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Volumn 78, Issue 1, 2004, Pages 75-81

Susceptibility to audiogenic seizure and neurotransmitter amino acid levels in different brain areas of IL-6-deficient mice

Author keywords

Audiogenic seizures; Electroshock; Epilepsy; Interleukin 6; Neuroactive amino acids

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID RECEPTOR AFFECTING AGENT; ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; INTERLEUKIN 6; TAURINE;

EID: 2442716072     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2004.02.004     Document Type: Article
Times cited : (28)

References (56)
  • 1
    • 17544374339 scopus 로고    scopus 로고
    • Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain
    • Ali C., Nicole O., Docagne F., Lesne S., MacKenzie E.T., Nouvelot A., et al. Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain. J. Cereb. Blood Flow Metab. 20:2000;956-966
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 956-966
    • Ali, C.1    Nicole, O.2    Docagne, F.3    Lesne, S.4    MacKenzie, E.T.5    Nouvelot, A.6
  • 3
    • 0032077767 scopus 로고    scopus 로고
    • Transgenic mice and cytokine actions in the brain: Bridging the gap between structural and functional neuropathology
    • Campbell I.L. Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology. Brain Res. Brain Res. Rev. 26:1998;327-336
    • (1998) Brain Res. Brain Res. Rev. , vol.26 , pp. 327-336
    • Campbell, I.L.1
  • 5
    • 0033215124 scopus 로고    scopus 로고
    • Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6 and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways
    • Carlson N.G., Wieggel W.A., Chen J., Bacchi A., Rogers S.W., Gahring L.C. Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6 and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J. Immunol. 163:1999;3963-3968
    • (1999) J. Immunol. , vol.163 , pp. 3963-3968
    • Carlson, N.G.1    Wieggel, W.A.2    Chen, J.3    Bacchi, A.4    Rogers, S.W.5    Gahring, L.C.6
  • 7
    • 0028598750 scopus 로고
    • Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice
    • Chiang C.S., Stalder A., Samimi A., Campbell I.L. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev. Neurosci. 16:1994;212-221
    • (1994) Dev. Neurosci. , vol.16 , pp. 212-221
    • Chiang, C.S.1    Stalder, A.2    Samimi, A.3    Campbell, I.L.4
  • 8
    • 8944262343 scopus 로고    scopus 로고
    • Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage
    • De Bock F., Dornand J., Rondouin G. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. NeuroReport. 7:1996;1125-1129
    • (1996) NeuroReport , vol.7 , pp. 1125-1129
    • De Bock, F.1    Dornand, J.2    Rondouin, G.3
  • 9
    • 0021259006 scopus 로고
    • Anticonvulsant actions of DS 103-282: Pharmacological studies in rodents and the baboon, Papio papio
    • De Sarro G.B., Croucher M.J., Meldrum B.S. Anticonvulsant actions of DS 103-282: pharmacological studies in rodents and the baboon, Papio papio. Neuropharmacology. 23:1984;525-530
    • (1984) Neuropharmacology , vol.23 , pp. 525-530
    • De Sarro, G.B.1    Croucher, M.J.2    Meldrum, B.S.3
  • 10
    • 0031039941 scopus 로고    scopus 로고
    • Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice
    • De Sarro G.B., Nava F., Calapai G., De Sarro A. Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice. Antimicrob. Agents Chemother. 41:1997;427-434
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 427-434
    • De Sarro, G.B.1    Nava, F.2    Calapai, G.3    De Sarro, A.4
  • 12
    • 0029014397 scopus 로고
    • Critical evaluation of animal models for localization-related epilepsies
    • Engel J. Jr. Critical evaluation of animal models for localization-related epilepsies. Ital. J. Neurol. Sci. 16:1995;9-16
    • (1995) Ital. J. Neurol. Sci. , vol.16 , pp. 9-16
