones, E.A. and Bergasa, N.V. (1990), Hepatology 11, 884-887.
17. Kirby, J., Heaton, K.W., and Burton, J.L. (1974), Br Med J 4, 693-695.
18. Bartholomew, T.C., Summerfield, J.A., Billing, B.H., Lawson, A.M., and Setchell, K.D. (1982), Clin Sci (Lond) 63, 65-73.
19. Freedman, M.R., Holzbach, R.T., and Ferguson, D.R. (1981), Am J Med 70, 1011-1016.
20. Clements, W.D., O'Rourke, D.M., Rowlands, B.J., and Ennis, M. (1994), Agents Actions 41(Spec No), C30,G31.
21. Gittlen, S.D., Schulman, E.S., and Maddrey, W.C. (1990), Gut 31, 96-99.
22. Thomas, D.A., Williams, G.M., Iwata, K., Kenshalo, D.R., Jr., and Dubner, R. (1992), Brain Res 585, 315-317.
23. Ballantyne, J.C., Loach, A.B., and Carr, D.B. (1988), Pain 33, 149-160.
24. Swain, M.G., Rothman, R.B., Xu, H., Vergalla, J., Bergasa, N.V., and Jones, E.A. (1992), Gastroenterology 103, 630-635.
25. Bergasa, N.V., Rothman, R.B., Vergalla, J., Xu, H., Swain, M.G., and Jones, E.A. (1992), J Hepatol 15, 220-224.
26. Bergasa, N.V., Alling, D.W., Vergalla, J., and Jones, E.A. (1994), J Hepatol 20, 85-90.
27. Thornton, J.R. and Losowsky, M.S. (1988), BMJ 297, 1501-1504.
28. Bergasa, N.V., Thomas, D.A., Vergalla, J., Turner, M.L., and Jones, E.A. (1993), Life Sci 53, 1253-1257.
29. Bergasa, N.V., Sabol, S.L., Young, W.S., 3rd, Kleiner, D.E., and Jones, E.A. (1995), Am J Physiol 268, G346-G354.
30. Bergasa, N.V., Vergalla, J., Swain, M.G., and Jones, E.A. (1996), Liver 16, 298-302.
31. Bergasa, N.V., Liau, S., Homel, P., and Ghali, V. (2002), Liver 22, 107-113.
32. Bergasa, N.V., Mohajer, B., Maisonneuve, I.M., et al. (1997), Life Sci 61, 1169-1175.
33. Yamaguchi, T., Nagasawa, T., Satoh, M., and Kuraishi, Y. (1999), Neurosci Res 35, 77-83.
34. Richardson, B.P. (1990), Ann NY Acad Sci 600, 511-519; discussion 519,320.
35. Kiefel, J.M., Cooper, M.L., and Bodnar, R.J. (1992), Brain Res 597, 331-338.
36. Schworer, H., Hartmann, H., and Ramadori, G. (1995), Pain 61, 33-37.
37. Browning, J., Combes, B., and Mayo, M.J. (2003), Am J Gastroenterol 98, 2736-2741.
38. Datta, D.V. and Sherlock, S. (1966), Gastroenterology 50, 323-332.
39. Franco, J. (1999), Curr Treat Options Gastroenterol 2, 451-456.
40. Bachs, L., Pares, A., Elena, M., Piera, C., and Rodes, J. (1989), Lancet 1, 574-576.
41. Loginov, A.S., Reshetniak, V.I., and Petrakov, A.V. (1993), Ter Arkh 65, 57-62.
42. Podesta, A., Lopez, P., Terg, R., et al. (1991), Dig Dis Sci 36, 216-220.
43. Ghent, C.N. and Carruthers, S.G. (1988), Gastroenterology 94, 488-493.
44. Cynamon, H.A., Andres, J.M., and Iafrate, R.P. (1990), Gastroenterology 98, 1013-1016.
45. Woolf, G.M. and Reynolds, T.B. (1990), J Clin Gastroenterol 12, 174-177.
46. Miguet, J.P., Mavier, P., Soussy, C.J., and Dhumeaux, D. (1977), Gastroenterology 72, 924-926.
