Severe thrombocytopenia after heparin therapy in a patient with unstable angina and recent stent implantation

Hellenic Journal of Cardiology

Volumn 46, Issue 3, 2005, Pages 242-246

  Sideris, Skevos K ^a,b   Bonios, Michael J ^a   Eftihiadis, Eftihios E ^a   Melexopoulou, Christina A ^a   Mousiama, Tereza A ^a   Diplaris, Kostas T ^a   Kogias, John S ^a  

^a General Hospital of Karditsa   (Greece)

^b NONE   (Greece)

Author keywords

Fondaparinux sodium; Heparin; Thrombocytopenia

Indexed keywords

FONDAPARINUX; LOW MOLECULAR WEIGHT HEPARIN; ANTICOAGULANT AGENT; ENOXAPARIN; POLYSACCHARIDE;

ADULT; ARTICLE; BLOOD ANALYSIS; CASE REPORT; CLINICAL FEATURE; HUMAN; LABORATORY TEST; MALE; STENT; THROMBOCYTOPENIA; UNSTABLE ANGINA PECTORIS; BLOOD; BLOOD VESSEL TRANSPLANTATION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ELECTROCARDIOGRAPHY; FOLLOW UP; INSTRUMENTATION; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; TRANSLUMINAL CORONARY ANGIOPLASTY;

ANGINA, UNSTABLE; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; ANTICOAGULANTS; BLOOD VESSEL PROSTHESIS IMPLANTATION; ELECTROCARDIOGRAPHY; ENOXAPARIN; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET COUNT; POLYSACCHARIDES; STENTS; THROMBOCYTOPENIA;

EID: 24644449336     PISSN: 10117970     EISSN: 10117970     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Warkentin T: Heparin induced thrombocytopenia: pathogenesis and management. Br J Haematol 2003; 121: 535-555.
2. Greinacher A: Heparin-associated thrombocytopenia. Biomed Progr 1994; 7: 53-56.
3. Haas S, Walenga M, Jeske P, Fareed J: Heparin-induced thrombocytopenia: clinical considerations of alternative anticoagulation with various glycosaminoglycans and thrombin inhibitors. Clin Appl Thromb Hemost 1999; 5: 52-59.
4. Betrosian AP, Zamparas PP: Heparin-induced thrombocytopenia. Hell J Cardiol 2004; 45: 198-207.
5. Amiral J, Bridey F, Dreyfous M, et al: Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thrombosis and Haemostasis 1992; 68: 95-96.
6. Warkentin T: Clinical picture of heparin-induced thrombocytopenia. In: Heparin induced thrombocytopenia, 2nd edition. Marcel Dekker, New York, 2001; 43-86.
7. Baglin TP: Heparin-induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment. J Clin Pathol 2001; 54: 272-274.
8. Rice L, Attisha K, Drexler A, Francis L: Delayed onset of heparin-induced thrombocytopenia. Ann Intern Med 2002; 136: 210-215.
9. Ling E, Warkentin T: Intraoperative heparin flushes and subsequent acute heparin induced thrombocytopenia. Anesthesiology 1998; 89: 1567-1569.
10. Girolami, Prandoni P, Stefani M, et al: The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractioned heparin: a prospective cohort study. Blood 2003; 101: 2955-2959.
11. Warkentin T, Kelton J: A 14 year study of heparin-induced thrombocytopenia. Am J Med 1996; 101: 502-507.
12. Warkentin TE: Recommendations of College of American Pathologists. Pathol Lab Med 2002; 126: 1414-1423.
13. Nand S, Wong W, Yuen B, Yetter A, Schmulbach E, Gross Fisher S: Heparin-induced thrombocytopenia with thrombosis: incidence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution. Am J Hematol 1997; 56: 12-16.
14. Kadidal VV, Mayo DJ, Home MK: Heparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three cases. J Intern Med 1999; 246: 325-329.
15. Warkentin TE: Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol 2003; 121: 535-555.
16. Izban KF, Lietz HW, Hoppensteadt DA, et al: Comparison of two PF4/heparin ELISA assays for the laboratory diagnosis of heparin-induced thrombocytopenia. Semin Thromb Haemost 1999; 25(suppl 1): 51-56.
17. Davidson S, Burman J, Ford E: Frequency of heparin platelet factor 4 antibodies in patients receiving heparin [abstract]. Thromb Haemost 1997; 79: 283.
18. Walenga JM, Jeske WP, Fasanella AR, Wood JJ, Ahmad S, Bakhos M: Laboratory diagnosis of heparin-induced thrombocytopenia. Clin Appl Thromb Hemost 1999; 5(suppl 1): S21-27.
19. Chong B, Burgess J, Ismail F: The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thromb Haemost 1993; 69: 344-350.
20. Greinacher A, Amiral J, Dummel V, Vissac A, Kiefel V, Mueller-Eckhardt C: Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin induced platelet activation test and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion 1994; 34: 381-385.
21. Ranze O, Eichner A, Lubenow N: The use of low molecular weight heparins in heparin-induced thrombocytopenia: a cohort study. Ann Hematol 2000; 79: 198.
22. Wallis E, Workman L, Lewis E, Steen L, Piffare R, Moran F: Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia. Am J Med 1999; 106: 629-635.
23. Rubin N, Rubin J: Treatment of heparin-induced thrombocytopenia with thrombosis (HITT) in pregnancy with fondaparinux. Blood 2003; 102: 4190.
24. Lian EC, Chua L, Oberstein E: Long-term use of fondaparinux in a patient with antiphospholipid syndrome, heparin-induced thrombocytopenia and refractoriness to coumarin. Blood 2003; 102: 4206.
25. Amiral J, Lormeau C, Marfaing-Koka A, et al: Absence of cross-reactivity of SR90107A/ORG31540 pentasacharide with antibodies to heparin/PF4 complexes developed in heparin-induced thrombocytopenia. Blood Coagul Fibrinolysis 1997; 8: 114-117.
26. Eriksson BI, Bauer KA, Lassen MR, Turpie AG; Steering Committee of the Pentasaccharide in Hip-Fracture Surgery Study: Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med 2001; 345: 1298-1304.
27. Dager W, Andersen J, Nutescu E: Special considerations with fondaparinux therapy: Heparin-induced thrombocytopenia and wound healing. Pharmacotherapy 2004; 24: 88-94. 247-248