Delivery of CD8+ T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: Delineation of cell invasive structures and permissive insertion sites

Infection and Immunity

Volumn 68, Issue 1, 2000, Pages 247-256

  Osička, Radim ^a   Osičková, Adriana ^a   Basar, Tümay ^a   Guermonprez, Pierre ^b   Rojas, Marie ^b   Leclerc, Claude ^b   Šebo, Peter ^a,c  

^a INSTITUTE OF MATHEMATICS   (Czech Republic)

^b INSTITUT PASTEUR   (France)

^c INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BACTERIAL ENZYME; BACTERIAL TOXIN; CD8 ANTIGEN; EPITOPE; HEMOLYSIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN;

ANTIGEN PRESENTING CELL; ARTICLE; BORDETELLA PERTUSSIS; DNA SEQUENCE; ESCHERICHIA COLI; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0342905401     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.68.1.247-256.2000     Document Type: Article

References (39)

1. Barry, E. M., A. A. Weiss, I. E. Ehrmann, M. C. Gray, E. L. Hewlett, and M. St. Mary Goodwin. 1991. Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation. J. Bacteriol. 173:720-726.
2. Basar, T., V. Havlíček, S. Bezoušková, P. Halada, M. Hackett, and P. Šebo. 1999. The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase toxin is crucial for toxin function independently of its acylation status. J. Biol. Chem. 274:10777-10783.
3. Bejerano, M., M. Nisan, A. Ludwig, W. Goebel, and E. Hanski. 1999. Characterization of the C-terminal domain essential for toxic activity of adenylate cyclase toxin. Mol. Microbiol. 31:381-392.
4. Bellalou. J., D. Ladant, and H. Sakamoto. 1990. Synthesis and secretion of Bordetella pertussis adenylate cyclase as a 200-kilodalton protein. Infect. Immun. 58:1195-2000.
5. Bellalou, J., H. Sakamoto, D. Ladant, C. Geoffroy, and A. Ullmann. 1990. Deletions affecting hemolytic and toxin activities of Bordetella pertussis adenylate cyclase. Infect. Immun. 58:3242-3247.
6. Benz, R., E. Maier, D. Ladant, A. Ullmann, and P. Šebo. 1994. Adenylate cyclase toxin (CyaA) of Bordetella pertussis: evidence for the formation of small ion-permeable channels and comparison with HlyA of Escherichia coli. J. Biol. Chem. 269:27231-27239.
7. Betsou, F., P. Šebo, and N. Guiso. 1993. CyaC-mediated activation is important not only for toxic but also for protective activities of Burdetella pertussis adenylate cyclase-hemolysin. Infect. Immun. 61:3583-3589.
8. Bottomly, K., L. Davis, and P. Lipsky. 1991. Measurement of human and murine interleukin 2 and interleukin 4, p. 6.3.1. In A. M. Kruisbeck, J. E. Coligan, D. H. Margulis, E. M. Shevach, and W. Strober (ed.), Current protocols in immunology. Wiley, New York, N.Y.
9. Confer, D. L., and J. W. Eaton. 1982. Phagocyte impotence caused by an invasive bacterial adenylate cyclase. Science 217:948-950.
10. Coote, J. G. 1992. Structural and functional relationships among the RTX toxin determinants of Gram-negative bacteria. FEMS Microbiol. Rev. 88: 137-162.
11. Fayolle, C., D. Ladant, G. Karimova, A. Ullmann, and C. Leclerc. 1999. Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase toxins carrying acytatoxic T cell epitope. J. Immunol. 162:4157-4162.
12. + T cell epitopes. J. Immunol. 156:4697-4706.
13. Glaser, P., D. Ladant, O. Sezer, F. Pichol, A. Ullmann, and A. Danchin. 1988. The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli. Mol. Microbiol. 2:19-30.
14. Gordon, V. M., W. W. Young, Jr., S. M. Lechler, M. C. Gray, S. H. Leppla, and E. L. Hewlett. 1989. Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells. J. Biol. Chem. 264:14792-14796.
15. + efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin. J. Biol. Chem. 273:18260-18267.
16. Guermonprez, P., D. Ladant, G. Karimova, A. Ullmann, and C. Leclerc. 1999. Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway. J. Immunol. 162:1910-1916.
17. Hackett, M., L. Guo, J. Shabanowitz, D. F. Hunt, and E. L. Hewlett. 1994. Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis. Science 266:433-435.
