Recurrent implantation failure in assisted reproduction: How to counsel and manage. B. Treatment options that have not been proven to benefit the couple

Reproductive BioMedicine Online

Volumn 11, Issue 3, 2005, Pages 382-391

  Urman, Bulent ^a,b   Yakin, Kayhan ^a   Balaban, Basak ^a  

^a AMERICAN HOSPITAL   (Turkey)

^b NONE   (Turkey)

Author keywords

Assisted reproduction; ICSI; IVF; Recurrent implantation failure

Indexed keywords

ACETYLSALICYLIC ACID; CYTOKINE; DANAZOL; HEPARIN; IMMUNOGLOBULIN; PHOSPHOLIPID ANTIBODY;

ANEUPLOIDY; BLASTOCYST; CELL TRANSPLANTATION; CLINICAL TRIAL; COCULTURE; DOSE RESPONSE; EMBRYO TRANSFER; EVIDENCE BASED MEDICINE; FERTILIZATION IN VITRO; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TOXICITY; GENETIC SCREENING; HATCHING; HIGH RISK PREGNANCY; HUMAN; IMMUNOTHERAPY; INTRACYTOPLASMIC SPERM INJECTION; LOW DRUG DOSE; LYMPHOCYTE; NIDATION; PATIENT COUNSELING; PATIENT SATISFACTION; REVIEW; RISK ASSESSMENT; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; TREATMENT FAILURE;

EID: 24644453976     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)60847-4     Document Type: Review

References (132)