    • Engel Jr., J.1
  • 13
    • 0023742573 scopus 로고
    • Seizure susceptibility in DBA and C57 mice: The effects of various convulsants
    • Engstrom F.L., Woodbury D.M. Seizure susceptibility in DBA and C57 mice: the effects of various convulsants. Epilepsia. 29:1988;389-395
    • (1988) Epilepsia , vol.29 , pp. 389-395
    • Engstrom, F.L.1    Woodbury, D.M.2
  • 14
    • 0022639039 scopus 로고
    • Acute and chronic acetazolamide administration in DBA and C57 mice: Effects of age
    • Engstrom F.L., White H.S., Kemp J.W., Woodbury D.M. Acute and chronic acetazolamide administration in DBA and C57 mice: effects of age. Epilepsia. 27:1986;19-26
    • (1986) Epilepsia , vol.27 , pp. 19-26
    • Engstrom, F.L.1    White, H.S.2    Kemp, J.W.3    Woodbury, D.M.4
  • 15
    • 0021330769 scopus 로고
    • Glutamate: A neurotransmitter in mammalian brain
    • Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42:1984;1-11
    • (1984) J. Neurochem. , vol.42 , pp. 1-11
    • Fonnum, F.1
  • 16
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) a molecule with both beneficial and destructive potentials
    • Gadient R.A., Otten U.H. Interleukin-6 (IL-6) a molecule with both beneficial and destructive potentials. Prog. Neurobiol. 52:1997;379-390
    • (1997) Prog. Neurobiol. , vol.52 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 17
    • 0029011967 scopus 로고
    • Chemoconvulsant seizure: Advantages of focally-evoked seizure models
    • Gale K. Chemoconvulsant seizure: advantages of focally-evoked seizure models. Ital. J. Neurol. Sci. 16:1995;17-25
    • (1995) Ital. J. Neurol. Sci. , vol.16 , pp. 17-25
    • Gale, K.1
  • 18
    • 0029970424 scopus 로고    scopus 로고
    • Changes in IL-6 concentrations following epilepsy surgery: Potential influence on carbamazepine pharmacokinetics
    • Gidal B.E., Reiss W.G., Liao J.S., Pitterle M.E. Changes in IL-6 concentrations following epilepsy surgery: potential influence on carbamazepine pharmacokinetics. Ann. Pharmacother. 30:1996;545-546
    • (1996) Ann. Pharmacother. , vol.30 , pp. 545-546
    • Gidal, B.E.1    Reiss, W.G.2    Liao, J.S.3    Pitterle, M.E.4
  • 19
    • 0036378562 scopus 로고    scopus 로고
    • Frequent seizures with elevated IL-6 at the eruptive stage of exanthema subitum
    • Go T., Nakamura K. Frequent seizures with elevated IL-6 at the eruptive stage of exanthema subitum. Eur. Pediatr. Neurol. 6:2002;221-223
    • (2002) Eur. Pediatr. Neurol. , vol.6 , pp. 221-223
    • Go, T.1    Nakamura, K.2
  • 20
    • 0032529722 scopus 로고    scopus 로고
    • Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: A quantitative immunogold analysis in rat hippocampus
    • Gundersen V., Chaudhry F.A., Bjaalie J.G., Fonnum F., Ottersen O.P., Storm-Mathisen J. Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus. J. Neurosci. 18:1998;6059-6070
    • (1998) J. Neurosci. , vol.18 , pp. 6059-6070
    • Gundersen, V.1    Chaudhry, F.A.2    Bjaalie, J.G.3    Fonnum, F.4    Ottersen, O.P.5    Storm-Mathisen, J.6
  • 21
    • 85046066318 scopus 로고
    • Genetic differences in fatal audiogenic seizures
    • Hall C.S. Genetic differences in fatal audiogenic seizures. J. Hered. 38:1947;3-6
    • (1947) J. Hered. , vol.38 , pp. 3-6
    • Hall, C.S.1
  • 22
    • 0028181690 scopus 로고
    • Expression of the alpha2-macroglobulin-encoding gene in rat brain and cultured astrocytes
    • Higuchi M., Ito T., Imai Y., Iwaki T., Hattori M., Kohsaka S., et al. Expression of the alpha2-macroglobulin-encoding gene in rat brain and cultured astrocytes. Gene. 141:1994;155-162
    • (1994) Gene , vol.141 , pp. 155-162
    • Higuchi, M.1    Ito, T.2    Imai, Y.3    Iwaki, T.4    Hattori, M.5    Kohsaka, S.6
  • 23
    • 0028800715 scopus 로고
    • Cytokines and the nervous system: I. Expression and recognition
