Nandrolone decanoate and load increase remodeling and strength in human supraspinatus bioartificial tendons

American Journal of Sports Medicine

Volumn 32, Issue 4, 2004, Pages 934-943

  Triantafillopoulos, Ioannis K ^a,b   Banes, Albert J ^b,c,d   Bowman Jr , Karl F ^b   Maloney, Melissa ^c   Garrett Jr , William E ^e   Karas, Spero G ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Flexcell International Corporation   (United States)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anabolic steroids; Bioartificial tendons; Material properties; Mechanical loading; Supraspinatus tendon

Indexed keywords

ANABOLIC AGENT; COLLAGEN; NANDROLONE DECANOATE; STROMELYSIN;

ADULT; AGED; ARTICLE; BIOARTIFICIAL ORGAN; BIOENGINEERING; BIOMECHANICS; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DRUG EFFECT; ENERGY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MECHANICAL STRESS; PRIORITY JOURNAL; ROTATOR CUFF; SHEAR STRENGTH; SUPRASPINATUS MUSCLE TENDON; TENDON;

ADULT; AGED; ANABOLIC AGENTS; BIOARTIFICIAL ORGANS; BIOMECHANICS; BONE REMODELING; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; NANDROLONE; ROTATOR CUFF; TENDONS; TISSUE ENGINEERING; WOUND HEALING;

EID: 2442712858     PISSN: 03635465     EISSN: None     Source Type: Journal    
DOI: 10.1177/0363546503261700     Document Type: Article

References (60)