1. Antinori S, Selman H, Caffa B et al. 1996 Zona opening of human embryos using a non contact UV laser for assisted hatching in patients with poor prognosis of pregnancy. Human Reproduction 11, 2488-2492.
2. Balaban B, Urman B 2003 Embryo culture as a diagnostic tool. Reproductive BioMedicine Online 7, 671-682.
3. Balaban B, Urman B, Alatas C et al. 2002 A comparison of four different techniques of assisted hatching. Human Reproduction 17, 1239-1243.
4. Balaban B, Urman B, Isiklar A, et al. 2001 The effect of pronuclear morphology on embryo quality and blastocyst transfer outcome. Human Reproduction 11, 2357-2361.
5. Balaban B, Urman B, Sertac A et al. 2000 Blastocyst quality affects the success of blastocyst stage embryo transfer. Fertility and Sterility 74, 282-287.
6. Balasch J, Creus M, Fabregues F et al. 1996 Intravenous immunoglobulin preceding in vitro fertilization-embryo transfer for patients with repeated failure of embryo transfer. Fertility and Sterility 65, 655-668.
7. Balmeceda J, Alam V, Roszjtein D et al. 1992 Embryo implantation rates in oocyte donation: a prospective comparison of tubal versus uterine transfers. Fertility and Sterility 57, 362-365.
8. Barmat L, Liu H, Spandorfer S et al. 1999 Autologous endometrial co-culture in patients with repeated failures of implantation after in vitro fertilization-embryo transfer. Journal of Assisted Reproduction and Genetics 16, 121-127.
9. Birdsall M, Lockwood G, Ledger W et al. 1996 Antiphospholipid antibodies in women having in vitro fertilization. Human Reproduction 11, 1185-1189.
10. Birkenfeld A, Mukaida T, Minichiello L et al. 1994 Incidence of autoimmune antibodies in failed embryo transfer cycles. American Journal of Reproductive Immunology 31, 65-68.
11. Blake D, Proctor M, Johnson N, Olive D 2002 Cleavage stage versus blastocyst stage transfer in assisted conception. Cochrane Database Systematict Reviews 2, CD002118.
12. Bongso TA, Fong CY, Ng CY, Ratnam SS 1994 Blastocyst transfer in human in vitro fertilization: the use of embryo co-culture. Cell Biology International 18, 1181-1189.
13. Bongso A, Ng S, Fong CY, Ratnam S 1991 Co-cultures: a new lead in embryo quality improvement for assisted reproduction. Fertility and Sterility 56, 179-191.
14. Braude P, Bolton V, Moore S 1988 Human gene expression first occurs between 4 and 8 cell stages of preimplantation development. Nature 332, 459-461.
15. Caglar G, Asimakopoulos B, Nikolettos N et al. 2005 Preimplantation genetic diagnosis for aneuploidy screening in case of repeated implantation failure. Reproductive BioMedicine Online 10, 381-388.
16. Chao K, Chen S, Chen H et al. 1997 Assisted hatching increases the implantation and pregnancy rate of in vitro fertilization (IVF)-embryo transfer (ET) but not that of IVF-tubal ET in patients with repeated implantation failures. Fertility and Sterility 67, 904-908.
17. Chaouat G, Ledee-Bataille N, Zourbas S et al. 2003 Cytokines, implantation and early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single theory concept. American Journal of Reproductive Immunology 50, 177-186.
18. Choudhury S, Knapp L 2001 Human reproductive failure: immunogenetic and interacting factors. Human Reproduction Update 7, 135-160.
19. Choudhury S, Knapp L 2000 Human reproductive failure I: immunological factors. Human Reproduction Update 7, 113-134.
20. Cohen J 1991 Assisted hatching of human embryos. Journal of in Vitro Fertilization and Embryo Transfer 8, 179-180.
21. Cohen J, Alikani M, Trowbridge J, Rosenwaks Z 1992 Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Human Reproduction 7, 685-691.
22. Cohen J, Inge K, Suzman M, Wiker S, Wright G 1989 Videocinematography of fresh and cryopreserved embryos: a retrospective analysis of embryonic morphology and implantation. Fertility and Sterility 51, 821-827.
23. Coulam C, Stephenson M, Stern C, Clark DA 1996 Immunotherapy for recurrent pregnancy loss: analysis of results from clinical trials. American Journal of Reproductive Immunology 35, 352-359.
24. Coulam CB, Krysa LW, Bustillo M 1994 Intravenous immunoglobulin for in vitro fertilization failure. Human Reproduction 9, 2265-2269.
