Endothelin-A-receptor antagonist LU 135.252 Inhibits the formation of ventricular arrhythmias caused by intrapericardial infusion of endothelin-1

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Kiss, O ^a   Geller, L ^a   Merkely, B ^a   Szabo, T ^a   Raschack, M ^a   Seres, L ^a   Zima, E ^a   Juhasz Nagy, A ^a   Horkay, F ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Endothelin (ET); LU 135.252 (LU); Monophasic action potential duration (MAPD); Ventricular arrhythmia

Indexed keywords

ANTIARRHYTHMIC AGENT; DARUSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DOG; DRUG MECHANISM; ELECTROCARDIOGRAM; ENDOCARDIUM; EPICARDIUM; HEART DEPOLARIZATION; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART OUTPUT; HEART RIGHT VENTRICLE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; ST SEGMENT ELEVATION;

EID: 0033744183     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00114     Document Type: Article

References (9)

1. A novel vasoconstrictor peptide produced by vascular endothelial cells
2. Effects of KRN2391, nicorandil and diltiazem on the changes in the electrocardiogram caused by endothelin-1 in anaesthetized rats
3. Proarrhythmic activity of intracoronary endothelin in dogs; relation to the site of administration and to changes in regional flow
4. Evidence for direct arrhythmic action of endothelin
5. Mechanism of endothelin-induced malignant ventricular arrhythmias in dogs
6. Intrapericardial infusion of endothelin-1 induces ventricular arrhythmias in dogs
7. Endothelin and ischaemic arrhythmias - Antiarrhythmic or arrhythmogenic?
8. Effects of endothelin-1 and the ETA-receptor antagonist, BQ123, on ischemic arrhythmias in anesthetized rats
9. The Endothelin-A antagonist LU 135 252 supresses ischemic ventricular extrasystoles and fibrillation in pigs and prevents hypoxic cellular decoupling