47. Galeazzi, R., Lorenzini, I., and Orlandi, F. (1980), Dig Dis Sci 25, 108-112.
48. Berg, C.L. and Gollan, J.L. (1992), Scand J Gastroenterol 192(Suppl), 43-49.
49. Yousef, I.M., Tuchweber, B., Vonk, R.J., Masse, D., Audet, M., and Roy, C.C. (1981), Gastroenterology 80, 233-241.
50. Prince, M.I., Burt, A.D., and Jones, D.E. (2002), Gut 50, 436-439.
51. Bergasa, N.V., Talbot, T.L., Alling, D.W., et al. (1992), Gastroenterology 102, 544-549.
52. Bergasa, N.V., Alling, D.W., Talbot, T.L., et al. (1995), Ann Intern Med 123, 161-167.
53. Wolfhagen, F.H., Sternieri, E., Hop, W.C., Vitale, G., Bertolotti, M., and Van Buuren, H.R. (1997), Gastroenterology 113, 1264-1269.
54. Bergasa, N.V., Schmitt, J.M., Talbot, T.L., et al. (1998), Hepatology 27, 679-684.
55. Terg, R., Coronel, E., Sorda, J., Munoz, A.E., and Findor, J. (2002), J Hepatol 37, 717-722.
56. Bergasa, N.V. and Jones, E.A. (1995), Gastroenterology 108, 1582-1588.
57. Mela, M., Mancuso, A., and Burroughs, A.K. (2003), Aliment Pharmacol Ther 17, 857-870.
58. Jones, E.A. and Dekker, L.R. (2000), Gastroenterology 118, 431,432.
59. Shawcross, D.L. and Jalan, R. (2001), Gastroenterology 121, 743,744.
60. Carson, K.L., Tran, T.T., Cotton, P., Sharara, A.I., and Hunt, C.M. (1996), Am J Gastroenterol 91, 1022,1023.
61. Schworer, H. and Ramadori, G. (1993), Lancet 341, 1277.
62. Schworer, H. and Ramadori, G. (1993), Clin Invest 71, 659-662.
63. Raderer, M., Muller, C., and Scheithauer, W. (1994), N Engl J Med 330, 1540.
64. Muller, C., Pongratz, S., Pidlich, J., et al. (1998), Eur J Gastroenterol Hepatol 10, 865-870.
65. Poupon, R.E., Balkau, B., Eschwege, E., and Poupon, R. (1991), N Engl J Med 324, 1548-1554.
66. Battezzati, P.M., Podda, M., Bianchi, F.B., et al. (1993), J Hepatol 17, 332-338.
67. Pares, A., Caballeria, L., Rodes, J., et al. (2000), J Hepatol 32, 561-566.
68. Vuoristo, M., Farkkila, M., Karvonen, A.L., et al. (1995), Gastroenterology 108, 1470-1478.
69. Matsuzaki, Y., Tanaka, N., Osuga, T., et al. (1990), Am J Gastroenterol 85, 15-23.
70. Goulis, J., Leandro, G., and Burroughs, A.K. (1999), Lancet 354, 1053-1060.
71. Gluud, C. and Christensen, E. (2002), Cochrane Database Syst Rev vol. 1, CD000551.
72. Glasova, H. and Beuers, U. (2002), J Gastroenterol Hepatol 17, 938-948.
73. Huet, P.M., Deslauriers, J., Tran, A., Faucher, C., and Charbonneau, J. (2000), Am J Gastroenterol 95, 760-767.
74. Fahey, S. (1999), J Adv Nurs 30, 506-512.
75. Witt-Sullivan, H., Heathcote, J., Cauch, K., et al. (1990), Hepatology 12, 98-105.
76. Goldblatt, J., Taylor, P.J., Lipman, T., et al. (2002), Gastroenterology 122, 1235-1241.
77. Fisk, J.D., Ritvo, P.G., Ross, L., Haase, D.A., Marrie, T.J., and Schlech, W.F. (1994), Clin Infect Dis 18(Suppl 1), S79-S83.