25. Cowchock S, Reece E, Balaban D et al. 1992 Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone to low dose heparin treatment. American Journal of Obstetrics and Gynecology 166, 1318-123.
26. Cruz J, Dubey A, Patel J et al. 1999 Is blastocyst transfer useful as an alternative treatment for patients with multiple in vitro fertilization failures? Fertility and Sterility 72, 218-220.
27. Daya S 2005 Aspirin and other adjuvants in assisted reproduction. In: Ben Rafael Z, Creatsas G, Shoham Z (eds) Proceedings of the 7th World Congress in Controversies in Obstetrics Gynecology and Infertility. E Oren, pp. 272-283.
28. Daya S 2003 Recurrent spontaneous early pregnancy loss and low dose aspirin. Minerva Gynecol 55, 441-449.
29. Dmowski W, Rana N, Michalowska J et al. 1995 The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates. Fertility and Sterility 63, 555-562.
30. Edi-Osagie E, Hooper L, Seif M 2003 The impact of assisted hatching on live birth rates and outcomes of assisted conception. Human Reproduction 18, 1828.
31. Empson M, Laserre M, Craig J, Scott J 2002 recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstetrics and Gynecology 99, 135-144.
32. ESHRE PGD Consortium Steering Committee 2002 ESHRE preimplantation genetic diagnosis consortium data collection III (May 2001). Human Reproduction 17, 233-246.
33. Fanchin R, Harmas A, Benaoudia F et al. 1998a Microbial flora of the cervix assessed at the time of embryo transfer adversely affects in vitro fertilization outcome. Fertility and Sterility 70, 866-870.
34. Fanchin R, Righini C, Olivennes F et al. 1998b Uterine contractions at the time of embryo transfer alter pregnancy rates after in vitro fertilization. Human Reproduction 13, 1968-1974.
35. Farhi J, Weisman A, Nahum H, Levran D 2000 Zygote intrafallopian transfer in patients with tubal factor infertility after repeated failure of implantation with in vitro fertilization-embryo transfer. Fertility and Sterility 74, 390-393.
36. Fehilly C, Cohen J, Simons R et al. 1985 Cryopreservation of cleaving embryos and expanded blastocysts in the human: a comparative study. Fertility and Sterility 44, 638-644.
37. Fiedler K, Wurfel W 2004 Effectivity of heparin in assisted reproduction. European Journal of Medical Research 9, 207-214.
38. Fisch B, Rikover Y, Shohat L et al. 1991 The relationship between in vitro fertilization and naturally occurring antibodies: evidence for increased production of antiphospholipid autoantibodies. Fertility and Sterility 56, 718-724.
39. Fluker M, Bebbington M, Zouves C. 1993 A prospective randomized comparison of zygote intrafallopian transfer and in vitro fertilization embryo transfer for non-tubal factor infertility. Fertility and Sterility 60, 515-519.
40. Freeman MR, Whitworth CM, Hill GA 1995 Granulosa cell co-culture enhances human embryo development and pregnancy rate following in-vitro fertilization. Human Reproduction 10, 408-414.
41. Gardner D, Lane M, Stevens J et al. 2000 Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertility and Sterility 73, 1155-1158.
42. Gardner D, Schoolcraft W, Wagley L et al. 1998 A prospective randomized trial of blastocyst culture and transfer in in vitro fertilization. Fertility and Sterility 69, 84-88.
43. Geva E, Amit A, Lerner-Geva L et al. 1995 Autoimmune disorders: another possible cause for in-vitro fertilization and embryo transfer failure. Human Reproduction 10, 101-104.
44. Ghazeerii G, Kutteh W 2001 Immunological testing and treatment in reproduction: frequency assessment of practice patterns at assisted reproduction clinics in the USA and Australia. Human Reproduction 16, 2130-2135.
45. Gianaroli L, Magli MC, Ferraretti AP et al. 2002 The role of preimplantation diagnosis for aneuploidies. Reproductive BioMedicine Online 4 (suppl. 3), 31-36.
46. Gianaroli L, Magli MC, Ferraretti AP et al. 1999 Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed. Fertility and Sterility 72, 837-844.
47. Gianaroli L, Magli MC, Munne S et al. 1997 Will preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy. Human Reproduction 12, 1762-1767.