1. Alway SE, Starkweather LA. Effect of anabolic steroids on new fiber formation and fiber area during stretch-overload. J Appl Physiol. 1993;74:832-837.
2. Banes AJ, Donlon K, Link GW, et al. Cell populations of tendon: a simplified method for isolation of synovial and internal fibroblasts: confirmation of origin and biologic properties. J Orthop Res. 1988;6:83-94.
3. Banes AJ, Weinhold P, Yank X, et al. Gap junctions regulate responses of tendon cells ex vivo to mechanical loading. Clin Orthop. 1999; 367(suppl):S356-S370.
4. Bartsch W. Anabolic steroids: action on cellular level. Wien Med Wochenschr. 1993;143:363-366.
5. Benjamin M, Ralphs JR. The cell and developmental biology of tendons and ligaments. Int Rev Cytol. 2000;196:85-130.
6. Bigliani LU, McIlveen SJ, Cordasco F, et al. Operative repair of massive rotator cuff tears: long term results. J Shoulder Elbow Surg. 1992;1:120-130.
7. Burkhart SS, Danacau SM, Pearce CE Jr. Arthroscopic rotator cuff repair: analysis of results by tear size and by repair technique-margin convergence versus direct tendon-to-bone repair. Arthroscopy. 2001;17:905-912.
8. Celotti F, Negri Cesi P. Anabolic steroids: a review of their effects on the muscles, of their possible mechanisms of action and of their use in athletics. J Steroid Biochem. 1992;43:469-477.
9. Chard MD, Cawston TE, Riley GP, et al. Rotator cuff degeneration and lateral epicondylitis: a comparative histological study. Ann Rheum Dis. 1994;53:30-34.
10. Cofield RH. Current concepts review: rotator cuff disease of the shoulder. J Bone Joint Surg Am. 1985;67:974-979.
11. David HG, Green JT, Grant AJ, et al. Simultaneous bilateral quadriceps rupture: a complication of anabolic steroid abuse. J Bone Joint Surg. 1995;77:159-160.
12. Dejardin LN, Arnoczky SP, Cloud GL. Use of small intestinal submucosal implants for regeneration of large fascial defects: an experimental study in dogs. J Biomed Mater Res. 1999;46:203-211.
13. Demling RH, Orgill DP. The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury. J Crit Care. 2000;15:12-17.
14. DeOrio JK, Cofield RH. Results of a second attempt at surgical repair of a failed initial rotator-cuff repair. J Bone Joint Surg. 1984;66:563-567.
15. Frankle MA, Leffers D. Anabolic androgenic steroids; a guide for the orthopaedic surgeon. Scientific exhibit at: Annual Meeting of the AAOS; 1989; Las Vegas, Nev.
16. Garvin J, Qi J, Maloney M, Banes A. A novel system for engineering bioartificial tendons and application of mechanical load. J Tissue Eng. 2003;9:967-979.
17. Gerber C, Fuchs B, Hodler J. The results of repair of massive tears of the rotator cuff. J Bone Joint Surg. 2000;82:505-515.
18. Gomez DE, Alonso DF, Yoshiji H, et al. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur J Cell Biol. 1997;74:111-122.
19. Grisby JS, Bergen WG, Merkel RA. The effect of testosterone on skeletal muscle development and protein synthesis in rabbits. Growth. 1976;40:303-316.
20. Hart DW, Wolf SE, Ramzy PI, et al. Anabolic effects of oxandrolone after severe burn. Ann Surg. 2001;233:556-564.
21. Hausmann DF, Nutz V, Rommelsheim K, et al. Anabolic steroids in polytrauma patients. Influence on renal nitrogen and amino acid losses: a double-blind study. J Parenter Enteral Nutr. 1990;14:111-114.
22. Hervey GR, Knibbs AV, Burkinshaw L, et al. Effects of methandienone on the performance and body composition of men undergoing athletic training. Clin Sci (Lond). 1981;60:457-461.
23. Hill JA, Suker JR, Sachs K, et al. The athletic polydrug abuse phenomenon: a case report. Am J Sports Med. 1983;11:269-271.
24. Iannotti JP, Bernot MP, Kuhlman JR, et al. Postoperative assessment of shoulder function: a prospective study of full-thickness rotator cuff tears. J Shoulder Elbow Surg. 1996;5:449-457.
25. Ireland D, Harall R, Curry V, et al. Multiple changes in gene expression in chronic human Achilles tendinopathy. Matrix Biol. 2001;20:159-169.
26. Karpaka JA, Pesola MK, Takala ES. The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon: a preliminary report. Am J Sports Med. 1992;20:262-266.
27. Kennedy JM, Eisenberg BR, Reid SK, et al. Nascent muscle fibers appearance in overloaded chicken slow-tonic muscle. Am J Anat. 1988;181:203-215.
28. Kirkland RT, Harrist RB, Clayton GW. Results of four years of intermittent human growth hormone (hGH) and fluoxymesterone therapy in hypopituitary dwarfism. Pediatrics. 1980;65:562-566.
29. Kramhoft M, Solgaard S. Spontaneous rupture of the extensor pollicis longus tendon after anabolic steroids. J Hand Surg [Br]. 1986;11:87-88.
30. Kubista M, Akareman B, Norden B. Characterization of interaction between DNA and 4′,6-diamidino-2-phenylindole by optical spectroscopy. Biochemistry. 1987;26:4545.
