Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line

AIDS

Volumn 13, Issue 14, 1999, Pages 1851-1855

  Gage, Julia R ^a   Breen, Elizabeth Crabb ^a   Echeverri, Angela ^a   Magpantay, Larry ^a   Kishimoto, Tadamitsu ^b   Miles, Steve ^a   Martínez Maza, Otoniel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

CD126'IL 6R'; CD130'gp130'; HHV 8; IL 6; U1 cells; vIL 6; Virokine

Indexed keywords

ANTIGEN P24; BLOCKING ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; RECOMBINANT INTERLEUKIN 6;

ARTICLE; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS ACTIVATION;

ANIMALS; ANTIGENS, CD; CELL LINE; CYTOKINE RECEPTOR GP130; HERPESVIRUS 8, HUMAN; HIV CORE PROTEIN P24; HIV-1; HUMANS; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MONOCYTES; RABBITS; RECOMBINANT FUSION PROTEINS; VIRAL PROTEINS; VIRUS ACTIVATION;

EID: 2442749667     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199910010-00006     Document Type: Article

References (31)

1. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994, 266:1865-1869.
2. Moore PS, Gao SJ, Dominguez G, et al. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J Virol 1996, 70:549-558.
3. Nicholas J, Ruvolo V, Zong J, et al. A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. J Virol 1997, 71:1963-1974.
4. Russo JJ, Bohenzky RA, Chien MC, et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). PNAS 1996, 93:14862-14867.
5. Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 1996, 274:1739-1744.
6. Neipel F, Albrecht JC, Ensser A, et al. Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol 1997, 71:839-842.
7. Nicholas J, Ruvolo VR, Burns WH, et al. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nature Med 1997, 3:287-92.
8. Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood 1995, 86:1243-1254.
9. Breen EC, Rezai AR, Nakajima K, et al. Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 1990, 144:480-484.
10. Poli C, Bressler P, Kinter A, et al. Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms. J Exp Med 1990, 172:151-158.
11. Okamoto M, Yasukawa K, Katsuura K, Baba M. Inhibition of interleukin-6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody. Biochem Molec Biol Int 1997, 43:733-40.
12. Burger R, Neipel F, Fleckenstein B, et al. Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood 1998, 91:1858-1863.
13. Molden J, Chang Y, You Y, Moore PS, Goldsmith MA. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vlL-6) activates signaling through the shared gp130 receptor subunit. J Biol Chem 1997, 272:19625-19631.
14. Nakajima K, Martínez-Maza O, Hirano T, et al. Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J Immunol 1989, 142:531-536.
15. Said JW, Chien K, Tasaka T, Koeffler HP. Ultrastructural characterization of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (CMV). J Pathol 1997, 182:273-281.
16. Chandran B, Smith MS, Koelle DM, Corey L, Horvat R, Goldstein E. Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs. Virology 1998, 243:208-217.
17. Chatlynne LG, Lapps W, Handy M, et al. Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Blood 1998, 92:53-58.
18. Zhu L, Wang R, Sweat A, Goldstein E, Horvat R, Chandran B. Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunoflourescence assays with HHV-8-infected BCBL-1 cells. Virology 1999, 256:381-392.
19. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995, 332:1186-1191.
20. Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996, 88:645-656.
21. Grandadam M, Dupin N, Calvez, et al. Exacerbations of clinical symptoms in human immunodeficiency virus type 1-infected patients with multicentric Castleman's disease are associated with a high increase in Kaposi's sarcoma herpesvirus DNA load in peripheral blood mononuclear cells. J Infect Dis 1997, 175:1198-1201.
22. Boshoff C, Endo Y, Collins PD, et al. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 1997, 278:290-294.
23. Kledal TN, Rosenkilde MM, Coulin F, et al. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997, 277:1656-1659.
24. Sarid R, Flore O, Bohenzky RA, Chang Y, Moore PS. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J Virol 1998, 72:1005-1012.
25. Sun R, Su-Fang L, Staskus K, et al. Kinetics of Kaposi's Sarcoma-associated Herpesvirus gene expression. J Virol 1999, 73:2232-2242.
26. Staskus KA, Sun R, Miller G, et al. Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and milticentric Castleman's Disease. J Virol 1999, 73:4181-4187.
27. Komanduri KV, Luce JA, McGrath MS, Herndier BG, Ng VL. The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusions. J Acquir Immune Defic Syndr Hum Retrovirol 1996, 13:215-226.
28. Breen EC, van der Meijden M, Cumberland W, Kishimoto T, Detels R, Martínez-Maza O. The development of AIDS-associated Burkitt's/small non-cleaved lymphoma is preceded by elevated serum levels of interleukin 6. J Clin Immunol, 1999 (in press).
29. Dourado I, Martínez-Maza O, Kishimoto T, Suzuki H, Detels R. Interleukin 6 and AIDS-associated Kaposi's sarcoma: a nested case control study within the Multicenter AIDS Cohort Study. Aids Res Hum Retrovir 1997, 13:781-788.
30. van der Meijden M, Gage J, Breen EC, Taga T, Kishimoto T, Martínez-Maza O. IL-6 receptor (CD126′IL-6R′) expression is increased on monocytes and B lymphocytes in HIV infection. Cell Immun 1998, 190:156-166.
31. Murakami-Mori K, Taga T, Kishimoto T, Nakamura S. The soluble form of the IL-6 receptor (slL-6R alpha) is a potent growth factor for AIDS-associated Kaposi's sarcoma KS cells; the soluble form of gp130 is antagonistic for slL-6R alpha-induced AIDS-KS cell growth. Int Immunol 1996, 8:595-602.