48. Gleicher N, Vidali A, Karande V 2002 The immunological 'Wars of the Roses': disagreements amongst reproductive immunologists. Human Reproduction 17, 539-542.
49. Gleicher N, Liu H, Dudkiewicz A, et al. 1994 Autoantibody profiles and immunoglobulin concentrations as predictors of in vitro fertilization success. American Journal of Obstetrics and Gynecology 170, 1145-1149.
50. Gleicher N, el-Roeiy A, Confino E, Freiberg J 1989 Reproductive failure because of autoantibodies: unexplained infertility and pregnancy wastage. American Journal of Obstetrics and Gynecology 160, 1376-1385.
51. Group TRMIT 1994 Worldwide collaborative observational study and meta-analysis on allergenic leukocyte immunotherapy for recurrent spontaneous abortion. American Journal of Reproductive Immunology 32, 55-72.
52. Habana A, Palter S 2001 Is tubal embryo transfer of any value? A meta analysis and comparison with the Society of Assisted Reproductive Technology Database. Fertility and Sterility 76, 286-293.
53. Herrler A, von Rango U, Beier HM 2003 Embryo-maternal signaling: how the embryo starts talking to its mother to accomplish implantation. Reproductive BioMedicine Online 6, 244-256.
54. Huisman G, Fauser B, Eijkemans M, Pieters M 2000 Implantation rates after in vitro fertilization and transfer of a maximum of two embryos that have undergone three to five days of culture. Fertility and Sterility 73, 117-122.
55. Johnson PM, Christmas SE, Vince GS 1999 Immunological aspects of implantation failure. Human Reproduction 14 (Suppl. 2), 26-30.
56. Kahraman S, Bahce M, Samli H et al. 2000 Healthy births and ongoing pregnancies obtained by preimplantation genetic diagnosis in patients with advanced maternal age and recurrent implantation failure. Human Reproduction 15, 2003-2007.
57. Kaider B, Price D, Rousev R, Coulam C 1996 Antiphospholipid antibody prevalence in patients with IVF failure. American Journal of Reproductive Immunology 35, 388-393.
58. Kling C, Magez-Zunker J, Jenisch S, Kabelitz D 2002 Experience with allogenic leukocyte immunization (AI) for implantation failure in the in vitro fertilization program. American Journal of Reproductive Immunology 48, 147-150.
59. Knutzen V, Stratton C, Sher G et al. 1992 Mock embryo transfer in early luteal phase, the cycle before in vitro fertilization and embryo transfer: a descriptive study. Fertility and Sterility 57, 262-267.
60. Kolibianakis E, Devroey P 2002 Blastocyst culture: facts and fiction. Reproductive BioMedicine Online 5, 287-295.
61. Kondera-Anasz Z, Sikora J, Mielczarek-Palacz A 2004 Leukemia inhibitory factor: an important regulator of endometrial function. American Journal of Reproductive Immunology 52, 97-105.
62. Kovacic B, Vlaisavljevic V, Reljic M, Cizek-Sajko M 2004 Developmental capacity of different morphological types of day 5 human morulae and blastocysts. Reproductive BioMedicine Online 8, 687-694.
63. Kowalski A, Lichenin M, Liu H et al. 1997 Mid-follicular anticardiolipin and antiphosphatidylserine antibody titers do not correlate with in vitro fertilization outcome. Fertility and Sterility 68, 298-304.
64. Kuliev A, Verlinsky Y 2004 Thirteen years experience of preimplantation diagnosis: report of the Fifth International Symposium on Preimplantation Genetics. Reproductive BioMedicine Online 8, 229-235.
65. Kutteh W 1996 Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low dose aspirin is superior to low dose aspirin. American Journal of Obstetrics and Gynecology 174, 1584-1589.
66. Kwak Kim JY, Chung Bang HS, Ng SC et al. 2003 Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Human Reproduction 18, 767-773.
67. Ledee-Bataille N, Lapree-Delage G, Taupin J et al. 2002 concentration of leukemia inhibitory factor (LIF) in uterine flushing fluid is highly predictive of embryo implantation. Human Reproduction 17, 213-218.
68. Lesney P, Killick S, Tetlow R et al. 1998 Embryo transfer - can we learn anything new from the observation of junctional zona contractions. Human Reproduction 13, 1540-1546.
69. Levitas E, Lunenfeld E, Har-Vardi I et al. 2004 Blastocyst stage embryo transfer in patients who failed to conceive in three or more day 2-3 embryo transfer cycles: a prospective randomized study. Fertility and Sterility 81, 567-571.