78. Prince, M.I., James, O.F., Holland, N.P., and Jones, D.E. (2000), J Hepatol 32, 368-373.
79. Prince, M.I. and Jones, D.E. (2000), Postgrad Med J 76, 199-206.
80. Cauch-Dudek, K., Abbey, S., Stewart, D.E., and Heathcote, E.J. (1998), Gut 43, 705-710.
81. Swain, M.G. (2000), Clin Sci (Lond) 99, 1-8.
82. Sokol, R.J., Devereaux, M., and Khandwala, R.A. (1991), J Lipid Res 32, 1349-1357.
83. Paradis, V., Kollinger, M., Fabre, M., Holstege, A., Poynard, T., and Bedossa, P. (1997), Hepatology 26, 135-142.
84. Sumida, S., Tanaka, K., Kitao, H., and Nakadomo, F. (1989), Int J Biochem 21, 835-838.
85. Reid, M.B., Stokic, D.S., Koch, S.M., Khawli, F.A., and Leis, A.A. (1994), J Clin Invest 94, 2468-2474.
86. Khawli, F.A. and Reid, M.B. (1994), J Appl Physiol 77, 317-324.
87. Swain, M.G. and Maric, M. (1997), Hepatology 25, 291-294.
88. Burak, K.W., Le, T., and Swain, M.G. (2001), Brain Res 892, 376-379.
89. Rovaris, M., Barnes, D., Woodrofe, N., et al. (1996), J Neurol 243, 536-542.
90. Tilg, H., Wilmer, A., Vogel, W., et al. (1992), Gastroenterology 103, 264-274.
91. Kent, S., Bluthe, R.M., Dantzer, R., et al. (1992), Proc Natl Acad Sci USA 89, 9117-9120.
92. Swain, M.G., Beck, P., Rioux, K., and Le, T. (1998), Hepatology 28, 1561-1565.
93. Swain, M.G. and Marie, M. (1995), Hepatology 22, 1560-1564.
94. Burak, K.W., Le, T., and Swain, M.G. (2002), Gastroenterology 122, 681-688.
95. Forton, D.M., Patel, N., Prince, M., et al. (2004), Gut 53, 587-592.
96. Watson, J.P., Jones, D.E., James, O.F., Cann, P.A., and Bramble, M.G. (1999), J Gastroenterol Hepatol 14, 1034-1040.
97. Prince, M.I., Mitchison, H.C., Ashley, D., et al. (2003), Aliment Pharmacol Ther 17, 137-143.
98. Turner, I.B., Myszor, M., Mitchison, H.C., Bennett, M.K., Burt, A.D., and James, O.F. (1994), J Gastroenterol Hepatol 9, 162-168.
99. Eriksson, L.S., Olsson, R., Glauman, H., et al. (1997), Scand J Gastroenterol 32, 179-186.
100. Lindor, K.D. (1997), N Engl J Med 336, 691-695.
101. Combes, B., Carithers, R.L., Jr., Maddrey, W.C., et al. (1995), Hepatology 22, 759-766.
102. Cook, N.F. and Boore, J.R. (1997), Br J Nurs 6, 811-815.
103. Wearden, A.J., Morriss, R.K., Mullis, R., et al. (1998), Br J Psychiatry 172, 485-490.
104. Sharpe, M. (1998), Am J Med 105, 104S-109S.
105. Deale, A., Chalder, T., Marks, I., and Wessely, S. (1997), Am J Psychiatry 154, 408-414.
106. Rouillard, S. and Lane, N.E. (2001), Hepatology 33, 301-307.
107. Stellon, A.J., Webb, A., Compston, J., and Williams, R. (1986), Bone 7, 181-185.
108. Hodgson, S.F., Dickson, E.R., Wahner, H.W., Johnson, K.A., Mann, K.G., and Riggs, B.L. (1985), Ann Intern Med 103, 855-860.
