The adenylate cyclase toxin from Bordetella pertussis - A novel promising vehicle for antigen delivery to dendritic cells

International Journal of Medical Microbiology

Volumn 293, Issue 7-8, 2004, Pages 571-576

  Simsova, Marcela ^a   Sebo, Peter ^a   Leclerc, Claude ^b,c  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b INSERM   (France)

^c INSTITUT PASTEUR   (France)

Author keywords

Antigen delivery; CD11b CD18; Cellular immune response; CTL; CyaA

Indexed keywords

ADENYLATE CYCLASE TOXIN; CD11B ANTIGEN; CD18 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; INTEGRIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERTUSSIS TOXIN;

AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BORDETELLA PERTUSSIS; CATALYSIS; CELL MEMBRANE; CELLULAR IMMUNITY; CONFERENCE PAPER; CYTOSOL; DENDRITIC CELL; DETOXIFICATION; GENETIC ENGINEERING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TARGET CELL;

EID: 2442712765     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00291     Document Type: Conference Paper

References (34)

1. Ballard, J. D., Collier, R. J., Starnbach, M. N.: Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc. Natl. Acad. Sci. USA 93, 12531-12534 (1996).
2. Barry, E. M., Weiss, A. A., Ehrmann, I. E., Gray, M. C., Hewlett, E. L., Goodwin, M. S.: Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, CyaC, for activation. J. Bacteriol. 173, 720-726 (1991).
3. Basar, T., Havlicek, V., Bezouskova, S., Halada, P., Hackett, M., Sebo, P.: The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status. J. Biol. Chem. 274, 10777-10783 (1999).
4. Basar, T., Havlicek, V., Bezouskova, S., Hackett, M., Sebo, P.: Acylation of lysine 983 is sufficient for toxin activity of Bordetella pertussis adenylate cyclase. Substitutions of alanine 140 modulate acylation site selectivity of the toxin acyltransferase CyaC. J. Biol. Chem. 276, 348-354 (2001).
5. El-Azami-El-Idrissi, M., Ladant, D., Leclerc, C.: The adenylate cyclase of Bordetella pertussis: a vector to target antigen presenting cells. Toxicon 40, 1661-1665 (2002).
6. El-Azami-El-Idrissi, M., Bauche, C., Loucka, J., Osicka, R., Sebo, P., Ladant, D., Leclerc, C.: Interaction of Bordetella adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the integrin interaction domain. J. Biol. Chem. 278, 38514-38521 (2003).
7. + T cell epitopes. J. Immunol. 156, 4697-4706 (1996).
8. Fayolle, C., Ladant, D., Karimova, G., Ullmann A., Leclerc, C.: Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope. J. Immunol. 162, 4157-4162 (1999).
9. Fayolle, C., Osickova, A., Osicka, R., Henry, T., Rojas, M. J., Saron, M. F., Sebo, P., Leclerc, C.: Delivery of multiple epitopes by recombinant detoxified adenylate cyclase of Bordetella pertusis induces protective antiviral immunity. J. Virol. 75, 7330-7338 (2001).
10. Gmira, S., Karimova, G., Ladant, D.: Characterization of recombinant Bordetella pertussis adenylate cyclase toxins carrying passenger proteins. Res. Microbiol. 152, 889-900 (2001).
11. Goletz, T. J., Klimpel, K. R., Leppla, S. H., Keith, J. M., Berzofsky, J. A.: Delivery of antigens to the MHC class I pathway using bacterial toxins. Hum. Immunol. 54, 129-136 (1997).
12. Goodwin, M. S., Weiss, A. A.: Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice. Infect. Immun. 58, 3445-3447 (1990).
13. Guermonprez, P., Ladant, D., Karimova, G., Ullmann, A., Leclerc, C.: Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway. J. Immunol. 162, 1910-1916 (1999).
14. Guermonprez, P., Khelef, N., Blouin, E., Rieu, P., Ricciardi-Castagnoli, P., Guiso, N., Ladant, D., Leclerc C.: The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18). J. Exp. Med. 193, 1035-1044 (2001).