70. Levran D, Farhi J, Nahum H et al. 2002 Prospective evaluation of blastocyst transfer versus zygote intrafallopian transfer in patients with repeated implantation failure. Fertility and Sterility 77, 971-977.
71. Levran D, Mashiach S, Dor J et al. 1998 Zygote intrafallopian transfer may improve pregnancy rate in patients with repeated failure of implantation. Fertility and Sterility 69, 26-30.
72. Lockwood C, Reece E, Romero R, Hobbins J 1986 Antiphospholipid antibody and pregnancy wastage. Lancet ii, 742-743.
73. Lok IH, Yip SK, Cheung LP et al. 2004 Adjuvant low dose aspirin therapy in poor responders undergoing in vitro fertilization: a prospective randomized double blind placebo controlled trial. Fertility and Sterility 81, 556-561.
74. Loutradis D, Drakakis P, Dallianidis K et al. 2004 A double embryo transfer on days 2 and 4 or 5 improves pregnancy outcome in patients with good embryos but repeated failures in IVF or ICSI. Clinical Experiments in Obstetrics and Gynecology 31, 63-66.
75. Luzzana C, Gerosa M, Riboldi P, Meroni P 2002 Up-date on the antiphospholipid syndrome. Journal of Nephrology 15, 342-348.
76. Magli MC, Gianaroli L, Ferraretti AP, Fortini D, Aicardi G, Montanaro N. 1998 Rescue of implantation potential in embryos with poor prognosis by assisted zona hatching. Human Reproduction 13, 1331-1335.
77. Mandelbaum J 1996 The effects of assisted hatching on the hatching process and implantation. Human Reproduction 11, 43-50.
78. Matsabayashi H, Sugi T, Arai T, et al. 2001 Different antiphospholipid antibody specificities are found in association with early repeated pregnancy loss versus recurrent IVF failure patients. American Journal of Reproductive Immunology 46, 323-325.
79. Menezo Y, Hamamah S, Hazout A, Dale B 1998 Time to switch from co culture to sequential defined media for transfer at the blastocyst stage. Human Reproduction 13, 2043-2044.
80. Menezo YJ, Sakka D, Janny L 1995 Co-culture of the early human embryo: factors affecting human blastocyst formation in vitro. Microscopy Research and Technique 32, 50-56.
81. Menezo Y, Guerin J, Czyba J 1990 Improvement of early human embryo development in vitro by co-culture on monolayers of Vero cells. Biology of Reproduction 42, 301-306.
82. Milki A, Hinckley M, Fisch B et al. 2000 Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations. Fertility and Sterility 73, 126-129.
83. Munné S, Sandalinas M, Escudero T et al. 2003 Improved implantation after preimplantation genetic diagnosis of aneuploidy. Reproductive BioMedicine Online 7, 91-97.
84. Munné S, Magli C, Cohen J et al. 1999 Positive outcomes after preimplantation diagnosis of aneuploidy in human embryos. Human Reproduction 14, 2191-2199.
85. Nakayama T, Fujiwara H, Tastumi K et al. 1998 A new assisted hatching technique using a piezo-micromanipulator. Fertility and Sterility 69, 784-788.
86. Ng S, Gilman-Sachs A, Thaker P et al. 2002 Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or women with normal pregnancy. American Journal of Reproductive Immunology 48, 77-81.
87. Nip M, Taylor P, Rutherford A, Hanock K 1995 Autoantibodies and antisperm antibodies in sera of follicular fluids of infertile patients: relation to reproductive outcome after in vitro fertilization. Human Reproduction 10, 2564-2569.
88. Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A et al. 2001 Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown etiology. Human Reproduction 16, 855-861.
89. Ober C, Karrison T, Odem R et al. 1999 Mononuclear-cell immunization in prevention of recurrent miscarriages: a randomized trial. Lancet 354, 365-369.
90. Ozturk O, Bhattacharya S, Saridogan E et al. 2004 Role of utero-ovarian vascular impedance: predictor of ongoing pregnancy in an IVF-embryo transfer programme. Reproductive BioMedicine Online 9, 299-305.
91. Pantos K, Makrakis E, Karantzis P et al. 2004a Blastocyst versus early cleavage embryo transfer: a retrospective analysis of 4165 transfers. Clinical Experiments in Obstetrics and Gynecology 31, 42-44.
92. Pantos K, Makrakis E, Stavrou D et al. 2004b Comparison of embryo transfer on day 2, day 3, and day 6: a prospective randomized study. Fertility and Sterility 81, 454-455.