18. Hackett, M., C. B. Walker, L. Guo, M. C. Gray, C. S. Van, A. Ullmann, J. Shabanowitz, D. F. Hunt, E. L. Hewlett, and P. Šebo. 1995. Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli. J. Biol. Chem. 270:20250-20253.
19. Hewlett, E. L., L. Gray, M. Allietta, I. E. Ehrmann, V. M. Gordon, and M. C. Gray. 1991. Adenylate cyclase toxin from Bordetella pertussis. Conformational change associated with toxin activity. J. Biol. Chem. 266:17503-17508.
20. Iwaki, M., A. Ullmann, and P. Šebo. 1995. Identification by in vitro complementation of regions required for cell-invasive activity of Bordetella pertussis adenylate cyclase toxin. Mol. Microbiol. 17:1015-1024.
21. Karttunen, J., S. Sanderson, and N. Shastri. 1992. Detection of rare antigen-presenting cells by the lacZ T cell activation assay suggests an expression cloning strategy for T cell antigens. Proc. Natl. Acad. Sci. USA 89:6020-6024.
22. Ladant, D. 1988. Interaction of Bordetella pertussis adenylate cyclase with calmodulin: identification of two separated calmodulin-binding domains. J. Biol. Chem. 263:2612-2618.
23. Ladant, D., P. Glaser, and A. Ullmann. 1992. Insertional mutagenesis of Bordetella pertussis adenylate cyclase. J. Biol. Chem. 267:2244-2250.
24. Ladant, D., S. Michelson, R. S. Sarfati, A.-M. Gilles, R. Predeleanu, and O. Bârzu. 1989. Characterization of the calmodulin-binding and of the catalytic domains of Bordetella pertussis adenylate cyclase. J. Biol. Chem. 264:4015-4020.
25. Mackman, N., J.-M. Nicaud, L. Gray, and I. B. Holland. 1985. Genetical and functional organisation of the Escherichia coli haemolysin determinant 2001. Mol. Gen. Genet. 201:282-288.
26. Mock, M., and A. Ullmann. 1993. Calmodulin-activated bacterial adenylate cyclases as virulence factors. Trends Microbiol. 1:187-192.
27. Osičková, A., et al. J. Biol. Chem., in press.
28. Rogel, A., and E. Hanski. 1992. Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocyles. Translocation of the toxin across the membrane. J. Biol. Chem. 267:22599-22605.
29. Rogel, A., R. Meller, and E. Hanski. 1991. Adenylate cyclase toxin from Bordetella pertussis. The relationship between induction of cAMP and hemolysis. J. Biol. Chem. 266:3154-3161.
30. Rose, T., P. Šebo, J. Bellalou, and D. Ladant. 1995 Interaction of calcium with Bordetella pertussis adenylate cyclase toxin. Characterization of multiple calcium-binding sites and calcium-induced conformational changes. J. Biol. Chem. 270:26370-26376.
31. Sakamoto, H., J. Bellalou, P. Šebo, and D. Ladant. 1992. Bordetella pertussis adenylate cyclase toxin. Structural and functional independence of the catalytic and hemolytic activities. J. Biol. Chem. 267:13598-13602.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
33. Saron, M. F., C. Fayolle, P. Šebo, D. Ladant, A. Ullmann, and C. Leclerc. 1997. Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus. Proc. Natl. Acad. Sci. USA 94:3314-3319.
34. + cytotoxic T cells. Infect. Immun. 63:3851-3857.
35. Šebo, P., P. Glaser, H. Sakamoto, and A. Ullmann. 1991. High-level synthesis of active adenylate cyclase toxin of Bordetella pertussis in a reconstructed Escherichia coli system. Gene 104:19-24.
36. Šebo, P., and D. Ladant. 1993. Repeat sequences in the Bordetella pertussis adenylate cyclase toxin can be recognized as alternative carboxy-proximal secretion signals by the Escherichia coli alpha-haemolysin translocator. Mol. Microbiol. 9:999-1009.
37. Szabo, G., M. C. Gray, and E. L. Hewlett. 1994. Adenylate cyclase toxin from Bordetella pertussis produces ion conductance across artificial lipid bilayers in a calcium and polarity-dependent manner. J. Biol. Chem. 269:22496-22499.
38. Tabor, S., and C. Richardson. 1985. A bacteriophage T7 RNA polymerase/ promoter system for controlled exclusive expression of genes. Proc. Natl. Acad. Sci. USA 82:1074-1078.
39. Welch, R. A. 1991. Pore-forming cytolysins of gram-negative bacteria. Mol. Microbiol. 5:521-528.