Electrophysiological and haemodynamic effects of endothelin ET A and ET B receptors in normal and ischaemic working rabbit hearts

British Journal of Pharmacology

Volumn 146, Issue 1, 2005, Pages 118-128

  McCabe, Christopher ^a,b   Hicks, Martin N ^b   Kane, Kathleen A ^a   Wainwright, Cherry L ^c  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

BQ 788; Endothelin 1; Monophasic action potential duration; Rabbit; Sarafotoxin; Working heart

Indexed keywords

ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; RECEPTOR SUBTYPE; SARAFOTOXIN S6C;

ACTION POTENTIAL; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; DRUG EFFECT; HEART ELECTROPHYSIOLOGY; HEART HEMODYNAMICS; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FIBRILLATION; MALE; NONHUMAN; PRIORITY JOURNAL;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; BLOOD PRESSURE; CORONARY CIRCULATION; DISEASE MODELS, ANIMAL; ENDOCARDIUM; ENDOTHELIN-1; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; OLIGOPEPTIDES; PERICARDIUM; PIPERIDINES; RABBITS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; VENTRICULAR FIBRILLATION; VIPER VENOMS;

EID: 24644441580     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706304     Document Type: Article

References (31)

1. BECKER, R., MERKELY, B., BAUER, A., GELLER, L., FAZEKAS, L., FREIGANG, K.D., VOSS, F., SENGES, J.C., KUEBLER, W. & SCHOELS, W. (2000). Ventricular arrhythmias induced by endothelin-I or by acute ischaemia: a comparative analysis using three-dimensional mapping. Cardiovasc. Res., 45, 310-320.
2. BEYER, M.E., HOVELBORN, T., DELEBAR, U. & HOFFMEISTER, H.M. (2004). Significance of the endothelin A receptor for the haemodynamic and inotropic effects of endothelin-1 in rats. Clin. Sci., 107, 467-475.
3. CROCKETT, T.R., SHARIF, I., KANE, K.A. & WAINWRIGHT, C.L. (2000). Sarafotoxin 6c (S6c) protects against ischaemia-induced cardiac arrhythmias in vivo and in vitro in the rat. J. Cardiovasc. Pharmacol., 36 (Suppl 1), S297-S299.
4. DOWNAR, E., JANSE, MJ. & DURRER, D. (1977). The effect of 'ischemic' blood on transmembrane potentials of normal porcine ventricular myocardium. Circulation, 55, 455-462.
5. DURU, F., BARTON, M., LUSCHER, T.F. & CANDINAS, R. (2001). Endothelin and cardiac arrhythmias: do endothelin antagonists have a therapeutic potential as antiarrhythmic drugs? Cardiovasc. Res., 49, 272-280.
6. FOZZARD, H.A. & MAKIELSKI, J.C. (1985). The electrophysiology of acute myocardial ischemia. Ann. Rev. Med., 36, 275-284.
7. FRANZ, M.R., FLAHERTY, J.T., PLATIA, E.V., BULKLEY, B.H. & WEISFELDT, M.L. (1984). Localization of regional myocardial ischemia by recording of monophasic action potentials. Circulation, 69, 593-604.
8. GELLER, L., MERKELY, B., SZOKODI, I., SZABO, T., VECSEY, T., JUHASZ-NAGY, A., TOTH, M. & HORKAY, F. (1998). Electrophysiological effects of intrapericardial infusion of endothelin-1. Pacing Clin. Electrophysiol., 21, 151-156.
9. HORKAY, F., GELLER, L., KISS, O., SZABO, T., VAGO, H., KEKESI, V., JUHASZ-NAGY, A. & MERKELY, B. (2000). Bosentan the mixed endothelin-A- and B-receptor antagonist suppresses intrapericardial Endothelin-1 induced ventricular arrhythmias. J. Cardiovasc. Pharmacol., 36 (Suppl 1), S320-S322.
10. ISHIKAWA, K., IHARA, M., NOGUCHI, K., MASE, T., MINO, N., SAEKI, T., FUKURODA, T., FUKAMI, T., OZAKI, S., NAGASE, T., NISHIKIBE, M. & YANO, M. (1994). Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc. Natl. Acad. Sci. U.S.A., 91, 4892-4896.
11. A receptor subtype mediates endothelin-induced contractility in left ventricular cardiomyocytes isolated from rabbit myocardium. J. Pharmacol. Exp. Therap., 294, 1047-1052.
12. KISS, O., GELLER, L., MERKELY, B., SZABO, T., RASCHACK, M., SERES, L., ZIMA, E., JUHASZ-NAGY, A. & HORKAY, F. (2000). Endothelin-A receptor antagonist LU 135.252 inhibits the formation of ventricular arrhythmias caused by intrapericardial infusion of endothelin-1. J. Cardiovasc. Pharmacol., 36 (Suppl 1), S317-S319.