93. Pehlivan T, Rubio C, Rodrigo L et al. 2003 Impact of preimplantation genetic diagnosis on IVF outcome in implantation failure patients. Reproductive BioMedicine Online 6, 232-237.
94. Phillips S, Dean N, Buckett W, Tan S 2003 Consecutive transfer of day 3 embryos and of day 5-6 blastocysts increases overall pregnancy rates associated with blastocyst culture. Journal of Assisted Reproduction and Genetics 20, 461-464.
95. Plachot M, Antoine JM, Alvarez S et al. 1993 Granulosa cells improve human embryo development in vitro. Human Reproduction 8, 2133-2140.
96. Preutthipan S, Amso N, Curtis P, Shaw R 1994 A prospective randomized crossover comparison of zygote intrafallopian transfer and in vitro fertilization embryo transfer in unexplained infertility. Journal of Medical Association of Thailand 77, 599-604.
97. Quinn P, Margalit R 1996 Beneficial effects of co-culture with cumulus cells on blastocyst formation in a prospective trial with supernumerary human embryos. Journal of Assisted Reproduction and Genetics 13, 9-14.
98. Racowsky C, Combelles C, Nureddin A et al. 2003 Day 3 and day 5 morphological predictors of embryo viability. Reproductive BioMedicine Online 6, 323-331.
99. Rote N, Stetzer B 2003 Autoimmune disease as a cause of reproductive failure. Clinical Laboratory Medicine 23, 265-271.
100. Rubinstein M, Marazzi A, Polak de Fried E 1999 Low dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: a prospective randomized double blind placebo controlled assay. Fertility and Sterility 71, 825-829.
101. Sakkas D, Jaquenoud N, Leppens G, Campana A 1994 Comparison of results after in vitro fertilized embryos are cultured in routine medium and in co-culture on Vero cells: a randomized study. Fertility and Sterility 61, 521-525.
102. Sallam H, Sadek S, Agemeya A 2003 Assisted hatching - a meta analysis of randomized controlled trials. Journal of Assisted Reproduction and Genetics 20, 332-342.
103. Schiewe M, Hazeleger N, Sclimenti C, Balmeceda J 1995 Physiological characterization of blastocyst hatching mechanisms by use of a mouse antihatching model. Fertility and Sterility 63, 288-294.
104. Schillaci R, Ciriminna R, Cefalu E 1994 Vero cell effect on in-vitro human blastocyst development: preliminary results. Human Reproduction 9, 1131-1135.
105. Scholtes M, Roozenburg B, Verhoeff A, Zeilmaker G 1994 A randomized study of transcervical intrafallopian transfer of pronucleate embryos controlled by ultrasound versus intrauterine transfer of four to eight cell embryos. Fertility and Sterility 61, 102-104.
106. Schulman J 1986 Delayed expulsion of transfer fluid after IVF/ET. Lancet 1, 44.
107. Shapiro B, Richter K, Harris D, Daneshmand S 2001 Dramatic decline in implantation and pregnancy rates in patients who undergo repeated cycles of in vitro fertilization with blastocyst transfer after one or more failed attempts. Fertility and Sterility 76, 538-542.
108. Sher G, Zouves C, Feinman M et al. 1998 A rational basis for the use of combined heparin/aspirin and IVIG; immunotherapy in the treatment of recurrent IVF failure associated with antiphospholipid antibodies. American Journal of Reproductive Immunology 39, 391-394.
109. Sher G, Feinman M, Zouves C et al. 1994 High fecundity rates following in vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin. Human Reproduction 9, 2278-2283.
110. Simon C, Mercader A, Garcia-Velasco J et al. 1999 Co-culture of human embryos with autologous human endometrial epithelial cells in patients with implantation failure. Journal of Clinical Endocrinology and Metabolism 84, 2638-2646.
111. Spandorfer D, Clark R, Park J 2003 Autologous endometrial co culture (AECC): an effective tool for patients with multiple failed IVF attempts. Fertility and Sterility 80 (Suppl. 3), S6.
112. Steck T, Giess R, Suetterlin MW et al. 2004 Leukaemia inhibitory factor (LIF) gene mutations in women with unexplained infertility and recurrent failure of implantation after IVF and embryo transfer. European Journal of Obstetrics, Gynecology, and Reproductive Biology 112, 69-73.