    • Hopkins S., Rothwell N. Cytokines and the nervous system: I. Expression and recognition. Trends Neurosci. 18:1995;83-88
    • (1995) Trends Neurosci. , vol.18 , pp. 83-88
    • Hopkins, S.1    Rothwell, N.2
  • 24
    • 0031934336 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha IL-1 beta, and IL-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy
    • Ichiyama T., Nishikawa M., Yoshitomi T., Hayashi T., Furukawa S. Tumor necrosis factor-alpha IL-1 beta, and IL-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/ encephalopathy. Neurology. 50:1998;407-411
    • (1998) Neurology , vol.50 , pp. 407-411
    • Ichiyama, T.1    Nishikawa, M.2    Yoshitomi, T.3    Hayashi, T.4    Furukawa, S.5
  • 25
    • 0033955359 scopus 로고    scopus 로고
    • Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB
    • Ichiyama T., Okada K., Lipton J.M., Matsubara T., Hayashi T., Furukawa S. Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB. Brain Res. 857:2000;246-251
    • (2000) Brain Res. , vol.857 , pp. 246-251
    • Ichiyama, T.1    Okada, K.2    Lipton, J.M.3    Matsubara, T.4    Hayashi, T.5    Furukawa, S.6
  • 28
    • 84951384024 scopus 로고
    • A simplified method of evaluating dose-effect experiments
    • Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-111
    • (1949) J. Pharmacol. Exp. Ther. , vol.96 , pp. 99-111
    • Litchfield, J.T.1    Wilcoxon, F.2
  • 29
    • 0038062630 scopus 로고    scopus 로고
    • Sox1-deficient mice suffer from epilepsy associated with abnormal ventral forebrain development and olfactory cortex hyperexcitability
    • Malas S., Postlethwaite M., Ekonomou A., Whalley B., Nishiguchi S., Wood H., et al. Sox1-deficient mice suffer from epilepsy associated with abnormal ventral forebrain development and olfactory cortex hyperexcitability. Neuroscience. 119:2003;421-432
    • (2003) Neuroscience , vol.119 , pp. 421-432
    • Malas, S.1    Postlethwaite, M.2    Ekonomou, A.3    Whalley, B.4    Nishiguchi, S.5    Wood, H.6
  • 30
    • 0017579832 scopus 로고
    • Glutamine synthetase: Glial localization in brain
    • Martinez-Hernandez A., Bell K.P., Norenberg M.D. Glutamine synthetase: glial localization in brain. Science. 195:1977;1356-1358
    • (1977) Science , vol.195 , pp. 1356-1358
    • Martinez-Hernandez, A.1    Bell, K.P.2    Norenberg, M.D.3
  • 31
    • 0025844833 scopus 로고
    • Effects of kainic acid on messanger RNA levels of IL-1 beta, Il-6, TNF alpha and LIF in the rat brain
    • Minami M., Kuraishi Y., Satoh M. Effects of kainic acid on messanger RNA levels of IL-1 beta, Il-6, TNF alpha and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176:1991;593-598
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 593-598
    • Minami, M.1    Kuraishi, Y.2    Satoh, M.3
  • 32
    • 0036896338 scopus 로고    scopus 로고
    • Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice
    • Misawa H., Sherr E.H., Lee D.J., Chetkovich D.M., Tan A., Schreiner C.E., et al. Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. J. Neurosci. 22:2002;10088-10093
    • (2002) J. Neurosci. , vol.22 , pp. 10088-10093
    • Misawa, H.1    Sherr, E.H.2    Lee, D.J.3    Chetkovich, D.M.4    Tan, A.5    Schreiner, C.E.6
  • 33
  • 34
    • 0026001943 scopus 로고
    • Genetic dissection of susceptibility to audiogenic seizures in inbred mice
    • Neumann P.E., Collins R.L. Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proc. Natl. Acad. Sci. U. S. A. 88:1991;5408-5412
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 5408-5412
    • Neumann, P.E.1    Collins, R.L.2
  • 35
    • 0025350288 scopus 로고
    • Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice
    • Neumann P.E., Seyfried T.N. Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice. Behav. Genet. 20:1990;307-323
    • (1990) Behav. Genet. , vol.20 , pp. 307-323