13. KISS, O., ZIMA, E., SOOS, P., KEKESI, V., JUHASZ-NAGY, A. & MERKELY, B. (2004). Intracoronary endothelin-1 infusion combined with systemic isoproterenol treatment: antagonistic arrhythmogenic effects. Life Sci., 75, 537-548.
14. MERKELY, B., GELLER, L., TOTH, M., KISS, O., KEKESI, V., SOLTI, F., VECSEY, T., HORKAY, F., TENCZER, J. & JUHASZ-NAGY, A. (1998). Mechanism of endothelin-induced malignant ventricular arrhythmias in dogs. J. Cardiovasc. Res., 31 (Suppl 3), S437-S439.
15. MERKELY, B., SZABO, T., GELLER, L., KISS, O., HORKAY, F., RASCHACK, M. & JUHASZ-NAGY, A. (2000). The selective endothelin-A-receptor antagonist LU 135.252 inhibits the direct arrhythmogenic action of endothelin-1. J. Cardiovasc. Pharmacol., 36 (Suppl 1), S314-S316.
16. MIYAUCHI, T., YANAGISAWA, M. & TOMIZAWA, T. (1989). Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction. Lancet, ii, 53-54.
17. MOLENAAR, P., O'REILLY, G., SHARKEY, A., KUC, R.E., HARDING, D.P., PLUMPTON, C., GRESHAM, G.A. & DAVENPORT, A.P. (1993). Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium. Circ. Res., 72, 526-538.
18. ONO, K., MASUMIYA, H., SAKAMOTO, A., CHRISTE, G., SHIJUKU, T., TANAKA, H., SHIGENOBU, K. & OZAKI, Y. (2001). Electrophysiological analysis of the negative chronotropic effect of endothelin-1 in rabbit sinoatrial node cells. J. Physiol., 537.2, 467-488.
19. SALVATI, P., CHIERCHIA, S., DHO, L., FERRARIO, R.G., PARENTI, P., VICEDOMINI, G. & PATRONO, C. (1991). Proarrhythmic activity of intracoronary endothelin in dogs: relation to the site of administration and to changes in regional flow. J. Cardiovasc. Pharmacol., 17, 1007-1014.
20. SARGENT, C.A., LIU, E.C., CHAO, C.C., MONSHIZADEGAN, H., WEBB, M.L. & GROVER, GJ. (1994). Role of endothelin receptor subtype B (ET-B) in myocardial ischemia. Life Sci., 55, 1833-1844.
21. SHARIF, I., KANE, K.A. & WAINWRIGHT, C.L. (1998). Endothelin and ischaemic arrhythmias - antiarrhythmic or arrhythmogenic? Cardiovasc. Res., 39, 625-632.
22. SZABO, T., GELLER, L., MERKELY, B., SELMECI, L., JUHASZ-NAGY, A. & SOLTI, F. (2000). Investigating the dual nature of endothelin-1: Ischaemia or direct arrhythmogenic effect? Life Sci., 66, 2527-2541.
23. TALUKDER HASSAN, M.A., NOROTA, I., SAKURAI, K. & ENDOH, M. (2001). Inotropic response of rabbit ventricular myocytes to endothelin-1: difference from isolated papillary muscles. Am. J. Physiol. Heart. Circ. Physiol., 281, H596-H605.
24. TOTH, M., SOLTI, F., MERKELY, B., KEKESI, V., HORKAY, F., SZOKODI, I. & JUHASZ-NAGY, A. (1995). Ventricular tachycardias induced by intracoronary administration of endothelin-1 in dogs. J. Cardiovasc. Pharmacol., 26 (Suppl 3), S153-S155.
25. VITOLA, J.V., FORMAN, M.B., HOLSINGER, J.P., KAWANA, M., ATKINSON, J.B., QUERTERMOUS, T., JACKSON, E.K. & MURRAY, J.J. (1996). Role of endothelin in a rabbit model of acute myocardial infarction: effects of receptor antagonists. J. Cardiovasc. Pharmacol., 28, 774-783.
26. WANG, Q.-D., HEMSEN, A., LI, X.-S., LUNDBERG, J.M., URIUDA, Y. & PERNOW, J. (1995). Local overflow and enhanced tissue content of endothelin following myocardial ischaemia and reperfusion in the pig: modulation by L-arginine. Cardiovasc. Res., 29, 44-49.
27. WOLK, R., COBBE, S.M., HICKS, M.N. & KANE, K.A. (1998). Effects of lignocaine on dispersion of repolarisation and refractoriness in a working rabbit heart model of regional myocardial ischaemia. J. Cardiovasc. Pharmacol., 31, 253-261.
28. WOLK, R., SNEDDON, K.P., DEMPSTER, J., KANE, K.A., COBBE, S.M. & HICKS, M.N. (2000). Regional electrophysiological effects of left ventricular hypertrophy in isolated rabbit hearts under normal and ischaemic conditions. Cardiovasc. Res., 48, 120-128.
29. WOLK, R., COBBE, S.M., HICKS, M.N. & KANE, K.A. (1999). Functional, structural and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy. J. Pharmacol. Exp. Therap., 84, 207-231.
30. YASUDA, M., KOHNO, M. & THARA, A. (1990). Circulating immunoreactive endothelin in ischaemic heart disease. Am. Heart J., 119, 801-806.
31. YORIKANE, R., KOIKE, H. & MIYAKE, S. (1991). Electrophysiological effects of endothelin-1 on canine myocardial cells. J. Cardiovasc. Pharmacol., 17, 159-162.