113. Stein A, Rufas O, Amit S et al. 1995 Assisted hatching by partial zona dissection of human pre-embryos in patients with recurrent implantation failure after in vitro fertilization. Fertility and Sterility 63, 838-841.
114. Stephenson M, Fluker M 2000 Treatment of repeated unexplained in vitro fertilization failure with intravenous immunoglobulin: a randomized, placebo controlled Canadian trial. Fertility and Sterility 74, 1108-1113.
115. Stern C, Chamley L, Norris H et al. 2003 A randomized double blind, placebo controlled trial of heparin and aspirin for women with in vitro fertilization implantation failure and antiphospholipid or antinuclear antibodies. Fertility and Sterility 80, 376-383.
116. Tanbo T, Dale P, Abyholm T 1990 Assisted fertilization in infertile women with patent fallopian tubes. A comparison of in vitro fertilization, gamete intrafallopian transfer and tubal embryo stage transfer. Human Reproduction 5, 266-270.
117. Taylor D, Ray P, Ao A et al. 1997 Paternal transcripts for glucose 6 phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three to four cell stage. Molecular Reproduction and Development 48, 442-448.
118. Tei C, Maruyam T, Kuji N et al. 2003 Reduced expression of alpha v beta3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: improvement by danazol treatment. Journal of Assisted Reproduction and Genetics 20, 13-20.
119. Tournaye H, Devroey P, Camus E et al. 1992 Zygote intrafallopian transfer or in vitro fertilization and embryo transfer for the treatment of male factor infertility: a prospective randomized trial. Fertility and Sterility 58, 344-350.
120. Urman B, Balaban B 2001 Paternal factors govern fertilization and early embryo development: lessons learned from intracytoplasmic sperm injection. Reproductive Technologies 10, 268-274.
121. Urman B, Yakin K, Balaban B 2005 Recurrent implantation failure in assisted reproduction: how to counsel and manage. A. General considerations and treatment options that may benefit the couple. Reproductive BioMedicine Online 11, 371-381.
122. Urman B, Balaban B, Yakin K, Isiklar A 2003 Outcome of blastocyst transfer according to availability of excess blastocysts suitable for cryopreservation. Reproductive BioMedicine Online 7, 587-592.
123. Urman B, Mercan R, Alatas C et al. 2000 Low dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study. Journal of Assisted Reproduction and Genetics 17, 586-590.
124. Van Blerkom J 1993 Development of human embryos to the hatched blastocyst stage in the presence or absence of a monolayer of Vero cells. Human Reproduction 8, 1525-1539.
125. Van Royen E, Mangelsehots K, De Neuborg D et al. 1999 Characterization of a top quality embryo, a step towards single embryo transfer. Human Reproduction 14, 2345-2349.
126. van Voorhis B, Syrop C, Vincent J et al. 1995 Tubal versus uterine transfer of cryopreserved embryos: a prospective randomized trial. Fertility and Sterility 63, 578-583.
127. Voullaire L, Wilton L, McBain J et al. 2002 Chromosome abnormalities identified by comparative genomic hybridization in embryos from women with repeated implantation failure. Molecular Human Reproduction 8, 1035-1041.
128. Waldenstrom U, Hellberg D, Nilsson S 2004 Low-dose aspirin in a short regimen as standard treatment in in vitro fertilization: a randomized prospective study. Fertility and Sterility 81, 1560-1564.
129. Wiemer KE, Watson AJ, Polanski V et al. 1991 Effects of maturation and co-culture treatments on the developmental capacity of early bovine embryos. Molecular Reproduction and Development 30, 330-338.
130. Wilding M, Forman R, Hogewind G et al. 2004 Preimplantation genetic diagnosis for the treatment of failed in vitro fertilization-embryo transfer and habitual abortion. Fertility and Sterility 81, 1302-1304.
131. Wilton L 2005 Preimplantation genetic diagnosis and chromosome analysis of blastomeres using comparative genomic hybridization. Human Reproduction Update 11, 33-41.
132. Yeung W, Lau E, Chan S, Ho P 1996 Co-culture with homologous oviduct cells improved the implantation of human embryos-a prospective randomized controlled trial. Journal of Assisted Reproduction and Genetics 13, 762-767.