    • Neumann, P.E.1    Seyfried, T.N.2
  • 36
    • 0021231817 scopus 로고
    • A single gene error of noradrenergic axon growth synchronizes central neurones
    • Noebels J.L. A single gene error of noradrenergic axon growth synchronizes central neurones. Nature. 310:1984;409-411
    • (1984) Nature , vol.310 , pp. 409-411
    • Noebels, J.L.1
  • 37
    • 0038185246 scopus 로고    scopus 로고
    • Exploring new gene discoveries in idiopathic generalized epilepsy
    • Noebels J.L. Exploring new gene discoveries in idiopathic generalized epilepsy. Epilepsia. 44(Suppl. 2):2003;16-21
    • (2003) Epilepsia , vol.44 , Issue.SUPPL. 2 , pp. 16-21
    • Noebels, J.L.1
  • 38
    • 0031830922 scopus 로고    scopus 로고
    • Elevated levels of interleukin-6 occur in cerebrospinal fluid from patients with recent epileptic seizures
    • Peltola J., Hurme M., Miettinen A., Keranen T. Elevated levels of interleukin-6 occur in cerebrospinal fluid from patients with recent epileptic seizures. Epilepsy Res. 31:1998;129-133
    • (1998) Epilepsy Res. , vol.31 , pp. 129-133
    • Peltola, J.1    Hurme, M.2    Miettinen, A.3    Keranen, T.4
  • 39
    • 0034308079 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-1 receptors antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures
    • Peltola J., Palmio J., Korhonen L., Suhonen J., Miettinen A., Hurme M., et al. Interleukin-6 and interleukin-1 receptors antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures. Epilepsy Res. 41:2000;205-211
    • (2000) Epilepsy Res. , vol.41 , pp. 205-211
    • Peltola, J.1    Palmio, J.2    Korhonen, L.3    Suhonen, J.4    Miettinen, A.5    Hurme, M.6
  • 40
    • 0036185123 scopus 로고    scopus 로고
    • Indicators of inflammation after recent tonic-clonic epileptic seizures correlate with plasma interleukin-6 levels
    • Peltola J., Laaksonen J., Haapala A.M., Hurme M., Rainesalo S., Kerano T. Indicators of inflammation after recent tonic-clonic epileptic seizures correlate with plasma interleukin-6 levels. Seizure. 11:2000;44-46
    • (2000) Seizure , vol.11 , pp. 44-46
    • Peltola, J.1    Laaksonen, J.2    Haapala, A.M.3    Hurme, M.4    Rainesalo, S.5    Kerano, T.6
  • 41
    • 0035857468 scopus 로고    scopus 로고
    • IL-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures
    • Penkowa M., Molinero A., Carrasco J., Hidalgo J. IL-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures. Neuroscience. 102:2001;805-818
    • (2001) Neuroscience , vol.102 , pp. 805-818
    • Penkowa, M.1    Molinero, A.2    Carrasco, J.3    Hidalgo, J.4
  • 42
    • 0028266906 scopus 로고
    • Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
    • Poli V., Balena R., Fattori E., Markatos A., Yamamoto M., Tanaka H., et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 13:1994;1189-1196
    • (1994) EMBO J. , vol.13 , pp. 1189-1196
    • Poli, V.1    Balena, R.2    Fattori, E.3    Markatos, A.4    Yamamoto, M.5    Tanaka, H.6
  • 44
    • 0037829339 scopus 로고    scopus 로고
    • Profound increase in sensitivity to glutamatergic - But not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6
    • Samland H., Huitron-Resendiz S., Masliah E., Criado J., Henriksen S.J., Campbell I.L. Profound increase in sensitivity to glutamatergic - but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J. Neurosci. Res. 73:2003;176-187
    • (2003) J. Neurosci. Res. , vol.73 , pp. 176-187
    • Samland, H.1    Huitron-Resendiz, S.2    Masliah, E.3    Criado, J.4    Henriksen, S.J.5    Campbell, I.L.6
  • 46
    • 0021848553 scopus 로고
    • A review of mouse mutants as genetic models of epilepsy
    • Seyfried T.N., Glaser G.H. A review of mouse mutants as genetic models of epilepsy. Epilepsia. 26:1985;143-150
    • (1985) Epilepsia , vol.26 , pp. 143-150
    • Seyfried, T.N.1    Glaser, G.H.2
  • 47