31. Lambert MI, St Clair Gibson A, Noakes TD. Rupture of the triceps tendon associated with steroid injections. Am J Sports Med. 1995;23:778.
32. Lewis L, Dahn M, Kirkpatrick JR. Anabolic steroid administration during nutritional support: a therapeutic controversy. J Parenter Enteral Nutr. 1981;5:64-66.
33. Liow RY, Tavares S. Bilateral rupture of the quadriceps tendon associated with anabolic steroids. Br J Sports Med. 1995;29:77-79.
34. MacGillivray MH, Kolotkin M, Munschauer RW. Enhanced linear growth responses in hypopituitary dwarfs treated with growth hormone plus androgen versus growth hormone alone. Pediatr Res. 1974;8:103-108.
35. Manicourt DH, Fujimoto N, Obata K, et al. Serum levels of collagenase, stromelysins-1, and TIMP-1. Age-related and sex-related differences in normal subjects and relationship to the extend of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis. Arthritis Rheum. 1994;37:1774-1783.
36. McNeilly CM, Banes AJ, Benjamin M, et al. Tendon cells in vivo form a three dimensional network of cell processes linked by gap junctions. J Anat. 1996;189:593-600.
37. Michelson CB, Askanazi J, Kinney JM, et al. Effect of an anabolic steroid on nitrogen balance and amino acid patterns after total hip replacement. J Trauma. 1982;22:410-413.
38. Michna H. Tendon injuries induced by exercise and anabolic steroid in experimental mice. Internat Orthop. 1987;11:157-162.
39. Miles JW, Grana WA, Eagle D, et al. The effect of anabolic steroid on the biomechanical and histological properties of rat tendon. J Bone Joint Surg Am. 1992;74:411-422.
40. Miniaci A, MacLeod M. Transfer of the latissimus dorsi muscle after failed repair of a massive tear of the rotator cuff: a two to five-year review. J Bone Joint Surg Am. 1999;81:1120-1127.
41. Nemoto O, Yamagishi M, Yamada H, et al. Matrix metalloproteinase-3 production by human degenerated intervertebral disc. J Spinal Disord. 1997;10:493-498.
42. Neviaser JS, Neviaser RJ, Neviaser TJ. The repair of chronic massive ruptures of the rotator cuff of the shoulder by use of a freeze-dried rotator cuff. J Bone Joint Surg Am. 1978;60:681-684.
43. Okada Y, Shinmei M, Tanaka O, et al. Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest. 1992;66:680-690.
44. Post M. Rotator cuff repair with carbon filament: a preliminary report of five cases. Clin Orthop. 1985;196:154-158.
45. Ralphs JR, Waggett AD, Benjamin M. Actin stress fibers and cell-cell adhesion molecules in tendons: organization in vivo and response to mechanical loading of tendon cells in vitro. Matrix Biol. 2002;21:67-74.
46. Riley GP, Curry V, DeGroot J, et al. Matrix metalloproteinase activities and their relationship with collagen remodeling in tendon pathology. Matrix Biol. 2002;21:185-195.
47. Riley GP, Harall RL, Constant CR, et al. Glycosaminoglycans of human rotator cuff tendons; changes with age and in chronic rotator cuff tendinitis. Ann Rheum Dis. 1994;53:367-376.
48. Riley GP, Harall RL, Constant CR, et al. Tendon degeneration and chronic shoulder pain: changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis. Ann Rheum Dis. 1994;53:359-366.
49. Rodeo SA, Suzuki K, Deng X, et al. Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel. Am J Sports Med. 1999;27:476-488.
50. Rogozkin V. Metabolic effects of anabolic steroid on skeletal muscle. Med Sci Sports. 1979;11:160-163.
51. Shahidi NT. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther. 2001;23:1355-1389.
52. Sheffield-Moore M. Androgens and the control of skeletal muscle protein synthesis. Ann Med. 2000;32:181-186.
53. Small J. Visualizing the actin cytoskeleton. Microsc Res Tech. 1999;47:3.
54. Stannard JP, Bucknell AL. Rupture of the triceps tendon associated with steroid injections. Am J Sports Med. 1993;21:482-485.
55. Tsuzaki M, Guyton G, Garrett W, et al. IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. J Orth Res. 2003;21:256-264.
56. Uhthoff HK, Sano H, Trudel G, et al. Early reactions after reimplantation of the tendon of supraspinatus into bone: a study in rabbits. J Bone Joint Surg Br. 2000;82:1072-1076.
57. Waggett AD, Benjamin M, Ralphs JR. Gap junction inhibitors abolish strain response in tendon cells in vitro. Trans Orthop Res Soc. 1999;24:630.
58. Warner JJ, Parsons IM IV. Latissimus dorsi tendon transfer: a comparative analysis of primary and salvage reconstruction of massive, irreparable rotator cuff tears. J Shoulder Elbow Surg. 2001;10:514-521.
59. Woo SL-Y, Ritter MA, Amiel D, et al. The biomechanical and biochemical properties of swine tendons: long-term effects of exercise on the digital extensors. Connect Tissue Res. 1980;7:177-183.
60. Wood TO, Cooke PH, Goodship AE. The effect of exercise and anabolic steroids on the mechanical properties and crimp morphology of the rat tendon. Am J Sports Med. 1988;16:153-158.