15. high dendritic cells. Eur. J. Immunol. 32, 3071-3081 (2002).
16. Hackett, M., Guo, L., Shabanowitz, J., Hunt, D. F., Hewlett E. L.: Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis. Science 266, 433-435 (1994).
17. Hackett, M., Walker, C. B., Guo, L., Gray, M. C., Van Cuyk, S., Ullmann, A., Shabanowitz, J., Hunt, D. F., Hewlett, E. L., Sebo, P.: Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli. J. Biol. Chem. 270, 20250-20253 (1995).
18. Haicheur, N., Bismuth, E., Bosset, S., Adotevi, O., Warnier, G., Lacabanne, V., Regnault, A., Desaymard, C., Amigorena, S., Ricciardi-Castagnoli, P., Goud, B., Fridman, W. H., Johannes, L., Tartour E.: The B subunit of Shiga toxin fused to a tumor antigen elicits CTL and targets dendritic cells to allow MHC class I-restricted presentation of peptides derived from exogenous antigens. J. Immunol. 165, 3301-3308 (2000).
19. Harvill, E. T., Cotter, P. A., Yuk, M. H., Miller, J. F.: Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity. Infect. Immun. 67, 1493-1500 (1999).
20. Hwang, Y. K., Kim, N. K., Park, J. M., Lee, K., Han, W. K., Kim, H. I., Cheong, H. S.: HLA-A2 1 restricted peptides from the HBx antigen induce specific CTL responses in vitro and in vivo. Vaccine 20, 3770-3777 (2002).
21. Karimova, G., Fayolle, C., Gmira, S., Ullmann, A., Leclerc, C., Ladant, D.: Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: implication for the in vivo delivery of CD8(+) T cell epitopes into antigen-presenting cells. Proc. Natl. Acad. Sci. USA 95, 12532-12537 (1998).
22. Kaufmann, S. H.: Immunity to intracellular bacteria. Annu. Rev. Immunol. 11, 129-163 (1993).
23. Khelef, N., Sakamoto, H., Guiso, N.: Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection. Microb. Pathog. 12, 227-235 (1992).
24. Khusmith, S., Sedegah, M., Hoffman, S. L.: Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+cytotoxic T-cell clone recognizing sporozoite surface protein 2. Infect. Immun. 62, 2979-2983 (1994).
25. Ladant, D., Glaser, P., Ullmann, A.: Insertional mutagenesis of Bordetella pertussis adenylate cyclase. J. Biol. Chem. 267, 2244-2250 (1992).
26. Ladant, D., Ullmann, A.: Bordetella pertussis adenylate cyclase: a toxin with multiple talents. Trends Microbiol. 7, 172-176 (1999).
27. +-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase. Infect. Immun. 70, 1002-1005 (2002).
28. Melief, C. J., Van Der Burg, S. H., Toes, R. E., Ossendorp, F., Offringa, R.: Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes. Immunol. Rev. 188, 177-182 (2002).
29. Osicka, R., Osickova, A., Basar, T., Guermonprez, P., Rojas, M., Leclerc, C., Sebo, P.: Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites. Infect. Immun. 68, 247-256 (2000).
30. Osickova, A., Osicka, R., Maier, E., Benz, R., Sebo, P.: An amphipathic alpha-helix including glutamates 509 and 516 is crucial for membrane translocation of adenylate cyclase toxin and modulates formation and cation selectivity of its membrane channels. J. Biol. Chem. 274, 37644-37650 (1999).
31. Otero, A. S., Yi, X., Gray, M. C., Szabo, G., Hewlett, E. L.: Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin. J. Biol. Chem. 270, 9695-9697 (1995).
32. Saron, M. F., Fayolle, C., Sebo, P., Ladant, D., Ullmann, A., Leclerc, C.: Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+T cell epitope from lymphocytic choriomeningitis virus. Proc. Natl. Acad. Sci. USA 94, 3314-3319 (1997).
33. + cytotoxic T cells. Infect. Immun. 63, 3851-3857 (1995).
34. Tartour, E., Benchetrit, F., Haicheur, N., Adotevi, O., Fridman, W. H.: Synthetic and natural non-live vectors: rational for their clinical development in cancer vaccine protocols. Vaccine 20, Suppl. 4, A 32-39 (2002).