    • 0028298627 scopus 로고
    • Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
    • Steffensen S.C., Campbell I.L., Henriksen S.J. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res. 652:1994;149-153
    • (1994) Brain Res. , vol.652 , pp. 149-153
    • Steffensen, S.C.1    Campbell, I.L.2    Henriksen, S.J.3
  • 48
    • 0035132958 scopus 로고    scopus 로고
    • Pro- and anti-inflammatory cytokines in children with febrile convulsions
    • Straussberg R., Amir J., Harel L., Punsky I., Bessler H. Pro- and anti-inflammatory cytokines in children with febrile convulsions. Pediatr. Neurol. 24:2001;49-53
    • (2001) Pediatr. Neurol. , vol.24 , pp. 49-53
    • Straussberg, R.1    Amir, J.2    Harel, L.3    Punsky, I.4    Bessler, H.5
  • 49
    • 0001908712 scopus 로고
    • Experimental detection, quantification and evaluation of anticonvulsants
    • D.M. Woodbury, J.K. Penry, & C.E. Pippinger. New York: Raven Press
    • Swinyard E.A., Woodhead J.M. Experimental detection, quantification and evaluation of anticonvulsants. Woodbury D.M., Penry J.K., Pippinger C.E. Epileptic drugs. 1982;111-126 Raven Press, New York
    • (1982) Epileptic Drugs , pp. 111-126
    • Swinyard, E.A.1    Woodhead, J.M.2
  • 50
    • 0020213940 scopus 로고
    • Cerebral glutamic acid decarboxylase activity and γ-aminobutyric acid concentrations in mice susceptible or resistant to audiogenic seizures
    • Sykes C.C., Horton R.W. Cerebral glutamic acid decarboxylase activity and γ-aminobutyric acid concentrations in mice susceptible or resistant to audiogenic seizures. J. Neurochem. 39:1982;1489-1491
    • (1982) J. Neurochem. , vol.39 , pp. 1489-1491
    • Sykes, C.C.1    Horton, R.W.2
  • 51
    • 0025958468 scopus 로고
    • Glutamine synthetase in oligodendrocytes and astrocytes: New biochemical and immunocytochemical evidence
    • Tansey F.A., Farooq M., Cammer W. Glutamine synthetase in oligodendrocytes and astrocytes: new biochemical and immunocytochemical evidence. J. Neurochem. 56:1991;266-272
    • (1991) J. Neurochem. , vol.56 , pp. 266-272
    • Tansey, F.A.1    Farooq, M.2    Cammer, W.3
  • 52
    • 0026781413 scopus 로고
    • Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons
    • Toulmond S., Vige X., Fage D., Benavides J. Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons. Neurosci. Lett. 144:1992;49-52
    • (1992) Neurosci. Lett. , vol.144 , pp. 49-52
    • Toulmond, S.1    Vige, X.2    Fage, D.3    Benavides, J.4
  • 53
    • 0037304144 scopus 로고    scopus 로고
    • Recent developments from genetic mouse models of seizures
    • Upton N., Stratton S. Recent developments from genetic mouse models of seizures. Curr. Opin. Pharmacol. 3:2003;19-26
    • (2003) Curr. Opin. Pharmacol. , vol.3 , pp. 19-26
    • Upton, N.1    Stratton, S.2
  • 54
    • 0015071185 scopus 로고
    • A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain
    • Van den Berg C.J., Garfinkel D. A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem. J. 123:1971;211-218
    • (1971) Biochem. J. , vol.123 , pp. 211-218
    • Van Den Berg, C.J.1    Garfinkel, D.2
  • 55
    • 0036340601 scopus 로고    scopus 로고
    • Increased plasma levels of pro- and anti-inflammatory cytokines with febrile seizures
    • Virta M., Hurme M., Helminen M. Increased plasma levels of pro- and anti-inflammatory cytokines with febrile seizures. Epilepsia. 43:2002;920-923
    • (2002) Epilepsia , vol.43 , pp. 920-923
    • Virta, M.1    Hurme, M.2    Helminen, M.3
  • 56
    • 0028266972 scopus 로고
    • Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death
    • Yamada M., Hatanaka H. Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res. 643:1994;173-180
    • (1994) Brain Res. , vol.643 , pp. 173-180
    • Yamada, M.1    Hatanaka, H.2


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