109. Mitchison, H.C., Malcolm, A.J., Bassendine, M.F., and James, O.F. (1988), Gastroenterology 94, 463-470.
110. Pares, A., Guanabens, N., Alvarez, L., et al. (2001), Hepatology 33, 554-560.
111. Newton, J., Francis, R., Prince, M., et al. (2001), Gut 49, 282-287.
112. Solerio, E., Isaia, G., Innarella, R., et al. (2003), Dig Liver Dis 35, 339-346.
113. Le Gars, L., Grandpierre, C., Chazouilleres, O., Berenbaum, F., and Poupon, R. (2002), Joint Bone Spine 69, 195-200.
114. Shih, M.S. and Anderson, C. (1987), Calcif Tissue Int 41, 187-191.
115. Almdal, T., Schaadt, O., Vesterdad Jorgensen, J., Lindgreen, P., and Ranek, L. (1989), J Intern Med 225, 207-213.
116. Bagur, A., Mautalen, C., Findor, J., Sorda, J., and Somoza, J. (1998), Calcif Tissue Int 63, 385-390.
117. Shiomi, S., Kuroki, T., Masaki, K., et al. (1994), J Gastroenterol 29, 605-609.
118. Menon, K.V., Angulo, P., Weston, S., Dickson, E.R., and Lindor, K.D. (2001), J Hepatol 35, 316-323.
119. Guanabens, N., Pares, A., Marinoso, L., et al. (1990), Am J Gastroenterol 85, 1356-1362.
120. Mitchison, H.C., Bassendine, M.F., Malcolm, A.J., Watson, A.J., Record, C.O., and James, O.F. (1989), Hepatology 10, 420-429.
121. Stellon, A.J., Davies, A., Compston, J., and Williams, R. (1985), Q J Med 57, 783-790.
122. Stellon, A.J., Webb, A., Compston, J., and Williams, R. (1987), Hepatology 7, 137-142.
123. Cuthbert, J.A., Pak, C.Y., Zerwekh, J.E., Glass, K.D., and Combes, B. (1984), Hepatology 4, 1-8.
124. Hay, J.E., Lindor, K.D., Wiesner, R.H., Dickson, E.R., Krom, R.A., and LaRusso, N.F. (1991), Hepatology 14, 257-261.
125. Guichelaar, M.M., Malinchoc, M., Sibonga, J., Clarke, B.L., and Hay, J.E. (2002), Hepatology 36, 895-903.
126. Pocock, N.A., Eisman, J.A., Hopper, J.L., Yeates, M.G., Sambrook, P.N., and Eberl, S. (1987), J Clin Invest 80, 706-710.
127. Hunter, D., De Lange, M., Snieder, H., et al. (2001), J Bone Miner Res 16, 371-378.
128. Kobayashi, S., Inoue, S., Hosoi, T., Ouchi, Y., Shiraki, M., and Orimo, H. (1996), J Bone Miner Res 11, 306-311.
129. Morrison, N.A., Qi, J.C., Tokita, A., et al. (1994), Nature 367, 284-287.
130. Keen, R.W., Woodford-Richens, K.L., Lanchbury, J.S., and Spector, T.D. (1998), Bone 23, 367-371.
131. Springer, J.E., Cole, D.E., Rubin, L.A., et al. (2000), Gastroenterology 118, 145-151.
132. Halmos, B., Szalay, F., Cserniczky, T., et al. (2000), Dig Dis Sci 45, 1091-1095.
133. Janes, C.H., Dickson, E.R., Okazaki, R., Bonde, S., McDonagh, A.F., and Riggs, B.L. (1995), J Clin Invest 95, 2581-2586.
134. Shiraki, M., Shiraki, Y., Aoki, C., and Miura, M. (2000), J Bone Miner Res 15, 515-521.
135. Nishiguchi, S., Shimoi, S., Kurooka, H., et al. (2001), J Hepatol 35, 543-545.
136. Price, P.A., Poser, J.W., and Raman, N. (1976), Proc Natl Acad Sci USA 73, 3374,3375.
137. Hodgson, S.F., Dickson, E.R., Eastell, R., Eriksen, E.F., Bryant, S.C., and Riggs, B.L. (1993), Bone 14, 819-827.
138. Herlong, H.F., Recker, R.R., and Maddrey, W.C. (1982), Gastroenterology 83, 103-108.
139. Diamond, T., Stiel, D., Mason, R., et al. (1989), J Clin Endocrinol Metab 69, 1234-1239.
140. Reddy, S.V. and Roodman, G.D. (1998), Crit Rev Eukaryot Gene Expr 8, 1-17.
141. Wong, B.R., Rho, J., Arron, J., et al. (1997), J Biol Chem 272, 25,190-25,194.
142. Anderson, D.M., Maraskovsky, E., Billingsley, W.L., et al. (1997), Nature 390, 175-179.
143. Hofbauer, L.C., Khosla, S., Dunstan, C.R., Lacey, D.L., Boyle, W.J., and Riggs, B.L. (2000), J Bone Miner Res 15, 2-12.
144. Szalay, F., Hegedus, D., Lakatos, P.L., et al. (2003), J Hepatol 38, 395-400.
145. Collier, J.D., Ninkovic, M., and Compston, J.E. (2002), Gut 50(Suppl 1), i1-i9.
146. Verma, A., Maxwell, J.D., Ang, L., et al. (2002), Osteoporos Int 13, 677-682.
147. Lindor, K.D., Janes, C.H., Crippin, J.S., Jorgensen, R.A., and Dickson, E.R. (1995), Hepatology 21, 389-392.
148. Lindor, K.D., Dickson, E.R., Baldus, W.P., et al. (1994), Gastroenterology 106, 1284-1290.
149. Eastell, R., Dickson, E.R., Hodgson, S.F., et al. (1991), Hepatology 14, 296-300.
150. Matloff, D.S., Kaplan, M.M., Neer, R.M., Goldberg, M.J., Bitman, W., and Wolfe, H.J. (1982), Gastroenterology 83, 97-102.
151. Pereira, S.P., O'Donohue, J., Moniz, C., et al. (2004), Aliment Pharmacol Ther 19, 563-570.
152. Camisasca, M., Crosignani, A., Battezzati, P.M., et al. (1994), Hepatology 20, 633-637.
153. Crippin, J.S., Jorgensen, R.A., Dickson, E.R., and Lindor, K.D. (1994), Am J Gastroenterol 89, 47-50.
154. Guanabens, N., Pares, A., del Rio, L., et al. (1992), J Hepatol 15, 345-349.
155. Guanabens, N., Pares, A., Monegal, A., et al. (1997), Gastroenterology 113, 219-224.
156. Watts, N.B., Harris, S.T., Genant, H.K., et al. (1990), N Engl J Med 323, 73-79.
157. Wolfhagen, F.H., van Buuren, H.R., den Ouden, J.W., et al. (1997), J Hepatol 26, 325-330.
158. Lindor, K.D., Jorgensen, R.A., Tiegs, R.D., Khosla, S., and Dickson, E.R. (2000), J Hepatol 33, 878-882.
159. Guanabens, N., Pares, A., Ros, I., et al. (2003), Am J Gastroenterol 98, 2268-2274.
160. Olsson, R., Mattsson, L.A., Obrant, K., and Mellstrom, D. (1999), Liver 19, 188-192.
161. Menon, K.V., Angulo, P., Boe, G.M., and Lindor, K.D. (2003), Am J Gastroenterol 98, 889-892.
162. Herrington, D.M. (2003), Circulation 107, 2-4.
163. Rossouw, J.E., Anderson, G.L., Prentice, R.L., et al. (2002), JAMA 288, 321-333.
164. Kocjan, T. and Prelevic, G.M. (2003), Curr Opin Obstet Gynecol 15, 459-464.